The study found that epigenetic modification of the HAND2 gene plays a critical role in endometrial cancer development. Hand2 methylation is already increased in premalignant endometrial lesions and predicts a poor response to progesterone treatment.
A recent UTHealth study found that nursing homes using high-density foam mattresses may not need to turn residents every two hours to prevent pressure ulcers. The study showed no difference in pressure ulcer incidence for residents turned at intervals of two, three, or four hours.
A new phase III trial has shown that trastuzumab and anthracyclines can be given sequentially to achieve high pathological complete response rates in HER-2 positive breast cancer patients. The treatment regimens had similar cardiac safety profiles, with no significant difference between concurrent and sequential administration.
A new study finds that men tend to support gender equality in the workplace and report higher job satisfaction when they believe a woman can become CEO. The research, which surveyed over 6,500 workers from six formerly socialist countries, suggests that promoting women's advancement leads to increased productivity and revenue for firms.
The university's premier biomedical instrument is expected to provide breakthroughs in treating animal and human health conditions, including cancer. The instrument uses thermal cell therapy and high-resolution imaging to target specific cells and tumors.
A new solar cell design featuring copper electrodes has surpassed traditional heterojunction cells in efficiency without special equipment or expensive materials. The innovative approach could disrupt the solar industry by reducing costs and increasing production capabilities.
Pancreatic cancer death rates have increased in whites but decreased in African Americans over the past few decades. The study found that while smoking prevalence has decreased in both groups, other risk factors such as obesity and low vegetable intake may be contributing to the rising mortality rates in whites.
The 2013 Houston Education Survey found African-Americans are the most likely to emphasize the importance of postsecondary education, followed by Asians and Latinos. The survey highlights educational disparities and income inequalities as key factors contributing to these gaps.
Researchers at Tel Aviv University have discovered a powerful mechanism that regulates the lifecycle of eosinophils, a type of white blood cell involved in allergies and autoimmune diseases. By targeting a specific receptor, scientists may be able to develop new treatments for eosinophilic disorders like asthma.
Extensive musical training affects brain structure and function, particularly when started before age 7. Research suggests that musical improvisation can rewire the brain, fostering plasticity and enhancing creativity, cognition, and learning.
Pregnant women with a history of bariatric surgery are at higher risk of giving birth to preterm or small-for-gestational age babies. The study found a lower risk of large babies in these women. Researchers conclude that women with bariatric surgery history should be counselled regarding their increased risk.
Novel therapies for nicotine and heroin addiction show promise, while research reveals underlying brain mechanisms driving compulsive disorders like addiction and pathological gambling. Understanding these processes may lead to non-pharmaceutical interventions and new treatment approaches.
A computer simulation reveals how intense plasma waves generate suprathermal electrons, which are critical to microchip fabrication. This breakthrough provides a first step toward controlling the plasma-surface interactions and increasing transistor density.
Researchers at Wayne State University have made a breakthrough discovery in the inflammatory stress mechanism driving rheumatoid arthritis. A specific IRE1a inhibitor was identified to prevent arthritis in animal models, offering new hope for treating this autoimmune disease.
Ex-Tropical Depression 30W is attempting to re-form in the Indian Ocean after dissipating over Nov. 8-10. The storm's re-generation is considered medium-probability for the next few days, with slow westward movement predicted.
A new study by the University of Manchester found that prosthetic hands are generally rated as more eerie and less human-like than robotic or human hands. However, prosthetic hands with a more human-like design were rated as less eerie.
Researchers have discovered a new method of delivering chemotherapy drugs directly to brain tumours using a polymer originally designed to mend broken bones. The therapy has shown promising results, reducing toxic side effects and potentially leading to more effective treatment and prolonged patient survival.
A study revealed RSV infection induces distinct global gene expression patterns in young children, identifying a 'biosignature' for diagnosis and disease severity assessment. The research also uncovered suppressed non-specific immune system genes and elevated inflammation genes in infants under 6 months.
A study published in the Journal of Consumer Research found that customers become emotionally attached to commercial spaces, leading to increased loyalty and commitment. This attachment is driven by factors such as authentic decor, high product quality, and a sense of security.
Dr. Rodriguez's award-winning research identified a potential new therapeutic approach to make T cells resistant to tumor suppression, enhancing anti-tumor activity and overcoming immune suppression. His findings suggest Notch-1 may be an effective new approach for T cell-based immunotherapy.
A new study found that aerobic exercise improves memory, brain health, and physical fitness in healthy aging adults. Researchers used non-invasive brain imaging techniques to detect brain changes earlier, revealing increased blood flow to the hippocampus and anterior cingulate region.
A recent study found that adults with developmental disabilities, such as autism and Down syndrome, face significant barriers to accessing healthcare. The research suggests that these individuals require more comprehensive and coordinated care, including preventive measures like cancer screening, to manage their complex health issues. ...
Researchers at PPPL have developed an online experiment that allows users to control a real physics laboratory from any location. The Remote Glow Discharge Experiment enables users to interact with a plasma discharge, observing and controlling its effects on the apparatus.
Penn Medicine researcher Ezekiel J. Emanuel recommends limiting US health care cost growth to match US economy's GDP growth for improved quality of care and transformed healthcare system. The proposal involves team-based care coordination, reduced hospitalizations, and more outpatient monitoring.
A $1.4 million project led by CWRU psychologist Julie Exline aims to understand the factors behind religious and spiritual struggles. The study will explore how spiritual conflicts arise, resolve, and impact individuals from different life stages, including college students, US adults, and military veterans.
The US has much higher medical costs and worse outcomes than other developed countries. A new study suggests that the increasing prices of drugs, medical devices, and hospital costs are driving the high healthcare costs in the country. Meanwhile, patients are further removed from understanding the true cost of their care.
A new study reveals that die-hard Oregon State Beavers fans reject ads from rival team Oregon Ducks, even if the ad is compelling. Highly identified fans are most affected by this bias, prioritizing their team loyalty over advertising messages.
The institute will utilize its high-throughput, human cell-based assays and induced pluripotent stem cells to analyze thousands of potential toxins. This collaboration aims to provide an early and relevant assessment of potential toxicities in a rapid and cost-effective manner.
A new experiment in Pennsylvania reveals insight into how insects fly and how to design tiny flying robots. The analysis improves understanding of insect flight and informs the design of small flying robots for various purposes.
Women who have undergone bariatric surgery are at increased risk of premature birth and low birth weight, according to a large registry study. The study suggests that prenatal care should be monitored extra carefully for these women.
The new guideline identifies four major groups of patients who will benefit from statin therapy to prevent stroke and heart attacks. Adopting a heart-healthy lifestyle is also crucial in preventing high blood cholesterol.
Researchers found that individuals with high conscientiousness traits are more likely to exhibit effective behavior in customer service situations. The study suggests that personality plays a significant role in shaping customers' experiences.
A WSU-led study finds that modifying a drug to target specific human proteins could lead to new treatments for cancers and immune-related diseases. Researchers discovered that simple modifications to the drug furamidine have a major impact on its ability to affect genes.
The Solar Wind Electron Analyzer (SWEA) will track how charged particles, such as planetary oxygen ions, escape the planet's atmosphere. By identifying electrons in the solar wind and Martian ionosphere, SWEA can determine where the boundary layer between the two regions is located.
Researchers discovered that electrons in cerium dioxide nanoparticles behave like a cloud, distributing themselves over the entire nanoparticle. This finding challenges the traditional model of electron behavior and opens up new avenues for research on nanomaterials.
Researchers found that plants with semi-dwarfism in wild Arabidopsis species have a mutated GA20ox1 allele, similar to those in rice and barley varieties bred for high yields. The mutation alters the gibberellin biosynthesis pathway, but other genes compensate for its effects.
A new intravaginal ring has been developed to deliver tenofovir and levonorgestrel, providing dual protection against HIV and unintended pregnancy. The ring shows promising results in preclinical trials, with local levels of tenofovir similar to those achieved with a gel.
Researchers at NYU College of Nursing have developed a new method to detect breast cancer-related lymphedema using Bioelectrical Impedance Analysis (BIA) ratios. The study found that BIA ratios can accurately identify lymphedema in breast cancer survivors, allowing for earlier treatment and better outcomes.
A new multi-million dollar collaboration aims to enable university researchers to harness the full potential of data-rich world in various scientific fields. The 5-year, $37.8 million initiative seeks to establish career paths for data scientists, build sustainable research ecosystems, and facilitate collaborations across institutions.
Researchers discovered that rotating plasma during disruptions can spread energy around the vessel, reducing heat load. The Alcator C-Mod team found spontaneous rotation in tokamaks, while DIII-D tested theory using 3D magnetic fields to control instability direction.
NASA satellites tracked Typhoon Haiyan's movement and provided rainfall data to help forecast its impact. The data showed the storm's flood potential increased significantly before its second landfall in northeastern Vietnam.
The Department of Defense has awarded Nemours a $3.9 million grant to evaluate how physicians use best practice guidelines and strategies to maintain clinical skills. The study will examine patterns in physicians' types of cases and their variability in practice for certain targeted medical conditions.
The new guideline broadens cardiovascular risk assessment to include stroke, providing new gender- and ethnicity-specific formulas. It aims to identify high-risk patients who may benefit from lifestyle changes or drug therapy.
Researchers at Berkeley Lab have developed a technique to image individual carbon nanotubes, allowing for the characterization of their electronic and optical properties. This breakthrough enables the identification of specific species of nanotubes in functional devices, crucial for advancing nanotube technology.
A Polish study has developed a new imaging modality using Magnetic Resonance Imaging-Ultrasound (MRIUS) to guide prostate biopsies, yielding higher sensitivity rates compared to traditional TRUS biopsies. The technology, which fuses MRI with TRUS images, allows for real-time guidance of targeted biopsies in office settings.
The Stanford team's molecular invention enhances the immune system's ability to kill cancer cells, while a Johns Hopkins University team develops a better heart shock system. Other notable inventions include a mechanical leech substitute and an early detection system for ovarian cancers.
A growing body of evidence shows that diet affects brain function and identifies patterns associated with eating disorders like binge eating. Targeted magnetic stimulation reduces severe eating disorder symptoms, while rats' impulsivity is linked to calorie consumption on binges.
Researchers in the UK found that organs from selected DCD donors with pre-hospital cardiac arrest had no significant impact on graft or transplant recipient survival compared to other deceased donors. The study suggests using these organs could boost the donor pool without adverse outcomes for liver transplant recipients.
Studies on armadillos, fruit flies, nematodes, and monkeys reveal insights into progressive blindness, brain structure, and decision-making. The findings also highlight the importance of animal models in understanding human brain function and developing medical diagnostic devices.
A cognitive-behavioral intervention called problem-solving education (PSE) may help reduce parental stress and depressive symptoms immediately after a child is diagnosed with autism spectrum disorder (ASD). Mothers of children with ASD report high levels of parental stress, depressive symptoms, and social isolation.
Researchers have identified a crucial intermediate step in the formation of plaque that causes type 2 diabetes. The protein amylin aggregates into plaques that kill cells, but animals resistant to the disease prevent this by targeting an earlier clumping process.
A Penn Medicine study finds that sons of cocaine-using fathers are less likely to want the drug and resistant to its effects. The research suggests that epigenetic changes caused by cocaine use can be passed down to the next generation, potentially making them less susceptible to addiction.
A new biosensor developed by Johns Hopkins University researchers can detect a protein associated with brain injuries, alerting doctors to devise new treatments or begin treatment more quickly. The device could help minimize brain damage and improve long-term outcomes for patients who undergo heart surgery.
Researchers at McMaster University have identified a protein called Xin that serves as a biomarker for muscle damage. Xin is only detectable after muscle injury and shows a strong correlation with the degree of damage, regardless of the cause.
Researchers have discovered that polymers can disrupt the way bacteria communicate with each other, leading to unexpected clustering behaviors. This finding has significant implications for the design of materials as antimicrobials, bioprocessing, and synthetic biology.
A large population study found that being overweight or obese is a significant risk factor for heart disease, regardless of the presence of metabolic syndrome. The study suggests that achieving and maintaining a healthy weight is crucial in reducing the risk of cardiovascular disease.
A study published in Neurosurgery found significant variations in hospitals' management of children with traumatic brain injury, particularly in ICP monitoring and craniectomy. The study analyzed data from over 7,000 children treated at 156 US hospitals and found that rates of these interventions varied significantly between hospitals.
Pregnancies with twins or higher-order multiple births cost significantly more due to increased maternal morbidities, cesarean sections, and neonatal intensive care. Strategies to minimize multiple embryo transfer are recommended to reduce the burden associated with multiple pregnancies.
A new study published in PLOS ONE found that high concentrations of tungsten are strongly linked with an increased occurrence of stroke. The research, conducted by the University of Exeter, analyzed data from a large US health survey and found that tungsten could be a significant risk factor for stroke, even in people under 50.
Researchers have created robotic devices that mimic the movement of clams and snails, enabling them to burrow into sand with reduced friction. These devices could find use in applications such as automatic tethers, anchoring systems, and underwater mining.