A new study by TSRI researchers provides a higher-resolution view of the Ebola virus life cycle, revealing key vulnerabilities that can be targeted with antiviral therapeutics. The findings also shed light on how the virus assembles its genetic material, which is critical for understanding its structure-based design.
Scientists developed a technique to enhance nanoparticle signals using an optical microcavity, achieving near fundamental diffraction limit resolution. This enables the study of individual nanoparticles' optical properties, promising potential breakthroughs in biology, chemistry, and nanoscience.
A mid-level solar flare was observed by NASA's SDO on June 25, 2015, reaching a magnitude of M7.9. The event has the potential to disturb the atmosphere, affecting GPS and communications signals.
Researchers have discovered a new insight into glacier behavior, revealing the rapid movement of glaciers backward and downward during calving events. This phenomenon helps scientists measure glacier calving remotely and improve sea-level rise predictions.
A UCLA study found that long-acting injectable risperidone significantly reduces symptoms of schizophrenia, especially in recently diagnosed patients. The medication showed better adherence and efficacy compared to daily oral pills, with only 5% experiencing symptom return within a year.
Researchers discovered differences in brain inflammation between people with Down syndrome and Alzheimer's disease alone. The study found higher levels of inflammatory markers M2b in Down syndrome-related Alzheimer's, highlighting the need for tailored treatments.
A new study provides the first detailed view of calling blue and fin whale distribution in Southern California, revealing a steady population trend for blue whales and an upward trend for fin whales. The research uses acoustic data collected from 2006-2012, indicating that fin whales are more likely to be detected further offshore.
Researchers at Stanford University have created an artificial crystal with a variable band gap using molybdenum disulfide, a material that can be stretched without breaking. This could lead to the development of more efficient solar cells that absorb energy from a broader spectrum of light.
Researchers at RIKEN discovered that photons exhibit a quantum spin Hall effect, leading to unusual properties and topological phenomena. This finding has implications for the development of optical devices and materials science.
A new report by Global Health Strategies highlights the dramatic health and economic benefits from investing in combating neglected tropical diseases. Countries are increasingly taking ownership of NTD programs, achieving substantial progress with innovative approaches. To reach WHO's 2020 targets, further scale-up is necessary.
A Drexel University study found that a high-quality appetizer can decrease the appreciation for a subsequent main dish. The researchers discovered this effect by comparing subjects' hedonic responses to pasta aglio e olio after consuming either a good or mediocre bruschetta appetizer.
A UCL-led study has found that a small molecule drug, trametinib, can delay the ageing process in animals, including fruit flies. The treated fruit flies lived 12% longer than average, staying healthier for longer.
A new UCLA study uses brain scans to identify patients with OCD who are more likely to relapse after cognitive-behavioral therapy. The research found that brain connectivity before treatment can predict worsening symptoms after treatment.
Northwestern University professor Fengqi You uses life-cycle analysis to make the production more environmentally and economically friendly. By restructuring the supply chain, he found that a network of pipelines can transport freshwater and shale gas, reducing trucks and exhaust emissions.
Electrical engineers have developed a method to increase the distance information can travel in fiber optic cables without distorting the signal. By using wideband frequency combs, they can predict and reversible crosstalk between communication channels, enabling longer transmission distances and cheaper networks.
Leading doctors and academics call for divestment from fossil fuel companies, citing the need to prevent runaway climate change and unprecedented harm to global health. The authors argue that shareholder engagement is ineffective in switching dependence on fossil fuels with renewables.
A third of patients reported using email to contact their doctors, while 18% used Facebook for the same purpose. Patients aged 25-44 were most likely to use these tools, with a desire to fill prescriptions also evident.
Researchers have developed a new tool that uses phylogenetic profiling to identify genes associated with genetic diseases and cancer. This approach can be used to analyze genes within the same network as known disease-related genes, such as BRCA1, and predict their biological functions.
A new online computer game has been shown to help people control their snacking impulses and lose weight, with participants losing an average of 0.7kg and consuming around 220 fewer calories a day. The game trains people to associate calorie-dense foods with 'stopping', reducing how much food they eat in laboratory tests.
University of Tokyo researchers created a single-step printing process to form highly conductive and stretchable connections on textiles. The ink, made of silver flakes, organic solvent, fluorine rubber, and fluorine surfactant, exhibited high conductivity even when stretched three times its original length.
Researchers at LCSB have successfully grown dopaminergic neurons in a three-dimensional cell culture system. The system models the natural conditions of the brain and is significantly cheaper than existing methods, allowing for the automation of drug testing.
India's abortion law is criticized for its arbitrary 20-week cut-off, compelling women to continue pregnancies against their wishes. This can lead to physical and mental trauma, unsafe abortions, and related maternal mortality.
Researchers use light therapy glasses to trigger neurotransmitters and reset sleep cycles in lung cancer patients. Studies found that 50-80% of lung cancer patients experience severe insomnia, which can persist for eight years after diagnosis.
A new approach to diagnose pneumonia in critically ill patients has been identified through a breath analysis method. The study found that chemically analyzing breath specimens can reveal bacterial infection in ventilated patients at risk of developing pneumonia, providing a potential game-changer for clinical practice.
A study using NASA satellite data found that collecting rainwater for vegetable irrigation in India can reduce water bills by up to 4,522 rupees per year. This can provide a profit of between 1,548 and 3,261 rupees per year, boosting cost savings and increasing quality of life.
A new study by Brigham Young University researchers provides a rigorous estimate that about 10 percent of working households in the US are poor. Households led by women, minorities, or individuals with low education are more likely to be poor but still employed.
Scientists designed a new biochemical pathway in E. coli that can efficiently produce isobutyl acetate from both glucose and acetate, increasing its yield to 75 percent. This breakthrough could have significant applications in biotechnology, particularly in the production of flavoring agents, solvents, and fuels.
Kasturi Haldar and Grant McFadden emphasize the importance of basic research in their articles on PLOS Pathogens. They share their personal experiences and highlight how fundamental research can lead to breakthroughs in fields like malaria, cancer, and inflammatory diseases.
A NYU study found that a life review writing workshop combined with student interactions enhances the sense of purpose for older adults living independently. The program showed significant benefits in promoting well-being and reducing depressive symptoms among community-dwelling seniors.
Scientists used Sandia's Z machine to verify the metallic phase of hydrogen, solving a long-standing discrepancy in Saturn's age. The experiment found that dense hydrogen can become atomic, releasing energy that could explain Saturn's temperature.
A new study found that certain pollutants penetrate further into the feto-maternal system, causing harm to fetuses. The research analyzed pollutant levels in cord blood and maternal tissues, revealing heavy metals like mercury and lead easily pass through the placental barrier.
Scientists at the University of York and GlaxoSmithKline Australia have made a groundbreaking genetic discovery in poppies that could lead to more effective painkillers. The discovery of the STORR gene provides new insight into how poppy plants produce morphine, a key step towards developing bespoke poppy varieties.
A study found that participants who were exposed to prejudiced comments posted by others showed an increase in their own levels of prejudice toward Asians. They also tended to post more prejudiced comments about Asians themselves. The researchers suggest that anti-prejudiced comments can have a beneficial impact in reducing racial bias.
Recent changes to EU regulations have led to an increase in imported pets from Eastern Europe, where rabies is endemic, raising concerns about the effectiveness of current checks. The study found that many stray and rescue dogs had low antibody levels against rabies, suggesting potential risks for these animals.
The study identifies two enzymes, KDM4A and KDM4C, which alter gene expression in embryonic stem cells to direct their differentiation into endothelial cells. The enzymes work through epigenetic modifications, changing the activity of genes without altering DNA itself.
Researchers found that lymph node metastases do not require new blood vessels but instead use existing ones, providing a mechanism for resistance to angiogenic therapies. The study suggests alternative treatments may be needed for patients at risk of lymph node metastasis.
Researchers at The Wistar Institute identified specific mutations in H3N2 viruses that made the 2014-2015 flu vaccine less effective. Antigenic drift, a phenomenon where viruses accumulate mutations to evade immune response, was found to be a key factor.
University of Alberta scientists investigate physical principles underlying prion protein formation, with potential applications for diseases like Alzheimer's and Parkinson's. Their recent discovery sheds light on microscopic mechanisms governing protein misfolding, offering a new step towards developing therapeutics.
Researchers found that urine samples with higher acidity actually hindered bacterial growth due to the presence of specific compounds called aromatics. On the other hand, samples with less acidity showed increased activity of siderocalin, a protein that deprives bacteria of iron.
The Head Start program empowered poor children and civil rights activists in Mississippi by including them in the administration of the programs. The program also taught black history and civil rights, providing an alternative to electoral power.
Researchers have developed new approaches to estimate overall solvent content, model disordered bulk solvent, and identify distinct electron density of ordered solvent molecules in macromolecular crystals. Advanced models are needed to improve understanding of the protein-solvent interface region.
A study highlights a significant safety concern with linear gadolinium-based contrast agents (GBCAs), which can lead to brain gadolinium deposits in patients. The researchers found that repeated use of these agents causes persistent MRI abnormalities and high total gadolinium concentrations in the deep brain, highlighting the need for ...
The hospital has successfully integrated two common imaging techniques to produce a three-dimensional anatomic model of a patient's heart. The technology combines computed tomography (CT) and magnetic resonance imaging (MRI) with echocardiography, enabling more accurate diagnoses and treatment plans.
Research suggests that medically complex patients with newly diagnosed Type 2 diabetes who receive early endocrinologist care have lower risk of cardiovascular events. The study, which analyzed Ontario health data, found that these patients had a 10-20% lower risk of heart attack, stroke, and death from coronary heart disease.
Researchers developed targeted therapy using immunoglobulin-A antibodies to neutralize specific receptors in polycystic kidneys. The strategy enables repurposing of existing monoclonal antibodies for PKD therapy, opening up new class of therapeutics.
Rettsyndrome.org announces new Translational Research Awards to tackle nonsense mutations in MECP2 gene, aiming to develop treatments for Rett syndrome. The awards include the Read-Through Program and Neuro-Habilitation grants, furthering research towards new pharmacologic treatments and improved clinical practices.
A recent case study reveals that infection preventionists spend an average of five hours and eight minutes per day collecting and reporting hospital infection data, leaving little time for hands-on patient care. This finding highlights the need for adequate staffing and resources to ensure effective infection control practices.
A single mutation in the H3N2 virus helped it evade the immune system's defenses, making last year's flu vaccine less effective. Researchers have identified this mutation as a key factor in the mismatch between the vaccine strain and circulating strains.
Experts identified strategies for optimizing EHRs to better manage CKD patients, including standardizing data storage and accessibility. Well-designed EHRs can monitor patient conditions, facilitate collaboration among providers, and support patient self-management.
Scientists at the University of Pennsylvania have identified a stem-like progenitor cell, called cardiomyoblast, that produces only heart muscle cells. This discovery is expected to accelerate research into cardiac therapies and potentially lead to new treatments for heart damage.
The Transparency and Openness Promotion (TOP) Committee has outlined new guidelines to strengthen transparency and reproducibility practices in science research. The guidelines aim to increase openness and confidence in findings by promoting the sharing of data, code, and research materials. By adopting these standards, researchers can...
A study found that chimpanzees are sensitive to behaviors towards infants and react emotionally to violations of social norms within their own group. They show a 'bystander effect' when an infant from another group is harmed, but not otherwise.
Researchers have identified over 14,000 genes in the blowfly genome, which can now be investigated for potential drug and vaccine targets. The discovery provides insights into the fly's molecular biology and its interactions with sheep, offering new avenues for combating the devastating flystrike disease.
Researchers at Boston Children's Hospital develop a new treatment strategy targeting nerve endings to combat allergic asthma. By selectively silencing sensory neurons called nociceptors, the approach reduces inflammation and bronchial twitchiness in mouse models of acute and chronic asthma.
Researchers found that songbirds rely on patterns in much the same way as people do when learning to recognize and categorize speech sounds. By training starlings to differentiate between complex auditory patterns, the study showed that birds can learn to categorize motifs into meaningful categories.
Scientists discover corals are already adapting to global warming through genetic variants that allow them to tolerate warmer waters. By exchanging coral immigrants, humans can help spread these heat-tolerant genes and boost reef survival.
NASA has developed a new technology to protect the James Webb Space Telescope from contamination, using Molecular Adsorber Coating (MAC) panels. The MAC panels capture outgassed molecular contaminants in the vacuum chamber, preventing them from affecting sensitive instrument components.
Scientists at Salk Institute and Sanford Burnham Prebys Medical Discovery Institute have developed a drug that inhibits the first step of autophagy, a process used by cancer cells to recycle nutrients. This breakthrough opens new avenues for treating resistant cancers.
A new study found that errors on memory and thinking tests may signal Alzheimer's disease up to 13-18 years before the disease can be diagnosed. Those who scored lower overall had an increased risk of developing the disease, with higher scores associated with a lower risk.
The UK Parkinson's Excellence Network is a multi-disciplinary effort bringing together patients, healthcare professionals, and social care experts to develop patient-centered care. The network aims to improve treatment and raise awareness of the need for better care, with a focus on education and service development.