Researchers identify Zelda protein as key player in activating genes critical for embryonic development. The protein opens up enhancer regions, allowing other regulatory factors to bind and activate associated genes.
Researchers propose that deep sleep strengthens immunological memories of previously encountered pathogens, enabling adaptive responses. Studies show that slow-wave sleep contributes to the formation of long-term memories of abstract information.
A cluster-randomized trial in rural Tanzania found that home-based counselling strategies had no effect on neonatal mortality, despite improvements in newborn care practices. Neonatal mortality decreased in both intervention and control groups, with better breastfeeding rates and handwashing practices reported in the intervention area.
A new study documents rare early Jurassic corals from New York Canyon in west-central Nevada, shedding light on coral recovery after the end-Triassic mass extinction event. The findings provide valuable information on biotic responses during this critical period.
Researchers at NCBS discovered that Purkinje cells have two modes of electrical signaling based on voltage: a constant 'up' state and a burst-like 'down' state. This allows the cells to choose whether to respond to instructions or not, and the study suggests that this mechanism may play a role in motor learning.
The remnants of Tropical Cyclone Niala were captured in a NASA infrared satellite image taken on September 29, 2015. The storm had ceased to qualify as a tropical cyclone by the time it was located approximately 405 miles south of Honolulu, Hawaii and moving west-northwest.
Researchers at Brown University used optogenetics to manipulate the brain's perception of novelty and familiarity in rats. They found that different frequencies of light stimulation could alter the rats' behavior, with 30-40 hertz inducing a sense of novelty and 10-15 hertz inducing a sense of familiarity.
Researchers evaluated two alternative strategies to prevent malaria in pregnancy, finding that dihydroartemisinin-piperaquine reduced clinical malaria by 84% and risk of anaemia by 22%. The new drug was also associated with lower risks of stillbirths and infant mortality.
The study found that teleconference settings reduced discussion times but had little impact on funding decisions. Panel discussions often resulted in poorer scores compared to initial pre-meeting scores.
Researchers used new water-tracing technology to determine how groundwater moves in the Sydney Basin, identifying four distinctive layers of rock that control groundwater movement. The study provides a baseline for assessing future impacts from mining operations, climate change, and groundwater abstraction.
The National Institute on Aging has awarded a grant of $3.567M to study mechanisms of Alzheimer's disease, with a focus on immune system cells that cause synapse damage.
Researchers found that a reduced early season irrigation schedule improves water efficiency in Georgia's humid climate while maintaining pecan tree health. The study showed a 38% reduction in irrigation water use with no significant impact on pecan quality or yield.
A new University of Utah study found that climate change negatively impacts birth weight, particularly in African countries. Exposure to reduced precipitation and increased hot days results in lower birth weights, with effects seen as early as the first trimester.
A study by Columbia University's Mailman School of Public Health found that young people identified as 'at risk' for mental problems described feeling stigmatized by symptoms, but not the label itself. Early intervention benefits may outweigh stigma concerns.
Tropical Storm Marty is being closely monitored by NASA's Global Precipitation Measurement (GPM) mission, which has detected substantial areas of rain on the eastern half of the storm. Heavy rainfall is expected to be a major threat to residents in western Mexico, with estimated amounts ranging from 2-12 inches.
A study analyzing civilian deaths in Syria from 2011 to 2015 found that explosive weapons had disproportionate lethal effects on women and children. Children were more likely to be fatal victims of air bombardments, shells, and ground level explosives than men or women.
The Lancet Oncology Commission highlights the vital role of primary care doctors in preventing, detecting, survivorship, and palliative care. Effective integration between primary and specialist care is crucial to meet the growing demand for cancer care.
The researchers calculated the new measurement for a critical characteristic -- mass -- of the top quark, opening the door to better understanding some of the deepest mysteries of our universe. The newly calculated measurement will help guide physicists in formulating new theories about quantum interactions and the nature of matter.
Researchers at Emory and Georgia Tech have developed inhibitory luminopsins that can modulate neuronal firing in culture and in vivo, enabling the study of ways to halt or prevent seizure activity. The tools use a glowing protein from coral as a light source, offering a cleaner alternative to traditional optogenetics.
Research from the South Asian Birth Cohort study suggests that South Asians may be at risk for developing type 2 diabetes immediately after birth due to higher levels of adipose tissue and waist circumference.
North Carolina State University researchers created an entropy-stabilized material made up of five different oxides in roughly equal amounts. The constituent atoms were evenly distributed and their placement in the crystalline lattice structure was random, proving that entropy can stabilize complex oxide alloys.
Researchers found that manipulating self-experienced pain affects empathy for pain in others through the endogenous opioid system. The study suggests empathy relies on simulation and is grounded in our own experiences, which may explain why feelings of others can affect us so immediately.
Researchers have created a new class of molecular motors that rotate unidirectionally at speeds of up to 1 kHz when exposed to sunlight at room temperature. This breakthrough enables the development of more versatile and precise nanomachines with unprecedented control over mechanical motion.
A State-of-the-Art review examines the impact of global food consumption on cardiovascular disease, highlighting the need for dietary patterns that reduce risk. The traditional Mediterranean diet is identified as an optimal choice, with suggestions to recreate it in other regions using similar food replacements.
A University of Leicester study found that high-risk and impulsive offenders require extra support to complete rehabilitation programs, with non-completers exhibiting higher levels of non-planning impulsivity. The research suggests that these offenders may benefit from additional pre-programme work or ongoing support during the program.
Scientists have identified a key mechanism in how excess water enters neurons, leading to brain swelling. A new shuttle system of ion transporters may be exploited to develop treatments for deadly edema.
A study by researchers from the University of Minnesota Medical School found that health care costs in one year were $18,000 higher in smokers with peripheral artery disease than non-smokers. Hospitalization rates among tobacco users with PAD were also significantly higher, at 49% within one year.
Native ASL signers acquire intonation in three stages: appearance, reorganization, and mastery. Young signers use certain features with different frequencies than adults.
A new app is being developed to educate NCAA football players on concussion awareness and encourage them to report real symptoms. The app, using virtual reality technology, aims to inspire student-athletes to prioritize their health and well-being.
Research suggests that universal TB screening of immigrants to Canada is costly and inefficient, with most cases detected from a small number of high-risk countries. The study recommends targeting screening on immigrants from countries with high TB rates, rather than universally.
Research found that changes in ocean circulation due to Antarctica's temperature had a profound impact on the amount of carbon dioxide absorbed from the atmosphere. When temperatures dropped, nutrient-rich waters rose closer to the Antarctic continent, allowing phytoplankton to thrive and absorb more CO2.
Researchers at Brigham and Women's Hospital have found a link between genetic risk factors for Alzheimer's disease and key immune cells, paving the way for new diagnostic tools and treatments. The study suggests that higher levels of TREM2 may be associated with increased risk of Alzheimer's disease.
Research finds that men are associated with creativity and innovative thinking in the workplace, while women's achievements are often undervalued. This bias is perpetuated by stereotypes and can impact career advancement and recognition.
A large study found that computer-aided detection (CAD) for mammography did not improve diagnostic accuracy in radiologists' interpretations. Despite increased use and FDA approval, CAD's effectiveness was not supported by the results, leading to calls for reduced reimbursement or reconsideration of its continued coverage.
Researchers link Chinese-made goods to higher CO2 emissions due to antiquated manufacturing processes and coal reliance. Developed countries can alleviate carbon pollution by improving manufacturing in China's most polluting regions.
Researchers found a dramatic increase in major storm occurrence along the New York City and New Jersey coast over the last 1,000 years. The combined effects of sea-level rise and changing hurricane characteristics have raised the likelihood of devastating flooding.
Tropical Storm Marty is expected to bring heavy rainfall and strong winds along the Mexican west coast, posing a threat of flooding and mudslides. The storm's maximum sustained winds are near 70 mph, with higher gusts and estimated central pressure at 990 millibars.
The NIH has announced a significant investment in research technology to better understand the placenta's function during pregnancy. This initiative aims to identify problems with the placenta earlier, enabling physicians to intervene more quickly and improve pregnancy outcomes.
A new clinical trial has found that cabozantinib, a second-line therapy, controls the growth of advanced kidney cancer more effectively than everolimus. The results show improved progression-free survival and lower tumor growth rates, indicating potential for prolonged survival.
A study found that fingerprint characteristics can identify an individual's ancestral background, with significant differences between European American and African American ancestry. Researchers analyzed right index-finger fingerprints of 243 individuals from diverse backgrounds to determine if patterns were specific to sex or ancestry.
Researchers believe ancient bacteria found in 20 million-year-old fossil may be related to Yersinia pestis, the bubonic plague. The discovery suggests plague may have been around for millions of years before humans existed.
Researchers developed a novel data-logging tag called ITAG to study small invertebrates' behaviors and physiology. The tag measures ocean conditions and animal responses at high resolution, providing valuable insights into their natural behaviors and adaptations.
Research suggests that tidally locked planets may have protective magnetic fields due to tidal heating, which helps maintain surface conditions conducive to life. This finding challenges the previous assumption that such planets are at mercy of their star.
A study found that the majority of active TB cases in Canada were linked to immigrants from Afghanistan, China, India, Pakistan, Philippines, and Vietnam. This suggests that developed countries can focus on screening for TB in high-risk immigrants rather than screening all arrivals.
Researchers from Harvard University found that Resident Registration Numbers in South Korea can be easily decrypted using computation and logical reasoning. The study reveals vulnerabilities in the encoding system, compromising individual privacy and urging a more robust redesign.
A new bi-specific antibody, DART, has been developed to bind HIV-infected cells to the immune system's killer T cells, potentially clearing HIV infection. The molecule was engineered using HIV-targeting antibodies and showed early promise in pre-clinical models.
Scientists have developed a new toolkit to examine the BRCA1 protein and its associated parts in near-native environments. This allows for direct visualization of macromolecular regulatory complexes in human patient-derived cancer cells, providing valuable insights into the molecular mechanisms underlying breast cancer.
A new study found that lowering the minimum drinking age to 18 in the US was associated with a rise in high school dropout rates. The research suggests that this policy change may have disproportionately affected vulnerable groups, including minority students. The study's lead author notes that state policies on drinking ages were ofte...
For patients with low pre-test probability of PE, applying PERC rule should guide diagnostic strategy. Imaging and testing can be reserved for those with high pre-test probability or contraindications to CT pulmonary angiography.
Researchers found that the return period for a storm producing a surge of 2.81 meters or greater has been reduced from 3,000 years to just 130 years since human-caused climate change began. This increase in storm surges is attributed to rising sea levels and more intense tropical storms.
A study by the University of Eastern Finland found that active senior travelers can be divided into three groups: Adventurous Experimenters, Meticulous Researchers, and Fumbling Observers. The use of technology is closely linked to travel behavior, and each group has unique preferences for destination choice and information technology ...
Researchers found that monkeys and humans perceive the Delboeuf illusion in a similar way, with both species misjudging dot size depending on outer ring size. This suggests that primates share similarities in their perceptual systems, making them an appropriate model for studying human perception.
Typhoon Dujuan approached Taiwan with sustained winds near 100 mph and cloud top temperatures of -81F, generating heavy rainfall. NASA satellites provided detailed data on the storm's clouds and winds, helping forecasters track its movement and expected landfall in southeastern China.
Researchers at Kobe University have developed a painless dermal monitoring method to detect neonatal jaundice in preterm infants. The study identified the optimal skin area for monitoring, allowing for continuous long-term tracking of bilirubin levels and reducing cases of cerebral palsy and hearing loss.
Researchers develop rapid and efficient method to target protein modification, enabling precise attachment of synthetic molecules. This technique has potential applications in antibody-drug conjugates for tumor therapy, outperforming existing methods.
The team uses multiwall carbon nanotubes and tiny rectifiers to create an antenna that captures light from the sun or other sources, producing a small direct current. The efficiency of the devices is below one percent, but the researchers hope to boost it through optimization techniques.
Researchers at Rice University and Baylor College of Medicine have successfully mapped the structural details of leiomodin 2, a protein critical to muscle cell function. The discovery offers a path forward for studying and treating nemaline myopathy, a hereditary disorder that weakens muscles.
Drinking sugar-sweetened beverages can lead to excess weight gain, a higher risk of developing type 2 diabetes, and cardiovascular disease. Fructose's unique role in metabolism contributes to these conditions.
Researchers found no barriers to prevent king crab populations from arriving on the shallow continental shelf if the water becomes warm enough. The arrival of these crustaceans could radically alter the ecosystem and diminish marine biodiversity globally.
A recent animal study broadens understanding of the flu virus's impact on the immune system, revealing a more dynamic process that engages multiple biological pathways. This research may lead to the development of more effective vaccines against influenza and other viruses.