Researchers have discovered that tumor cells secrete exosomes containing proteins capable of transforming neighboring cells into tumor cells, promoting tumor growth. Dicer protein is identified as a key factor in this process and may serve as a biomarker or therapeutic target.
A new gene therapy treatment has demonstrated effectiveness in a canine model of DMD, skipping exons to produce functional dystrophin protein. The treatment was well-tolerated and resulted in high levels of dystrophin expression, with muscle strength increasing at higher doses.
Researchers found that Parkin triggers 'cellular suicide' in damaged nerve cells, depending on the degree of damage, and may help weed out faulty neurons. This discovery could lead to a new understanding of how Parkinson's disease arises.
The Extreme Ultraviolet and X-ray Irradiance Sensors (EXIS) Flight Model 2 instrument for NOAA's GOES-S satellite has successfully completed its Pre-Shipment Review. The instrument is now complete and will be placed into storage until spacecraft integration begins.
A study estimated embodied methane and nitrous oxide emissions in beef, chicken, and pork from livestock to countries where they are consumed. The researchers found a 19% increase in 'hidden' emissions over the past 20 years, with Russia receiving most of its emissions from Brazil and Argentina.
A study published in PLOS ONE reveals that Thousand Cankers Disease (TCD) is a native disease that has gone rogue, threatening the health of black walnut trees. The fungus, Geosmithia morbida, and its long-time host beetle have co-evolved, creating a complex that can spread rapidly across landscapes.
Two cholesterol management guidelines agree that nearly all patients with chronic kidney disease should receive statins, but 50% of those recommended are not taking them. The study found the Pooled Cohort risk equations to be accurate among people with CKD, indicating a valid tool for estimating heart disease risk.
Researchers at Northwestern University have developed a method to isolate atomically thin sheets of molybdenum disulfide (MoS2), a promising material for optoelectronics and electronics. The process uses copolymer-assisted gradient ultracentrifugation, allowing for scalable isolation of single-layer, bilayer, or trilayer MoS2 sheets.
Researchers analyzed samples from the Sudbury Basin and found chondritic platinum group elements, which suggest a comet impact. The distribution of these elements indicates that the impactor was indeed a comet.
Researchers at Washington State University have discovered a promising technology to expand the hard cider industry by mechanical harvesting of cider apples. The study found that machine harvesting can provide up to four times less labor than hand harvesting, resulting in significant cost savings and improved efficiency for orchards.
A study published in Current Biology found that aggressive chimpanzee males sire more offspring, suggesting sexual coercion is an adaptive strategy for males. Genetic evidence showed that high-ranking males who intimidate females when they are not swollen had more reproductive success.
Scientists at MD Anderson Cancer Center identified a long non-coding RNA called BCAR4 as playing a key role in the hedgehog signaling pathway's contribution to breast cancer metastasis. The study suggests that targeting this pathway with locked nucleic acids may provide a new approach for treating aggressive breast cancers.
The structure determination of a lipid scramblase reveals a novel protein architecture that enables the transport of lipids across cell membranes. The discovery provides insight into the activation of the protein by calcium and has implications for understanding previously unknown mechanisms of lipid transport.
Scientists analyzed gravitational effects of the Moon on thermosphere to predict satellite collisions. Incorporating these results in atmospheric models can refine accuracy and keep satellites separate from space junk.
Researchers found that males who consistently bully females tend to father more babies with their victims. Long-term aggression, particularly by high-ranking males, increased paternity success.
The UCI team has created a new technology called Integrated Comprehensive Droplet Digital Detection (IC 3D) that can detect bacterial invaders in blood samples with unprecedented speed and accuracy. In as little as 90 minutes, IC 3D can identify bacteria at single-cell sensitivity without the need for cell culture.
Climate models predict a 50% increase in lightning strikes across the US due to global warming, which will lead to more human injuries and wildfires. The study used precipitation and cloud buoyancy data from climate models and found that these two parameters can predict lightning strikes with high accuracy.
A majority of obese people in Britain deny being obese, describing themselves as 'just right' or 'very overweight' instead. The study suggests that media coverage and public health campaigns may be contributing to this phenomenon, as people become less likely to recognize the health risks associated with their weight.
Research at Brunel University found that individuals with autism spectrum disorder (ASD) have trouble interpreting changing facial expressions. This impaired ability affects their judgment of others' emotional states and identity.
The article highlights the link between animal health, human health, and the environment in the emergence of infectious diseases. Key findings include the need to build capacity in developing regions and the importance of One Health approach.
A recent study published in Nature found that a specific brain protein called beta-catenin influences how the brain manages stress and depression. The research suggests that activating this protein may provide a new model of treating depression by bolstering resilience against stress.
A single-dose Ebola vaccine given to primates through their noses and lungs protected them against infection for at least 21 weeks. The vaccine's effectiveness could help prevent the spread of Ebola and other diseases through unintentional pricks.
A new study by researchers at NYU's Steinhardt School of Culture, Education, and Human Development found that an educational approach focused on executive functions improved academic learning in kindergarten. The findings suggest that programs like Tools of the Mind can have lasting benefits for children, particularly those in poverty.
Researchers found that mosquitoes acquired a love for human body odor and key genes drive this preference. The study suggests that humans provide an ideal lifestyle for mosquitoes, with access to water and large groups, contributing to their evolution as disease vectors.
Researchers found that African Americans have impaired blood flow regulation in the brain, contributing to a greater risk of stroke and other cerebrovascular diseases. The study suggests underlying mechanisms of blood vessel dysfunction occur in relatively young and healthy African Americans.
Researchers at Boston University will identify biomarkers for TB infection and disease progression, aiming to reduce mortality rates. The study aims to develop new tools for preventing and treating TB, a deadly disease affecting millions globally.
Researchers at UC Davis and Northwestern University have found an investigational medication to effectively treat children with life-threatening seizures, resolving symptoms without adverse effects. The medication, a formulation of allopregnanolone, showed promising results in two clinical cases, where patients were weaned off general ...
Researchers analyzed whole-genome sequences of 17 supercentenarians, but found no rare protein-altering variants significantly associated with extreme longevity. One individual did carry a variant associated with a heart condition, which had little impact on their health.
Scientists suggest using natural vibrations in one material to boost superconductivity in another, opening a new chapter in the quest for room temperature superconductors. The study reveals that iron selenide superconductor operates at much higher temperatures when placed atop STO material.
The EMBO Young Investigator Programme selects 27 young researchers to build their independent teams and achieve recognition. The programme provides support for laboratory management, non-scientific skills training, and access to core facilities.
Researchers discovered that homing pigeons use an internal gyroscope to guide themselves home, even when encountering disturbances in the gravity field. The study found that birds initially set a bearing home by comparing their home gyroscope setting with their local gyroscope reading.
Astronomers have discovered a galaxy, AzTEC-3, that gives birth to 1,100 suns annually, creating about three suns each day. This ancient galaxy is one of the earliest examples of a starburst galaxy, fuelled by massive material and galactic mergers.
A new study published in the Journal of Experimental Biology found that climate change is affecting the survival abilities of coastal crabs. The researchers found that while the crabs can adapt to a warming climate, they will not have enough energy for other activities beyond basic survival.
People with social anxiety disorder tend to think their friendships are worse than they really are, but a new study reveals this perception may be misplaced. The study found that friendships of people with social anxiety disorder were not significantly worse than those without the disorder, contrary to their self-reported experiences.
A new study found that older women with moderate to severe breathing disruptions during sleep are more likely to experience a decline in their ability to perform daily activities. The research suggests that treatment of sleep-disordered breathing may help prevent functional decline.
New research reveals distinct differences in early human embryo development among overweight and obese women compared to those of a healthy weight. These differences may have long-term health implications for their children.
Researchers at INRS have developed a new class of multiferroic materials for solar cells, increasing conversion efficiency to 8.1%. The team's triple-layer coating captures different wavelengths of light, converting more light into electricity.
A new study by Katrin Rentzsch and Michela Schröder-Abé found that unrealistic views of one's academic abilities can damage a child's relationship with others in the classroom. Students who tend to feel unrealistically superior to their peers are less liked by them, even at habitual levels.
A new mouse model demonstrates that a genetic mutation in the FOXP1 gene leads to brain degeneration, causing perception and behavior problems. The study provides valuable insights into the molecular mechanisms underlying autism.
A recent survey found that nearly two-thirds of employees who have been diagnosed with depression reported challenges related to thinking on the job, resulting in reduced productivity. The Right Direction initiative aims to increase awareness of depression in the workplace and provide resources for employers to support their employees.
A recent study by Dr. Ahmed Dahir Mohamed found that Modafinil slowed down reaction times and impaired the ability to respond in a timely manner in healthy participants. The drug did not improve cognitive performance or enhance creativity, contrary to its marketed claims.
A study of over 40,000 soldiers found a significantly elevated suicide rate among those hospitalized for psychiatric disorders, with the highest-risk group accounting for 52.9% of post-hospital suicides.
The Brain & Behavior Research Foundation has awarded NARSAD Distinguished Investigator Grants to 15 scientists conducting innovative projects in neurobiological and behavioral research. The grants are valued at $1.5 million and aim to understand and treat psychiatric disorders affecting one in four people.
The PRESERVE study aims to determine the safety and effectiveness of IVC filters in preventing pulmonary embolism. It will enroll 2,100 patients at over 60 centers across the US and assess patient outcomes every six months for up to two years.
Researchers at KU Leuven discovered that HIV's integration site determines disease progression. The team found that manipulating the integration site can lead to faster disease progression in some cases, but also opens up possibilities for developing new therapies by targeting safer regions of host DNA.
Researchers at the University of Basel have created a helical molecule with unique properties, where one strand winds around a central axis like a staircase banister. This 'twisted world' enables dynamic changes in chirality, opening up new possibilities for basic research and industrial applications.
A new study found that people are contaminated with several toxic flame retardants, including TCEP, a carcinogen linked to cancer and reproductive harm. The study identifies biomarkers for detection in urine samples, opening up research into the group of chemicals.
Research on giant otters reveals a wide range of unique vocalizations used for communication. With 22 adult vocalization types and 11 neonate vocalization types, the study suggests an intricate relationship between vocalizations and social behavior.
A new care bundle implemented in four UK hospitals has achieved a significant reduction in the number of deaths following emergency abdominal surgery. The bundle, which includes five key elements, resulted in a 38% decrease in death rate from 16% to 10%.
A study published in JAMA Surgery found that nearly a quarter of patients who underwent initial breast conservation surgery had a subsequent surgical intervention. The study, which included over 316,000 patients, identified patient and tumor factors associated with repeat surgeries.
Researchers are experimenting with smart spaces that track users' gestures and separate shadows from light, enabling a continuous flow of data wirelessly. The integrated visible light communication project aims to bridge the gap in VLC's practical systems and networking problems.
Scientists at Scripps Research Institute found that moving forward trains the brain to perceive the world normally and calibrates time perception. The study's findings have implications for treating sensory processing disorders like autism and could lead to retraining the brain after stroke or other conditions.
A new study found that moderate consumption of high-fructose and high-glucose beverages has little impact on the metabolic health of weight-stable, physically active adolescents. The researchers suggest that physical activity can help mitigate some of the negative effects of drinking sugary drinks.
A study of over 43,000 children with head trauma found that falls were the most common cause of head injuries in children under 12, while assaults, sports, and car crashes were more prevalent in teenagers. The findings suggest that CT scans may be overused during diagnosis, and could help policy makers develop injury-prevention measures.
Researchers have developed an optical oscilloscope with 20 times the resolution of conventional electronics, enabling low-power, high-speed processing on compact chips. The technology is made possible by a collaboration between industry partners Alnair Labs Corporation and Australian academia.
Rice University researchers have developed PhyloNet, an open-source software package that models more detailed evolutionary networks from genetic data. The software uses a maximum likelihood method to infer network models that better describe the evolution of certain groups of species than traditional tree models.
Research reveals genetic differences between catsharks in the Mediterranean and North East Atlantic, suggesting they may be more vulnerable to over-fishing. The study's findings also highlight sex-specific migration patterns among catshark populations.
Researchers have identified new properties in microbes causing conjunctivitis, enabling the bacterium to stick to and damage the eye surface. The discovery may lead to the development of a new vaccine to prevent this infection.
Researchers have confirmed a critical brain reward pathway involving glutamate, linking it to the activation of the dopamine system. This discovery sheds light on the neurobiology of drug addiction and opens new avenues for research into motivation disorders.
A study at Massachusetts General Hospital identified nitric oxide's impact on SIRT1 protein, which regulates inflammation in various aging-related disorders. Blocking nitric oxide effects may disrupt this inflammatory process and prevent conditions like diabetes, atherosclerosis, and Parkinson's disease.