A study of 388 patients found that recipient diagnosis, not donor age or tissue preservation methods, is associated with corneal transplant failure. Transplant recipients with keratoconus had a lower risk of graft failure than those with endothelial dysfunction.
Researchers have developed a new web-based application called Supramap that maps genetic mutations of pathogens onto the globe. The tool uses geographic information to track the spread of diseases across time and space, predicting hotspots of disease reemergence.
Research found that IL-8 and MIF gene polymorphisms significantly increased the risk of severe atrophic gastritis and intestinal metaplasia, particularly when H. pylori infection was present. This study provides a basis for therapeutic decisions, such as H. pylori eradication therapy, to prevent gastric cancer progression.
Richards' work on deep-Earth research led to a better understanding of the Earth's inner-core rotation and the detection of seismic waves. He also applied seismological methods to study nuclear weapon test explosions and their implications in politics and science.
A new LSU study reveals that increased Latino employment in low-skill jobs has displaced blacks from labor markets, leading to higher murder rates in urban black communities. The research attributes this trend to US immigration policies over several decades.
An international team of researchers has discovered a four-protein complex that promotes breast cancer metastasis. The complex, involving Myc, Skp2, Miz1, and p300, is a key regulator of RhoA gene expression. Targeting this complex could lead to the development of new drugs to thwart breast cancer migration and invasion.
Researchers have discovered three new genes associated with age-related macular degeneration, including two involved in the cholesterol pathway. The study increases understanding of DNA variations that predict individual risks of AMD and provides clues for developing effective therapies.
Researchers confirm that early treatment for selected infants with retinopathy of prematurity (ROP) improves their vision through 6 years of age. Doctors can identify high-risk infants by examining certain eye characteristics, such as blood vessel appearance and location.
Art Frankel led a team to update national seismic hazard maps, vastly improving public policy and building codes across the US. The new maps were used directly in building codes, enhancing earthquake safety nationwide.
Gastric bypass surgery has become increasingly common, but follow-up care is crucial for patient success. Registered dietitians can assess, monitor, and counsel patients to improve adherence and reduce nutrient deficiencies.
Operation Mend provides life-changing surgeries to military personnel severely injured in Iraq and Afghanistan. The program also offers treatment for post-traumatic stress and traumatic brain injuries, as well as patient support and family accommodations.
Children with more body fat and less endurance have stiffer arteries than their fitter counterparts, according to new research. The study found that identifying these children early could help prevent cardiovascular disease and diabetes.
Research papers published in Geophysical Research Letters reveal changing precipitation patterns in Europe, increased gully activity on Mars indicating liquid water, and thick water ice observed in lunar craters near the Moon's north pole. These findings suggest potential impacts on flooding and climate change.
New strains of Salmonella are emerging in HIV-infected individuals in Africa, causing severe disease by invading blood and bone marrow cells. These multi-drug resistant strains can lead to death in one in four cases due to the loss of immune cells in HIV patients.
The study found that Poly-ICLC treatment increased lung bacterial load and damage in mice infected with Mycobacterium tuberculosis. This was attributed to the recruitment of myeloid immune cells, which supported bacterial growth and exacerbated lung damage.
Researchers have discovered that targeting the blood-brain barrier can slow the accumulation of a protein associated with Alzheimer's disease. The study shows that activating a certain receptor in the brain can increase the expression of a blood-brain barrier protein that transports beta-amyloid out of the brain.
Researchers discovered that specific inflammasome components protect against colitis and cancer in mice. Mice lacking these components developed more severe colitis and larger tumor burdens, highlighting the complex role of inflammasomes in human disease.
The American Academy of Neurology has issued a guideline to help determine when people with Alzheimer's disease or another type of dementia should stop driving. The guideline recommends doctors use the Clinical Dementia Rating (CDR) scale to identify individuals at increased risk of unsafe driving. Caregivers and family members can als...
Researchers found that larvae of a new species, Ctenopelta porifera, traveled over 300 kilometers from a nearby population to settle in the affected area. The discovery challenges the widely accepted assumption that life re-populates an area through local adult populations.
A 10-year population-based study found significant declines in hospital admissions for heart attacks, angina, stroke, asthma, emphysema, pneumonia, and bronchitis after the implementation of smoke-free legislation in Toronto, Canada. The largest decline was observed after the 2001 ban on smoking in restaurants.
A new study suggests that the first Americans were better equipped to handle the challenges of the Younger Dryas period, which saw a rapid return to glacial conditions. The researchers found that cooling temperatures and environmental changes did not pose significant adaptive challenges to Paleoindian groups.
A study published in Psychological Science found that people who have a stronger association between death and self are more likely to attempt suicide. This association can be measured using an Implicit Association Test (IAT), which may provide a new tool for identifying and predicting clinical behaviors that are not reported verbally.
Researchers have invented a 'smart' insulin protein molecule that binds less to cancer receptors and self-assembles under the skin. This new form of insulin reduces the risk of cancer associated with obesity and excess insulin in Type-2 diabetes patients.
A new study by University of Iowa researchers found that individuals with amnesia retain emotional responses to happy and sad movie clips, even when they cannot recall the content. This challenges traditional views on memory loss and highlights the importance of caring for patients with Alzheimer's disease.
Severe adverse effects, such as burns and scarring, have been reported from untrained laser hair removal operators. The Canadian Medical Association Journal recommends setting minimum training standards for operators to ensure safe and effective procedures.
A study published in Canadian Medical Association Journal found no scientific evidence to support the claim that smoking in cars is 23 times more toxic than in other indoor environments. The 23 times estimate originated from a media report and has been widely cited, but its lack of basis in fact poses credibility issues.
Researchers at UTHealth are developing new strategies to derive hematopoietic stem cells from pluripotent stem cells, which could potentially treat blood diseases. Additionally, they are exploring gene-corrected induced pluripotent stem cells for treating two pediatric lung diseases, Surfactant Protein B Deficiency and Cystic Fibrosis.
A study demonstrated the transfer of maternal thyroid hormones to the fetus in vivo, critical for fetal development. This finding clarifies indirect evidence of maternal thyroid hormone passage to the fetus during pregnancy, with significant implications for the development of the nervous system and overall quality of life.
Research on the Devon Island ice cap shows a steady decline in ice volume and area since 1985, primarily due to warmer summers. The ice cap's thinning also exposes dark soil, increasing melt rates and posing concerns for shipping and sea level rise.
Researchers solve the decade-old mystery of fragile human embryonic stem cells by discovering two novel synthetic small molecule drugs that promote cell survival. The team also unravels the mechanisms behind e-cadherin's role in cell signaling, providing a new understanding of stem cell biology and paving the way for potential therapies.
A University of Illinois study found that a specific omega-6 fatty acid is critical for maintaining healthy skin. Without this acid, mice developed severe ulcerative dermatitis, which was reversed when the acid was added to their diet.
A recent survey of women undergoing gynecologic surgery found that most were not concerned about the effects on their sex lives, despite 37% expressing worries about reduced desire after sterilization. Hormone levels are not affected by these procedures.
Certain children with Type 1 retinopathy of prematurity benefit from early treatment, showing improved vision at age 6. In contrast, those with Type 2 disease do not see a significant benefit from early treatment at this age.
A new study based on women's self-reports suggests that many who live with chronic psychological abuse still see certain positive traits in their abusers, such as dependability and being affectionate. The study found that over half of the surveyed women (54%) saw their partners as highly dependable.
A new study found that just one pulse of artificial light at night damages circadian cell division, a key process affected in cancer. The research reveals changes in gene expression, including genes connected to cancer formation and anti-cancer defense.
African-American male youths are disproportionately represented in US prisons due to early-life conditions and educational system limitations. Implementing practices like parental engagement, teaching motor skills, and community mentorship can help counteract these challenges and promote a sense of acceptance and responsibility.
Researchers developed an experimental imaging technique using gold-silver nanocages to detect hollow nanocages and solid nanoparticles in the bloodstream, enabling clear images without background fluorescence. This method shows improved performance with higher contrast and brightness than conventional fluorescent dyes.
A Stanford University School of Medicine and Lucile Packard Children's Hospital study found that many patients with severe eating disorders are misdiagnosed due to restrictive diagnostic criteria. The study indicates that patients who barely meet the full diagnostic criteria for anorexia or bulimia may be just as sick, highlighting the...
Consuming foods with high glycemic index increases the risk of coronary heart disease in women due to higher levels of blood glucose and triglycerides. A study found that a diet rich in high-glycemic index carbohydrates, rather than overall carbohydrate intake, is associated with greater risk of heart disease in women.
A study published in Pediatrics found that adolescent drinking increases the risk of benign breast disease, a precursor to breast cancer. The study, which followed over 6,900 girls aged 9-15, showed that girls who drank more frequently had higher rates of benign breast disease.
A Purdue University study shows that grinding switchgrass into fine bits to improve its flowability is unnecessary, as it doesn't change the morphological characteristics important for flow. By milling switchgrass through a 6.4 mm screen, processors can save energy and money
A study found that individuals with Alzheimer's disease experience lean mass loss, which is associated with decreased brain volume and cognitive performance. This loss of muscle mass may be an early indicator of the progression of dementia, highlighting its potential as a sensitive measure for changes in body composition.
UCLA researchers have made a direct recording of mirror neurons in the human brain, showing they are more widely distributed than previously thought. The study found that specific subsets of mirror cells increased activity during action execution but decreased it when observing an action.
A study of 740 medical interns found that those with long work hours, medical errors, and a history of major depression were more likely to develop depressive symptoms. The study also identified a genetic variant associated with an increased risk of depression in high-stress situations.
Scientists discover that a small genetic change controls the response to pheromones in moths, allowing males to find female mates of their own species. This finding sheds light on the evolution of sexual communication and speciation in moths.
Researchers at the Salk Institute found that direct interactions between amino acids and nucleotide triplet anticodons helped establish matching pairs, leading to the modern genetic code. The study provides the first in vivo data shedding light on the origin and evolution of the genetic code.
A new endoscopic scanning technique called EPSS has been developed to detect dysplasia in Barrett's esophagus, a precursor to esophageal cancer. The technique uses polarized light scattering spectroscopy to identify cellular changes on a subcellular scale, enabling early detection and potentially improving treatment outcomes.
The University of Arizona Superfund Research Program will receive $14 million to investigate metal-laden dust, water contamination and their health effects. The program aims to minimize mine dust and water leachate, stabilize arsenic residuals, and monitor pollutant distribution in air and water.
Researchers discovered breast stem cells are exquisitely sensitive to oestrogen and progesterone, a finding that explains decades of evidence linking breast cancer risk to exposure to female hormones. The discovery also revealed the RANK ligand pathway is responsible for indirect control of breast stem cells in pregnancy.
Bacteria recognize and develop resistance to vancomycin through a specific sensing mechanism. The discovery provides new understanding of the molecular basis of vancomycin resistance and represents an essential first step in developing new antibiotics that can evade bacterial sensing mechanisms.
Researchers at MIT and Harvard developed a new sensor to measure the rate of cell mass accumulation, finding that individual cells exhibit varying growth rates. The discovery sheds light on how cells control their growth, with implications for understanding cancer development.
A team of MIT researchers has developed a novel method to mimic photosynthesis by splitting water into oxygen and hydrogen atoms using modified viruses as biological scaffolding. This process can be powered directly by sunlight, skipping intermediate steps, and shows fourfold improvement in efficiency.
A new method has been developed to identify genetic mutations in active genes, enabling studies of disease effects and improving diagnostic accuracy. This technique allows researchers to study specific cellular processes and identify minority cells in tissue samples.
The Kavli Institute at Cornell is shifting its focus from a think tank to a proving ground for pushing the limits of nanotechnology. Under new leadership, it will fund projects and researchers to create novel instruments and tools for next-generation microscopies and optoelectronic nanocharacterization.
A study by Einstein researchers suggests that a mutated protein accumulation may be key to understanding the disease. The defective huntingtin protein interferes with cellular autophagy, leading to toxicity and cell death.
The global maternal mortality ratio declined from 422 in 1980 to 320 in 1990 and 251 in 2008, with developing countries making significant progress. The study found that HIV accounts for nearly one out of every five maternal deaths, with six countries accounting for more than half of all maternal deaths.
Researchers at the University of North Carolina have discovered that the Ku protein plays a crucial role in repairing damaged DNA strands. This breakthrough has significant implications for understanding the development of cancer and other age-related diseases.
This BSSA tip sheet documents the long history of earthquake monitoring by the Southern California Seismic Network (SCSN), detailing its evolving sensitivity over time. Researchers also examine the predictive capability of models to estimate ground shaking during large earthquakes in the San Francisco Bay Area.
Scientists at University of Western Ontario discovered a biological link between stress, anxiety, and depression by identifying the connecting mechanism in the brain. A small molecule inhibitor was developed to selectively target depression and treat it more effectively.
Scientists propose general rules governing the assembly of filaments into thicker and twisted ribbon-like fibers using Atomic Force Microscopy images and polymer physics concepts. The model accurately predicts the formation of Amyloid fibers, with potential applications in understanding neurodegenerative diseases.