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Science News for October 2, 2011


La Jolla Institute discovers previously unknown cell interaction key in immune system attacks

Researchers at La Jolla Institute have identified a previously unknown molecular interaction between protein kinase C theta and CD28 that is essential for T lymphocyte activation. This discovery opens up a novel therapeutic avenue for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis by blocking the cellular inter...

SourceLa Jolla Institute for Immunology·JournalNature Immunology·DateOct 2, 2011

La Jolla Institute discovers novel mechanism for preventing infection via body's mucosal borders

Researchers at the La Jolla Institute identified a previously unknown mechanism generating protective immune memory cells to fight recurring infections at mucosal linings. This discovery could lead to the creation of new and more effective vaccines by triggering the newly identified mechanism, particularly for Listeria and HIV.

SourceLa Jolla Institute for Immunology·JournalNature Immunology·DateOct 2, 2011

Modeling cancer using ecological principles

A new study uses the Tilman model of competition between invasive species to understand how prostate cells invade bone marrow and take over the microenvironment. The research reveals that cancer cells follow a similar path to ecological invasions, highlighting the potential for ecological modeling to understand metastasis.

SourceBMC (BioMed Central)·JournalTheoretical Biology and Medical Modelling·DateOct 2, 2011