A new UCSF study examines the role of key molecule PKCγ in regulating the food clock, which is disrupted by irregular eating patterns. The findings have implications for understanding diabetes, obesity, and other metabolic syndromes.
Researchers say targeting extraoral taste receptors in the gut could release hormones that signal fullness, mimicking meal effects and aiding weight loss. Additional studies are needed to identify effective drug targets for obesity treatment.
A new study challenges previous views on miR-205's function in breast cancer. Research found that miR-205 is overexpressed in transformed cells and contributes to the abnormal morphology of acini. The findings suggest miR-205 can act as an oncogene, promoting cell growth or inhibiting apoptosis.
Eczema is a persistent skin rash that can be triggered by inadequate Ctip2 protein, leading to inflammation and immune dysfunction. Researchers have identified two ways in which improper Ctip2 function contributes to eczema, paving the way for personalized treatments and new therapies.
New research sheds light on the complexities of learning problems in neurofibromatosis 1 patients. The study found that both increased RAS function and reduced dopamine levels contribute to cognitive dysfunction in individuals with NF1. Developing personalized therapies is now a priority.
NASA's Hubble Space Telescope has been providing amazing images of the universe since April 1990, while the next-generation James Webb Space Telescope will reveal mysteries of the universe in much greater detail. The new free e-Books offer interactive resources and insights into both telescopes' science and technology.
The new dedicated network, Science DMZ, will enable WSU researchers to transmit and receive large amounts of data quickly, across the campus or around the world. This upgrade will greatly speed up their ability to work, moving research forward with faster downloads and improved collaboration.
Researchers found that six weeks of resistance training significantly improved blood markers of cardiovascular health in young African-American men, but not Caucasian men. This suggests that resistance exercise training is more beneficial in young African-American men.
Researchers found that Xbp1s regulates liver metabolic switch after eating, while low iron accelerates H. pylori-induced gastric cancer. Additionally, p62 is crucial for brown fat thermogenesis, and dendritic cells play a protective role in atherosclerosis.
Scientists have identified a new type of nerve cell in the brain that regulates heart rhythm and blood pressure. The discovery may lead to new ways of treating cardiovascular diseases.
Forensic experts at Uppsala University identified the remains of Carin Göring, wife of Nazi leader Herman Göring, through DNA analysis. The researchers matched mitochondrial and nuclear DNA with historical records, confirming her identity.
Researchers analyzed over 400 patient records to find that the proportion of early-stage lung cancer cases identified by CT scans increased by almost 50% during a recent 10-year period. However, only half of these cases would meet criteria for lung cancer screening under existing guidelines.
Drs. William Y. Kim and James W. Mier have received $250,000 grants to conduct innovative translational kidney cancer research. Their projects aim to personalize kinase therapy and explore the mechanism of HDM2 antagonists in blocking tumor angiogenesis.
Research found that low iron levels accelerate H. pylori-induced carcinogenesis in rodents and humans, increasing the risk of gastric cancer. Iron deficiency is associated with more virulent H. pylori strains and greater inflammation, highlighting the importance of iron levels in identifying high-risk patients.
The study reveals differences in the speed of evolution among globular clusters, with fast-aging clusters experiencing core collapse within a few hundred million years. In contrast, slow-aging clusters would take several times the current age of the universe to undergo core collapse.
Research suggests that cooler climates led to increased biodiversity in marine fauna, while warmer temperatures caused species to become extinct. The study's findings indicate that climate fluctuations played a significant role in the emergence and extinction of species.
Theoretical physicists created models to study van der Waals-Casimir-Polder (vdW-CP) force, which depends on electron diffusion. This finding could contribute to designing minimally invasive surface probes for quantum computer hardware architectures.
A five-year NIH grant supports a program to develop resident genomic pathology curriculum, expanding pathologists' role in interpreting and acting on genomics data. The initiative aims to bridge the gap between genetic research and practical application in patient care.
Researchers Xiao-Gang Wen and collaborators introduce a new system for classifying symmetry-protected phases of matter, potentially increasing our ability to design states of matter for superconductors and quantum computers. This reclassification provides insight into the fascinating world of quantum entanglement.
Thomas Jefferson University researchers have identified new pathways that drive aggressive forms of prostate cancer. Elevated levels of Cyclin D1b function as a novel biomarker for lethal metastatic disease in prostate cancer patients.
Researchers at JBEI identified the first enzyme capable of boosting galactan in plant cell walls, increasing the amount of sugars that can be fermented into fuels. This discovery provides an important new tool for engineering advanced bioenergy fuel crops.
A massive low-pressure area dropped over a foot of snow in some Midwestern states, prompting severe warnings and weather advisories. The AIRS instrument on NASA's Aqua satellite captured an infrared image showing the heaviest precipitation areas at -63.6°F (-53.5°C) near New England states.
Scientists propose that early life forms utilized deep-sea hydrothermal vents to harness energy, driving the emergence of complex cellular structures. The new theory explains why all living organisms conserve energy in the form of ion gradients across membranes.
A retrospective analysis of over 36,000 patients with colon cancer found that those with early stage disease and diabetes or high blood pressure have a greater risk for cancer return and death compared to patients without these conditions. High lipid levels were also found to be protective against recurrence.
Researchers at Johns Hopkins University have developed a method to control the fate of human stem cells, producing two types of smooth muscle cells necessary for building tiny networks of veins and arteries. This breakthrough could lead to new treatments for heart disease, diabetes, and cancer.
Retaining certain compounds normally excreted by the kidneys can cause insulin resistance in kidney disease patients. Treating mice with a prebiotic reduces these compound levels, preventing insulin resistance and related lipid abnormalities.
Researchers have identified five small wasp species that directly attack the younger life stages of the pine wood nematode vector Monochamus galloprovincialis. The study, published in ZooKeys, highlights the potential for these tiny insects to control a major pest affecting southwest Europe pine stands.
A new study by Johns Hopkins Bloomberg School of Public Health reveals that primary care physicians feel unprepared to address obesity due to inadequate medical education. Despite this, they support additional training and practice-based changes to improve their skills. Key findings include the importance of nutritionists and dietitian...
PNNL has been honored with three 2013 Excellence in Technology Transfer awards for developing innovative technologies such as redox flow batteries for renewable energy storage, radiogel products for targeted radiation therapy to fight cancer, and Ion Mobility Spectrometers for explosives detection. These technologies are expected to be...
Researchers at Virginia Tech Carilion Research Institute invent a way to directly image biological structures at their most fundamental level, providing a gateway to understanding dynamic systems in structural biology. The technique has successfully imaged viruses and other biological structures in their natural environments.
A research team led by Professor Zamaneh Kassiri has discovered that boosting TIMP3 levels can prevent the development of abdominal aneurysms. The study found that a protein called MMP2, despite being a contributor to heart and vascular disease, did not cause aneurysms when combined with TIMP3 deficiency.
Women deficient in vitamin D early in pregnancy are more likely to deliver babies with lower birth weights. Maternal vitamin D deficiency may impact fetal growth by reducing calcium absorption and glucose production, leading to a higher risk of small for gestational age births.
A study on Arabidopsis thaliana reveals its genetic diversity can help crops adapt to environmental stresses. Dr. Sarah Assmann explores the plant's ability to tolerate climate change, drought, and poor soils.
A recent study published in PLOS Genetics found a specific set of genes interacting to regulate pain sensitivity in humans. The research used exome sequencing to analyze DNA samples from individuals with varying levels of pain sensitivity, revealing distinct patterns of genetic variants in each group.
Rensselaer Polytechnic Institute is establishing a fellowship in astrobiology thanks to a $480,000 gift from the Emily Landecker Foundation. The James P. Ferris Fellowship will support graduate students pursuing research in the interdisciplinary field of astrobiology.
Researchers from the Institute of Solid State Physics found that superconductivity is intrinsic to a bismuth-based layered material when doped with silver. The material's characteristics were measured using x-ray diffraction, magnetic susceptibility, electrical transport, and thermal transport.
Scientists studying a rare meteorite from the outer asteroid belt discovered it has a unique, diverse composition, shedding light on the asteroid's surface processes. The Sutter's Mill meteorite is an ideal sample for preparing cosmochemists for upcoming space missions.
Researchers identified ADF and cofilin as crucial proteins in the shape change of young brain cells, enabling them to develop connections with other cells. The study found that these proteins facilitate neurite formation, which is essential for brain development and regeneration.
Researchers found that microRNA-26a suppresses melanoma cell growth while leaving healthy cells unharmed. Reintroducing microRNA-26a to melanoma cell lines led to a marked decrease in cancer cell survival, suggesting it as a potential therapeutic target for melanoma treatment.
A new study reveals that motivation and study skills, not intelligence, are key to long-term growth in math achievement. Students who were intrinsically motivated, used effective learning strategies, and avoided rote learning showed more growth in math ability.
The Higgs boson's detection completes the standard model of particle physics, where particles interact with a Higgs field to obtain mass. Researchers used a $5.5-billion-dollar atom-smasher and two massive particle detectors to spot the elusive boson.
A study found that peacock courtship calls attract distant females, suggesting a potential advantage for males in securing mates. The calls may serve as a form of advertising, warning predators of the male's vulnerability and increasing his attractiveness to females.
Researchers identify protein kinase Akt as a regulator of cancer stem cell biology, linking its hyperactivation to cancer resistance. The findings suggest that targeting Akt could be a new approach for killing cancer stem cells in cancer therapy.
Researchers at U of T discovered a major source of evolutionary differences among species by analyzing hundreds of thousands of genetic messages in equivalent organs across 10 different vertebrate species. Alternative splicing has dramatically changed the structure and complexity of genetic messages during vertebrate evolution.
Researchers investigated five cell types in CNS transplantation, finding none showed significant repair benefits. Despite differences in immune responses, only a few cells survived, highlighting the need for further research to better understand cell graft induced tissue damage.
Researchers at the University of Georgia have identified a new target for stroke treatments using candesartan, which increases brain-derived neurotrophic factor and stimulates angiogenesis. This approach has the potential to improve recovery outcomes for stroke patients and may also benefit veterans with traumatic brain injuries.
Researchers found a compound called ebselen effectively inhibits the thioredoxin reductase system in Helicobacter pylori, which causes gastric ulcers, and Mycobacterium tuberculosis, which causes tuberculosis. Ebselen's mechanism targets bacteria lacking glutathione.
Researchers used brain imaging technique to examine patterns of brain connectivity in adults with chronic back pain and without. They found specific brain regions became less connected, predicting worsening chronic pain, suggesting potential biomarker for chronic pain perception.
The JAMA Network has announced new titles for its specialty journals, including JAMA Pediatrics, JAMA Neurology, and JAMA Internal Medicine. Starting January 1, 2013, these journals will have a new embargo schedule, with content available on the For the Media site at specific times.
Researchers have identified a new drug target, 4'-Phosphopantetheinyl Transferase PptT, which is essential for Mycobacterium tuberculosis (Mtb) growth and survival. This discovery offers hope for the development of new TB treatments that can shorten treatment duration and combat drug-resistant strains.
Researchers have discovered 33 new species of trapdoor spiders in the American Southwest, adding to the genus Aptostichus, which now contains 40 species. The newly described species inhabit various habitats across California, from coastal sand dunes to alpine environments.
Columbia University researchers have created the first-ever atlas of immune cells in the human body, providing a unique view of T lymphocyte distribution and function. The study found that T cells are highly compartmentalized, with each tissue having its own complement of T cells.
Researchers have successfully transplanted genetically modified adipose cells into mice with liver disease, demonstrating their potential as a therapy. The study used bioluminescent imaging to track the cells' migration and engraftment in the liver, revealing their ability to persist for up to two months.
A brain imaging study found that THC, the psychoactive ingredient in cannabis, reduces the emotional reaction to pain but does not reduce the intensity of pain. The study suggests that individual responses to cannabis-based pain relief may vary greatly.
A recent study by Vall d'Hebron Institute of Oncology has led to the redefinition of hormone-sensitive breast tumours, improving diagnosis and treatment outcomes. Gene expression analysis revealed discrepancies between histopathological data and molecular profiles, prompting a new definition that incorporates progesterone receptor levels.
Researchers discovered that embryo growth is controlled by oscillating gene expression in neighboring cells, resulting in well-proportioned animals. The speed of this wave determines the size of future vertebrae, with faster waves indicating larger vertebrae.
Researchers sequenced the genomes of two bat species to understand genetic mechanisms underlying flight and immunity. The study found unique changes in genes related to DNA damage repair and innate immune system, which may have evolved to minimize negative effects of reactive oxygen species generated during flight.
A University of Missouri study found that conflicts over personal space and fairness are associated with higher anxiety and depression in adolescents. Parents can use household rules such as knocking before entering a sibling's room to resolve disputes and promote healthy psychological development.
A new study found that six months of steroid treatment didn't reduce relapse rates or side effects in children with nephrotic syndrome, challenging previous assumptions about optimal treatment strategies. The research highlights the need for new treatment strategies to prevent frequent relapses in this disease.
Researchers at Aldrich Materials Science have discovered a liquid-free process to design Metal Organic Frameworks (MOFs), enabling the production of high-purity MOF products suitable for sensors, detectors, and electronic/magnetic materials. The discovery extends to new classes of 3D-structured materials with unique properties.