Researchers found elevated concentrations of synaptic soluble amyloid-β (Aβ) oligomers in early-stage AD patients compared to controls. The study suggests that therapies targeting synaptic Aβ oligomers may be more effective than anti-amyloid therapies in preventing or delaying AD-related dementia.
Berkeley Lab researchers developed a novel glass-polymer hybrid electrolyte that is compliant and conductive at room temperature. The new material shows signs of being compatible with promising next-generation cathode candidates such as sulfur and high-voltage lithium nickel manganese cobalt oxide.
A large inner city hospital in England found that almost three-quarters of weekend emergency care cases are linked to excess alcohol intake, resulting in significant costs for urban emergency care departments. The analysis, published online, reveals substantial costs for treating alcohol-related cases, with an annual bill of £1 million.
A recent study shows that material purchases provide repeated doses of happiness over time, whereas experiential purchases offer a more intense but fleeting experience. Researchers found that people felt more satisfaction with experiential purchases six weeks after Christmas.
Researchers pinpoint child-pedestrian behaviors that lead to auto accidents, revealing age-related differences in hazard perception. Children as young as 13 need training to recognize road crossing hazards and distinguish safe from hazardous situations.
A study of women's experiences with labor delays found that many are willing to abandon their ideal birth plans for a safe delivery. The key challenge for healthcare professionals is to effectively transition from choice to care in uncertain situations.
The WATCHMAN device is more cost-effective than warfarin and NOACs for reducing strokes in patients with non-valvular atrial fibrillation, according to a study led by Dr. Reddy. The device achieved cost effectiveness relative to warfarin at seven years and NOACs at 16 years, generating annual cost savings thereafter.
A Yale University study found that group prenatal care substantially improves health outcomes for both mothers and their infants. Women who received group care had lower rates of small birth size, preterm delivery, and low birthweight compared to those with individual care.
A study by Purdue University researchers found that LED lighting did not negatively affect greenhouse tomato fruit quality and demonstrated a potential alternative to overhead HPS supplementation. Physicochemical measurements showed slight variation among fruits grown under different lighting regimes.
A new study finds that prehistoric farming and non-farming societies in North America and Europe experienced the same long-term annual growth rate of 0.041 percent, challenging the notion that agriculture accelerated population growth.
Researchers from the University of Cambridge developed a new smartphone-based system called SegNet, which can identify objects in road scenes in real-time, even without GPS. The system has been successfully tested on city roads and motorways, and could potentially be used as a warning system for driverless cars.
A new study published in International Journal of Epidemiology found that high fitness levels do not offset the increased risk of death associated with obesity. Men with higher aerobic fitness had a lower risk of death compared to those who were obese, regardless of their fitness level.
Researchers at NUS Cancer Science Institute found that USP15 protein regulates the TGF-β pathway by interacting with SMURF2. This interaction enhances stability of the TGF-β receptor and leads to increased cancer progression. The study suggests USP15 as a novel therapeutic target for treating cancers with hyperactivated TGF-β pathways.
The LUX-Lung 7 trial shows afatinib significantly improved progression-free survival, time-to-treatment failure and objective response rate compared to gefitinib. Afatinib is considered the EGFR tyrosine kinase inhibitor of choice for first-line treatment in patients with EGFR mutation-positive non-small-cell lung cancer.
The KEYNOTE-010 trial shows that pembrolizumab improves median survival in all PD-L1-positive patients compared to docetaxel. Patients with higher PD-L1 staining benefit the most, with a hazard ratio of 0.54 and 0.50 at two doses of pembrolizumab.
A new study by the University of Liverpool's Institute of Infection and Global Health has found HIV infection to be the leading risk factor for stroke in young African adults. The incidence of stroke is increasing across sub-Saharan Africa, with many cases occurring in young adults with low prevalence of established risk factors.
A team of researchers from North Carolina State University has developed a technique for remotely controlling soft robots by manipulating elastic polymers with magnetic nanoparticles. By arranging the nanoparticles into parallel chains, they can control the movement and direction of the soft robots.
The study visualizes the human brain's neural anatomy, revealing previously unidentified connections between the brainstem and forebrain. These connections support the concept of an integrated central homeostatic network in the brain.
Researchers from Linköping University discovered that energy-time entanglement is vulnerable to attack, allowing eavesdropping on traffic without detection. They propose countermeasures to solve the problem.
A University of Southampton professor suggests that evolution's ability to learn from past experiences could explain the emergence of complex designs in nature. This idea challenges traditional views of evolution as a blind process, instead revealing its capacity for adaptation and problem-solving.
Researchers propose a mathematical theory explaining grid cell activity, enabling precise representation of spatial position and direction. The framework combines population-vector decoding with grid scale progression to maximize spatial resolution.
The National Science Foundation has awarded $37 million to fund research on co-robots that can collaborate with people, advancing the development of robots for critical tasks like infrastructure inspection and manufacturing. The awards support projects across various fields, including healthcare and search-and-rescue operations.
Researchers found that maintaining potassium levels low in an insect's blood is crucial for survival during cold exposure. The study, published in Scientific Reports, suggests that the Malpighian tubules play a key role in regulating salt balance in insects.
Researchers found that radioactive matter migrates more quickly through fractured carbonate rock when it has leaked from a tank near surface waste sites and geological repositories. Intrinsic colloid formation increases the mobility of leaked radioactive materials in the environment.
A USC study surveyed 3,310 ninth-grade students and found that those with moderate mental health problems who vape e-cigarettes have emotional and behavioral issues midway between smokers and non-vapers. E-cigarette use has tripled among teens in recent years, with flavors like Skittles enticing young people.
Researchers found that low doses of Ambien enhance synaptic GABA signaling, a type of nerve-cell activity beneficial for recovery. The study's results suggest potential therapeutic benefits for humans, but need replication before clinical trials can begin.
Researchers found that a specific COMT gene variant is associated with higher cortisol levels in stressed Japanese macaques, leading to more aggressive behavior. This study provides insight into the genetic basis of stress hormone production in non-human primates and its potential connections to human behavior.
A recent study of Laguna del Maule volcanic field reveals dramatic uplift over the past 8 years, mirroring similar events in the past 10,000 years. The research suggests that sustained input of new magma underground is the most likely cause of this rapid deformation.
A recent study by University of Notre Dame researchers finds that people in states relying heavily on ballot initiatives are happier than those in other states. This 'happiness benefit' is particularly pronounced among lower- and middle-income individuals, who often lack representation in conventional policymaking processes.
A Saint Louis University researcher proposes concrete steps to stem police shootings of black males, citing high homicide rates and racial biases in policing. Implementing body cameras, community review boards, and addressing prejudice are key recommendations.
A new NASA study finds that accurately accounting for climate drivers like aerosols and land use changes is crucial for predicting future global temperatures. The research calculated the temperature impact of each variable based on historical observations, revealing their complexity and correcting earlier underestimations.
A study spanning six continents found that lakes are warming at an average rate of 0.61 degrees Fahrenheit per decade, outpacing ocean and atmospheric warming rates. This rapid heating threatens algal blooms, water resources, and fisheries globally.
A new study found that 95% of families made at least one error in car seat use, and 91% made a serious error. The most common mistakes included loose harnesses, incorrect installations, and low chest clip positions.
Researchers found that patients with IBS have reduced sensitivity in their gut nerves, contradicting previous theories of over-sensitivity. This desensitization could be a protective measure to prevent overstimulation.
Researchers from McMaster University successfully tracked individual catalyst nanoparticles during heating using advanced electron microscopy techniques. This breakthrough could lead to the development of less expensive catalysts, such as platinum-iron nanoparticles, reducing dependence on imported oil and greenhouse gas emissions.
Researchers discovered a unique antibiotic molecule that triggers a bacteria's adaptation strategy, enabling it to resist the drug. The resistant bacteria undergoes morphological changes and can move away from the antibiotic, allowing it to survive and spread.
Researchers at MIT's Microsystems Technologies Laboratories show promise in building microelectromechanical systems (MEMS) using affordable and high-quality desktop fabrication devices. This allows for production of useful MEMS at significantly lower costs without compromising quality, enabling new markets and applications.
Researchers have elucidated the structure of mTORC1, a crucial protein complex involved in cellular signaling and disease regulation. The study reveals detailed interactions between partner proteins, shedding light on the mechanism of rapamycin-induced changes, which affects substrate specificity and pharmaceutical effects.
Researchers found a significant shift from using 'which' to 'that' in relative clauses, particularly among writers who also avoid the passive voice and end sentences with prepositions. This study demonstrates the importance of prescriptive grammar as a social force in shaping English language usage.
A UCL-led study reveals that oxygen levels in oceans and atmosphere rose to support animal life 100 million years earlier than previously thought. This finding suggests that increased oxygen may have kick-started early animal evolution, rather than a change in animal behavior.
A UCL-led team used sophisticated imaging to track the degradation of disposable Lithium batteries in real-time, revealing internal structural damage that affects performance. The study provides valuable insights for manufacturers to predict battery performance and optimize material design.
The Friedrich-Alexander-Universität Erlangen-Nürnberg is launching a new consultation model called 'Beratung für gesundes Altern' (BegA) in January 2016. This non-clinical project aims to provide prevention-oriented advice and support to older adults, helping them prepare for potential losses of function due to aging.
Researchers at Rice University and Ohio State University found that chronic inflammation is linked to depression, with concentrations of inflammatory markers CRP and IL-6 elevated by up to 50% in patients. Activities like yoga, meditation, NSAIDS, and exercise can help treat depression caused by chronic inflammation.
Researchers found that overqualification leads to more favorable reactions among employees and better job performance. By normalizing overqualification in the workplace, managers can encourage a positive influence on behaviors such as citizenship and teamwork.
Dendritic cells (DCs) process and present antigens to cytotoxic T cells through cross-presentation. Researchers found that a delayed fusion between phagosomes and lysosomes enhances antigen presentation. This mechanism helps DCs induce effective immunity against pathogens, while preventing the uptake of 'self' antigens.
A new study found that pre-adolescent children who have sustained sports-related concussions have impaired brain function two years following the injury. The research suggests that childhood concussions may have a lasting impact on cognitive performance, with potential lifelong academic and vocational consequences.
Turn-taking in human communication appears to have origins in primate gestural interactions, predating the development of language. This double-tasking of comprehension and production may motivate compact clause structures in all languages.
The Deutsche Forschungsgemeinschaft is funding 14 new Research Units and one Clinical Research Unit, totaling €35 million. The research collaborations aim to address pressing issues in their respective fields, including neutrino mass hierarchy and creative processes.
Researchers discovered that aggressive tumors hijack an export pathway in cells to lay the groundwork for cancer progression and resistance to chemotherapy. Blocking this pathway may help restore tumor vulnerability to chemotherapy.
A new cell culture technique called VOGIM allows the formation of tumor blood vessels and their interaction with immune cells to be observed in real-time. This enables the study of tumor growth, cell death, and the influence of medications on these developments without live animal testing.
The number of compounded hormone therapy prescriptions has reached 26-33 million a year, with sales expected to continue growing despite potential risks. The lack of clinical data and quality control concerns over these products is alarming.
A team at HZB has developed an alternative method for representing microstructures in polycrystalline materials, utilizing Raman microspectroscopy. This non-invasive technique allows for orientation distribution mapping without specimen preparation, enabling analysis under ambient conditions.
NASA's Aqua satellite captured temperature data on the storm's remnant low pressure area after it made landfall in Caraga / Manay, Davao Oriental. The remnant area is expected to bring moderate to occasionally heavy rains and isolated thunderstorms over several regions.
The PALOMA3 trial confirms the efficacy of combining palbociclib with fulvestrant in Asian patients with hormone receptor-positive, HER2-negative advanced breast cancer. The combination shows positive results in progression-free survival for postmenopausal women, while a longer follow-up is needed to confirm overall survival.
Researchers discovered a BAP1 mutation in four unrelated US families, suggesting a possible link between the gene and various cancers. The study's findings have important implications for cancer prevention and early detection, particularly for melanomas.
Researchers developed simulations of the human heart using computational modeling, aiming to create personalized treatment strategies for patients with reduced cardiac function. The project uses virtual personalized heart models to predict CRT feasibility and optimize pacemaker setup.
The Magnetospheric Multiscale (MMS) mission is providing unprecedented insights into magnetic reconnection, a process that drives giant magnetic bursts and oscillations in Earth's magnetic fields. Scientists are using MMS' high-resolution measurements to better understand the role of magnetic reconnection in shaping the space environme...
Researchers at the University of Leicester suggest that supermassive black holes can grow up to 50 billion solar masses before their gas discs collapse, starving them of fuel. Without a disc, the black hole would stop growing, marking a significant limit on its size.
A study published in the British Journal of Cancer found that higher magnesium intake may lower the risk of pancreatic cancer. Researchers analyzed data from over 66,000 men and women and discovered a significant association between magnesium consumption and reduced pancreatic cancer incidence.
Researchers created a mechanically durable hydrogel using an elastic silk-like protein called aneroin, which has improved mechanical properties compared to collagen and silkworm silk. The aneroin hydrogel provided an adequate environment for cell growth, proliferating mammalian cells with healthy morphology.