Researchers at Einstein College of Medicine presented multiple studies on risk factors and predictors of aMCI and dementia in older adults, including the impact of perceived stress, diet, and coping mechanisms. The findings suggest that early detection of cognitive decline is crucial for implementing effective preventive interventions.
The American Academy of Pediatrics has published new Choosing Wisely recommendations for reducing unnecessary tests and treatments in newborn care. The guidelines focus on avoiding routine use of antibiotics, anti-reflux medications, x-rays, MRIs, and overnight lung activity monitoring to improve health outcomes and reduce costs.
A Dartmouth team has successfully synthesized molecules that induce rapid apoptosis in leukemia cells, paving the way for further study of their biological mechanism of action. The findings hold promise for developing novel therapeutic strategies against cancer and other diseases linked to abnormal cell death.
Researchers found that many older Americans with diabetes are not meeting clinical targets for blood sugar, cholesterol, and blood pressure levels. Despite using less stringent guidelines, the study revealed significant racial disparities in diabetes control, particularly among women.
A new study by Harvard T.H. Chan School of Public Health found that low birth weight combined with an unhealthy adult lifestyle can increase the risk of developing type 2 diabetes. The researchers analyzed data from over 149,000 healthy men and women and found that 18% of cases were attributable to the combined effect of low birth weig...
A national clinical trial involving two effective drug combinations will be compared in a new study. The trial, led by Dr. Michael B. Atkins at Georgetown Lombardi Comprehensive Cancer Center, aims to determine the best sequencing of treatment regimens for patients with melanoma.
A 10-point questionnaire, known as the Alcohol Use Disorders Identification Test (AUDIT), is more effective than measuring blood alcohol level in detecting patients with at-risk drinking behaviors. The study found that up to 50% of trauma patients have alcohol in their bloodstream, and brief interventions can lead to a 50% reduction in...
Recent studies published in Journal of Animal Science explore ways to boost beef and dairy production using marginal lands and fibrous byproducts. Benefits include reduced costs, improved ecological balance, and opportunities for new producers to enter the market.
A doctor argues that long sleeved white coats spread infection and lead to avoidable harm and cost to patients. He advocates for banning doctors and medical students from wearing white coats to reduce hospital acquired infections in India.
A new study found that a Birmingham, Ala., neighborhood's community revitalization project led to an increase in physical activity among residents. Residents' expectations of improved safety and access to green spaces were key factors in their increased exercise habits.
Doctors warn that commercial interests are driving the continued recommendation of calcium and vitamin D supplements for osteoporosis treatment, despite a lack of evidence showing their benefit. The authors argue that industry influence is fuelling enthusiasm for these supplements, which are highly profitable.
Researchers at Michigan State University have developed a new 3-D model of a giant star's last moments, which could help explain how these stars explode. The model addresses previous limitations, including the shape of the star and the lack of fuel source, paving the way for a deeper understanding of supernova mechanisms.
Researchers used iPSC-derived renal progenitors to treat acute kidney injury in mice, showing improved recovery with reduced fibrosis and necrosis. The study's findings suggest that paracrine actions of the cells, rather than integration, led to therapeutic effects.
A new study published in Nature Geoscience suggests that Earth's first crust was torn from the planet and lost to space due to asteroid bombardment, leading to the evolution of its plate tectonics, magnetic field and climate. This phenomenon, known as impact erosion, helps explain why Earth is habitable while Venus is not.
A new study led by Duke Medicine shows that bystander-initiated CPR substantially increased survival from cardiac arrest. The early application of CPR was associated with improved patient survival compared to situations where patients waited for EMS-initiated CPR and defibrillation.
Researchers developed a semiconducting polymer fibre that glows and supports healthy cell growth. The fibre's fluorescent properties enable tracking of its interaction with living tissue for up to 90 days.
Ancient and modern genetic data reveal that Native American ancestors entered the Americas as a single wave approximately 23,000 years ago. The research also shows that ancestral Native Americans split off into two branches around 13,000 years ago, coinciding with glacier melt and the opening of routes into North America's interior.
A new clinical trial found that tamsulosin improves the passage of larger kidney stones, with 83.3% of patients treated with the medication passing their stones compared to 61% on placebo. However, for small kidney stones, time remains the best cure, according to lead author Jeremy Furyk.
A new website, the Chemical Probes Portal, aims to guide researchers in selecting better-quality chemical probes, reducing errors and wasting time and money. The platform crowdsources knowledge from leading researchers, providing up-to-date comparative information to help users choose the best probe for their needs.
A Phase III trial found that conditional cash transfers for school attendance had no effect on reducing HIV incidence among high-school aged women in South Africa. However, these women reported fewer risk behaviors, such as fewer sex partners and less unprotected sex.
A clinical study found that young, single black women in South Africa and men who have sex with men (MSM) and transgender women (TGW) in the US and Thailand adhered to a daily pill regimen for HIV prevention. The study suggests that daily PrEP dosing is an effective strategy for this population.
A new study finds that economic factors, including consumption and production changes, account for the majority of the decline in US carbon dioxide emissions from fossil fuels. The analysis used Structural Decomposition Analysis to tease apart the various contributions of six different factors related to energy use and CO2 emissions.
Researchers found that yeast modify their genomes to produce more ribosomes in response to excess calories, enabling faster replication and optimal growth. This study reveals a new mechanism by which organisms can adapt to environmental changes.
Researchers found that feeding high concentrations of soybean meal improved growth and immune response in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). The study suggests that isoflavones in soybean meal may have antiviral properties, helping to alleviate the effects of PRRSV.
A new study found that starting antiretroviral therapy early reduces the risk of both serious AIDS-related events and serious non-AIDS-related events, including cancer, cardiovascular disease, and death. The study shows a significant benefit of early treatment regardless of age, sex, or geographic region.
Researchers at UT Southwestern Medical Center found that increasing cyclic adenosine monophosphate (cAMP) in brain cells can improve stress response and potentially treat depression. The study's findings suggest a new therapeutic target for depression treatment, offering hope for patients who have not responded to existing therapies.
Researchers are examining the relationship between telomere length and age-related diseases, with the goal of understanding why some people remain healthy into old age while others develop chronic disease. The £2 million study will provide a rich resource for researchers studying various diseases, including heart disease and cancer.
A new phase III trial will examine two treatment sequences for advanced melanoma patients, with half receiving an investigational combination of immunotherapy drugs first and the other half receiving a different sequence. Researchers aim to find the best treatment sequence to extend patient survival.
A study published in the Journal of Neurosurgery: Spine found that retired professional rugby players exhibit more severe symptoms of cervical spine degeneration, including narrower vertebral canals and greater muscle mass. The researchers suggest that stronger paraspinal muscles may aid in controlling spinal pain in this group.
A phase 2 trial found that AS03 and MF59 adjuvants increased immune responses to an inactivated H7N9 influenza vaccine, with AS03-adjuvanted formulations inducing the highest antibody response. The study suggests AS03 as a first-line adjuvant for H7N9 vaccines in adults.
Korean scientists developed a light-activated, mussel protein-based bioadhesive that closes wounds quickly and heals without inflammation or scars. Animal studies proved its superiority to existing options, making it an ideal tissue bonding material for various medical applications.
A recent study published in The BMJ found that regular consumption of sugary drinks is positively associated with type 2 diabetes, independent of obesity status. The study estimated that two million new-onset type 2 diabetes events in the US and 80,000 in the UK could be related to sugar sweetened beverage consumption over 10 years.
The MoveSense app uses a smartphone's sensor data to continuously monitor oxygen saturation levels, enabling accurate tracking of cardiopulmonary fitness. The app can predict patient stability and alert doctors to potential health issues, providing a new tool for managing chronic diseases.
Researchers found that sleep loss for one night altered the regulation and activity of clock genes in human tissues, particularly in adipose tissue and skeletal muscle. This could suggest a link between disrupted circadian rhythms and impaired glucose tolerance and metabolic pathologies.
A recent genetic study has uncovered a previously unknown wave of migration to the Americas, linking Native Americans in the Amazon to indigenous people in Australasia. The research suggests that Population Y, an ancestral group from the ice sheets, contributed to the DNA of today's Amazonians.
Researchers found no statistically significant association between pioglitazone use and bladder cancer risk. However, a small increased risk was observed, as well as associations with increased prostate and pancreatic cancer risks.
Researchers have recreated firefly bioluminescence in the lab using a chemical reaction between luciferin and oxygen. The discovery could lead to new applications in medicine, such as more efficient light therapy for patients with certain diseases.
Dr. Li Gan receives the Inge Grundke-Iqbal Award for her influential research on progranulin and amyloid accumulation in mouse models of Alzheimer's disease. Her work may protect against brain changes associated with the disease.
A study by the University of California Irvine found that economic downturns, rather than increased natural gas use, were responsible for a 11% decrease in climate-changing carbon dioxide emissions in the US. This shift was driven by changes in consumer demand and industrial output.
Researchers have taken a closer look at the geology deep beneath the Tibetan Plateau using gravity data captured by satellite. The analysis offers some of the clearest views ever obtained of rock moving up to 50 miles below the plateau, revealing a complex interplay of wavy patterns at the boundary between the crust and mantle.
A two-year study by UCSF researchers found that smokers who switched to low-nicotine cigarettes were unable to quit smoking in the long term. Despite initial drops in nicotine levels, participants' smoking habits rebounded when they returned to regular cigarettes.
Researchers have tracked the movement of internal waves in the South China Sea, revealing that they are generated daily from internal tides. These massive underwater waves can reach heights of over 170 meters and travel hundreds of kilometers, playing a crucial role in global climate regulation and marine ecosystems.
Researchers found that aging actually offers significant protection against oxidative stress, as the endothelium adapts to regulate ROS and minimize cell death. This adaptation helps ensure arteries of older individuals can still function properly.
Researchers at University of Rochester find that a classical beam of light can fail Bell's Inequality test if entangled, suggesting that the boundary between quantum and classical worlds is not as clear-cut as thought. The study reveals that some features of the real world require entanglement, a key ingredient of quantum physics.
A recent study reveals that ßCTF, a protein precursor to amyloid beta, initiates abnormalities leading to neuron loss in early Alzheimer's pathology. Drugging ßCTF levels may help slow or stop Alzheimer's progression.
The Institute for Clinical and Economic Review (ICER) has launched a new program to provide independent analysis on pricing linked to patient benefit for new FDA-approved drugs. The program will produce public reports near the time of FDA approval, providing a transparent basis for price negotiations and coverage decisions.
A new virus-like particle vaccine has been developed to protect against a wide variety of influenza viruses. The vaccine was shown to provide significant protection against many different flu strains, including avian H5N1 and H7N9 viruses, which have caused many human cases and deaths in recent years.
Researchers at the International School of Advanced Studies (SISSA) found that newborn brains process language using cognitive mechanisms similar to those of adults. They demonstrated that babies are sensitive to the edges of words and can differentiate between sequences with or without edge changes.
A new genomic analysis pinpoints the arrival of the first Americans to Siberia around 23,000 years ago, with subsequent migrations leading to distinct populations in North and South America. The study also reveals genetic admixture from East Asians and Australo-Melanesians, suggesting limited isolation from the Old World.
Researchers from the University of Calgary developed an ear tag-attached accelerometer unit to monitor rumination and feeding behavior in beef cattle. The technology was able to identify feeding activity correctly 95% of the time, but only identified rumination activity correctly 49% of the time.
Researchers found an association between dicloxacillin treatment and decreased international normalized ratio (INR) levels among patients taking warfarin or phenprocoumon. This finding suggests that physicians should be aware of potential interactions and monitor INR levels accordingly.
Researchers discovered that a yeast byproduct can inhibit the white-nose syndrome fungus, which has killed millions of bats. The compound, tt-farnesol, is produced by Candida albicans and targets the fungus specifically without disrupting other cave ecosystem components.
A study by Northwestern University found that new fathers experience significant weight gain, averaging 3.5 to 4.5 pounds, which can lead to increased risks of heart disease, diabetes, and cancer. Pediatricians are in a unique position to counsel dads on maintaining their health due to the lack of personal physicians among new fathers.
Researchers create a virus-like particle vaccine cocktail that expresses different subtypes of the hemagglutinin protein, providing cross-protective immunity against multiple subtypes. The study shows that 95% of mice vaccinated with the investigational cocktail were protected against eight different influenza strains.
Researchers used brain scans to identify a predictor of response to treatment with SSRIs, the first-line drug treatment for PTSD. The study found that patients who showed less activation in the right ventrolateral prefrontal cortex prior to treatment were more likely to improve with SSRI therapy.
Researchers at University of California, San Diego School of Medicine have developed a novel treatment regimen that effectively treats hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus type 1 (HIV), with a 97% success rate
A genome-scale study reveals that all present-day Native Americans descended from a single migration wave into the Americas, arriving no earlier than 23,000 years ago. The ancestral population diversified into two basal branches around 13,000 years ago.
New research finds that HIV treatment for illicit drug users promotes improved health, socio-economic stability, and quality of life. Consistent ART treatment reduces homelessness and involvement in activities like sex work or street-based income generation.
A new study suggests that ultra-brief pulse stimulation is almost as effective as standard ECT in treating severe depression, but with significantly fewer cognitive side effects. The treatment has the potential to benefit up to 10,000 Australians who have not responded to first-line treatments.
The research team at PolyU has established Hong Kong's first breast milk nutrient database, revealing that the DHA level in over 80% of breast milk meets the recommended intake for infants. The study suggests that breastfeeding mothers consume adequate amounts of omega-3 rich fish and other nutrients to support infant growth.