Parkinson's patients experience changes in body weight due to non-motor disorders, worsening their quality of life. Research highlights the role of depression, cognitive impairment, sensory disturbances, and motivation towards food consumption in altering eating habits.
Researchers discovered that WNT signaling molecules are crucial for cellular reprogramming, a process similar to regenerative processes in organisms. This finding has significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.
Researchers at Cardiff University are exploring a new method to detect the origins of gamma-ray bursts using giant space 'microphones' that can pick up gravitational waves created by black holes. By analyzing these waves, scientists may uncover information about the mass and collision history of star and black hole systems.
Researchers have determined that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. This knowledge could help identify an earlier clinical outcome measure of disease severity, enabling doctors to provide more aggressive supportive care for patients.
Researchers have uncovered a mechanism that explains why many ALS drugs fail as the disease progresses: the brain's pumps become more active and remove both toxins and medicine. Blocking these pumps improves drug efficacy in mouse models.
A novel combination therapy using low-dose chemotherapy with an antiangiogenic treatment, 3TSR, improved survival rates in an animal model of ovarian cancer. The treatment resulted in tumor regression, improved blood flow, and more efficient delivery of chemotherapy drugs with reduced side effects.
A new algorithm called Above Local Elevated Respiratory Illness Threshold (ALERT) uses routinely collected data to signal the start of elevated influenza activity. The tool allows users to customize results based on their institution's historical data, helping them determine when to declare flu season and take extra precautions.
A new technique allows ultrasound to penetrate bone and metal, enabling medical professionals to monitor blood flow in the brain or treat brain tumors more effectively. The metamaterial structure offsets distortion caused by these 'aberrating layers,' increasing wave energy transmission by up to 88%.
A study found that obesity causes subclinical heart muscle injury and increases the risk for heart failure, even in people without overt heart disease. Obesity was independently associated with increased troponin levels, a marker of heart damage.
A rarely seen tapeworm, Spirometra erinaceieuropaei, has been sequenced for the first time, revealing its genetic secrets. The parasite was detected in a UK resident's brain after traveling 5cm from one side to the other.
A new study shows that citizen science projects contribute to direct impacts on conservation, including shift in formal professions, initiation of new organizations, and influencing social circles towards the cause. Volunteer participation has also been found to increase knowledge and concern for wildlife rooted in science.
Researchers have developed a potent and systematic AC inhibitor, tilting the balance between pro-aging/death and pro-life chemical signals in favor of death. The compound may be used as 'chemosensitizers' to enhance anti-tumoral drug efficacy.
Researchers uncover fossils of Cambaytherium thewissi, a 54.5-million-year-old animal that provides a window into the common ancestor of horses, rhinos, and tapirs. The discovery supports the idea that Perissodactyla evolved in India while it was an island.
Researchers discovered sustained human habitation and farming between 2,500-3,400 meters above sea level 3,600 years ago on the Tibetan Plateau. This finding challenges previous understanding of human adaptation to high altitudes.
A study by Indiana University PhD candidates found that heterosexuals are equally supportive of legal benefits for same-sex couples as they are for heterosexual couples, but are less supportive of PDA. Gay and lesbian individuals were also found to be less supportive of certain public displays of affection due to safety concerns.
UTMB professors Scott Weaver and Slobodan Paessler received national awards from the American Society of Tropical Medicine and Hygiene. They are making significant contributions to understanding and controlling tropical diseases, including Ebola, mosquito-borne illnesses, and influenza.
A neural pathway in the habenula enables animals to predict dangers and update their expectations based on actions and new outcomes. The study's findings have implications for understanding anxiety and panic disorders, suggesting a potential therapeutic target for improving behavioral learning.
Salk scientists unveil a new method that enables detection of fleeting protein interactions, which could dramatically accelerate cancer drug discovery. The ReBiL method, published in Cell Reports, provides an immediate platform to screen for badly needed new drug candidates.
Researchers from Argonne National Laboratory and Brookhaven National Laboratory discovered the atomic structure of uranium dioxide changes significantly when it melts. The study enhances understanding of reactor safety during meltdown scenarios.
Scientists have determined the complete structure of the influenza virus polymerase, a key machine that makes copies of the virus' genetic material and reads out instructions. The high-resolution structure reveals how the polymerase works as a whole, providing new insights into its function and potential targets for drug design.
A team of geoscientists discovered a buried canyon beneath the Yarlung Tsangpo River, which helped reconstruct the gorge's geological history. The findings show that rapid tectonic uplift, not river capture, formed the Tsangpo Gorge and its steep form.
Hee Oh, a Yale University mathematician, has been awarded the 2015 AMS Ruth Lyttle Satter Prize for her groundbreaking work on dynamics on homogeneous spaces and its connections to number theory. Her research brings together seemingly disparate fields in a beautiful way.
A new study from UNC's Frank Porter Graham Child Development Institute reveals that disruptions in child care negatively affect children's social development as early as age 4. However, the effects of child care instability are not unduly large, and some types of instability appear to have no negative impact on children.
A study of 600 teenage boys found that up to 28% were inaccurate in estimating their weight status. The majority had a normal weight, but some underestimating or overestimating, leading to unhealthy behaviors like dieting and skipping meals.
Research reveals that human incisors grow quickly in the second trimester of fetal development, allowing them to erupt at six months. This rapid growth is thought to be an adaptation for early weaning, as it enables babies to transition from breast milk to solid foods sooner.
Scientists at Cincinnati Children's Hospital Medical Center have identified a class of lead compounds that successfully recognize a key target in the Ras signaling pathway, opening the door to future development of therapies. The lead compound NSC-658497 was found to be effective at blocking SOS1-mediated molecular signaling in the Ras...
The University of Louisville Department of Pediatrics has received a one-year, $50,000 grant from the St. Baldrick's Foundation to hire a nurse coordinator for neuroblastoma and sarcoma patients on clinical trials. The grant aims to provide additional access to clinical trials for local patients without having to travel elsewhere.
The STING pathway plays a crucial role in detecting tumor cells and promoting an aggressive anti-tumor response. Activating the pathway triggers production of chemical signals that help the immune system identify tumor cells and generate killer T cells.
A phase I clinical trial has demonstrated that ASP8273 causes tumour shrinkage in patients with treatment-resistant non-small cell lung cancer (NSCLC) who have both the EGFR and T790M mutations. The overall response rate is 78%, comparable to other drugs in development.
The National Science Foundation has awarded $31.5 million to develop and use co-robots that work cooperatively with people, advancing fundamental understanding of robotic sensing and motion. These robots will perform critical tasks safely and resiliently near humans.
Researchers at UW-Madison identified 1,300 host cell proteins the virus may use to infect cells, testing each protein to see whether eliminating it interferes with viral infectivity. The study aims to develop new drugs targeting cellular machinery rather than attacking the virus itself.
A study found that women in positions of power exhibit more symptoms of depression, while men with similar authority levels have fewer symptoms. The researchers suggest that women face chronic stress due to negative stereotypes and resistance from colleagues and superiors.
Researchers from CNIO discovered that a derivative of vitamin B3, nicotinamide riboside, prevents the development of liver tumors and induces tumor regression in mice. The study suggests that boosting NAD+ levels may have beneficial effects on cancer.
Heavy January rains in Svalbard caused record-breaking snow avalanches, making roads impassable. The extreme event also affected reindeer populations and permafrost temperatures, highlighting the increasing impact of climate change on Arctic ecosystems.
China's vast seawall, covering over half its coastline, faces criticism for ecological costs and lack of protection. The wetland ecosystems support millions of migratory birds and produce 28 million tons of fishery products, underappreciated services that threaten with unsustainable development
A new review finds that genetic variation may prevent some individuals with type 2 diabetes from benefiting from supervised exercise regimens. The study suggests that targeted interventions and treatments could help those who do not respond to exercise, offering a potential new approach for managing the condition.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism suggests that testosterone has a limited impact on menopausal women's interest in sex and sexual function. Psychosocial factors such as emotional well-being and intimate relationships are found to be stronger contributors to sexual health.
A Johns Hopkins University-led team has discovered a rich variety of organic carbon species in deep fluids, suggesting they could spark the formation of diamonds and potentially become food for microbial life. These findings, published in Nature Geoscience, provide new insights into the Earth's mantle and its role in the origin of life.
Researchers discovered that a key Ebola virus protein can trigger an excessive immune response, leading to massive inflammation and increased vascular permeability. This finding suggests a potential new target for reducing the severity of Ebola disease.
A new study published by Point Blue Conservation Science found that aggressive removal of conifers can restore aspen stands in the Sierra Nevada, increasing groundwater, enriching soils, and supporting biodiversity. The study's authors used bird species to measure the effectiveness of the restoration approach.
Researchers have discovered that the yellow fever virus replicates primarily in the liver, causing significant damage to liver cells. A new clinical parameter has been identified, which could help manage cases of yellow fever, allowing for earlier diagnosis and treatment.
Veronica Garcia, a UT graduate student, has been awarded a Robert D. Watkins Graduate Research Fellowship to study the molecular mechanisms of Alzheimer's disease and other disorders. The fellowship aims to increase diversity in microbiological sciences research.
A rare species of tapeworm, Spirometra erinaceieuropaei, found in the brain has its genome sequenced for the first time. The study identifies genes providing resistance to certain treatments and potential targets for known cancer drugs.
Researchers at Lomonosov Moscow State University developed a new method to estimate the magnetic field of an exoplanet. They successfully estimated the magnetic moment of the hot Jupiter HD 209458b, which is relatively small compared to Earth's magnetic field.
Researchers at the University of Pennsylvania School of Medicine have uncovered a molecular clock that regulates multiple phases of circadian cycles, allowing genes with related functions to oscillate in synchrony. This discovery has implications for developing more efficient pharmaceutical regimens and minimizing side effects.
A model inspired by epidemic disease spreading is used to analyze over 700 Amyloid-beta protein imaging datasets, concluding that misfolded protein propagation can be mathematically described. The study identifies genetic and demographic factors influencing this phenomenon in healthy aging and Alzheimer's disease progression.
Researchers found that caffeine can block cocaine's direct effects on the estrus cycle, potentially treating cocaine addiction. The study suggests a new approach to addressing sex differences in cocaine addiction.
Researchers developed a new biomarker called SDMA that can identify chronic kidney disease in cats earlier than existing tests. Special diets have been shown to slow the progression of this disease once identified, and may help extend the lives of affected cats.
A recent study found that tropical rickettsial illnesses, such as scrub typhus and murine typhus, can cause poor pregnancy outcomes, including stillbirth and premature birth. The study highlights the need for more research on the impact of these illnesses on pregnancy outcomes in South-East Asia.
A US policy giving priority to prior organ donors has been shown to significantly reduce waiting times and improve the quality of organs received. Living donors who later need a transplant experience much shorter waits and receive higher-quality kidneys compared to those on the waiting list without donation history.
Researchers found that university graduates in Canada report high levels of mastery, but also experience overwork, job pressure, and work-to-family conflict. These stressors undermine mastery, posing the biggest threat to Canadians' sense of control.
Researchers have developed a new computational model that can predict and identify gut metabolites produced by microorganisms, which could lead to improved diagnosis and treatment of GI diseases. The model focused on aromatic amino acids and predicted over 49 different metabolites exclusive to the microbiota.
A team of researchers reveals that dendritic cells activate killer T cells through a protein named STING, which links DNA damage to interferon-β production. This suggests novel strategies for boosting radiotherapy effectiveness and combining it with immune system therapies.
Researchers developed a sound-based training approach to enhance brain's distractibility, improving focus in aged rats and humans. Training reduced distraction-related errors and improved memory and attention spans.
A study by Brigham Young University researchers found that people say they care about online security but behave otherwise, ignoring malware warnings. Brain data is a better predictor of security behavior than self-response, suggesting a need to fortify the 'weakest link' in security.
Researchers at USC Health Sciences identified a new population of nail stem cells that can self-renew or differentiate into multiple tissues, including nail and skin. These stem cells play a crucial role in nail repair, but their potential to generate additional types of tissue is still unknown.
A team of researchers has discovered an ancient, deep canyon in South Tibet, which rules out a popular model explaining the formation of Himalayan gorges. The canyon is thousands of feet deep and was carved by a river that once flowed into the Tibetan Plateau.
Researchers used computational modeling to examine the role of genetic mutations in cancer growth, finding that genes never observed in cancers may be the best targets for therapy. Targeting these 'never mutations' in combination with therapies targeting driver genes was found to be highly effective.
A study by the American Sociological Association finds that job authority increases symptoms of depression among women due to interpersonal tension and negative stereotypes. In contrast, having job authority decreases symptoms of depression among men, as they are viewed as strong leaders with consistent status beliefs.
Researchers at The Scripps Research Institute (TSRI) have discovered how a mutant gene called Tmie can cause deafness from birth. They found that reintroducing the gene in mice restored the process underpinning hearing, suggesting new treatment options for hearing loss.