Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
Researchers at Princeton University found that intense rainfall leads to a decrease in tree growth and an increase in grass growth on the African savanna. This is because trees struggle to utilize excess water, while grasses can absorb it quickly, giving them a competitive advantage.
A survey found that physicians in training who work long duty hours are more likely to smoke, with surgeons having the highest prevalence. Social factors such as a colleague or superior who smokes also contribute to the likelihood of smoking among health care professionals.
Researchers found that yoga exercises improve pulmonary function and exercise capacity comparable to traditional pulmonary rehabilitation methods. Yoga-based programs may be a cost-effective alternative for COPD management.
A study found that larger protected areas, especially those in high population density regions, are more likely to undergo a downgrading event. The researchers highlight the need for conservation planners to consider the robustness of protected areas towards future economic and demographic changes.
A new study shows that patients with sleep apnea are at a higher risk of developing gout. The incidence rate of gout was found to be 60% higher among those with sleep apnea compared to similar-weight comparators.
A study using 21 years of global wind data found that following optimal routes reduces travel time by 26.5% and increases survival rates. This suggests migratory routes may be under strong natural selection, with potential evolutionary advantages.
A new experimental treatment regimen combining a drug delivery system and URMC-099 has been shown to effectively combat HIV, reducing the need for daily medication. The nanoformulated protease inhibitor and URMC-099 prolonged therapeutic effects by increasing drug concentration in immune cells.
The School of Public Health will compare the SafeCare model, teaching parenting skills, with standard case management approach in a three-year project assessing parent and child well-being and reducing maltreatment risk. The study aims to provide information for better-informed health decisions.
Researchers mapped the human brain's experience of gratitude using Holocaust survivors' testimonies, revealing areas responsible for feelings of reward and moral cognition. The study also showed that gratitude enhances empathy and understanding of historical events.
Most drug residues discharged to wastewater originate from private households, according to a study by Leuphana University. The researchers found that health care facilities, such as hospitals and psychiatric clinics, emit significantly lower levels of contaminants, highlighting the need for stricter regulations on medication disposal.
A study of over 30,000 patients found that Crohn's disease and ulcerative colitis share similar genetic markers, suggesting a continuum of disorders. Genetic data can help identify misdiagnoses and inform treatment guidelines.
Researchers at KAIST and UCLA developed a method to manipulate membrane protein folding in a natural environment, revealing cooperative folding behavior. The study used magnetic tweezers to induce unfolding and refolding, allowing for the mapping of folding energy landscapes and kinetic rates.
A shortened radiotherapy schedule has been shown to have similar efficacy as a conventional course in treating low-risk prostate cancer. The study found that patients treated with the shorter schedule experienced no significant decrease in cancer control compared to those treated with the longer conventional schedule.
A blood test that detects Alzheimer's disease presence has shown promise in early detection, allowing patients to make beneficial lifestyle changes to slow or halt disease progression. This discovery provides hope for those affected by the disease, enabling them to take proactive steps before symptoms emerge.
Akinori Awazu's research reveals that active nuclear deformations play a significant role in determining intra-nuclear chromosome architectures. The study suggests that these dynamic changes contribute considerably to the segregation pattern formation of euchromatin and heterochromatin.
A study published by the University of Texas M. D. Anderson Cancer Center found that intensity modulated radiation therapy (IMRT) reduced severe pneumonitis and improved chemotherapy tolerance in patients with locally advanced non-small cell lung cancer compared to conventional radiation therapy.
Researchers at WashU Medicine found that premature babies have weaker brain connections, particularly in networks linked to attention, communication, and emotions. Early intervention may improve outcomes for these children.
A pilot study found early insulin therapy to be as effective as 15 months of oral therapy, improving A1C levels from 10.1% to 6.7% in insulin-treated group and 9.9% to 6.8% in oral therapy group, with no severe hypoglycemia reported
A population-based case-control study found that childhood infections are associated with a three-fold higher occurrence of premature acute coronary syndromes (ACS) later in life. The study suggests that infection may potentiate the impact of traditional risk factors on developing early cardiovascular disease.
John Wesley Miller, a UA College of Engineering alumnus and pioneer in energy efficiency and green building, has received the 2015 Lasting Legacy Award. His contributions to environmentally sustainable construction have been recognized through his work on projects such as Biosphere 2 and Armory Park del Sol, which showcase innovative t...
A small phase I clinical trial found that an FDA-approved leukemia drug improved cognition, motor skills, and non-motor function in patients with Parkinson's disease and Lewy body dementia. The drug, nilotinib, also reduced toxic proteins linked to disease progression.
A study found that pacemaker checks can identify asymptomatic atrial fibrillation (AF), allowing for early initiation of anticoagulation to prevent strokes. The research involved 223 patients who received a pacemaker and showed that nearly all with undiagnosed AF needed anticoagulation to reduce stroke risk.
A new study by King's College London researchers provides the first clinical evidence on the mental health impact of human trafficking, finding high levels of post-traumatic stress disorder (PTSD) and depression among patients. The study reveals complex needs of trafficked individuals, including childhood abuse and adulthood trauma.
Researchers found that sniffing and gasping prevented syncope in patients with vasovagal syncope. The study used a head-up tilt test to mimic standing up quickly, but interrupted the reflex with sniffing or gasping, avoiding falls in blood pressure and heart rate.
A new UCL study has highlighted genes involved in schizophrenia and obesity, which could aid in developing improved prevention and treatment strategies. Variants in CRHR1 and SNORD115 were found to be more common in obese subjects, suggesting that disruptions in these genes may increase the risk of obesity.
Researchers have discovered a link between Diamond-Blackfan anaemia and increased cancer susceptibility, using a new animal model that recapitulates key characteristics of the disease. The study found that patients with DBA are predisposed to lymphomas and solid tumours due to mutations in the RPL11 protein.
Researchers at MIT developed a system that can automate big-data analysis, identifying patterns and designing feature sets. The system was tested in three data science competitions, achieving accuracy rates up to 96% and completing tasks in just 2-12 hours compared to human teams.
The US Nuclear Science Advisory Committee has released a new long-range plan for nuclear physics research, prioritizing investments in particle accelerators and neutrino studies. The plan recommends focusing on existing facilities like Jefferson Lab's 12 GeV Upgrade to unlock new scientific opportunities.
NASA's GPM satellite analyzed Koppu's intensifying storm system on October 15, revealing an eye forming near its center. Rainfall rates reached over 133 mm per hour in intense thunderstorms just southwest of the storm's center.
A study published in Global Change Biology predicts that a warmer future with normal rainfall will leave California's coast redwoods with a significantly different climate than they have experienced for decades. The study also suggests that redwood forest bioclimate will expand by 34 percent northward from the coast of California into ...
Low-impact development technologies, such as green roofs and rainwater tanks, can help reduce waste and protect natural stream ecosystems. Researchers propose a shift towards distributed infrastructure to capture and reuse stormwater runoff, offering a solution to California's drought and environmental challenges.
Researchers identified key metabolic changes that occur in patients with myeloma and those at risk of developing the disease. The findings suggest a potential drug target to prevent progression from benign MGUS to cancerous myeloma.
Researchers found that spider monkeys can distinguish between ripe and unripe fruit odors with over 70% accuracy, a skill honed through coevolution with tropical trees. The study suggests that a species' sense of smell is not inherently good or bad, but rather adaptive to their ecological niche.
The UMass Amherst team aims to develop tools and techniques that enable data management systems to protect private data from being used for unintended purposes. They plan to use differential privacy, adding statistical noise to query outputs to ensure accurate information while protecting individual privacy.
Researchers have discovered a protein in malaria that can bind to a sugar molecule found in many types of cancer. This binding enables anti-cancer drugs to be delivered precisely to tumors. The findings offer new potential for treating various cancers, including melanoma and lung cancer.
Three NIH-funded studies found that a genetic mutation linked to ALS and FTD impairs nuclear transport in neurons, leading to defects in gene expression. Researchers suggest therapies targeting nucleocytoplasmic transport may be effective in treating these diseases.
Tropical Storm Champi was over Guam and the Marianas Islands when NASA-NOAA's Suomi NPP satellite captured a visible image of the storm. The Visible Infrared Imaging Radiometer Suite (VIIRS) instrument showed strongest thunderstorms in its western quadrant and over Guam.
A new study found that nearly half of camels in parts of Kenya have been infected with the Middle East Respiratory Syndrome (MERS) virus. The research suggests camels may be a major reservoir host for the virus and a potential source of infection in humans.
Researchers led by Assia Shisheva found a novel interaction partner of the ArPIKfyve-Sac3 complex in the brain, which binds Synphilin-1 and prevents its aggregation. This discovery may lead to new therapeutic approaches for reducing cytoplasmic aggregates in Parkinson's disease.
A study by researchers at North Carolina State University found that mobile device users are more susceptible to security errors while multitasking. The researchers created a simulated app store experience and asked participants to identify the safest app, with only half choosing correctly.
Physicists from France and Russia have discovered magnetic disturbances resembling little oscillating stars in a 2D superconductor layer. These 'nanostars' are caused by a single magnetic atom and are more sustainable than previous observations, bringing us closer to developing quantum computers.
A digital health application facilitated early detection and treatment of COPD exacerbation symptoms, with patient adherence exceeding 90% and response times to worsening COPD symptoms in less than 11 hours. The app uses a symptom score system to generate alerts and provide evidence-based treatment recommendations.
Researchers developed a method to speed up optical fibers by digitally re-twisting data streams, using a technique inspired by MIMO technology in radio communication. The breakthrough could solve the insatiable needs of data-driven social media platforms like Facebook and YouTube.
Researchers cast doubt on lunar impact date methods by analyzing meteorite-impact zircons, suggesting contextual information loss upon separation from host rocks. This may affect our understanding of the late heavy bombardment on the young Moon, which could influence life's emergence timeline.
Biochemists at Oregon State University have made a fundamental discovery about protein structure that sheds light on how proteins fold and change shape. The findings reveal the first direct views of specific details of one aspect of protein folding in a way that had not been considered possible.
New Jersey researchers used neuroimaging to investigate reading deficits in patients with subacute left hemispheric stroke. They found associations between phonological deficits and lesions in the anterior temporal lobe and mid-fusiform gyrus. This study may lead to targeted interventions for acquired reading deficits, benefiting indiv...
Scientists at Brigham and Women's Hospital have developed a method to create kidney structures from adult stem cells, which could be used to study diseases such as chronic kidney disease and test new therapies. These kidney structures can model the development of kidney abnormalities and susceptibility to drug toxicity.
A recent study reveals that large solar storms can go undetected by current indices, which could lead to significant disruptions in power supply and communication networks. The researchers developed a new Local Disturbance index for Spain (LDiñ) to accurately assess geomagnetic perturbations in the region.
Researchers develop new algorithm to simulate water evaporation at molecular scale, matching theoretical and real-world observations. The tool enables the study of various heat transfer problems, including rapid cooling of computer chips and energy conversion devices.
A new international study is recruiting over 8,000 UK parkrun participants to assess the link between recreational running and osteoarthritis. The HALO study will follow participants for 15 years to identify potential benefits and risks of regular running.
Researchers are developing a new eye lens that can adjust focus automatically, using liquid crystals to tackle age-related conditions like presbyopia and cataracts. The lens could be implanted in a quick surgical procedure, offering hope for millions of people affected by these vision problems.
Researchers developed a new material fortified with nanodiamonds that can combat bacterial infections in teeth. The nanodiamond-enhanced gutta percha showed promise in preventing residual infection and promoting healthy tooth regeneration.
Researchers at Berkeley Lab discovered unique thermal properties in black phosphorus nanoribbons, with high directional anisotropy in thermal conductivity at temperatures greater than 100K. This finding has implications for designing energy-efficient devices, as the lattice orientation of patterns can affect thermal conductivity.
Tropical Depression 19E continues to move through the Eastern Pacific Ocean, with poorly organized cloud patterns and a small area of deep convection. The depression is forecast to strengthen into a tropical storm later this week.
A new study found that the signatories to the Public Health Responsibility Deal alcohol labelling pledge are not fully meeting their pledge. Labelling information frequently falls short of best practice, including poor legibility and clarity.
A UCLA-led study suggests that brief interventions in primary care clinics can significantly reduce risky drug use among patients. Participants who received brief advice and follow-up coaching reported a 33% reduction in their drug use over three months.
A new USGS guide provides 100 photos to identify harmful algal blooms in freshwater bodies. The images aid in distinguishing between toxic cyanobacteria blooms and non-toxic ones, helping communities protect themselves from toxin exposure.
Scientists at Jena University have discovered how bacteria infect plants by hijacking the regulation of flower development, preventing normal growth and sexual reproduction. The study sheds light on the molecular reasons behind this phenomenon, where infected plants 'become the living dead'.
Researchers at University at Buffalo have discovered that the Huntingtin protein controls the movement of Rab proteins in neurons, which can lead to neurological problems if disrupted. The study sheds light on an enduring neuroscience mystery: the root causes of Huntington's disease.