Researchers found PHF21A gene mutated in patients with Potocki-Shaffer syndrome, leading to malformations and intellectual disability. The gene plays a crucial role in neuron survival, and its suppression can lead to brain cell death.
Researchers developed a biomimetic strategy delivering clot-busting nanotherapeutics directly to obstructed blood vessels, dissolving blood clots while minimizing bleeding side effects. The approach has significant implications for treating major causes of death such as heart attack and stroke.
Researchers at UNC School of Medicine used injections of non-depleting antibodies to rapidly reverse the onset of Type I diabetes in mice. The treatment maintained disease remission indefinitely without harming the immune system, with some animals remaining free of diabetes after over 400 days.
A new study published in Perspectives on Psychological Science suggests that employees' interests are a stronger predictor of job performance than overall interest scores. The research found that those whose interest profiles matched their job profiles were more likely to perform well, help others, and stay with the company longer.
Researchers have successfully identified natural elemental fluorine in a special fluorite called 'fetid fluorite' or 'antozonite', which emits an intense odor when crushed. The discovery resolves a long-standing debate and provides insight into the properties of fluorine, a highly reactive element.
University of Oklahoma physicists collaborated with 1,700 U.S. scientists on the Higgs boson search project. The international effort resulted in the discovery of a new particle consistent with the Higgs boson.
Researchers found that whirlpools, or eddies, in the North Atlantic Ocean sustain phytoplankton growth, allowing them to thrive in shallower waters with ample sunlight. This discovery helps explain the timing and patchy appearance of the massive spring blooms.
A new study suggests that Mars Curiosity rover may be able to find evidence of ancient life on Mars by probing optimal depths and locations for organic molecules. The research indicates that the rover's drilling range could detect simple carbon-containing molecules within 10 cm beneath the surface.
Researchers found that climate change led to a collapse of coral reefs in the eastern Pacific for 40% of their total history, spanning 4,000 years. The study suggests that similar collapse could occur again due to current climate patterns.
A new CU-Boulder-led study reveals that rising nitrogen deposition is altering sensitive ecosystems in Rocky Mountain National Park. Plant communities are already showing changes under ambient conditions, with potential impacts on biodiversity and aquatic life.
Regular exercise has clear benefits for physical and mental health, making it a key factor in reducing mortality rates. Health professionals should consider exercise levels as a vital sign to provide more help for patients to adopt exercise regimes.
A recent Vanderbilt University Medical Center study has found that obesity is associated with a higher risk of acute kidney injury (AKI) following cardiac surgery. The study, which followed 455 cardiac surgery patients, found that a higher body mass index (BMI) was linked to a greater risk of AKI, with patients weighing more than avera...
Physicists at the Large Hadron Collider have observed a new particle, sparking hopes that it could be the elusive Higgs boson. The discovery is based on data collected in 2011 and 2012, with more analysis expected later this year.
A recent study found that women who believe in intensive parenting are more likely to experience stress, depression, and lower life satisfaction. Mothers who endorsed these attitudes had moderate levels of stress and depression, with approximately 23% showing symptoms of depression.
A study published in Journal of Biological Chemistry found that prostate cancer cells lacking the protein SPDEF are unable to establish colonies at possible sites of metastasis, highlighting a potential biomarker for untreated cancers. Researchers hope to regulate SPDEF expression to prevent cancer cell metastasis.
Researchers at Ohio State University found that the loss of microRNA-125b (miR-125b) shuts down normal cell metabolism and enables cancer cells to proliferate. The study reveals a new mechanism by which chronic lymphocytic leukemia (CLL) develops, providing potential targets for new drugs.
A UBC study found that witnesses of workplace bullying are more likely to want to leave their jobs than those who experience it firsthand. This highlights the significant impact of bullying on employees and organizations.
Researchers identified a protein called LIF as crucial for the growth of female iPS cells, which contain two copies of the X-chromosome. This discovery offers new insights into how iPS cells form and could lead to improved human models for studying disease and testing new drugs.
A team of researchers led by the University of Saskatchewan discovered that small volcanic eruptions can inject aerosols into the stratosphere, cooling the Earth's surface. The study used data from the Canadian Space Agency's OSIRIS instrument to analyze the effects of a 2011 eruption in Eritrea.
Tropical Storm Daniel formed off western Mexico's coast and strengthened into a tropical storm, with NASA's TRMM satellite capturing images of its rainfall and towering clouds. Research shows that a hot tower in the eyewall is twice as likely to intensify within six hours than without one.
A pooled analysis of 11 randomized clinical trials found that higher doses of vitamin D (above 800 IUs) significantly reduced the risk of fractures in older adults. In contrast, lower doses showed no benefit for fracture prevention.
Project 1640 has achieved unprecedented high-contrast imaging, revealing celestial objects 1 million to 10 million times fainter than the star at its center. The instrument can darken speckles far beyond any previous capability, effectively carving a dark square in the speckle background centered on the star.
Researchers in India have developed a system to detect and block cellphone use by drivers while driving. The technology, based on RFIDs, aims to reduce road traffic deaths by minimizing distractions caused by cell phone conversations.
Researchers from the UK and Hong Kong are working together on eight new projects exploring themes such as parenting styles, education, and global issues. The collaboration aims to drive research excellence through intensive interaction and promote scientific exchanges between the two countries.
A meta-analysis suggests that freezing all embryos for later transfer in a non-stimulated cycle may improve implantation and pregnancy rates, reducing the risk of ovarian hyperstimulation syndrome (OHSS) associated with fresh embryo transfers. The study found a relative risk of 1.31 for clinical pregnancies, with higher ongoing pregnan...
Dr. Markus Schubert from Helmholtz Association aims to investigate fluid dynamics in bubble column reactors using X-ray visualization. The goal is to optimize processes and systems for efficient conversion of desired products, saving resources and energy.
Researchers derived iPS cells from patients with genetic forms of Parkinson's and found common signs of distress in neurons, including abnormalities in mitochondria. The cells' responses to treatments depended on the type of Parkinson's each patient had.
Researchers at St. Michael's Hospital found that surgical residents trained in a simulated environment outperformed those with conventional training, scoring significantly higher on technical performance and multiple-choice tests. This innovative approach aims to reduce preventable medical errors and improve patient safety.
A joint study by Stefan Reichmuth and Reinhold Glei reveals the Koran's term 'dīn' changed meaning from 'law' to 'religion' in Latin translations, with implications for European understanding of Islam. This shift reflects a gradual development in Western philosophy, paralleling Judaism and Christianity.
Hermit crabs have an underdeveloped sense of smell compared to vinegar flies, but humidity enhances their olfactory system. They primarily respond to water-soluble polar odorants like acids and aldehydes.
A study published in the British Medical Journal found that simple exercises, such as turning head and nodding neck, reduced dizziness within weeks and improved quality of life for over a year. The researchers urge GPs to distribute exercise booklets to patients with persistent dizziness.
Researchers found that individuals prioritize reciprocity over network structure when deciding to cooperate. This challenges traditional theories on cooperation among individuals. The study, published in PNAS, used a social conflict prototype called the Prisoner's Dilemma and involved 1,200 Aragon secondary students.
Researchers at Stanford University School of Medicine have successfully sequenced a fetus's genome using only a maternal blood sample. The new approach, published in Nature, has significant implications for prenatal diagnosis and could bring genetic testing one step closer to routine clinical use.
Researchers identify a causal link between the oncometabolite metabolite2-hydroxyglutarate and the onset of acute myeloid leukemia. The study demonstrates how a metabolite can cause cancer, setting the stage for developing inhibitors to block the mutation.
New research establishes a link between postoperative delirium and prolonged loss of cognitive function in cardiac surgery patients. Interventions to prevent delirium may help cardiac patients avoid long-term cognitive consequences.
Researchers have developed a novel magnetic memory that can store information in the form of resistance variations. By applying an electric pulse, the metal-organic molecule can be switched between a conductive, magnetic state and a low-conductive, non-magnetic state.
The European Society of Human Reproduction and Embryology announces a breakthrough in fertility preservation, with Italy's first successful pregnancy and live birth after cryopreserving ovarian tissue. The technique has shown promising results, even after lengthy storage periods.
NTU hosts international students, top water experts, and Young Water Talents Symposium to share knowledge on sustainable water management. The university's five-year strategic plan focuses on sustainability research, with S$849 million dedicated to the field.
Researchers from A*STAR have identified a novel signalling pathway controlling both obesity and atherosclerosis in mice. The study found that Wip1-deficient mice were resistant to weight gain and atherosclerosis through increased autophagy, highlighting a potential new approach for treating these conditions. Further investigation into ...
Researchers at the University of Warwick discovered that strawberry extracts positively activate the Nrf2 protein, decreasing blood lipids and cholesterol levels. This activation reduces the risk of developing heart disease and diabetes by counteracting post-meal blood glucose and low-density lipoprotein.
The US Department of Energy supports the search for the Higgs particle through the Large Hadron Collider. Thousands of American scientists and graduate students contributed to this research.
A new clinical study by the National Heart, Lung, and Blood Institute found that eltrombopag improved blood cell production in 11 out of 25 participants with severe aplastic anemia. The drug was well-tolerated, with few side effects, and six patients showed significant improvements in all three types of blood cells.
A systematic analysis found that most developing countries have made limited progress towards halving childhood hunger by 2015. The study estimates that the global developing world has less than a 5% chance of meeting this target, with significant improvements seen in Asia and Latin America.
A study published in Nature found that a cloud of dust circling a young star disappeared within three years, contradicting the commonly accepted timescale for dust removal. This sudden disappearance suggests that planet formation may be much faster or more efficient than previously thought.
Scientists have discovered a 'constant cloud' of potent inflammatory molecules surrounding the cells responsible for diseases like thickening of the arteries and rheumatoid arthritis. Monocytes, a type of white blood cell, were found to be surrounded by this constant cloud, which was propelled through the cell wall by lysosomes.
The yak genome provides new insights into high-altitude adaptation, with distinct gene expansions related to sensory perception and energy metabolism. The study also identified genes that may play important roles in regulating body response to hypoxia and optimizing energy from poor foods.
Researchers used human parkour athletes to simulate orangutan movements and found that swaying is the most efficient way to cross trees. This finding helps explain why orangutans spend most of their lives in trees despite their large size and low-energy diet.
Researchers have identified the interfascicular matrix (IFM) as essential for tendon function, suggesting it may be critical in preventing tendon overuse injuries. The finding has significant implications for understanding and treating tendon disorders that cost the UK economy billions of pounds annually.
A policy of single embryo transfer (SET) has been associated with a reduction in overall perinatal mortality for IVF and ICSI babies. SET has also been linked to lower risks of preterm birth and low birth weight, as well as sequelae such as prematurity and neonatal complications.
Researchers reprogrammed asthma-promoting immune cells in mice, reducing airway damage and inflammation. The discovery identifies a potential target for new treatments of chronic inflammatory diseases.
New research suggests that normal cells within the tumor, part of the tumor microenvironment, may supply factors that help cancer cells grow and survive despite anti-cancer drugs. The study found that hepatocyte growth factor (HGF) is linked to BRAF inhibitor drug resistance in melanoma.
A study by University of Iowa researchers found that cystic fibrosis makes airways more acidic, reducing bacterial killing. Making the airway liquid less acidic with baking soda restores normal bacterial killing levels.
A study from the University of Leeds found that seabirds control when their young leave home through hormone levels corticosterone, not parental care. Chicks show a surge in this hormone 60 days before fledging, prompting parents to reduce food provisioning.
Researchers at the virtual Helmholtz Institute PolarTime are studying the inner clock of Antarctic krill to understand its impact on the marine ecosystem under climate change. They will investigate the principles and evolution of endogenous biological rhythms and clocks in pelagic organisms.
A new initiative establishes Online Identification Keys (OIK) as a derivative of Data Papers, facilitating interactive key construction and citation mechanism. MOSCHweb is a software platform that enables the creation of online keys, providing biologists and general users with benefits.
A new study published in The Lancet found that developing countries have made progress in reducing child malnutrition but still struggle to meet the UN's Millennium Development Goal target. The research analyzed data from over 7 million children worldwide and estimated that only 61 of 141 countries have a 50% chance of meeting the goal.
A new study by University of British Columbia researchers reveals substantial increases in plastic pollution along the northern Pacific coast, with 92.5% of beached northern fulmars found to contain plastics
Researchers at Harvard University have successfully created room-temperature quantum bits that can store information for nearly two seconds. This achievement is a significant step towards building a functional quantum computer and opens up new possibilities for various applications such as quantum cash and secure communications.
Food expert Kelly Brownell argues that government regulation is necessary to counterbalance the food industry's influence. The industry prioritizes profits over public health, distorting science and compromising scientists to achieve its goals. Voluntary changes are insufficient to address the obesity crisis.
West Nile virus infection causes breakdown of two vital proteins, claudin and JAM, leading to accelerated degradation of the blood-brain barrier. Researchers hope to design drugs that prevent brain infection by understanding this mechanism.