A landmark study across many cancer types reveals that the universe of cancer mutations is much bigger than previously thought. The team's work expands the list of known genes tied to these cancers by 25 percent.
A study by the University of Georgia found that people with impulsive personalities are more likely to experience food addiction, a compulsive pattern of eating similar to drug addiction. This is associated with obesity, highlighting the need for new treatments to address compulsive eating habits.
Researchers have developed a new mouse model for metastatic prostate cancer, called RapidCaP, which reveals a specific role for Myc as a driver of metastasis in prostate cancer. The study suggests that targeting the Myc gene may provide a new approach to cure incurable prostate cancer.
The Journal of Facade Design and Engineering is a peer-reviewed, open-access journal focused on the building envelope, aiming to improve building technologies and process management. Funded by NWO, it invites papers on facade design, engineering, and industrial innovations to disseminate science into practice.
Multicellularity has evolved in at least 25 plant and animal lineages, with different developmental pathways and mechanisms. The critical point is that natural selection acts on functional traits, allowing for multiple evolutions of multicellular organisms via various cellular biology aspects.
A new study published in Diabetologia confirms that working-age adults with diabetes are at a higher risk of influenza compared to non-diabetic individuals. The research suggests that vaccinating this group could be cost-effective and mitigate healthcare costs associated with flu-related hospitalizations.
Researchers at SISSA investigated the structural elements of prion proteins, finding that misfolding originates in the N-terminal region. This knowledge is crucial for developing drugs and therapeutic strategies against diseases like Creutzfeldt-Jakob disease.
A simple protein test may help predict survival rates for patients with head and neck cancer by identifying HPV-positive tumours. This test could allow doctors to choose more appropriate treatments, leading to better outcomes for patients.
Researchers at Case Western Reserve University have found that individual cells in the hippocampus use small electrical fields to stimulate and synchronize neighboring cells, spreading activity layer by layer. This discovery suggests a possible novel target for seizure-blocking medicines.
Dr. Jeremy Robinson, a researcher at the Naval Research Laboratory, has won the Presidential Early Career Awards for Scientists and Engineers for his groundbreaking work on graphene. He is building on his brother's research to develop new sensors and applications for nanoelectronic communication.
Researchers found that emergency patients were 59% less likely to have repeated CT scans, 44% less likely for ultrasounds, and 67% less likely for chest X-rays when both hospitals shared patient records. The study suggests health information exchanges (HIEs) may deliver efficiency they promise.
Researchers at VIB and Ghent University discovered a protein complex that regulates the transition from cell division to cell specialization in leaves. By extending the activity of this complex, more cells divide, resulting in larger leaves.
Researchers found that fetal surgery activates a mother's T cells, which normally reject foreign organs. In mice, this activation leads to preterm labor and fetal death. The study provides possible clues to the high rate of preterm labor after human fetal surgery.
A systematic review found that patient decision support interventions have inconsistent results in reducing healthcare spending, with some studies predicting savings ranging from $8 to $3,068 per patient. The impact on treatment utilization rates was mixed and the quality of economic analyses varied.
Researchers have established a new biomarker for stress in wild animals, using hair cortisol concentration (HCC) to monitor polar bears affected by global climate change. The technique has been successfully applied to analyze cortisol levels in polar bear hair samples from the past century.
Scientists are conducting a Phase 1 clinical trial of EDP-788, an oral antibiotic targeting methicillin-resistant Staphylococcus aureus (MRSA) infections. The trial will evaluate the safety and pharmacokinetics of the drug in healthy participants.
Scientists from the University of Manchester identified Leri's pleonosteosis as caused by extra genetic material on chromosome 8. The condition is also linked to scleroderma and offers opportunities for understanding and treating both diseases.
A new wireless surveillance system, TernCam, reduces battery life without compromising image quality. The system enables real-time visual data collection and has successfully transmitted signals in severe weather conditions.
Chi-Huey Wong, a professor of chemistry at The Scripps Research Institute, has been awarded the 2014 Wolf Prize in Chemistry for his groundbreaking work on synthesizing complex carbohydrates and glycoproteins. His research methods have led to breakthroughs in understanding cancer progression and developing vaccines and therapeutics.
Researchers have made refinements to a technique combining MRI and near-infrared spectroscopy (NIRS) to improve image quality and accuracy in detecting breast cancer. The new design allows for increased coverage of the chest, providing improved visibility for 'hard-to-see' areas, and has shown promising results in clinical trials.
A Phase I clinical trial is underway to evaluate the safety and dosing of a personalized vaccine targeting cancer stem cells in patients with recurrent glioblastoma multiforme. The vaccine aims to boost the immune system's ability to recognize and destroy cancer cells, potentially leading to improved treatment outcomes.
Carnegie Mellon University researchers Roberta Klatzky and J. David Creswell develop a new sensory integration model to explain the mechanisms underlying unconscious priming, which affects how we think and behave in social contexts. The model provides a clearer understanding of when and why primes influence behavior.
Researchers found that interplanetary dust particles carry both water and organics needed for the origin of life. This mechanism could also work for exoplanets, enabling water formation through solar wind irradiation. The discovery sheds light on the Moon's OH and water ice, as well as asteroid and comet origins.
Barton's team will develop interconnected, web-based analysis and visualization tools to discern complex relationships among societies and their environments. The project aims to create new insights into socio-ecological systems and make them accessible to the general public, policymakers, and stakeholders.
Researchers Sarj Patel and Tom Rau aim to identify biomarkers of TBI through blood samples, improving diagnosis and treatment. The goal is to understand how localized injuries affect the entire brain.
Researchers developed a reliable 3-D MRI imaging technique to study premature brain development. This allows for early identification of delayed tracts and potential treatments, enabling proactive therapies within weeks of birth.
A study by researchers at the University of California, Davis found that growing up in space weakens a key immune system pathway in Drosophila flies. The Toll pathway was 'non-functional' in space-raised flies, but showed improvement under hypergravity conditions.
A new study by Matthew Ravosa and colleagues at the University of Notre Dame reveals that dietary influences play a crucial role in shaping the human skull. Contrary to long-held assumptions about hard object feeding, the research suggests that early human ancestors, such as Australopithecus, relied on tough foods year-round.
Researchers at the University of Leicester have found two versions of a protein called Cryptochrome in wild populations of fruit flies, both with different amino acids that affect the circadian clock. The study suggests that this variation is functionally important and actively maintained by natural selection.
A Baylor University study found a positive association between religiosity and loving attitudes toward other racial and ethnic groups, but not those who violate values. Researchers studied 389 religiously diverse adults in an online survey to examine the relationship between religiosity and love of neighbors.
A study by Northwestern University found that doctors who use electronic health records in the exam room spend about a third of their visits looking at computers, leading to missed nonverbal cues. The study suggests that interactive screen sharing could improve doctor-patient interaction and contribute to better-designed technology.
A recent study by Loyola Medicine finds that many internists feel ill-equipped to care for adult childhood cancer survivors due to inadequate education and training. The study highlights the need for primary care physicians to have access to survivorship care plans and guidelines.
New research reveals that humans have actively managed Southeast Asian rainforests for over 11,000 years by clearing vegetation to plant food-bearing plants. Pollen samples and archaeological findings indicate repeated disturbances to vegetation since the end of the last ice age.
Astronomers plan observations of supernova SN 2014J with NASA/ESA Hubble Space Telescope and other space missions. The event provides an opportunity to study how interstellar dust affects its light.
Increased inflammation after infections impairs brain's ability to form spatial memories by disrupting neural circuits involved in learning and memory. The study used PET scans to measure effects of inflammation on glucose consumption in the brain, revealing a decrease in glucose metabolism in the Medial Temporal Lobe.
Scientists at King's College London argue that biobank donors should have unrestricted access to data derived from their own material. This move aims to increase reciprocity and partnership between donors and researchers, recognizing the donor's agency in decision-making processes.
A new analysis of 63 animal studies found that industry-sponsored studies had less favorable results than non-industry funded studies. This highlights the role of selective reporting and methodological problems in communicating research findings.
A study in PLOS Genetics found that HIV drug resistance mutations can spread rapidly within a patient, leading to a homogeneous or heterogeneous viral population. The researchers estimate the effective population size of HIV to be around 150,000, which may help inform treatment strategies and predict resistance evolution.
A research team led by USF Health's Michael White and Elena Suvorova aims to identify new factors required for malaria-related parasites' growth. The study may lead to the development of new therapies against malaria, a deadly mosquito-borne disease.
Researchers tracked six dogs and their owner on group walks to measure social behavior and determine personalities. Dogs that consistently took the lead were more responsive to training, older, and more aggressive than those that followed.
Researchers at Duke University found that long-term spinal cord stimulation improved symptoms of Parkinson's-like disease in rats, protecting critical neurons and promoting better survival. The treatment may offer a new option for managing the condition.
Research reveals frog calls create ripples used by rival males to assess competition, but also detectors for predators like frog-eating bats. The study shows how complex communication can have costs and benefits through different sensory channels.
Researchers found that females who mated with preferred males produced more offspring and were better able to cope with infection from Salmonella compared to offspring sired by non-preferred males. The fitness benefits were due to tolerance to infection rather than immune resistance.
Studies demonstrate the utility of ultrasound in emergency medicine, yielding rapid and accurate diagnoses. Clinician-performed cardiac ultrasound has been shown to improve prognostic value, with significant correlation between GP and cardiologist measurements.
The Opportunity rover has discovered evidence of conditions that support the chemistry of life in Mars' past, earning a spot in Science magazine. The 10-year-old rover explored Martian geology and environmental processes, searching for signs of habitability and life.
Scientists have created a new statistical method to analyze individual cells, allowing for more accurate detection of cell properties. By combining data from multiple cells, researchers can reduce errors and overcome statistical noise, leading to better understanding of cellular behavior and development.
Researchers developed a tool to predict which direction a breast cancer tumor is most likely to go and how it will respond to chemotherapy. The study's findings reveal general rules, including genetic diversity within tumors and the importance of analyzing individual cells.
Researchers at MIT have developed flexible materials with nanoscale wrinkles that can control the wavelengths and distribution of waves, including sound and light. This technology could lead to new diagnostic tools for diseases like cancer and enable advanced noise-cancellation systems.
A recent study published in Medical Care found that psychiatric symptoms such as insomnia and emotional distress have a significant impact on work-related outcomes. The study suggests targeting symptoms, rather than disorders, may help lessen the work impact of mental health issues.
The genome of the world's oldest continuously surviving cancer, a transmissible genital cancer in dogs, has been sequenced. The cancer carries about two million mutations and is believed to have arisen 11,000 years ago. Analysis reveals that the cancer still harbors genetic variants from its ancient host.
The study demonstrates how cyanide and carbon monoxide are safely bound to an iron atom to construct an enzyme that can generate hydrogen gas. This discovery sheds light on the unusual chemistry involved in binding small molecules to metal atoms, a crucial step towards producing hydrogen using abundant metals.
Researchers found that males' ability to monopolize a female drives the evolution of their sexual traits. Some species invest more in weapons, while others prioritize large testes for fertility. The study looked at over 300 species and revealed surprising variations in male investment.
A new study found that US consumers changed their eating habits significantly between 2003 and 2011, leading to a decline in calorie consumption. The changes persisted independent of economic conditions, suggesting that public health efforts and increased awareness about healthy eating played a crucial role.
A new genus of rove beetles, Morphogenia, has been discovered in the Brazilian Amazon, featuring remarkable sexual dimorphism between males and females. The study highlights the vast number of species within this group, with over 9,000 known species, yet much still to be discovered about their ecology.
A recent study published in BMC Medicine has found that living in a household with a spouse who has type 2 diabetes can increase the risk of developing the condition. The research team analyzed data from six studies and found that spousal diabetes was associated with a 26% increased risk of developing type 2 diabetes.
Researchers find that people can detect unpleasant odors in sweat after exposure to toxins, potentially indicating an early immune response. The study suggests that there may be biomarkers for illness in the form of volatile substances from the body.
Studies found that African-American hemodialysis patients with sickle cell trait received about 13% more anemia medications than those without the trait to achieve the same level of hemoglobin. The presence of sickle cell trait was also more common among dialysis patients, affecting approximately 10% of study participants.
A South American tree species, Embothrium coccineum, has adapted to form cluster roots to access limited phosphorus in volcanic soils. Cluster root formation is stimulated by low soil nitrogen levels, enabling small seedlings to maintain adequate foliar P levels.
Researchers at Albert Einstein College of Medicine developed a mouse model with fluorescently tagged beta-actin mRNA, allowing them to observe the molecular processes that culminate in memories. The study revealed a novel mechanism by which brain neurons control the synthesis of beta-actin protein.
Researchers at VCU Massey Cancer Center are studying how the ACA affects cancer screening in low-income women and employed married women with breast cancer. The study found that Medicaid expansions increased breast and cervical cancer screening, particularly among low-income women, suggesting a positive effect of near-universal coverag...