Researchers have discovered how and why an anti-cancer therapy stops working when tumor cells become starved of oxygen. This new understanding could lead to the development of more effective therapies for cancer treatment.
Researchers at Harvard School of Public Health discovered that cells move in a group, propelled by forces from within and nearby cells, to fill spaces. This phenomenon, dubbed 'kenotaxis,' could improve understanding of disease mechanisms and inform potential drug targets.
The study found 5 genetic regions linked to the onset of migraine and identified 12 genetic regions associated with migraine susceptibility. The regulation of these pathways may be important to the genetic susceptibility of migraines, which affects approximately 14% of adults and is a debilitating disorder.
A pilot program for CalPERS reduced healthcare costs for members undergoing hip and knee replacements by 19%. The program, which provided list of designated facilities that met quality requirements, resulted in lower prices for procedures performed at non-designated facilities.
Researchers at RIKEN have developed a new sugar and water-based solution called SeeDB that turns tissues transparent in just three days without disrupting their shape or chemical nature. This technique enables the visualization of neuronal circuitry inside a mouse brain, revealing detailed wiring patterns and single-fiber resolution.
A team of researchers at Massachusetts General Hospital has found that CRISPR-Cas RNA-guided nucleases can cause off-target mutations in human cells, with rates potentially higher than at targeted sites. This limitation highlights the need to improve the precision of these gene-editing tools for therapeutic applications.
Researchers mapped the genome's 3D structure, finding that selected exons are exposed and accessible to transcription machinery. This reveals a new mechanism by which the genome's folding regulates gene expression and splicing.
The EHRA White Book reports on arrhythmia treatments in 55 ESC member countries, with a focus on lead extractions. Lead extraction data reveals significant morbidity and mortality worldwide.
A recent study published in Nature reveals that septins play a crucial role in activating the calcium channel on T cell surfaces, allowing them to fight disease. This discovery provides new insights into the intricate pathways involved in turning on T cells and could lead to the development of more targeted drugs.
Patients with paroxysmal atrial fibrillation (AF) show signs of depression, sleeping disorders, and low levels of physical activity, despite physicians rating their quality of life higher. Good communication between physicians and patients is crucial for adherence to medications and long-term prognosis.
A study found that low-income uninsured adults are less likely to have chronic conditions like hypertension, diabetes, and hypercholesterolemia. However, those with these conditions are more likely to be undiagnosed or uncontrolled.
New research funded by the Economic and Social Research Council reveals that athletes who recognize early when a goal is unattainable are more successful at achieving their main career goals. Athletes with self-motivation find it harder to disengage from an impossible goal, leading to psychological distress.
Plants perform accurate arithmetic division to adjust their rate of starch consumption, using internal clocks and molecular signals. This calculation helps them prevent starvation and make efficient use of food, with the goal of boosting crop yield.
Research suggests H7N9 has a lower fatality risk than H5N1 but higher risk than pandemic H1N1. Between 0.16% and 2.8% of symptomatic patients are at risk of dying, highlighting the need for continued vigilance against the virus.