A recent study published in Arthritis & Rheumatism found a rapid increase in knee replacement surgeries among women aged 50-59, with incidences higher in younger age groups. The study's findings suggest that more data is needed on the long-term effects of knee replacement surgeries in younger patients.
A new computer model developed at the University of Illinois can simplify the transition from field to biorefinery by optimizing operations to reduce costs and greenhouse gas emissions. The model takes into account regional attributes such as weather, crop yield, farm size and transport distances, and can run millions of simulations.
A study found that consumers generally prefer more precise or granular information when making decisions. In product descriptions, choosing fine-grained units like '28 minutes' instead of coarse terms like 'half an hour' influences consumer perceptions.
Researchers found that regorafenib slowed tumor progression and lengthened patient lives by 29% compared to placebo. The median survival time increased from 5 months to 6.5 months, with a 23% reduced risk of cancer-related death.
Researchers at Scripps Research have identified a compound that can repair specific defects in RNA, a key step in developing treatments for incurable diseases like Huntington's. The new technology targets toxic RNA defects associated with Spinocerebellar ataxia and Kennedy disease.
Researchers at the University of Florida have discovered a key amino acid, methionine, that is effective in killing caterpillars threatening the US citrus industry. The discovery uses a genetically related surrogate and has potential applications for organic poultry production.
Scientists have identified a gene family that can help breed grasses with improved properties for diet and bioenergy. The research, published in PNAS, could lead to the production of multi-use crops where grain is used for food and feed while straw is used to produce energy efficiently.
Researchers discovered that topical application of imiquimod recruits plasmacytoid DCs to the tumor site, converting them into tumor-killing effector cells. A new mechanism for IFN-alpha suppression was also identified, targeting epigenetic regulation of nuclear cccDNA minichromosome.
New research aims to create algorithms mimicking human brain sound processing to enhance speech intelligibility in noisy situations. The goal is to develop a brain-inspired speech enhancer that can identify sound sources and reduce the stigma associated with hearing aids.
The study reveals that Raf-1 regulates cell adhesion, enabling cells to form new bonds and new blood vessels. The discovery may lead to cancer treatment approaches by targeting Raf-1 and disrupting tumor environments.
A pediatric research project aims to collect long-term clinical data on children with conditions detected in newborn screening, enabling researchers to develop new tests and interventions. The project has the potential to transform treatments for rare childhood diseases.
A group of international health experts is calling for a special UN session to focus global attention on mental, neurological, and substance use disorders. The authors outline three broad areas of action needed, including enhancing access to evidence-based care and expanding knowledge about MNS disorders.
A Canadian-led research team has developed a new model to anticipate disease outbreaks at mass gatherings like the Olympics. By integrating global and local surveillance, they can create a more effective approach to preventing infectious disease risks.
A physical activity program has been shown to improve behavioral scores in children with ADHD, as observed by both parents and teachers. The study suggests that structured group physical activity can have positive effects on behavior in various settings of the child's life.
A new vaccine has been developed to protect against group B meningococcal disease, a major cause of meningitis in high-income countries and some developing regions. The vaccine was found to be highly effective in adolescents aged 11-17 years, with 99-100% protection after two or three doses.
UC Berkeley researchers found that gossip can have positive outcomes, such as helping people police bad behavior and prevent exploitation. Gossiping also made volunteers feel better when they were able to pass on information to alert others.
The University of Leicester and Leicester City Council are leading a £2.4 million project to develop green traffic management systems in European cities and towns. The three-year project aims to improve road congestion and urban environments using space and information technologies.
Researchers have discovered that myocilin deposits can lead to vision loss in glaucoma patients. The study, published in the Journal of Molecular Biology, explores one of the molecular origins of glaucoma and potentially leads to new treatments.
A Cochrane Review found inconsistencies with published reports of oseltamivir's efficacy and safety profile, raising questions about its use. The analysis showed that the drug did not reduce hospital treatment needs despite reducing symptom alleviation time.
The University of California, Riverside has received a $2 million award to build solar arrays and advanced battery storage systems for electric vehicles. The project will also install an electric trolley and grid management system to provide clean energy to clean vehicles efficiently.
Researchers at the University of Washington discovered that fruit flies use polarization patterns of natural skylight to maintain their heading while traveling. This finding suggests that many insects possess a navigational system, which could be studied using genetics research.
Researchers developed a new approach to motion capture technology, identifying the 'kick' serve as a high-risk tennis serve for shoulder injury. By analyzing player movement without markers, they found that this serve generates larger forces on muscles crossing the shoulder joint, promoting injury.
US study finds that nearly three-quarters of headphone-wearing pedestrian injuries are fatal, mostly among young adult males and under 30 years old. Headphones can mask warning sounds, leading to distraction and sensory deprivation, increasing the risk of accidents.
Physicists at Vienna University of Technology have found a way to break the limits on viscosity, with implications for understanding superfluid helium and quantum theory. The results, published in Physical Review Letters, suggest quark-gluon-plasma can exhibit extremely low viscosity, even below previously established bounds.
The Galileo program seeks to bridge the precision fiber optic controls and long-baseline astronomical interferometry technical communities to enable faster imaging of objects in geosynchronous orbit. By harnessing the power of flexible fiber optics, researchers aim to create a new means of better, faster imaging of objects in GEO.
Researchers found that imiquimod converts plasmacytoid DCs into tumor-killing effector cells, clearing tumors in a mouse model of melanoma. This discovery has implications for antitumor therapies targeting both skin cancers and other types.
Researchers used neutron scattering to study molecular motion in a silica nanopore, gaining insight into how surface interactions affect chemistry. Understanding these interactions can help tailor materials for specific outcomes, such as catalysis and drug delivery.
Researchers from Kansas State University have found that LED lights can prolong the shelf life of certain beef products, making them more appealing to customers. This cost-saving solution could result in significant revenue for retailers and tax gains for the state.
Researchers discovered a new bacterial growth process that occurs at a single end or pole of the cell, which could lead to new antibacterial strategies. The study found that this polar growth process is broadly distributed among many different bacterial taxa.
Researchers found increased brain cell activity in adolescent rats in an unusual area called the dorsal striatum, associated with habit formation and decision-making. This suggests that adolescents may be more susceptible to developing disorders like addiction and depression due to their unique brain response to reward.
Researchers at Stanford University have used a computer algorithm to find markers that predict how deadly bladder cancer will be, offering faster and more accurate analysis of cancer risk. The test can be performed by someone with little training and may help identify patients with the most aggressive subtype before it becomes invasive.
Researchers have successfully replicated the evolution from single-celled organisms to multicellular clusters in a laboratory setting, mirroring the transition that led to life on Earth. The experiment involved natural selection and brewer's yeast, resulting in cooperative cell clusters that exhibit genetic similarity.
Researchers at Max Planck Institute develop simple process for artemisinin synthesis using waste product from current production as starting substance. The new method uses photochemistry to incorporate an endoperoxide group into the molecule, producing large volumes of artemisinin under controlled conditions. This could cover global de...
A large Scandinavian study confirms that combined oral contraceptive pills reduce dysmenorrhoea, with women experiencing less pain and improved daily activities. The study also highlights the independent effects of increasing age and childbirth on symptom severity.
Researchers have created new microtweezers capable of manipulating objects to build tiny structures, print coatings for advanced sensors, and grab live stem cell spheres. The tool enables the precision printing of chemical or protein dots onto microcantilevers, which can detect chemicals in air and water.
New research by the University of Exeter suggests that our subconscious plays a significant role in how we respond to danger. Participants in the study showed a primitive response to fear-inducing stimuli, contradicting their conscious assessments of danger. This finding has implications for anxiety disorders and treatment.
Researchers identified the 32-atom 'baby crystal' through computer simulations and experimentally confirmed its structure using scanning tunneling microscope images. The discovery provides insight into how small crystals form larger units.
A recent study by University of Massachusetts Amherst researchers found that sleep preserves and enhances unpleasant emotional memories. Contrary to previous assumptions, sleep was associated with maintaining the strength of initial negative feelings, rather than softening their effects.
Researchers have made significant progress in detecting and treating gastrointestinal cancers with new biomarkers, test, and treatments. Studies show promising results for detecting early stage pancreatic cancer and improving survival in patients with metastatic colorectal cancer.
A new study has found that stomach cells from the cardia region may give rise to esophageal adenocarcinoma, a particularly lethal form of esophageal cancer. The research suggests a link between chronic inflammation and bile acid reflux in the development of this disease.
Research finds a significant association between pulmonary TB and EGFR mutations in lung cancer patients. The study reveals that tumors with these mutations respond well to targeted therapies, offering new hope for treatment.
Researchers have discovered a key to stopping brain cancer cell growth and migration by inhibiting a specific signaling pathway. The study, published in Nature: Oncogene, shows that targeting the Mer pathway can make brain cancer cells more sensitive to chemotherapy and prevent them from escaping to other areas of the brain.
A devastating neurodegenerative disease called Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) has been linked to defective mitochondria in neurons. The research reveals an important common link with other neurodegenerative diseases, offering renewed hope for those affected.
Researchers have sequenced the nuclear genome of Schistosoma haematobium, a parasitic worm linked to bladder cancer and HIV/AIDS. The discovery offers insights into how the parasite induces malignant bladder cancer and provides a biological roadmap for developing new disease interventions, including drugs and vaccines.
The report explores complex consequences of excess nitrogen on ecological communities, human health, and agriculture. Strategies to maximize efficient use of fertilizer and mitigate agricultural sources are also presented.
Pioneering engineers have found a way to produce highly valuable activated carbon from the invasive Marabú shrub, which could help alleviate Cuba's ecological problems and provide clean drinking water for developing countries. The process uses technology developed by researchers at the University of Strathclyde.
Researchers successfully converted stem cells from umbilical cords into oligodendrocytes, critical cells that insulate nerves in the brain and spinal cord. The breakthrough offers new hope for treating spinal cord injuries and multiple sclerosis by injecting healthy oligodendrocytes into the body.
A study published in the Journal of Behavioral Decision Making found that people tend to overestimate their willingness to engage in embarrassing public performances. However, inducing immediate emotions can help reduce this illusion of courage. The research has practical implications for understanding human behavior and decision-making.
A survey of 900 nurses reveals that a strong attachment to healing and nursing is the only variable identified by all three age groups. The study found six independent variables that influenced nurses' intentions to continue nursing, with work variables being most important for older nurses.
A new study reveals that inmates with severe mental illnesses have lower recidivism rates than those with substance abuse issues or no diagnosis. The research, published in the International Journal of Law and Psychiatry, found that those with mental illnesses alone had better outcomes even compared to those with no problems.
A study of over 16,000 nurses found that EHRs lead to more efficient nursing care, better coordination, and patient safety. Nurses in hospitals with fully implemented basic EHRs were less likely to report unfavorable patient safety issues.
The new resource, Seeking Drug Abuse Treatment: Know What to Ask, highlights critical questions people should ask when choosing a treatment program. It recommends five key questions to help individuals and families make an informed choice during a stressful time.
A study found that blocking a protein called AMPK helps increase animal mobility and reduce nerve cell death in animal models of amyotrophic lateral sclerosis (ALS). The findings suggest energy deficits may contribute to neurodegenerative disorders like ALS, offering new directions for treatment.
A study by Boston Children's Hospital reveals that neurologically impaired children account for increasing hospital resources in children's hospitals, with 25% of bed days and 29% of hospital charges attributed to them. This highlights the need for improved care coordination and better patient outcomes.
Research from Michigan Medicine shows a 15% increase in post-liver transplant kidney failure among recipients since the implementation of Model of End Stage Liver Disease (MELD) allocation. Modifiable risk factors identified include African American race, hepatitis C, and pre-transplant diabetes.
Researchers found that grass smut fungi can form hybrids with other species, which could lead to new plant diseases and accelerated evolution. The discovery was made possible by the collaboration of RUB Geobotany Laboratory and Heinrich Heine Universität in Düsseldorf.
Researchers identified a biochemical chain of events leading to activation of a protein-cleaving enzyme called hepsin on the surface of breast tumor cells. Hepsin breaks down basement membrane proteins, allowing tumor cells to escape and invade surrounding tissues.
During economic downturns, wealthy consumers tend to cut back on non-essential expenses like dining out or traveling, prioritizing essential goods. This shift is driven by a desire to maintain relative social status amidst reduced peer spending.
A new endoscope has been developed to locate and clear out gallstones and lesions without removing the entire gallbladder. The device uses a tiny ultrasonic probe to detect small stones and a horn-shaped 'absorbing box' to suck out fine, difficult-to-remove sludge-like gallstones.
A population-based surveillance system has been set up to assess the impact of pneumococcal conjugate vaccines (PCVs) on invasive pneumococcal disease and radiological pneumonia in children in The Gambia. Evidence of sustained reduction in these diseases due to PCVs is crucial for vaccine introduction and ongoing use.