Researchers at Brown University have created an unprecedentedly detailed description of a kinase complex, which could lead to new therapeutic drugs for diseases such as Alzheimer's and cancer. The team discovered a unique binding site, called KIS, that plays a crucial role in the complex's formation.
Climate change is expected to force sea creatures to migrate several hundred kilometres to find suitable habitats, driven by rising water temperatures and seasonal changes. This poses significant challenges for marine biodiversity hotspots and fisheries management.
A Scripps Research Institute scientist has successfully produced a simpler relative of Taxol called eudesmane and created a retrosynthesis pyramid to produce target compound. The researchers hope that the innovation will lead to understanding of nature's processes and develop more widely applicable techniques.
Researchers have identified two peptides that target an enzyme in cancerous cells, leading to a rise in tumor suppressor protein p53 levels and cell death. The discovery shows promise for new cancer treatments.
The ICRISAT-led team has completed the genome sequence of pigeonpea, a legume crop grown by millions of poor farmers worldwide. With this breakthrough, scientists can now identify genes for drought tolerance and improve crop productivity, tackling pests and disease constraints in production.
A recent HIV study has identified SAMHD1, a protein that prevents the virus from replicating in certain cells. The research provides a blueprint for designing new drugs to treat HIV infection.
Researchers at University of Toronto have made a significant breakthrough in understanding the alignment of energy levels in advanced materials, enabling more efficient organic solar cells and OLEDs. This discovery is crucial for developing sustainable technologies that can secure our energy future.
A study found that patients with juvenile idiopathic arthritis who responded well to etanercept treatment had lower disability scores, younger age at onset, and fewer disease-modifying antirheumatic drugs used before treatment. These factors are associated with a better long-term outcome.
A study used the Sleeping Beauty transposon system to profile genes driving colorectal cancer, identifying over 200 genes that can be disrupted. These findings provide strong evidence for driver mutations in human tumours and lay the foundation for more effective targeted treatments.
A new device combines optical frequency-domain imaging and near-infrared fluorescence to provide simultaneous structural and molecular images of internal arterial surfaces. This integrated approach can assess key factors linked to the risk of clot formation, enabling a 'stent checkup' for patients at risk.
Researchers at Uppsala University have examined the mechanism of gene transcription and found that genes active in the brain are transcribed with a special mechanism. During fetal development, there is a larger proportion of RNA molecules containing introns compared to fully developed brains.
Researchers discovered a novel microbe that produces methane, a potent greenhouse gas, in Arctic permafrost. The microbe's genome revealed genes for nitrogen fixation, making it a potentially key player in the Earth's carbon cycle.
A team of researchers at the University of Texas MD Anderson Cancer Center found that pyruvate kinase M2 (PKM2) has an unexpected role in regulating cell proliferation and tumor formation in brain cancer. PKM2's ability to bind to beta-catenin in the cell nucleus is essential for its function, and its levels are correlated with brain t...
Researchers at Northwestern University have developed a computational method to quickly identify metal-organic frameworks (MOFs) with high potential for natural gas storage. The new algorithm rapidly generates and tests hypothetical MOFs, leading to the discovery of over 300 promising structures.
A new study finds weak evidence supporting exercise referral schemes as a means of increasing physical activity and improving health outcomes in sedentary individuals. Despite the importance of physical activity, the study highlights the need for targeted and effective schemes to address the growing public health issue.