A Penn study reveals that low levels of mitochondrial DNA in tumor cells from aggressive breast cancer patients can lead to the development of metastatic properties. The research, published in Oncogene, breaks ground in understanding cancer progression and may offer a biomarker for personalized treatment approaches.
A study by the American College of Allergy, Asthma and Immunology reveals that asthma sufferers allergic to cats has more than doubled over an 18-year period. Those with asthma are also 32% more likely to be allergic to cats than those without asthma.
Research suggests that pregnant women who receive allergy shots may reduce their child's risk of asthma, food allergies, and eczema. Allergy shots, also known as immunotherapy, can modify and prevent disease progression.
A study by Timothy Craig, MD, found that allergy shots decrease anxiety and depression in those allergic to wasp, bee, and ant stings. Allergy shots are the only treatment known to modify disease progression, making them life-saving for severe allergy sufferers.
Researchers found that the immune system's JunB gene causes liver cells to become inflamed during hepatitis, leading to irreversible damage. The study proposes a new mechanism by which AP-1 acts as a double-edged sword in the liver, contributing to both viral defense and disease progression.
A cross-linguistic study found that words signaling problems with understanding, such as 'Huh?', have similar form and function in languages worldwide. This discovery sheds light on the evolution of human communication and the role of universal linguistic devices.
A new study from the University of British Columbia's Sauder School of Business found that people are more likely to donate when their token support is private, not public. Publicly showing support on social media can actually decrease the likelihood of donating later.
The sun recently emitted a powerful X1.1 flare, disturbing the layer where GPS and communications signals travel. Increased flares are common during the sun's peak activity cycle, which is currently ramping up toward solar maximum conditions.
A study by the American College of Allergy, Asthma and Immunology found that children in southeastern and southern states are more likely to develop hay fever. Climate factors such as temperature, precipitation, and UV index contribute to this increase.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered an enzyme, Wip1 phosphatase, that plays a critical role in regulating tumour growth. By inhibiting the action of this enzyme, cancer growth can be stunted and tumours can be cured without developing resistance.
Super-Typhoon Haiyan maintained its structure and remained a powerful Category 5 tropical cyclone as it exited the western Philippines. The storm brought heavy rainfall potential and thunderstorms to various regions, with warnings still in effect across the country.
Researchers at Massachusetts General Hospital found that mice lacking TRPC5 were protected from losing kidney filter function following kidney injury. Pharmacological inhibition of TRPC5 also protected animals from protein loss in the urine.
A study found that Boston-area military veterans diagnosed with PTSD experienced flashbacks and unwanted memories after the Boston Marathon Bombing in April 2013. The researchers urge healthcare systems to be prepared to treat individuals affected by such tragedies.
Individuals with a known gelatin allergy can experience mild to severe reactions from the flu shot, including hives, sneezing, and difficulty breathing. Precautions should be taken when receiving the vaccine, such as having a board-certified allergist administer it.
Researchers found that Oxantel inhibits biofilm formation by targeting an enzyme crucial for bacterial growth, offering a potential therapy for periodontitis. Periodontitis is linked to various health risks, including diabetes, heart disease, and certain cancers.
Researchers identified KDM2A as a histone demethylase associated with non-small cell lung cancer. Induced KDM2A expression increased cell proliferation and invasiveness through ERK1/2 signaling pathway activation.
Adult females are more prone to allergies, asthma and autoimmune diseases compared to males, with gender differences changing after puberty. Genetics play a role in determining allergy and asthma risk, with personalized medicine being key to effective treatment.
A TGen-led study reveals TWEAK-Fn14 as a key drug target for preventing cancer spread, particularly brain cancer. Four compounds inhibit the binding of TWEAK to Fn14, including L524-0366, which suppressed glioma cell migration without cytotoxic effects.
Elderly patients who start dialysis after age 75 have a high mortality rate, with half dying within one year. Healthier elderly patients do better than those with declining health.
The CO2CARE EU project has successfully demonstrated the safe and sustainable closure of a CO2 storage site, meeting key requirements for geological carbon capture and storage. The Ketzin pilot site's termination marks the first site to be closed within a scientific project.
A new method predicts the time from Alzheimer's disease onset to full-time care, nursing home residence, or death with high specificity. The method uses a complex model based on data gathered from a single patient visit and can predict outcomes such as time to assisted living or incontinence.
A study by Michigan Medicine found that female family physicians are more likely to order the HPV test for low-risk women aged 30-65 compared to their male counterparts. The likelihood of ordering the test also varies among clinics and physician training levels.
Scientists have discovered a molecule called CNFy produced by the bacteria Yersinia pseudotuberculosis, which facilitates the infection process by manipulating the host cells' molecular switches. This allows the bacteria to inject toxins into immune cells more efficiently, leading to inflammation and tissue damage.
A team of researchers has identified a family of enzymes crucial for cancer growth in p53 mutant cells. Targeting these enzymes with novel agents may prevent the growth of p53 mutant cancers, benefiting patients with breast, ovarian, lung, colorectal, and brain tumors. The study suggests that inhibiting Type 2 PIP kinases could shut do...
Researchers have discovered that zebrafish chemicals can differentiate human stem cells into muscle cells in the laboratory, making muscle cell therapy a more realistic clinical possibility. The discovery has the potential to revolutionize treatments for muscular dystrophy and diabetes.
The global prevalence of kidney failure treatment is skyrocketing, with a 165% increase in dialysis treatments over the past two decades. Dialysis therapy has seen significant growth, particularly in countries with universal access, where adjusted prevalence increased by 134%.
A USC study has identified a cellular signaling pathway that converts healthy mesenchymal stem cells in the jaw into tumor cells, leading to benign but potentially harmful tumors. The researchers hope that this understanding can be used to develop target-specific treatments for these tumors.
Researchers identify genes that promote stem cell self-renewal and tissue repair, opening up possibilities for metabolic drugs to enhance regeneration. A network of RNA-binding proteins regulates stem cell function and tissue growth during fetal development.
An international team of researchers urges the development of science needed to manage climate risks and capitalize on unexpected opportunities. Climate preparedness research integrates social and climate science, engineering, and other disciplines.
Research suggests that living through war leads to increased solidarity among members of one's own group, shifting motivations toward greater equality. This effect is most pronounced when the war experience occurs during middle childhood and adolescence, leaving a lasting impact on psychology.
A new study by Professor Terry Sloan and Professor Sir Arnold Wolfendale found that changes in solar activity had a negligible impact on global temperatures. The researchers compared data on cosmic rays entering the atmosphere with global temperature records, concluding that less than 14% of the twentieth century's warming was attribut...
A recent study published in Nutrition found that higher chocolate consumption is associated with lower total and central body fat levels in European adolescents. The researchers controlled for other factors, such as diet and physical activity, to reach this conclusion.
Researchers developed a saliva test for diagnosing acute kidney injury, found Mediterranean diet linked to reduced risk of chronic kidney disease, and explored mindfulness meditation's benefits on blood pressure in patients with kidney disease. Initiating dialysis can cause significant burdens and loss of independence in elderly patients.
A University of Michigan Health System study found that prenatal group visits for expectant Japanese women who discussed childbirth and baby care topics with peers felt less anxious and better prepared. The groups allowed women to connect on a personal level, share experiences, and take control of their pregnancy.
Researchers discovered that the SLC24A5 gene plays a crucial role in skin pigmentation variation among South Asians. The study found evidence of positive selection for this gene in North India but not in South India, highlighting an intriguing interplay between natural selection and demographic history.
Researchers found that Cul4 modifies histone proteins to weaken their interaction with chaperones, leading to genomic instability and tumor formation. The study suggests that cancer cells may have evolved mechanisms to disrupt proper nucleosome assembly, affecting genome stability.
Breast cancer cells with high levels of microsomal glutathione S-transferase-1 (MGST-1) resistant to chemotherapy can be killed using nanoparticles carrying doxorubicin. This approach enhances the effectiveness of drug treatment while minimizing adverse reactions.
Research team develops co-assembly approach to create complex nanostructures with preprogrammed properties. The nanoparticles, resembling caterpillar larva, can be designed with specific functions and stimuli responsiveness.
Allergy expert Dr. David Stukus debunks common myths, including artificial dyes, vaccines, at-home blood tests, dietary restrictions, and pet allergies. He emphasizes the importance of consulting a board-certified allergist for proper evaluation and treatment.
NASA satellites captured high-resolution images of Super-Typhoon Haiyan, revealing a powerful eye and widespread thunderstorms. The storm's maximum sustained winds reached 165kts (190mph) with heavy rain potential due to extremely cold cloud top temperatures.
A new study finds that 65% of Americans agree clinicians should be involved in explaining DTC genetic test results. This concern is shared by physician groups and medical journals, highlighting the importance of doctor guidance on interpreting genetic risks.
A peptide fragment derived from cow's milk, lactoferricin B25, exhibits potent anticancer capability against human stomach cancer cell cultures. This finding provides support for the potential therapeutic agent for gastric cancer treatment.
A randomized trial found that lowering salt intake reduces excess fluid volume, blood pressure, and protein excretion in the urine of people with CKD. This could lead to a 30% reduction in risk of progressing to end-stage kidney disease.
A new study finds that high temperatures and low rainfall influence trachoma transmission in Africa, with eye-seeking flies more active at higher temperatures and abundant in areas with low rainfall. The World Health Organization aims to eliminate blinding trachoma by 2020, but understanding all factors affecting the disease is crucial.
A recent study led by Ohio State University researchers reveals that the virus that causes cervical cancer can directly damage host DNA and contribute to cancer development. The study used whole-genome sequencing to investigate the relationship between HPV and human genomes in cancers.
Researchers at Rice University discovered that the accumulation of von Willebrand factor (VWF) in heart valve tissues contributes to their progressive hardening with age. As tissues from pig valves are commonly used to make human heart-valve replacements, VWF helps regulate blood clotting in both pigs and humans.
Researchers at University of Copenhagen and University of Edinburgh identified 53 genes that regulate cell adhesion in embryonic stem cells. This new insight will enable scientists to maintain stem cells more effectively and efficiently manipulate adult cells to revert to a stem cell-like stage.
Dartmouth researcher Scott Williams found that a person can have multiple DNA mutations in different parts of their body, resulting in varying genotypes. These discoveries challenge traditional views on human uniqueness and may impact forensic analysis, paternity testing, and genetic screening.
Bariatric surgery can help obese kidney disease patients lose weight, but it comes with a higher risk of complications and mortality. The study found that 61% of patients lost weight after surgery, but experienced 16 adverse events, including two deaths related to surgical complications.
Scientists at Boston Children's Hospital discover that enhancing cell metabolism is key to tissue repair, opening new avenues for regenerative treatments. They found that reactivating the dormant Lin28a gene enhances mitochondrial metabolism, leading to enhanced wound healing and regeneration.
A Swedish study found that birth before 32 weeks is associated with increased risks of retinal detachment in childhood, adolescence and young adult life. The research indicates the need for ophthalmologic follow-up in children and adults born extremely and very prematurely.
Researchers have developed software that can learn from a patient's normal and seizure electrical activity to predict when another seizure may occur. This allows for an early warning system, potentially enabling people with epilepsy to live safer lives by avoiding hazardous situations before a seizure begins.
Researchers discovered that the Lin28a protein enhances tissue repair in adult mice, promoting hair regrowth and repairing damaged ears and digits. This finding opens up potential treatments for adults using drugs to boost wound healing and cellular metabolism.
A new study found that seven in 10 primary care patients with anxiety disorders eventually received adequate medication or psychotherapy, but this took years and was less likely for minorities. The study also showed that people with higher education levels were more likely to receive care.
A recent study published in the Journal of Nutrition Education and Behavior found that three educational sessions on nutrition had a significant impact on the knowledge and behaviors of 118 low-income women. The classes used a holistic approach and experiential learning, covering topics such as shopping, cooking techniques, and food se...
Research finds that war exposure during key periods of life strengthens affinity for one's own group, promoting nation-building or conflict cycles. The study involved participants from war-torn Georgia and Sierra Leone, who showed greater willingness to reduce inequality with partners from their village or school.
A UCSF scientist suggests that complex gene expression mechanisms in humans may have evolved to counter viral infections, rather than for overall organism development. This idea challenges conventional wisdom about the evolution of eukaryotic cells.
A new computational method, LACHESIS, has been developed to quickly assign, order and orient DNA sequencing information along entire chromosomes. This approach can validate chromosomal abnormalities in cancer research and pave the way for low-cost, high-quality genome assemblies.
A study by Georgia Tech researchers found that people in the US and South Korea prefer wearing e-textiles on their wrists and forearms, with minimal acceptance for other locations. Cultural differences play a significant role in perceptions of wearable technology, with Americans focusing on ease of use and South Koreans prioritizing mo...
Recent advances in robotics enable the creation of prosthetics that mimic natural movement, allowing users to navigate stairs and uneven ground with reduced stress. Studies have shown improved walking speed, decreased energy expenditure, and reduced fall rates compared to passive prostheses.