A team of researchers at MD Anderson Cancer Center has identified a cancer-promoting protein's pathway into the cell nucleus and discovered how it fuels brain tumor growth. By targeting this pathway, they hope to develop new treatments for glioblastoma multiforme, the most common and lethal form of brain cancer.
A study suggests that eliminating payments for consultations commonly billed by specialists led to a net increase in spending on visits to both primary care physicians and specialists. The change was intended to be budget neutral, but it ultimately resulted in higher fees paid for office visits and increased intensity of coding.
Dr. Debra Auguste aims to develop targeted treatments for four metastatic breast cancer populations using engineered liposomes that deliver short interfering RNA to inhibit tumor progression and metastasis. The goal is to enhance cooperative binding, reduce cell migration, and improve treatment efficacy.
Researchers identified a molecular mechanism underlying antifibrinolytic drug-induced seizures. Antifibrinolytics inhibit glycine receptors, leading to seizures, but isoflurane treatment prevents this effect.
Imtiaz A. Khan, a GW professor, is studying the effects of microsporidia on HIV patients using a $1.6 million federal grant. His project aims to regulate CD8+ T cells to prevent complications in immunocompromised individuals.
A robotic laser system developed by Carnegie Mellon University and CTC uses high-powered lasers to remove coatings from fighter and cargo aircraft. The system promises to reduce labor, waste volume, environmental risk, and overall cost, making it an environmentally superior alternative to traditional methods.
Rates of hemorrhage for older warfarin patients are significantly higher than reported in clinical trials. Hemorrhage rates were found to be 11.8% in the first 30 days and 3.8% over a 13-year period.
Swans are found to have more common hip joint problems than previously believed, with CT scans revealing lesions in all five examined birds. The injuries likely occur during landing on hard surfaces, and the study suggests that computerized tomography is a better diagnostic tool for avian patients.
A new study suggests that lack of nutrients like folate and vitamin B12 may be associated with specific subtypes of depression. Melancholic depressive symptoms were linked to lower folate intake, while non-melancholic symptoms were tied to an increased risk of metabolic syndrome.
Researchers at Harvard University have developed a new device that can absorb 99.75% of infrared light on demand, using a tunable material with exceptional optical properties. The device has wide-ranging applications in thermal imaging, spectroscopy, and energy harvesting.
A new model developed by Concordia researcher Mohammed Othman takes into account workers' personality strengths and differences to create a more efficient workforce planning system. The result is a significant cost savings of 7.1% compared to traditional approaches.
A team of scientists has discovered an ancient thriving colony of microbes in the brine of Lake Vida, Antarctica, which is estimated to have been isolated for over 2,800 years. The microbes live in a highly saline environment with high concentrations of ammonia and nitrous oxide.
The American College of Cardiology and European Society of Cardiology disagree on mandatory ECG screenings. The ACC suggests $69 billion over 20 years to save 4,813 lives, while experts like Antonio Pelliccia argue cultural and policy obstacles hinder widespread adoption.
Soft Robotics is a peer-reviewed journal dedicated to the science and engineering of soft materials in mobile machines. The journal covers topics such as device development, flexible electronics, and control and simulation of highly deformable structures.
Scientists from Bangalore and Mainz have developed a new method for cooling ions using collisions with cold atoms. This process enables the storage of ions in ion traps at stable conditions for longer periods, which could lead to the formation of molecular ions in space.
Scientists have found metabolically active bacteria in the brine of an Antarctic lake sealed under ice for over 2,800 years. The discovery provides new boundary conditions on life's limits and suggests that chemical reactions between the brine and underlying sediment generate energy for microbes.
A new study from the University of Maryland School of Medicine has identified the orbitofrontal cortex as a critical brain area involved in value-guided behavior, decision-making, and learning. The research suggests that damage to this area can lead to decreased ability to use prior experience to make good decisions.
A study found that exercise programs on stationary bicycles improve Parkinson's disease symptoms, with faster pedaling leading to greater brain connectivity and motor ability improvements. The therapy is low-cost and effective, even for patients who don't need forced-rate exercise.
Researchers propose a mechanism by which life may have gotten its start in the early Earth's chemical environment. A mathematical model reveals that networks of molecules with self-perpetuating capabilities can give rise to complex systems and potentially life.
The US Preventive Services Task Force has updated its recommendations for hepatitis C screening in asymptomatic adults. The new guidelines suggest that targeted screening may be beneficial, as up to two-thirds of infected patients are missed by routine screening methods. However, there is currently no direct evidence that screening imp...
Researchers found that drugs like TXA and EACA associated with a four-to-six-fold increase in post-operative seizures. Adjusting these drug doses and maintaining sedation levels can help reduce the risk of seizure.
A Kansas State University study found that exercising with a teammate perceived as better increases workout time and intensity, but only when the partner is approximately 40% more skilled. Over time, this motivation can lead to significantly longer exercise sessions.
A University at Buffalo study examines maar craters, finding that their shape and ejecting distance are more accurate measures of an eruption's force. The findings could help scientists estimate the size of future volcano eruptions.
Researchers from Chinese Academy of Sciences and Tsinghua University presented additional, previously unknown geometries corresponding to all possible kinematical algebras. These geometries are classified into three relativistic geometries, absolute-time geometries, and absolute-space geometries, each with unique properties.
Scientists have discovered a method using shrubs to create historical climate data on glaciers, providing more accurate predictions of future changes. The method allows researchers to extend the current record of glacier melting back by many decades, giving them a better understanding of how glaciers behave in the summer.
A Rice University-led study has uncovered an elaborate mechanism allowing bacteria to begin preparing for survival even as it delays the decision to form a spore. The research found that nested 'feedforward' loops enable cells to process information while executing the program, making an accurate decision without delay.
Researchers will deploy sensors to analyze streambed conditions, measure water flow, and evaluate restoration efforts in a historic creek on campus. The project aims to enhance the watershed and restore part of lower Hunnicutt Creek as part of Clemson's Intelligent River initiative.
Scientists have spotted a second Pac-Man thermal shape on Tethys, confirming that high-energy electrons can dramatically alter an icy moon's surface. The discovery suggests a more complex and varied process in the Saturn system.
A study by Ohio State University researchers found that writing down thoughts and then disposing of the paper can reduce their influence on mental judgments. Participants who threw away the paper showed no difference in their attitudes towards positive or negative thoughts, suggesting that physical action influences thought use.
Scientists at Johns Hopkins Medicine have successfully used human stem cells to test how diseased cells respond to drugs, paving the way for faster and cheaper drug development. The study identified a promising compound for treating Riley-Day syndrome and demonstrated the potential for tailored treatments for individual patients.
A study by Henry Ford Hospital found that a significant number of CT scans for cervical spine injuries could be avoided if physicians followed the National Emergency X-Radiology Study (NEXUS) criteria. The study showed that adherence to these guidelines reduced unnecessary CT scans from 24% to 16%.
A coronal mass ejection (CME) with speeds of 375 miles per second reached the sun's surface in November 2012, marking the third Earth-directed CME since November 20. The event may cause geomagnetic storms and auroras near the poles, but is unlikely to disrupt electrical systems or GPS communications.
A team of researchers at the University of Pennsylvania has developed flexible, low-voltage electronic circuits using cadmium selenide nanocrystals. The new technology offers improved performance and manufacturing cost compared to traditional silicon-based electronics, enabling potential biomedical and security applications.
Researchers found that gastric bypass and adjustable gastric banding produce similar therapeutic benefits in obese patients. Both procedures equally improved insulin sensitivity and glucose tolerance after weight loss, with weight loss itself being the primary driver of these effects.
Tropical Depression 26W is threatening islands within Micronesia with heavy rain and strong winds. NASA's TRMM satellite imagery showed large, fragmented thunderstorms containing heavy rain and towering convective towers indicating intensification.
Researchers at Huntsman Cancer Institute have discovered a new drug with high potential to treat Ewing sarcoma by targeting the EWS/FLI protein. The study found that an enzyme called lysine specific demethylase (LSD-1) interacts with EWS/FLI to turn off gene expression in Ewing sarcoma.
Researchers suggest that physicians use tools from behavioral economics and social psychology to motivate patients to control their chronic diseases. Techniques include helping patients form specific plans, breaking big goals into smaller tasks, and using cash payments as a motivator.
The University of California - Los Angeles Health Sciences successfully performed the nation's first
A short burst of moderate exercise enhances memory consolidation in healthy older adults and those with mild cognitive impairment. Exercise immediately after viewing pleasant images improved recall in both groups compared to those who did not exercise.
Despite the devastating effects of smoking on cancer treatment and survival, many cancer patients struggle to quit due to various obstacles. Nicotine addiction, limited access to support programs, and socioeconomic status are just a few of the hurdles that hinder smoking cessation.
Researchers at Temple University and the University of Pennsylvania identified a key protein, MCUR1, that regulates calcium entry into mitochondria. This discovery may lead to new treatment opportunities for diseases involving excessive calcium in cells.
Researchers from University of Zurich found turning off specific cytokines reduces Alzheimer's amyloid-ß deposits by 65% in mice. Behavioral testing showed substantial improvements when p40 molecule-blocking antibody was administered, suggesting potential human therapy.
Researchers successfully engineered Arabidopsis plants to reduce xylan content and improve breakdown of carbohydrate into simple sugars. The resulting plants exhibit improved saccharification properties, allowing for better production of biofuels from plant biomass.
Researchers found that natural killer cells in patients quickly eliminate anticancer viruses used to treat brain tumors, reducing their effectiveness. Blocking these immune cells may help improve treatment outcomes for glioblastoma patients.
The CSIRO sensor uses technology similar to mineral deposit detection, providing valuable geological information and avoiding unnecessary drilling. The device has the potential to help clear landmines and renew exploration efforts at abandoned sites.
Researchers discover Arih2 gene essential for immune system function, potentially leading to treatment breakthroughs for chronic infections like HIV and hepatitis. The gene's role in regulating the immune response could lead to new treatments that reinvigorate the immune system and help clear these infections.
A study published in Genome Biology reveals a link between transposable elements and the expression of stem cell-specific long noncoding RNAs. ERV transposition may have given rise to these lincRNAs, which have important regulatory roles.
A new study found that frequent cognitive activity in late life is associated with higher diffusion anisotropy values in the brain, indicating better microstructural integrity. The research suggests that keeping the brain occupied can have positive outcomes and may help maintain brain health in older adults.
A new therapeutic technique repairs and rebuilds skeletal muscle using a combination of mesoangioblast stem cells and hydrogel cell-carrier matrix. The study demonstrates improved engraftment, survival, and integration of the stem cells into regenerating muscle fibers.
The study provides a high-quality genome sequence of an East-Asia watermelon cultivar and resequencing of 20 watermelon accessions, shedding light on the molecular basis of disease resistance and evolutionary history. The results reveal clusters of resistance genes and tandem duplications as potential evolutionary bases for these traits.
A new study reveals that fetal alcohol exposure alters brain structure and metabolism in children, with MRI techniques showing statistically significant thinning of the corpus callosum. Diffusion weighted imaging also detected increased diffusion, indicative of neurological disorders or brain damage.
A new study found severe dissolution of pteropod shells in Southern Ocean waters due to ocean acidification. The tiny snails are a valuable food source for fish and birds, and their shells dissolving may increase vulnerability to predation and infection.
A study examining attitudes towards government responses after extreme weather events found that perceptions of helplessness can lead to a lack of personal action to prevent flooding. The research, led by the University of Exeter, highlights the need for governments to adapt to climate change and invest in flood resilience.
Researchers have identified over 700 novel proteins in the herpesvirus genome, many of which are surprisingly small and complex. This discovery provides new insights into the biology of the herpesvirus and highlights the importance of analyzing the products actually produced from the genome.
Researchers found that adding fall history to risk assessment tools improves fracture prediction accuracy, especially in men. The study used data from the Hertfordshire Cohort and showed that incorporating fall history into models increased predictive capacity by six percent.
Johns Hopkins researchers identified a protein called JMJD2C that helps breast cancer cells spread by unlocking genes. The discovery confirms the protein's role in breast cancer progression and offers a potential target for anti-cancer therapy.
Climate change is affecting all regions in Europe, causing a range of impacts on society and the environment. Higher temperatures, decreased precipitation in southern regions, and melting glaciers are among the key findings.
Researchers observed synchronized swimming in pilot whales as a response to external threats, highlighting their social structure and affiliative behaviors. The study revealed that these cetaceans form permanent partnerships and change their diving behavior in the presence of vessels.
The Britain in 2013 magazine features articles on various pressing problems facing British society, including climate change, hospital mergers, retail sector trends, and Scottish independence. The publication highlights the impact of ESRC-funded research on these issues, offering solutions and insights for a better future.
A team of researchers from the Public University of Navarre has developed a new algorithm for improving the real-time capture of 3-D images, enabling applications in fields like 3-D video recording and intelligent systems. The technique uses stereoscopic vision to compare pairs of images and yields better results than previous algorithms.