Researchers have discovered a way to enhance chemotherapy's impact by inhibiting the cellular quality-control mechanism NMD, which helps breast cancer cells survive. This strategy primes cells for apoptosis and increases cell death rates.
Astronomers studied 72 large cluster collisions using Hubble and Chandra observations. They found dark matter continues straight through collisions without slowing down, interacting even less with itself than previously thought.
A recent study found that mandatory arrest policies may increase law enforcement notification of intimate partner violence but also deter women from reporting due to fear of retaliation and mistaken arrests. The researchers suggest that variations in experiences and attitudes toward police should be considered in policy decisions.
A new study suggests that cellphone bill shock warnings can be more costly for consumers as carriers adjust plans and fees to maintain profits. The researchers found that average consumers pay an extra $33 under billing alerts.
Researchers developed two predictive models to identify patients at risk for serious complications after joint replacement surgery. The first tool identifies patients with conditions like chronic obstructive pulmonary disease and congestive heart failure, while the second model predicts which patients require intensive care unit admiss...
Dr. Vakoc's work reveals an essential connection between epigenetic regulation and oncogenesis, leading to potential new therapeutic approaches for leukemias and other cancers. He will present his lecture at the AACR Annual Meeting 2015.
A team of investigators has developed the first fully implantable micropacemaker for fetal use, which has received FDA approval as a Humanitarian Use Device. The device is designed to treat fetuses with complete heart block, a condition that significantly slows the heart rate and impairs its ability to pump blood.
Researchers applied GSH to various experiments, demonstrating its suitability for describing complex granular media behavior regardless of flow speed. This approach resolves previous limitations in explaining granular material flows at low and high speeds.
This special issue delves into the latest research on molecular gastronomy, perception of food, growing crops, obesity, and diet's impact on the circadian clock. Researchers discuss the science behind cooking techniques, flavor creation, and how chefs are pioneering new fermentation reactions.
A Penn Medicine study found that modern technology for healing distal femur fractures is as safe and effective as its more established alternative without a potential shortfall of the older approach. Surgeons' improved decision-making using fewer screws has resulted in decreased technical problems associated with locked plating.
The UK Government has invested £25.7 million in the University of Edinburgh to create a new biology complex with state-of-the-art laboratory space, focusing on biological research and tissue repair. The complex will integrate three research areas, including infection and global health, synthetic biology, and epigenetics.
Researchers from CNIO have developed a new anti-obesity treatment that reduces body weight and improves metabolic syndrome symptoms in obese mice and monkeys. The treatment, CNIO-PI3Ki, selectively targets the storage of nutrients in excess, leading to weight loss without affecting other tissues or brain function.
A team of researchers from Michigan State University studied the feral chicken population on the Hawaiian island of Kauai to understand their genetic origins. The study found evidence of hybridization between ancient Red Junglefowl and domestic chickens, suggesting that the population may have originated from interbreeding.
A recent study published in Science reveals that dark matter particles do not interact with themselves when galaxy clusters collide, contradicting the view that they consist of proton-like particles. This finding challenges a major theory and raises new questions about the nature of dark matter.
Researchers developed a wearable collision warning device to help patients with peripheral vision loss avoid collisions. The device gave auditory warnings only when users approached obstacles, reducing collisions by 37% and improving mobility performance.
Researchers warn that increased antibiotic use in livestock could lead to decreased effectiveness in humans. A study found that global demand for animal protein is rising dramatically, driving antimicrobial consumption.
The Intergovernmental Panel on Climate Change (IPCC) has criticized the 2°C temperature rise target as 'utterly inadequate' for protecting those at most risk from climate change. Limiting warming to 1.5°C could prevent severe impacts, preserve ecosystems, and ensure food security, says Petra Tschakert.
Scientists at Rockefeller University successfully adapted CRISPR-Cas9 gene editing to the Aedes aegypti mosquito, which transmits hundreds of millions of people annually with deadly diseases. The researchers aim to understand how different genes help the species operate as a disease vector and create new ways to control its spread.
Boosting crop yields through high-performance computing, genetic engineering, and modifying plant anatomy may be the solution to increasing global food demand by 2050.
Dr. Mitchell Gail recognized for pioneering statistical work in cancer research, including breast cancer risk prediction models. His research has led to the development of widely used tools like the NCI's Breast Cancer Risk Assessment Tool.
The International Human Frontier Science Program Organization has awarded eight young researchers with a total of $300,000 over three years to establish their independent laboratories. The awardees will support training in cutting-edge, interdisciplinary research focused on the life sciences.
Researchers mapped how neurons fired in the brain of a sea slug while it moved, revealing large groups of co-active neurons that can be dramatically simplified and interpreted. This approach may help understand how brain networks change in disease states and how drugs act to restore normal brain function.
A study of 2.7 million US breast cancer patients found that surgeons are increasingly removing only the 'gatekeeper' lymph nodes, rather than all underarm lymph nodes, when a biopsy shows cancer. This shift is attributed to the lower risks for patients who undergo sentinel lymph node biopsy alone.
A team of physicists has calculated the tiny neutron-proton mass difference using a powerful supercomputer, verifying the theory of the strong interaction. The finding confirms that neutrons are slightly more massive than protons, with a 0.14% difference, and opens up new possibilities for simulations of quarks and nuclear particles.
The updated guidelines offer a state-of-the-art basis for clinical care of patients with MTC, highlighting areas in need of further investigation. The revised recommendations aim to improve overall survival for these patients by developing more effective drugs or combinations of drugs.
Marine ecologists track striped marlins in Pacific Ocean using satellite tags, revealing their preferred habitat in the epipelagic layer within 8 degrees C of sea surface temperature. The study's findings may help reduce undesired catch and target higher-value species.
A new engineered protein-based medicine has been shown to overcome radiation resistance in leukemia by selectively binding to leukemia cells and amplifying the potency of radiation therapy. In mouse models, this precision medicine improved survival rates in aggressive human leukemia with minimal side effects.
A study found that injecting stem cells during rotator cuff surgery improved healing and durability of tendons. After 10 years, 87% of patients who received stem cell injections had intact rotator cuffs, compared to 44% without treatment.
A new jumping spider species, Stenaelurillus albus, with a unique mating plug has been discovered in the Western Ghats of India. The study also re-describes another species and highlights the presence of mating plugs in Salticidae families.
Researchers at UT Dallas created new materials that can stretch up to seven times their length while remaining tougher than Kevlar, absorbing up to 98 joules per gram. These nanofibers exploit electromechanical properties to form strong attractions between molecules.
A new study found that women have better outcomes than men following total knee and hip replacement surgeries, with lower rates of complications and revision surgeries. Men are more likely to experience heart attacks, infections, and require revisions after surgery.
Military veterans with avoidant coping strategies exhibit higher symptoms of depression and generalized anxiety, but emotional support reduces negative impacts. Problem-focused coping with high emotional support is linked to lower depression and anxiety symptoms.
Researchers discovered a genetic mutation causing a child's immune system dysfunction, leading to severe influenza. The study suggests that interferon amplification dependent on IRF7 expression is needed for protection against the virus.
Dr. Mindy H. Li, MD, received the 2015 ACMG Foundation/PerkinElmer diagnostics Travel Award for her groundbreaking research on phenotypes and electronic health record systems in pediatric individuals with intellectual disability. The award recognizes her scientific merit and supports medical genetic researchers.
A long-term study found that green zones have more than doubled coral trout biomass since the 1980s, while fished reefs experienced stable numbers and increases in large, reproductively-mature fish. Effective protection networks help reef fishes cope with stresses and maintain populations.
A study published in Science reveals that swirling ocean currents, known as eddies, play a significant role in delivering carbon from phytoplankton blooms to the deep ocean. The research, led by Melissa Omand, found that these currents transport small, non-sinking phytoplankton cells to depths of up to 1,000 meters.
Researchers found that bats follow a set of 'traffic rules' when foraging, including chasing, turning, and avoiding collisions. The bats swap leadership roles during these interactions by copying the previous individual's flight direction up to 500 milliseconds earlier.
A Louisiana State University chemistry professor has secured a grant to study the habits of the elusive three-toed amphiuma. The research aims to document the animal's life cycle and determine if they are territorial using radio transmitters, underwater cameras, and video recordings.
A committee of lymphoma experts identified key priority areas in infrastructure and research to advance treatments. The Roadmap for Discovery and Translation in Lymphoma outlines priorities to improve understanding of lymphoma biology across diverse subtypes.
A study found that Mexican Americans spend a high proportion of their later years with some form of disability, highlighting the need for community assistance and long-term care. Women born in Mexico suffer from prolonged disability, emphasizing the importance of addressing health disparities.
Researchers developed a tissue culture model to study latent tuberculosis infection, finding that the human immune system generates an early response that protects against active disease. However, some bacteria can adapt and survive in these high-pressure environments, increasing the risk of reactivation.
Researchers at Dana-Farber Cancer Institute have identified Eya1 as a critical protein in both normal brain development and the development of medulloblastoma. Lowering Eya1 levels in mice with medulloblastoma reduced death rates from the disease by half, suggesting it as a prime target for new treatments.
A lack of disclosure and elevated cancer risk are experienced by the LGBTQI community due to reduced access to healthcare and insurance. Researchers suggest training staff in LGBTQI competencies and collecting gender identity and sexual orientation data to improve patient care.
The Tasmanian swift parrot is facing a severe population collapse, with its numbers projected to halve every four years. The research emphasizes the need for urgent protection measures to preserve the bird's forest habitat and prevent its potential extinction within 16 years.
Researchers discovered that bacteria can use magnetite to create a 'natural battery' by loading and discharging electrons. This mechanism has implications for cleaning up toxic metals and could be adapted for other types of bacteria, expanding its potential uses.
A recent study has found that post-traumatic stress disorder (PTSD) is associated with a nearly 50% greater risk of developing heart failure among veterans. The research adds to growing evidence linking PTSD and heart disease, suggesting a potential causal relationship between the two conditions.
A new study finds that high-fat diets produce changes in gut microbiome, leading to altered behavior and cognitive function. Mice with high-fat diet-induced gut microbiota showed increased anxiety, impaired memory, and signs of brain inflammation.
Dr. Lucile Adams-Campbell is recognized for her scientific work in cancer epidemiology and health disparities, as well as her dedication to mentoring minority researchers. She will receive the AACR-MICR Jane Cooke Wright Lectureship at the AACR Annual Meeting 2015.
The University of Surrey's new CUSP center aims to explore the connection between prosperity and sustainability. The five-year program will investigate how people's aspirations for a good life intersect with environmental constraints, aiming to elaborate a vision for sustainable prosperity.
Researchers have developed a new Ebola vaccine based on the 2014 virus strain, showing it to be safe and provoking an immune response. In a phase 1 clinical trial, participants receiving high doses of the vaccine had a 100% positive immune response rate.
A new review of 5,903 participants found limited evidence supporting xylitol's ability to prevent tooth decay, particularly with fluoride toothpastes. The review concluded that xylitol-containing products showed little to no benefit in preventing dental cavities.
Researchers at Johns Hopkins Bloomberg School of Public Health analyzed over 81 published journal articles and found that raw milk is associated with nearly 100 times more risk of foodborne illness than pasteurized milk. The study strongly discourages the consumption of raw milk, especially among elderly, pregnant women, and children.
A Mayo Clinic study found that frequent attendance at work site wellness centers led to significant weight loss and healthcare cost savings. Members who visited the Dan Abraham Healthy Living Center (DAHLC) more than 360 times were 72% more likely to experience weight loss, with corresponding reductions in healthcare costs.
A large longitudinal survey of Norwegian mothers found that children with autism spectrum disorder were two-and-a-half times more likely to have persistent gastrointestinal (GI) symptoms than children with typical development. The study also found that these symptoms appeared in infancy and persisted through age 3.
Researchers at the University of Copenhagen have created a video of thousands of progenitor cells in the pancreas making decisions, revealing that stem cells behave like individuals with social interactions influencing their choices. This study could lead to improved control over insulin-producing endocrine cells for diabetes treatment.
Research in the Bay of Biscay found liver pathologies, tumors, and other health problems in deep-water fish, linked to human-caused pollution. The study also discovered the first case of an intersex condition in a deep water fish species.
Cardiff University has received a $25.8m investment to establish the UK's first Compound Semiconductor Research Foundation, set to drive innovation in semiconductor technology. The foundation will strengthen partnerships between the university and IQE Plc, a leading global Compound Semiconductor wafer supplier.
A study from the University of Eastern Finland found that risk factor levels even below accepted thresholds can be harmful when several risk factors cluster. Clustered risk factors were linked to elevated liver enzymes in overweight children, particularly those with a common PNPLA3 gene mutation.
A new study reveals that adults treated with ECMO have better survival rates when cared for at hospitals that use the treatment frequently. The research analyzed data from over 56,000 patients across 290 hospitals worldwide, finding significant variation in survival rates between centers.
Louis Nirenberg, a NYU mathematician, and John Nash, a Princeton professor, have been awarded the Abel Prize for their work on nonlinear partial differential equations. Their contributions significantly impact geometric analysis, with far-reaching consequences felt more strongly today than ever before.