A new TB vaccine candidate called AERAS-422 is undergoing clinical trials to evaluate its safety and immunogenicity. The vaccine aims to interrupt TB at all stages of infection, including initial infection, latency, and reactivation.
Researchers at the University of Nevada, Reno have demonstrated a successful method for transforming wastewater sludge into electrical power. The process uses an innovative fluidized bed system to produce a solid fuel that can be used to generate electricity.
Researchers Tali Sharot and Cristina M. Velasquez improved on a previous experimental design to test subliminal decision making. The study found that participants' evaluations of chosen destinations increased after blind choice, suggesting a psychological mechanism to reduce tension from rejecting alternatives.
A research team led by Edward Yu has discovered the crystal structures of pumps that remove heavy metal toxins from bacteria, allowing them to resist antibiotics. This finding provides a better understanding of bacterial resistance and could help drug researchers develop treatments to combat it.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a new cell signaling pathway that controls cell growth and development. This pathway, part of a global DNA damage response, turns off 136 genes that can promote aberrant cell division and cancer.
Researchers have identified a specific gene circuit that acts as a 'switch' to tell cells when to divide. This discovery may help scientists better understand cell biology and establish a library of cancer-causing pathways.
A team of researchers has identified a gene, MTHFD1L, that appears to increase the risk of developing late-onset Alzheimer's disease. The study found individuals with the variation may be nearly twice as likely to develop the disease compared to those without the variation.
A study published in the American Journal of Public Health found that increasing taxes on alcoholic beverages significantly reduces disease, injury, crime, and death rates. Doubling state alcohol taxes could lead to a 35% reduction in mortality, as well as decreases in STDs, violence, and crime.
A study published by a CU-led team reveals that three genes in jawless vertebrates may have been key to the development of jaws in higher vertebrates. The findings suggest that creating a jaw in a jawless ancestor was a relatively simple matter of altering when and where these few genes are used.
A new, less expensive catalyst for hydrogen purification has been discovered using platinum on standard support metal oxides. The research team developed a platinum-based catalyst that is highly active and stable at low temperatures, reducing the need for rare-earth elements like cerium.
Rensselaer researchers discovered that delayed communication in networks can lead to a decline in performance, even if initial coordination is increased. The study's findings have implications for various network systems, including computer networks and social media.
A pilot study revealed that patients prefer a robotic arm with manual mode, which requires more thought and interaction, despite performing tasks less well in this mode. The researchers aim to develop a hybrid model with an adaptive interface for individualized use.
A new study reveals that immune cells directly interact with and damage neurons in multiple sclerosis, leading to inflammation and neuronal injury. The findings suggest a potential therapeutic target for treating the incurable disease, by modulating calcium levels within neurons.
Researchers successfully recreated the conditions deep in the Earth's mantle to study the behavior of post-perovskite, a mineral that helps explain faster seismic waves. The discovery provides new insights into the earth's internal heating and cooling processes.
A new material, a potential ingredient for microbicides, dramatically lowers HIV infection rates by targeting the mediator between the virus and cells. The coating molecule blocks SEVI's interactions with both the virus and immune cells, preventing at least one way for HIV to attach.
A genetic variant reducing disease susceptibility is more prevalent in urban populations, suggesting exposure to TB led to its evolution. The study analyzed DNA samples from 17 populations across Europe, Asia, and Africa, revealing a link between city history and genetic resistance.
Researchers at The Walter and Eliza Hall Institute have discovered a new pathway used by malaria parasites to infect human cells, providing a potential vaccine target. Blocking both the glycophorin and CR1 pathways results in a 90% decrease in parasite infection, suggesting an effective vaccine could significantly reduce malaria cases.
Researchers found that long noncoding RNA MALAT1 plays a key role in regulating pre-mRNA splicing, a critical step in protein production. This study suggests that MALAT1's regulation of splicing factors may contribute to cancer development.
Researchers at Caltech have developed a new type of material made out of silicon that could lead to more efficient thermoelectric devices. The material is composed of a thin film with a grid-like arrangement of tiny holes, which slows down phonons and lowers its thermal conductivity.
A study found that malnutrition and inflammation status are key to understanding the effects of high cholesterol on kidney disease patients. Patients with malnutrition and/or inflammation had an inverse relationship between cholesterol levels and cardiovascular events, unlike those without these conditions.
Scientists at IRB Barcelona discover that raltegravir cancels function of essential protein in herpesvirus replication, offering potential target for new drug development. Human cytomegalovirus, the most deadly and widespread herpes virus, shows vulnerability to raltegravir treatment.
A recent Editorial in The Lancet highlights the need for strong leadership and education to redefine surgery's role and extend its benefits to wider populations. Key findings include inadequate operating theatres, anaesthetic cover, and emergency care provision, as well as surgeons' absence from healthcare debates and positions of power.
Two new species of horned dinosaurs, Utahceratops gettyi and Kosmoceratops richardsoni, have been found in Grand Staircase-Escalante National Monument in southern Utah. The discovery provides insight into the biogenographic provinciality of Western North American dinosaur communities.
A new flood-mapping computer system is being developed to help emergency medical services crews navigate flooded roads in real-time. The system, led by UH Professor Gino Lim, will use color-coded maps to indicate the severity of flooding on major road segments.
Researchers at the University of Southern Mississippi have developed a new material that mimics cilia, allowing for control and potential use in sensing and monitoring applications. The material responds to various stimuli, enabling its application in detecting toxins, oxygen levels, or other environmental factors.
A study found that divisive primaries held after mid-April negatively impact incumbent general election performance, particularly those held close to the election. Challengers struggle to recover from primary battles due to limited time and resources.
Researchers at Van Andel Research Institute created a bioreactor to study shunt systems used in hydrocephalus treatment. The device helps prevent cells from blocking shunt catheters, potentially reducing complications and improving patient outcomes.
A University of Oklahoma research team has discovered a compound that can suppress the growth of pathogenic microbes and keep other oral microorganisms in check. This finding may lead to new treatments for thrush and related Candida infections.
A team of researchers at UC San Diego will study the impact of low oxygen levels on cells and tissue in the heart, lung, and brain. The study aims to understand molecular mechanisms that contribute to low oxygen tolerance or susceptibility in diseases such as stroke and pulmonary hypertension.
A study analyzing Canadian data shows a decline in breast cancer incidence among postmenopausal women as hormone therapy prescriptions fell. The decline, which coincided with a drop in hormone replacement therapy use, suggests that HRT may be linked to an increased risk of breast cancer.
Research from Utrecht University reveals that anger and sadness amplify pain equally in both women with and without fibromyalgia. The study also found that emotional sensitization of pain may be especially detrimental in people who already have high pain levels.
The study analyzed the impact of climate change on spotted hyena survival in Europe over 10,000 years ago. The researchers found that while climate change was a factor in the hyenas' disappearance, it was not the sole cause.
A study by LDI researchers found that vitamin C supplementation improved mood states in hospitalized patients, but had no effect on vitamin D levels. The treatment is simple, safe, and cheap, with major clinical practice implications.
The Magnetic Energy Recovery Switch (MERS) harnesses and recycles residual magnetic power to control electrical flow, significantly reducing lighting energy consumption by 39 percent. The technology has the potential to reduce the Navy's total energy consumption from alternative sources by 40% by 2020.
Two new studies reveal racial disparities in kidney disease among African Americans, including higher rates of kidney failure, premature death, and lower rates of living donor transplants. The findings emphasize the importance of addressing these disparities to improve health outcomes for this population.
Researchers from Ohio State University found that urban bird nests have lower nest survival rates due to human-provided food sources like trash cans and birdfeeders. Despite higher predator numbers in urban areas, these birds are less likely to be attacked because they can feed themselves.
Dr. Susanne Wetzel's NSF-funded research aims to develop protocols for secure, private, and fair collaboration without trusted third-party intervention. The project seeks to resolve the issue of policy reconciliation, allowing parties to collaborate while preserving their privacy.
Researchers successfully recreated the extreme conditions found at the Earth's core-mantle boundary, enabling them to study the behavior of a unique mineral called post-perovskite. This discovery sheds light on how seismic waves travel through this region and provides insights into Earth's internal heating and cooling processes.
A new study uses a novel imaging method to analyze underwater video of the well riser, affirming heightened estimates of the leak's volume and total oil escaped into the open ocean. The scientists estimate 4.4 million barrels were released, close to the government's recent consensus.
Scientists have found that global groundwater stocks are shrinking at an alarming rate, with the rate of depletion more than doubling between 1960 and 2000. This rapid loss of water could lead to severe consequences for a growing human population, including food insecurity and social unrest.
Successful carotid artery surgery halves the risk of stroke over the next 5 years and provides long-term benefit for up to 10 years. The procedure is recommended for asymptomatic patients under 75 years old who have narrowed neck arteries, as it significantly reduces the risk of disabling or fatal strokes.
The NIH will fund a five-year research initiative to identify and treat HIV-positive inmates in the US prison system. The goal is to reduce HIV transmission and improve public health by linking those in incarceration to antiretroviral therapy and medical care.
Researchers found that patients disenrolling from hospice care had nearly five times the healthcare costs of those remaining with hospice. This is due to increased hospitalizations and emergency department visits.
Two Elsevier medical titles, Color Atlas of Clinical Hematology and Kumar & Clark's Clinical Medicine, won first prize in their respective categories at the BMA Medical Book Competition. The awards recognize the quality and expertise in these medical texts.
A genome-wide association study has identified a gene, MTHFD1L, associated with an increased risk of late-onset Alzheimer's disease. Individuals with a particular variation in this gene may be twice as likely to develop the disease.
Researchers at the Walter and Eliza Hall Institute are investigating different aspects of parasite biology, with a focus on developing new treatments. Dr Chris Tonkin is studying Apicomplexan parasites to understand their invasion mechanisms and identify potential targets for drugs.
A Canadian Patient Safety Institute-led research team, led by Dr. Diane Doran and Dr. Régis Blais, has been awarded $1 million to investigate the safety risks of healthcare services provided in homes. The two-year study aims to improve patient safety outcomes in home care services.
Cardiovascular Innovation Institute researchers have received a $2.027 million grant from the National Institutes of Health to further develop an implantable pump for patients with single ventricle heart disease. The device has the potential to revolutionize treatment by reducing surgeries and improving survival rates.
Researchers found that adopting School-Wide Positive Behavioral Interventions and Supports (SWPBIS) significantly improved student behavior and academic achievement. The study, published in the Journal of Positive Behavior Interventions, showed that SWPBIS was effective in reducing suspensions and office discipline referrals in element...
A study by Columbia University's Mailman School of Public Health found that nearly all NYC public school students have access to convenient, energy-dense foods within a short walk. Small grocery stores and bodegas are common sources of unhealthy food, with higher concentrations near schools attended by low-income and minority students.
The Phase II study will establish the optimal dosing regimen and then be tested in Kenya, Mozambique, South Africa, and Uganda. The TB vaccine candidate has been shown to have an acceptable safety profile in early-stage clinical trials.
Researchers discover normal protein function, not cell buildup, causes muscle weakness and other symptoms of a rare neurodegenerative disease. The finding offers hope for treatment and a new model for understanding the mechanism at work in common nervous system disorders like Parkinson's and Alzheimer's diseases.
A pilot study has been funded to evaluate a new approach to weight loss and physical activity in people at increased cardiovascular risk. The Waste the Waist programme aims to encourage behaviour change through lifestyle modifications, targeting individuals who are at risk of developing diabetes and cardiovascular disease.
Researchers found that patients with occupations requiring high verbal skills had greater tissue loss on the right side of the brain, while those with low verbal skills had greater loss on the left. This effect was most pronounced in the temporal lobes of the brain.
Research suggests that periodontal disease may affect more American adults than previously estimated, with a potential 50% increase in prevalence. The study highlights the importance of maintaining good oral health and regular dental check-ups to prevent gum disease.
Scientists have detected gas escaping from Mercury using NASA satellites designed to view the Sun's atmosphere. The STEREO mission has recorded evidence of a 'tail' of emission surrounding the planet, similar to comet-like features observed on Earth and in images taken by the MESSENGER satellite.
A multicenter study published in the New England Journal of Medicine shows that transcatheter aortic-valve implantation resulted in significantly lower rates of death among patients who cannot undergo surgery. The procedure demonstrated safety and effectiveness for this life-threatening illness in unsuitable candidates.
A study by Penn State researcher Christopher Scheitle found that people who leave strict religious groups are more likely to report poorer health than those who remain in the group. The study analyzed data from over 30,000 cases and found that only about half of former members reported excellent health.
A new study from Örebro University suggests that smoking during pregnancy can harm a child's motor control and coordination, with boys potentially affected to a greater extent. The study, based on over 13,000 children, found that those whose mothers smoked at least nine cigarettes a day during pregnancy had difficulty completing physic...
A global consortium led by Carnegie Mellon aims to develop technology-based methods for measuring students' understanding of STEM coursework. The Measuring Learning Consortium, supported by HP Catalyst Initiative, will create a new breed of technology-enabled embedded assessments to measure STEM competencies.