Researchers identified distinct cancer signatures linked to treatment response in breast tumors, which could help personalize treatment for patients. The study found mutations in genes like TP53 and MAP3K1 associated with good response to aromatase inhibitors, while others like MALAT1 predicted poor outcomes.
Research using fMRI scans found that sleep loss significantly amplifies anticipatory activity in deep emotional brain centers, especially the amygdala. Participants who were more anxious showed the greatest vulnerability to the aggravating effects of sleep deprivation.
Researchers have developed chemical compounds that selectively block the attachment of sugar molecules to cells, potentially leading to new treatments for chronic inflammation, autoimmune diseases, and cancer. The new tools can help scientists understand how glycans influence cell function and behavior.
A study using MRI scans found that sleep deprivation disrupts the higher brain areas responsible for making food choices, rather than basic reward centers. This impairment may explain the link between sleep loss and obesity.
A recent study using brain scans found that sleep-restricted individuals exhibit a distinct neural response to unhealthy foods, activating reward centers more intensely than those with adequate sleep. This response is associated with increased consumption of fattening foods after sleep restriction.
University of Montreal researchers developed a strategy to monitor protein assembly by integrating fluorescent probes throughout the linear protein chain. This approach enables capturing snapshots of protein shape at each stage of assembly, shedding light on how proteins self-assemble into working nanomachines.
Scientists have identified four new genes that predispose people to the most common type of migraine, without aura. The study provides further evidence for the role of molecular signaling in migraine and opens new avenues for research into its causes.
Researchers have imaged S-layer of Geobacillus stearothermophilus bacterium down to atomic scale, revealing chainmail-like structure that provides tough yet flexible protection and allows nutrients to diffuse in and out. This discovery holds promise for developing new vaccines by exploiting the ability of S-layers to self-assemble.
The Hypoglycemia-Hyperglycemia Minimizer (HHM) System successfully detects blood glucose highs and lows, automatically adjusting insulin delivery to safely manage type 1 diabetes. The study's findings lay the groundwork for further clinical trials and a potential game-changer for millions living with the condition.
Scientists have discovered that the controlled release of microRNA miR-675 slows down placental growth before birth, regulating a key factor in healthy pregnancy. This finding has important implications for understanding how environmental signals and diet may influence fetal development.
In a post-hoc analysis, elderly patients with type 2 diabetes treated with JANUVIA achieved similar blood sugar reductions as those treated with a sulfonylurea. Notably, patients taking JANUVIA experienced significantly less hypoglycemia, with an incidence of 6.2% compared to 28.2% in patients taking a sulfonylurea.
A new study found that early and aggressive glucose-lowering treatment can significantly reduce the risk of progression to diabetes in people with prediabetes. The research analyzed data from over 3,000 patients who experienced periods of normal glucose regulation, revealing a 56% reduction in diabetes risk.
NASA TRMM satellite data shows Tropical Depression Kuena experiencing weaker rainfall rates between June 6 and 7. The storm's intense rainfall rates were found in convective storms that reached heights above 15km.
Young adults were more likely to gain health insurance or stay on their parents' plans after the Affordable Care Act's passage. Many struggled with medical debt and skipped care due to cost, with those without insurance facing greater challenges.
Researchers at Moffitt Cancer Center have developed a synthetic vaccine that induces tumor clearance in 100% of mice with HPV16-induced tumors. The vaccine, called TriVax-HPV, generates large numbers of cytotoxic T-cells targeting viral proteins, offering an alternative to conventional therapies for cervical cancer.
Researchers found that direct reciprocity alone is insufficient for high levels of cooperation, emphasizing the need for population structure. Repetition can also boost cooperation when individuals interact with similar types, but excessive repetition can harm it.
Researchers at George Washington University have received over $860,000 in federal funding to study the effects of earthquakes on nuclear reactor cores. The study aims to simulate fuel rod vibrations and assess potential damage during an earthquake, which could lead to radioactive material release.
Patients with active psoriatic arthritis (PsA) treated with Ustekinumab 90mg achieved a 24.9% improvement in ACR50, compared to 8.7% in the placebo group. The study also showed significant improvements in DAS28-CRP responses and clinical meaningful changes in HAQ-DI.
Biofuels' environmental benefits are overstated due to neglected GHG emissions and flawed Life Cycle Analysis models. The study highlights the omission of CO2 from vehicles using ethanol and biodiesel as a key contributor to this overestimation.
Researchers at UMass Amherst identify fundamental mechanism for spontaneous emergence of complex patterns like wrinkles and crumples. The discovery confirms theoretical predictions and reveals unusual sequence of transitions underlying these morphological complexities.
The Mia J. Tegner Memorial Research Grants support research on the history of ocean ecology, aiming to predict future impacts from human interactions. The 2012 grants were awarded to four researchers studying various marine ecosystems, including Antarctica and the eastern Mediterranean seascape.
A Michigan State University study reveals that easy online access and personal devices have made the digital divide disappear during vacations. People are using their phones to plan, check weather forecasts, and access local information, showing a significant shift in how travelers use technology on holiday.
Researchers have discovered that Mars' interior contains more water than previously thought, with implications for the planet's geological history. Additionally, a study of ancient stromatolites suggests that reef-building may have occurred earlier than previously believed, challenging current models of ecosystem development.
A new study found that smoking significantly affects the response to anti-TNF treatment in patients with rheumatoid arthritis, as measured by disease activity scores and clinical indices. Smoking cessation strategies may help maximize treatment effectiveness and improve quality of life for these patients.
Researchers have found that concussion victims have unique spatial patterns of brain abnormalities that change over time. DTI and EZ-MAP analysis reveal distinct patterns of low and high fractional anisotropy, suggesting a response to injury and potential compensatory mechanisms.
Engineers at NASA's Goddard Space Flight Center are integrating instruments on the first of four MMS spacecraft decks in a newly fabricated cleanroom. The mission aims to investigate magnetic reconnection, a fundamental process affecting space weather and modern technological systems.
Researchers found that overexpressing 14-3-3 proteins can make tumors resistant to chemotherapy. The study, led by Julián Cerón and Simó Schwartz Jr., reveals a key role for the par-5 gene in DNA damage response and genomic stability.
Piramal Imaging will present data from five florbetaben studies, including a pivotal Phase III trial that will provide the basis for regulatory submission later this year. The company is developing an innovative and proprietary tracer portfolio to address major clinical needs in Alzheimer's disease and other conditions.
UT researchers successfully test technology to insulate and stabilize central solenoid, a critical component in experimental fusion reactor. The technology uses a glass fiber and epoxy mixture to provide electrical insulation and strength.
A CU-Boulder-led team has found a handful of bacteria, fungi and archaea in rocky soils on South American volcanoes, exhibiting unique energy conversion methods. The discovery sheds light on the limits of life on Earth, suggesting that certain organisms can survive without photosynthesis.
A Wayne State University School of Medicine study found that 90.7% of patients with hypertension also had hidden heart disease, emphasizing the need for early detection and treatment. The study's results have significant implications for preventing cardiovascular disease in high-risk populations.
Researchers discovered a commonality among superconductors, Bose-Einstein condensates, magnets, crystals, neutron stars, and cosmic strings. The Nambu-Goldstone boson theory applies to all these phenomena, predicting or designing unusual behavior in new materials.
A recent study published at EULAR 2012 found that obese patients with psoriatic arthritis have a lower chance of achieving minimal disease activity when treated with anti-TNFs. However, following a hypocaloric diet can increase the likelihood of achieving treatment goals.
Researchers found that sleep-deprived medical staff have difficulty controlling speed and maintaining a straight line while driving, particularly in monotonous conditions. The study suggests providing rest opportunities for staff before driving home and implementing safety measures such as taxis and electronic systems to alert drivers.
Researchers discovered that ADAM28 inhibits VWF-mediated apoptosis in cancer cells, leading to increased lung metastases. Inhibition of ADAM28 expression or activity significantly reduced lung metastases and increased cancer cell apoptosis.
A new study reveals that lung changes are a primary manifestation of rheumatoid arthritis (RA) in ACPA-positive patients. The study found HRCT abnormalities and local production of ACPA in the lungs of patients before RA onset, suggesting site-specific extra-articular changes as the initiating event of the immune response.
A UA systems engineering doctoral student has developed a simulated operations system to increase mining efficiency, which earned him the IIE research award. The system can coordinate scheduling decisions in near-real time and has been demonstrated with real-world coal mines.
The new peer-reviewed journal Big Data will facilitate discussions on harnessing big data to solve global problems. It aims to bring together researchers, analysts, and policymakers to address the challenges and discover breakthroughs in big data technologies, policies, and innovations.
A new study validates the RABBIT Risk Score as a tool to predict serious infections in RA patients treated with anti-TNFs or DMARDs. The score successfully predicted infections in patients with ≥1 risk factor, including chronic lung disease and age above 60 years.
A new study published at EULAR 2012 found that patients with early menopause are 50% less likely to develop severe rheumatoid arthritis. The research also revealed a link between hormonal changes and distinct pathways leading to disease progression. Early menopause was associated with a milder form of the chronic inflammatory disease.
The NIH has awarded $400,000 to Arizona State University's Kevin Bennett to develop a non-invasive method for detecting nephritis, a common form of kidney disease. The new technology uses magnetic resonance imaging and magnetic nanoparticles to extract information about the kidney's function and location.
Research by Dr. Avery Nathens found that seriously injured car accident victims are 30% more likely to survive at least 48 hours if taken directly to a trauma centre. However, fewer than half of those injured in Ontario are taken directly to a trauma centre.
Baricitinib demonstrates dose-dependent efficacy in active rheumatoid arthritis, with 76% of patients achieving ACR20 response compared to 41% on placebo. Patients also showed significant improvements in disease activity and functional outcomes.
Queen's University has received a $2 million donation from RBC to support the new RBC Queen's University Water Initiative. The initiative aims to raise awareness about the impact of industrial development and agriculture on watershed health and water supplies through research, education, and hands-on training.
Researchers have discovered a highly complex structure in the mantis shrimp's club that enables it to withstand 50,000 high-velocity strikes. The unique structure could inspire new materials for military body armor, vehicle frames, and aircraft frames, reducing weight while maintaining impact resistance.
Researchers developed an ocular pulse amplitude test to detect carotid artery stenosis, a known stroke risk factor. The test could be performed by ophthalmologists during routine exams and may help prevent strokes.
Researchers at Johns Hopkins Bloomberg School of Public Health have identified the function of a series of proteins within the mosquito that transduce a signal to trigger an immune response against the malaria parasite. The study found that manipulating these proteins through genetic engineering can create a malaria-resistant mosquito.
A new experiment shows that light exhibits both electric and magnetic fields simultaneously, violating classical physics, and demonstrating its quantum mechanical nature. The study's findings have implications for understanding the behavior of other systems and developing quantum computers.
A team of IRCM researchers led by Dr. André Veillette has elucidated a poorly understood molecular mechanism associated with human immune disorder XLP disease.
A new study suggests that HIV superinfection rates are equivalent to primary HIV infections among a general heterosexual population. Researchers used ultra-deep sequencing to detect even the lowest levels of circulating HIV strains and found 7 cases of superinfection out of 149 tested individuals.
Using synthetic diamond, researchers achieved a record-breaking memory time of over one second at room temperature, surpassing previous materials that required cryogenic cooling. This breakthrough opens up potential for novel solid-state quantum sensors and quantum information processing applications.
The AGA Research Foundation awards 11 high school students $2,500 grants to perform digestive disease or nutrition research for a minimum of 10 weeks. The program aims to stimulate interest in gastroenterological research careers and has identified nearly 223 students since its creation.
A recent study found that rain affects waterbird communities in urban estuaries, influencing their populations and diversity. Heavy rainfall leads to increased nutrient runoff, reducing small invertebrate populations and changing the dynamics of waterbird communities.
A new study identifies a unique alliance of proteins that plays a major role in the development of heart failure. Chronic high levels of adrenaline spur activation of PAR1, which causes cardiac dysfunction. Targeting either protein in the pathway may hold promise for treatment.
Researchers examine past five years of underwater deliveries by HealthNet midwives to determine maternal and baby health indicators, aiming to improve reproductive health care. The study's findings will inform national policy and contribute to the field's adoption of health information technology.
A new study by Professor Mark Stein identifies a 'manic culture' of denial, omnipotence, and triumphalism among bankers, economists, and politicians leading up to the 2008 credit crisis. This behaviour led to excessive risk-taking and catastrophic consequences.
A study presented at EULAR 2012 found that biologic treatments significantly reduce mortality risk in rheumatoid arthritis patients. Achieving early and sustained remission is associated with improved overall survival.
Researchers at Columbia University Medical Center have identified a brain receptor called Gpr17 that appears to play a central role in regulating appetite. Blocking the action of this protein, which is also found in humans, could lead to new drugs for preventing or treating obesity.
A new meta-analysis suggests that people with pre-diabetes are at increased risk of stroke, but the precise degree of this threat depends on the medical definition used. Researchers found that those with fasting glucose levels between 110-125mg/dL carry a 21% higher chance of suffering a future stroke.
Researchers developed a multi-target approach to treat tumors using fruit flies, creating an investigational compound AD80 that targets multiple cancer genes. Tested in mouse models, AD80 proved far more effective and less toxic than standard cancer drugs.