Experiences can modify genes involved in memory formation and drug use, leading to long-term brain changes. This epigenetic phenomenon affects normal development and abnormal processes like depression and psychiatric disease.
Researchers found that large pulses of organic material sink to the deep seafloor, providing enough food for years at a time. The study used multiple instruments to track marine snow and its impact on life in the deep.
Researchers found that patients surveyed at federally supported community health centers generally reported high-quality care, with excellent or very good ratings for overall quality of services, clinician care, and referrals. The study also found that higher patient ratings of access to care and patient-centered communication were ass...
Researchers found that a specific molecular process controls B cell activation and differentiation, leading to impaired antibody production. The study highlights the importance of genes like IL-21 receptor, STAT3, and CD25 in B cell function, with mutations causing debilitating effects in patients.
Scientists have developed a system that can construct its own network of tracks, transport cargo, and dismantle the tracks using DNA and nano-scale motors. The system is powered by ATP fuel and uses motor proteins to control the movement of cargo across the network.
Researchers analyzed 21,309 Chinese individuals and identified only two independent low-frequency coding variants with moderate effect on disease risk. These findings suggest that the overall genetic risk for psoriasis is largely driven by other factors, contradicting previous assumptions about the role of coding variants.
Studies show that absence of serotonin receptors during early development leads to highly aggressive behavior in mice, while adolescents exhibit increased impulsivity to danger. The findings have potential applications for treating disorders related to impulsivity and aggression.
The new peer-reviewed journal brings together knowledge on pneumonia's pathogenesis, treatment, and prevention, featuring original research articles and expert analysis.
A new EU fishing ban faces criticism from researchers who say it may not be enough to ensure sustainable fisheries. The study, published in the journal Fisheries Research, highlights the need for a more comprehensive approach to reducing fishing mortality and increasing selective fishing practices.
A new '1-stop' radiotherapy technique has shown non-inferiority to traditional treatment in reducing breast cancer recurrence. The TARGIT trial found a single dose of targeted radiation during or soon after surgery reduced local recurrence risk by 80% compared to standard radiotherapy.
This year's AAPS Fellows were recognized for their research and scholarly contributions in various fields of pharmaceutical sciences, including immunology, drug delivery, and clinical pharmacology. Notable recipients include Sathy Balu-Iyer, who developed a mechanistic model to understand immunogenicity of biotherapeutics.
New research reveals that sleep plays a crucial role in consolidating visual task learning through specific brain frequencies. Brainwaves of 15 volunteers were measured during sleep and training to demonstrate increased sigma power in the visual cortical area, leading to improved performance on the task.
Researchers identify 18F-NaF as a promising tool to detect high-risk coronary plaques in patients with stable and unstable heart disease. The study suggests that this non-invasive technique could transform the way doctors identify, manage, and treat patients at risk of heart attacks.
Researchers have identified a molecule that regulates fibrotic disease, offering hope for treating damaged organs. Removing this molecule or using experimental drugs has been shown to reduce scar tissue in mice, with implications for human treatment.
Researchers at the University of Adelaide and The University of Queensland discovered that zinc 'jams shut' a protein transporter in deadly bacteria, preventing manganese uptake. This finding opens the way for designing antibacterial agents to target essential transporters.
Research reveals new roles for sex hormones like estrogen in the cognitive function of females, including memory and interpreting social cues. Estrogen replacement therapy may help prevent stress-related memory loss in post-menopausal women.
Researchers Leaf Huang, Sukyung Woo, Shyh-Dar Li, and Raj Suryanarayanan received awards for their groundbreaking work on non-viral gene therapy, tumor evasion mechanisms, nanomedicine, and physical pharmacy. Their research holds promise for future development of clinically effective gene and anti-cancer therapies.
Scientists have found the cause of a genetic disease, pancreatic agenesis, in previously unexplored regions of DNA. The condition affects babies and leads to diabetes and digestive issues.
Research at the University of Montreal found that even 20 minutes of moderate exercise three times a week during pregnancy enhances brain activity in newborns. The study suggests that this early stimulation can lead to improved cognitive and motor development in children.
Researchers discovered genetic differences between African Americans and European Americans that affect blood clot formation, providing a potential explanation for the racial disparity in heart disease outcomes. The study highlights the need for personalized treatment approaches based on an individual's genetic profile.
New studies reveal exercise and diet play crucial roles in treating depression, aging, and learning in teenagers. Lifestyle changes, such as yoga, meditation, and regular exercise, show promise for preserving movement function, improving memory, and boosting mood.
Researchers at UC San Diego have developed a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters. This approach enables the generation of more complete genome sequences from single cells, including E. coli and individual neurons from the human brain.
A recent study by Gladstone researchers reveals that specific stretches of DNA, called human accelerated regions (HARs), control the development of uniquely human characteristics. HARs were found to be crucial in human ancestors becoming distinct from our closest primate relatives.
Scientists have gained a deeper understanding of multiple sclerosis, revealing warning signs and potential treatments. Researchers found that antibodies can break past the brain's protective barrier to attack the optic nerves and spinal cord, causing MS symptoms.
A study led by UC San Diego scientists reveals a new way in which RNA-binding proteins govern regulated gene expression, expanding potential targets for therapies. The discovery challenges existing models and has implications for the treatment of neurodevelopmental disorders and certain cancers.
Scientists at Saint Louis University have discovered a potential novel therapeutic approach to treat fibrotic diseases by targeting the Transforming Growth Factor (TGF) beta protein. Removing a gene that makes alpha v integrins blocks TGF beta activation, and treatment with a small molecule compound replicates this effect.
A significant link has been found between high levels of exposure to particulate matter by first responders at Ground Zero and the development of kidney damage. Albuminuria, a sign of kidney disease, was significantly higher in those with high exposure levels.
A new study found that kidney failure patients who experienced discrimination and mistrust in healthcare had poorer quality of life. Patients who reported greater medical mistrust and lower trust in their physicians also showed decreased quality of life.
African-American patients with chronic kidney disease have a faster decline in kidney function due to genetic variations, particularly the APOL1 gene variant. The study suggests that reducing the effect of this gene could lead to a significant decrease in progressive kidney and end-stage kidney disease in blacks.
A new Dartmouth study suggests that chronic dieters overeat when their brain regions that balance impulsive behavior and self-control are disrupted. This depletion reduces a person's ability to engage in self-control by reducing connectivity between brain regions involved in cognitive control and rewards.
Recent studies highlight the effects of combination therapy with ACE inhibitors and ARBs on kidney function decline and cardiovascular events. Additionally, genetic variants of the APOL1 gene are found to increase CKD progression in African Americans.
First responders at Ground Zero experienced significant kidney damage after exposure to particulate matter. The study found a linear trend between level of exposure and measures of poor kidney function.
A large-scale online study found that altering task parameters can significantly impact learning rates in cognitive training. The research showed that making tasks more challenging led to greater improvements in spatial recall and attention, with effects being dose-dependent.
A recent study has found that the APOL1 gene variant is independently associated with a more aggressive course of disease, particularly in African-Americans. The variant is linked to twice the rate of CKD progression and loss of kidney function in those with chronic kidney disease.
Lumosity presents new data on measuring cognitive training improvements, finding larger doses lead to greater gains and training gains strongly predict transfer effects. A reliability assessment of the BPT shows it is a powerful tool for evaluating the effectiveness of cognitive training.
Two clinical trials present new hope for treating patients with kidney disease: a phase 2 trial of ZS-9 shows significant reductions in blood potassium levels, while another trial of abatacept plus cyclophosphamide fails to improve renal response in lupus nephritis. Researchers explore these findings at Kidney Week 2013.
A study published in JAMA found that coprescribing calcium-channel blockers with clarithromycin increases the risk of hospitalization with acute kidney injury and hypotension. The risk was highest among patients taking nifedipine, suggesting a need for quality improvement initiatives to mitigate this largely preventable drug-drug inter...
Studies suggest that consuming more fruits and vegetables can counteract the negative effects of dietary acid on kidney health. Research found that individuals with hypertensive nephropathy who received extra fruits and vegetables or an oral alkaline medication experienced preserved kidney health, while those with high dietary acid lev...
Researchers developed a simple dot test called the Triplets Learning Task (TLT) to assess dopamine loss in Parkinson's disease. The test shows promise as a non-invasive way to evaluate dopamine deficiency and may lead to new ways to improve treatment for PD patients.
Two studies present findings that consuming at least two soft drinks per day may increase excretion of protein in the urine, a hallmark of kidney dysfunction. Moderate fructose intake also increases salt reabsorption by the kidneys, which could contribute to diabetes, obesity, and hypertension.
A new study links preeclampsia during pregnancy to a higher risk of developing kidney failure. Researchers analyzed data from Olmsted County, MN and found that individuals with preeclampsia were more likely to develop kidney failure later in life, but this association was attenuated when diabetes and hypertension were considered.
Genetic variants in the APOL1 gene increase the risk of kidney disease progression and end-stage renal disease in African Americans. Approximately 1 in 10 blacks possess high-risk variants, which speed up kidney disease progression and substantially increase the risk of developing kidney failure.
Triferic effectively delivers iron to the body's bone marrow, maintaining hemoglobin levels without rapid flux, a safer alternative to current intravenous injection methods. The study demonstrated its effectiveness in preventing iron overload and iron deficiency in 300 patients with chronic kidney disease undergoing dialysis.
Researchers at Penn Medicine are studying health care disparities among people with disabilities through the Mrs. A and Mr. B Project, a collaborative effort with Virtual Ability, Inc. The project aims to provide patients with information to make informed decisions about their medical care.
Researchers develop method to transmit plant viruses using whiteflies, providing a means of interfering with plant-contamination and cultivating resistant plants. This technique has been published in JoVE's video format due to its difficulty in describing complex details through traditional text-only journals.
A new study finds that treatment with abatacept appears to halt the course of focal segmental glomerulosclerosis (FSGS) in patients, preventing proteinuria and promoting remission. Abatacept has been shown to be effective in treating patients with recurrent disease and those at high risk for kidney failure.
A team of researchers at Montana State University has verified that microorganisms produce methane by swimming towards hydrogen gas. The discovery sheds light on the movement of biological cells towards hydrogen gas and its implications for climate change, carbon cycle, and early Earth processes.
Researchers have created a method for producing high-quality aluminum nitride (AlN) layers with atomic-scale thickness and at half the temperature of other methods. This breakthrough expands the potential for new advanced specialty materials in next-generation electronics.
Young salmon scatter in all directions after entering the ocean, contrary to previous assumptions that most head north immediately. The study provides critical insights into salmon behavior and factors influencing survival, such as water temperature and predator presence.
A gut hormone test may predict the extent of metabolic improvement caused by gastric bypass surgery. The test measures GLP-1 responsiveness, which varies from patient to patient and correlates with glucose metabolism improvements.
A new estimate suggests that more than 600,000 bats likely died from wind turbine collisions in the contiguous US in 2012. Bat populations are already under stress due to climate change and disease, making this figure particularly worrisome for their already slow growth rates.
Researchers found that inhibiting ion channel TRPC5 limits kidney filtration loss after injury, suggesting a new therapeutic target. The study demonstrates the protective effects of TRPC5 inhibition on kidney function and provides hope for treating kidney failure.
The National Institute of Allergy and Infectious Diseases is sponsoring a Phase I clinical trial for an investigational genital herpes vaccine candidate, called HSV529. The trial aims to test the safety and immune response of the vaccine in adults aged 18-40 with previous HSV-2 or HSV-1 infections.
A recent animal study from Georgetown University Medical Center suggests that 'cold turkey' withdrawal from morphine can trigger a decline in mental health. Researchers found that treating addicted animals with morphine both increased protective CCL5 protein and decreased pro-inflammatory cytokines, suggesting a beneficial effect.
Researchers suggest that specific parts of food can be safe for consumption in individuals with food allergies, and substitutes can be eaten safely. For example, someone with an egg allergy may be able to tolerate egg yolk but not the whites.
A new study reveals that edited RNA and invasive DNA contribute to individual variation in humans by regulating gene expression. The study found a 20% difference in life span and eye color between individuals with varying levels of ADAR activity.
A new scorpion species, Euscorpius lycius, has been discovered in the ancient Lycia region of Turkey, adding to the total of five known species within the genus. The newly found species is relatively small, ranging from 2-2.5 cm in length and has a pale color with darker pedipalps.
Astronomers observed two nearby supernovae, SN 2012im and SN 2013ek, in spiral galaxy NGC 6984 using NASA's Hubble space telescope. The recent image reveals the second star that has exploded, forming a new Type Ib supernova visible near the center of the galaxy.
A new clinical score test for patients with sore throats can reduce antibiotic use by almost 30% and improve symptoms more quickly. The FeverPAIN score considers fever, pus infection, rapid attendance, inflamed tonsils, and cough or cold symptoms to determine if antibiotics are needed.
Nicolas G. Bazan, MD, PhD, receives the Polish Academy of Sciences' Professor Miroslaw M. Mossakowski Medal for his groundbreaking work on neurodegenerative diseases. Bazan's contributions to research on Alzheimer's, stroke, and other conditions have led to the development of multiple patented therapies.