A new study found that contact lens discomfort is associated with degradation of the lipid layer in the tear film. Applying a liposomal eyelid spray increased stability of the tear film and improved dry eye symptoms, suggesting potential benefits for patients with contact lens discomfort.
A new study by Duncan Simester and Juanjuan Zhang suggests that firms should allow their sales people to 'waste' energy on internal negotiations, making the process wasteful on purpose. This approach can increase trust in sales force and is profitable for firms.
A new study published in Immunity reveals that placental growth factor (PlGF) in the spleen activates harmful immune responses leading to high blood pressure. Mice genetically engineered to lack PlGF were protected from hypertension-related damage, suggesting PlGF as a potential therapeutic target.
Researchers found a long-term pattern in salinity-driven sea level changes globally, with increases in the Pacific Ocean and decreases in the Atlantic. This salinity effect accounts for approximately 25% of total sea level change, emphasizing its importance in assessments.
A new survey by NORC at the University of Chicago reveals that nine in ten employers offering insurance are unfamiliar with objective quality metrics, despite valuing plan quality ratings. Employers cite cost to employees as a key consideration when selecting health plans.
A new vaccine is being developed to prevent canine gum disease, a common condition that affects most dogs by three years of age. The vaccine targets the most common types of bacteria causing periodontal disease in dogs.
Scientists have created a massive map of direct protein interactions, revealing dozens of new cancer genes involved in lymphoid tumours. The study's findings shed light on how proteins 'stick together' to form the network, enabling researchers to pinpoint potential targets for treatment.
A new randomized controlled study, SPADE symptom pentad, investigates sleep problems, pain, anxiety, depression, and energy/fatigue in primary-care patients. The study aims to improve patient care by exploring how symptom scores can benefit physicians' treatment.
A University of Minnesota study found that natural genetic variation in a protective antiviral enzyme, APOBEC3H, can limit HIV-1 replication if the virus has weak Vif. This discovery opens doors to potential treatments by targeting Vif's ability to disable APOBEC3.
A multi-centre clinical trial suggests that a combination of three targeted drugs may be more effective than one drug for certain patients with advanced BRAF-mutated colorectal cancer. The treatment, which includes encorafenib, cetuximab, and alpelisib, showed improved efficacy and extended progression-free survival in patients.
A recent study using LiDAR technology has uncovered the ancient Roman goldmines in Spain, including channels, reservoirs, and a double river diversion. The findings provide new insights into the labour-intensive extraction process and highlight the importance of geo-archaeology in understanding Roman mining techniques.
Tropical Storm Adjali formed on November 16, 2014, and started dissipating two days later. GPM data showed moderate rainfall rates near the storm center, with rain falling at over 69 mm/hour per hour. The storm dissipated in the Southern Indian Ocean by November 20.
Researchers used a scanning tunneling microscope to create atomic-scale maps of quantum dot surface structures, pinpointing defect locations that limit device performance. This breakthrough should help manufacturers tweak synthesis processes to produce higher-quality nanomaterials for photovoltaics and other applications.
A study by Denis Duboule's team found that the formation of digits and external genitals involves a similar group of genes, with small modifications controlling their development. The researchers used chromosome conformation capture to demonstrate that a single regulatory DNA sequence controls both processes.
A recent study published in Nature sheds new light on how species diverge, finding that prolonged periods of landscape stability are more important than dramatic geographical changes. The research shows that longer the length of time a species can inhabit an area, the more likely it will disperse and diverge.
Research suggests that Peruvian coastal waters provide suitable habitat for endangered South Pacific green turtles, with healthy populations found in two sites off the southern and northern coasts. The study highlights the importance of conservation measures to protect these vulnerable species from pollution, bycatch, and illegal catch.
Researchers found that people with strong emotion recognition skills are perceived as more socially and politically skilled by colleagues and supervisors. They also earn significantly higher incomes. The study controlled for various factors affecting employee income and replicated its findings in a second study.
The Endocrine Society suggests a single dose of IV zoldedronate as the first-choice treatment for Paget's disease. This option can put the condition into remission for up to six years, making it a preferred choice over oral medications with gastrointestinal side effects.
Agricultural production contributes to a quarter of the increase in seasonal carbon cycle, with corn accounting for two-thirds of the crop contribution. The study highlights the impact of human activity on the planet and improves models of global climate.
A new model developed by University of Maryland researchers links intensive agriculture to increased atmospheric carbon dioxide levels, revealing a strong correlation between the Green Revolution and Earth's metabolism. The study found that crop production tripled while land planted with major crops grew by 20 percent, leading to incre...
The first issue of the 'From Policy to Practice' publication series from The Gerontological Society of America explores the impact of policies on pain care for older adults. Chronic pain affects 100 million Americans, costing the nation $635 billion annually, and this publication aims to address these issues.
An international team of researchers identified approximately 6600 genes whose expression levels vary within a restricted range in both mice and humans. These genes, which represent about one-third of active genes across tissues in both species, reflect evolution's constraint on their expression to maintain cellular housekeeping.
Steven Blusk's groundbreaking discovery of Xi_b'- and Xi_b*- particles has major implications for the study of quark dynamics. The unique mass of each particle is attributed to a heavyweight b quark and angular momentum, with the Xi_b*- state being slightly heavier due to its aligned spins.
Researchers at NYU Langone Health found that infection with a common virus helped mice repair damaged intestinal tissue and restore their immune defenses. The study suggests that the virome, or natural presence of viruses in the gut, plays a crucial role in maintaining health and fighting infections.
A study found that living kidney donors are at a higher risk of gestational hypertension and preeclampsia during pregnancy. Despite this, most women who become pregnant after donating a kidney have healthy pregnancies.
A French study found that men are more likely to help women wearing high heels than those wearing flat shoes. The study suggests that men associate high heels with femininity and attractiveness. Men were also quicker to start chatting with women wearing heels, indicating a stronger instinct to be helpful.
Children who receive a heart transplant quickly are predicted to have better quality-adjusted survival rates, even if they have antibodies that may attack the new heart. Transplanting with the first suitable heart is also cheaper than waiting for a better-matched organ.
Researchers found minimal increased risk in one study and a 50% reduced risk in another, leading to continued use of calcium channel blocker medications. The study's results contradict a previous report suggesting a higher risk of breast cancer among women taking the medication.
Researchers at Washington State University explore green alternatives to traditional salt, sand, and chemicals for snow and ice control. The focus is on reducing the environmental impact of these substances, which can contaminate groundwater and harm wildlife.
Researchers have found that mice and humans share similar genetic and biochemical programs for regulating gene activity, but also exhibit striking differences. The study provides insights into gene regulation and the use of mouse models to study human biology and disease.
Researchers have discovered that a significant number of mouse genes do not behave like their human counterparts, suggesting that science will need to rethink the role of the lab mouse. The findings come from the ongoing mouse ENCODE project and indicate that similar genes in humans and mice are expressed in different ways.
A catastrophic landslide, one of the largest known on Earth's surface, took place in southwestern Utah over 21 million years ago. The Markagunt gravity slide, measuring 1,300 square miles, is comparable in size to the Heart Mountain slide discovered in northwest Wyoming.
A recent study by Indiana University researcher Jonathon Beckmeyer found that adolescents' alcohol use is influenced by their close friends' use, regardless of peer consumption perceptions. Parents can encourage teens to make friendships with non-alcohol-using friends to help prevent teen alcohol use.
The Equitable Science Curriculum for Integrating Arts in Public Education project integrates arts and sciences to help elementary students grasp basic scientific concepts. The program, launched with $6.4 million NSF funding, uses creative movement and visual arts to enhance learning and reduce cognitive load.
A team of researchers has mapped the 'mission control centers' of the mouse genome, which are responsible for regulating gene activity. This discovery sheds light on why studies in mice cannot always be replicated in humans and highlights the importance of regulatory regions in common chronic human diseases.
Researchers found a link between the APOE e4 allele and increased risk of cardiovascular disease, as well as lower HDL cholesterol levels. Higher cholesterol in older adults may be associated with longevity, challenging current cholesterol-lowering medication practices.
Researchers used high-tech solutions to identify and relocate problem tigers in India, reducing human-wildlife conflict near protected areas. The stripe-matching software and individual histories helped make informed decisions on handling conflict-prone big cats.
New research suggests that racial discrimination, family issues, and economic constraints contribute to acculturative stress among Latina immigrants. Family support, however, acts as a protective factor against psychological distress. The study found that acculturative stress levels varied depending on individual circumstances.
A new study published in the International Journal of Environmental Research and Public Health found that e-cigarettes significantly reduced tobacco cravings. In an 8-month study, participants who used e-cigs showed a significant decrease in tobacco cigarette use, with 21% quitting smoking altogether.
Researchers at NTU Singapore have developed a novel biomarker that can detect tumour cells and release anti-cancer drugs, opening up new doors in nanomedicine, bioimaging, and cancer therapeutics. The biomarker uses near-infrared light to penetrate deep tissue without causing damage to healthy cells.
Case Western Reserve researchers have identified a protein mutation that prevents proper gonadal tissue development, leading to cancer and other issues. The discovery highlights the importance of the SRY protein in regulating male sex determination and has implications for understanding birth defects and cancer.
Researchers have identified an enigmatic object named SDSS1133, which could be a recoiling black hole ejected from its parent galaxy. The discovery, made using high-precision equipment and observations with the Hubble Space Telescope, presents a unique opportunity to study gravitational waves and their detection.
A recent study by Dana Bardolph found that female authors are underrepresented in American archaeology journals, accounting for less than 29% of published articles. The research suggests a pervasive gender bias in academia and publishing, with potential factors including authorial behavior and the submission process.
Researchers found that agricultural production, particularly corn, boosts the productivity of four leading food staples, significantly modifying the annual cycle of atmospheric CO2 in the Northern Hemisphere. This growth contributes up to a quarter of the total increase in seasonal carbon exchange, and possibly more.
Georgia Tech researcher Mark Riedl develops Lovelace 2.0 Test to evaluate artificial intelligence's human-level creativity, moving beyond the limitations of the Turing Test. The new test requires agents to create artifacts that demonstrate a range of human-like intelligent capabilities.
Researchers at Salk Institute develop a powerful dual-drug therapy that doubles the survival rate of mice with lung cancer and halts cancer in pancreatic cells. The treatment combines two existing drugs, Zometa and rapamycin, to successfully target KRAS mutation.
The Pitt Quantum Repository aims to create an open, mobile-ready database of accurate quantum calculations for molecules. This will enable students to visualize and understand molecular structures in 3D, improving learning outcomes.
A team of international researchers has detailed the functional parts of the mouse genome and compared them with those in humans, finding that certain processes are preserved through time. The study reveals new insights into mammalian biology and human illness mechanisms.
Researchers found that bacterial infections due to Staphylococcus aureus aggravate neurodermatitis by triggering the formation of myeloid-derived suppressor cells, which suppress both harmful and beneficial immune responses in the skin. This can lead to chronic inflammation, itching, and social stigmatization in patients.
A study analyzing Twitter data from over 700,000 tweets found that New Yorkers resumed normal mobility less than 24 hours after Hurricane Sandy. The researchers observed similar geographical and statistical distributions of locations before and after the hurricane, suggesting resilience in human movement during the disaster.
Queen's researchers have discovered a volcanic ash cloud that traveled from Alaska to Northern Ireland and beyond, overturning previous assumptions about ash deposits. The discovery has significant implications for the aviation industry and environmental science, highlighting Queen's impact on a global scale.
A team at Florida State University has made a new discovery about how human genetic material replicates within a cell's nucleus. The findings could lead to novel treatment options for cancer patients and those who benefit from stem cell-based therapies.
Researchers at Memorial Sloan Kettering Cancer Center have made a breakthrough discovery that may lead to a reliable diagnostic test for predicting which patients will respond to immunotherapy drugs like ipilimumab. The study found that tumors with high numbers of gene mutations are more likely to benefit from the treatment.
A Vanderbilt study reveals a significant increase in the number of women with early-stage breast cancer choosing mastectomy over breast conservation surgery. The trend was most pronounced among younger women and those with smaller tumors, suggesting factors other than disease burden are at play.
The study found that astrocyte hyperactivity is caused by energy carriers like ATP, leading to calcium fluctuations and changes in brain perfusion. The research suggests a novel potential approach for treating Alzheimer's disease by mitigating the hyperactivity of these cells.
Researchers discovered a vast network of lakes and rivers at the Gamburtsev Mountains' base, preserved by thick ice. The study explains how the blanket of ice has halted erosion, stalling aging of the mountains at higher elevations.
A new study by University of Illinois psychologist Karen D. Rudolph found that early puberty triggers psychological, social-behavioral and interpersonal difficulties that predict elevated levels of depression in both boys and girls. Early maturation was particularly detrimental to girls, who experience immediate psychological and envir...
Physicists at the University of Groningen have discovered a new manganese compound produced by tension in the crystal structure of terbium manganese oxide. The discovery could lead to the creation of new nanoscale circuits.
A new study by researchers at Michigan Medicine reveals significant variations in the quality and content of clinical cancer guidelines. The guidelines, published within the last six years, have average scores ranging from 27% to 90%, suggesting a wide disparity in treatment recommendations.
A laser used for tattoo removal has been found to improve facial acne scarring in a small study. The treatment showed significant improvement in skin appearance and texture, with patients reporting satisfaction rates of 25-100%. Additional research is needed to confirm these findings.