A modified rabies virus expressing a protein from the MERS virus protects mice against both diseases. The dual compound could lead to an effective human vaccine for Middle East Respiratory Syndrome and prevent its spread in camels.
A retrospective observational study found that patients receiving CT scans for atraumatic headaches in the emergency room were less likely to return within 30 days. The study suggests that CT scans may provide reassurance to patients, preventing return ED visits.
Researchers have discovered that TET proteins, which modify methyl groups attached to cytosine, influence gene expression and facilitate the removal of these marks. This dynamic modulation is critical for driving developmental gene expression programs in early embryos, particularly in neural tissue formation.
Researchers at Albert Einstein College of Medicine found that brain activity while walking and talking can predict the risk of falling. The study, published in Neurology, involved 166 healthy older adults who were asked to perform tasks such as walking and reciting letters. The researchers found that elevated brain activity during thes...
A team of scientists used numerical methods to investigate the glass transition behavior of binary mixtures under supercompressed conditions. They found that the dynamic facilitation theory correctly predicted the relaxation dynamics in these systems, supporting its applicability to hard disk systems at high pressure.
A study examining late-life couplehood in assisted living found benefits of companionship, support, and affection. Fellow residents can play an important role in shielding against negative health outcomes associated with marital transitions.
Scientists at University of California San Diego determined the 3D structure of CCR2 simultaneously bound to two inhibitors, providing insights for developing anti-inflammatory drugs. The study reveals how these molecules turn the receptor 'off' by blocking natural chemokine binding and preventing inflammatory signal transmission.
Researchers at Oregon State University found that northern sockeye salmon can thermostate to find water temperatures that meet their physiological needs, reducing energy expenditure during heat waves. By moving to tributary plumes or deeper water, the fish conserve energy and avoid extreme temperatures.
Researchers at MIT have developed a fast and precise printing process that can fabricate electronic surfaces for a wide range of applications. The team has created stamps made from carbon nanotubes that can print electronic inks onto rigid and flexible surfaces, enabling the creation of high-performance, fully printed electronics.
A recent study published in Frontiers in Psychology shows that learning strategies are crucial for academic success among underachieving students. The research highlights the importance of reinforcing these strategies and promoting autonomy and responsibility in teachers and parents. By targeting interventions inspired by overachievers...
A team of astronomers from institutions around the world has processed images from the Kilo Degree Survey to make one of the most precise measurements ever made of cosmic shear, a subtle variant of weak gravitational lensing. The results suggest that dark matter in the cosmic web is less clumpy than previously believed.
A new study suggests that persistent job insecurity over a 25-year career can lead to increased psychological distress among older workers. The research found that stress from perceived job insecurity was particularly high among minorities and those without a high school degree, and that this stress can have significant impacts on health.
A study published in ACS Central Science reveals that MAO activity increases with Aβ plaque formation in patients with Alzheimer's, suggesting it could serve as a biomarker for diagnosis and monitoring. The research also identified three distinct phases of MAO activity that change along with disease progression.
Tropical Cyclone 05B has formed over the Anadaman and Nicobar Islands, with maximum sustained winds near 40 mph. The storm is expected to move northwest toward India, making landfall by Dec. 12 south of Visakhapatnam.
Researchers at Mayo Clinic found that inherited pathogenic variants in genes BARD1 and RAD51D increase a woman's likelihood of developing breast cancer. The study also confirmed the involvement of other genes such as ATM, CHEK2 and PALB2 in breast cancer risk.
A study led by Dr. Steven A. Rosenberg identified a method to target the cancer-causing protein produced by a mutant form of the KRAS gene, leading to cancer regression in a patient with colorectal cancer. The treatment involved infusing tumor-infiltrating lymphocytes into the patient, which recognized and attacked the mutated cells.
Researchers from Vetmeduni Vienna analyzed MUP genes and proteins in wild house mice, finding no variation among individuals. The study refutes the 'barcode hypothesis' that MUPs provide individual signatures for kin recognition.
Researchers in Frankfurt confirm the quantum-mechanical tunnel effect in deep-frozen helium molecules. The study reveals that over 75% of bonding time can be explained by this effect.
Researchers have developed a novel live-cell imaging method that allows for dynamic, high-resolution visualization of cell interactions. The Photonic Crystal Enhanced Microscope (PCEM) can quantify and measure cell adhesion, a critical process involved in cell migration, differentiation, division, and death.
Researchers at MIT's CSAIL have developed a new system that analyzes correspondences between images and spoken descriptions to train speech-recognition systems. The system can potentially provide automatic speech recognition for less-resourced languages, leading to fully automated translation capabilities.
Researchers found that harmine increases proliferation of human neural progenitor cells by inhibiting DYRK1A, leading to a 70% increase in new neural cell generation. This effect may lead to potential therapeutic applications for depression and neurodegenerative diseases.
A study by the University of Warwick found that around 50% of participants believed they had experienced fictitious events, such as taking a childhood hot air balloon ride. The findings have significant implications for fields like forensic investigations, therapy treatments, and courtrooms, where memories are used to inform decisions.
A genetic difference in the FADS1 gene affects levels of LDL- and HDL-cholesterol, as well as the risk for allergies, inflammatory diseases, and certain types of cancer. This imbalance is thought to have evolved over time due to changes in human diet.
A new blood test can detect Merkel cell carcinoma (MCC) earlier and more effectively than traditional imaging studies. The test uses an immune system marker to identify patients at high risk of recurrence, allowing for earlier treatment with immune therapy.
A personalized cancer vaccine significantly improved outcomes for patients with acute myeloid leukemia (AML) in a clinical trial, showing protection from relapse in most patients and minimal side effects. The vaccine stimulated powerful immune responses against AML cells, using the body's own defense systems to fight cancer.
Researchers at IRB Barcelona identify CD36 as a general marker of metastatic cells, which are responsible for initiating and promoting metastasis in several types of human tumors. High-fat diets have been shown to enhance the formation of metastases in mice inoculated with oral cancer cells.
Patients with large breast tumors and no axillary lymph node signs before chemotherapy showed low risk of recurrence with SLNB. Follow-up data revealed high disease-free survival rates comparable to ALND, suggesting SLNB as a safe alternative.
A new study found that optimism is associated with a significantly reduced risk of dying prematurely among women. The most optimistic women had a nearly 30% lower risk of dying from any disease analyzed in the study, including cancer, heart disease, and infection.
A study published in Neurology found that higher levels of brain activity in the prefrontal cortex were associated with a higher risk of falls in healthy older adults. The association remained even after accounting for other factors, such as slow walking speed and frailty.
A new study found that sweet potato peptide, produced from the water wasted during processing, helps reduce body weight and fat levels in mice fed high-fat diets. The peptide activates appetite suppression and controls lipid metabolism, suggesting a potential slimming effect.
A study by the American Chemical Society found that all tested plastic teethers contained BPA and other endocrine-disruptors, which can leach out into water. The researchers detected a range of parabens and antimicrobials in most teethers, raising concerns about infant exposure to potentially toxic chemicals.
A new study examines data from a high-risk group of children with depressed parents to identify signs and symptoms preceding new-onset MDD during adolescence. Analyzed clinical antecedents found irritability and fear/anxiety associated with the first onset of adolescent MDD, highlighting multiple routes to the condition.
Researchers discovered two genetic mutations in the CCND1 and CCND2 genes in a subset of acute myeloid leukemia patients. These mutations were found in 15% of patients with t(8;21) AML, making them a potential target for new therapies.
Supportive care, including pain relief and medication to prevent side effects, remains insufficient for many cancer patients, especially those on government-funded schemes in India. This can lead to delayed treatment cycles and poor quality of life. Researchers emphasize the need for better policies and access to effective treatments.
Researchers used whole exome sequencing to analyze nearly 7,400 patients, identifying a genetic cause in 28 percent. The study shows that multiple genes can be involved in complex diseases, leading to imprecise diagnoses. A unified analysis combining clinical and genetic features provides more precise diagnoses.
Patients with longer delays were more likely to receive palliative treatment, while early diagnosis and treatment improve cancer outcomes. The study found that patients and primary care physicians contributed significant delays, highlighting the need for increased patient awareness about symptoms and screening.
Researchers at the University of Illinois found that mice lacking functional copies of the Bco1 gene had lower blood concentrations of testosterone and smaller prostates. The study suggests that Bco1 may also play a role in regulating prostate growth and androgen synthesis, challenging current understanding of carotenoid metabolism.
A diet rich in magnesium may lower risk of coronary heart disease, stroke and type-2 diabetes. Researchers found people with higher magnesium intake had a lower risk of these diseases compared to those with lower intake.
Researchers at ICIQ and ETH have developed a new process to produce polyalcohols from biomass using two consecutive metallic catalysts featuring molybdenum and ruthenium. This method is more sustainable, cheaper, and efficient than traditional biochemical processes that require controlled temperatures, concentrations, and pH.
Researchers found significant alterations in brain networks of PD patients with mild cognitive impairment, indicating complex structural brain network disruption rather than individual white matter degeneration. The study suggests using MRI to monitor the disease and predict cognitive complications.
The Earth's critical zone is a vital layer that supports life and human activities. Research in this area reveals the importance of time, depth, and coupling in understanding the zone's dynamics. This knowledge helps predict and mitigate negative effects, such as soil degradation and water quality issues.
Researchers at UC Riverside found that when teens view their parents' parenting tactics more negatively, they show elevated levels of aggressive behaviors. The study highlights the importance of adolescents' evaluation of their parents' responses to challenging behaviors.
A new 17-gene signature derived from leukemia stem cells can predict AML patients' response to standard treatment, enabling clinicians to tailor treatment and improve patient care. The LSC17 score has been shown to accurately identify high-risk patients who are less likely to be cured by standard therapy.
A study by Michel Laroche and Marcelo Nepomuceno found that people with certain world views react differently to thoughts of death. Compulsive shoppers are more likely to buy when thinking about mortality, while anti-consumers resist consumption more strongly.
Scientists at Swiss Federal Laboratories for Materials Science and Technology (EMPA) are working on a novel treatment approach for blood poisoning. They aim to remove bacteria from the blood using magnetic purification, which could potentially replace antibiotics in some cases.
Researchers have developed a diabetes drug that slows experimental Parkinson's disease progression by regulating mitochondrial function and reducing inflammation. Human trials are set to begin next year, offering hope for the first treatment to target the underlying disease.
The UA Steele Children's Research Center is studying autoimmune disease triggers with a $1.73 million NIH grant, focusing on dendritic cells and immune tolerance. The research aims to identify new targets for therapeutic approaches to restore tolerance in patients with autoimmunity.
Researchers have developed a virtual reality system that generates real-time 3D images from CT data for enhanced visualization. This allows surgeons to interact with detailed models of bones, tissues, and blood vessels, streamlining the surgical planning process.
A study by NC State University researchers found that adult-born olfactory neurons play a crucial role in processing novel food odors, but not aversive odors. The researchers used chemogenetic methods to selectively silence these neurons and observed the impact on behavior.
A UBC study found that new moms transitioning to expressed breast milk typically stop breastfeeding earlier than peers, raising concerns about infant health. The research suggests inadequate lactation support may contribute to this trend.
A recent study from the University of Eastern Finland found that hip fracture risk is higher among those with Alzheimer's disease. Regular assessments of medications and targeted interventions such as exercise, home safety assessment and modification, and medication reviews are proposed as feasible approaches to reduce this risk.
Research from NASA's Cassini mission data implies Saturn's moons may have formed from the planet's rings rather than being captured by it, with some moons migrating away at an unexpected rate
The researchers used spectroscopy to visualize the arginine finger bonded to the GTP molecule at high precision, revealing how its snap affects geometry and charge distribution. This discovery has implications for understanding switch processes in the body and developing treatments for cancer and genetic diseases.
Researchers found that administering amlodipine alongside chelation therapy effectively reduces cardiac iron in patients with thalassemia major, potentially combating heart failure and fatal arrhythmias. The treatment is considered safe and inexpensive, with no significant side effects.
A study analyzing marine sediment cores reveals East Greenland's ice sheet underwent deep glacial erosion over the past 7.5 million years, responding to global climate change. This finding challenges previous theories on complete and extended deglaciation, suggesting a more complex history of ice sheet dynamics.
Two studies published in Nature offer new perspectives on the past behavior of Greenland's ice sheet, with one suggesting continuous presence for seven million years while another proposes it was nearly ice-free for at least 280,000 years. The findings highlight the complexity and dynamic nature of the ice sheet.
A team led by Stéphane Dorbolo found that a disk of ice becomes highly mobile due to a levitating layer of water between it and the smooth surface on which it rests and melts. By controlling the flow dynamics of the melted ice, they can direct its motion.
Scientists have gained fresh insight into dark matter, a key component of the universe. Using powerful telescopes to analyze distant galaxies, they found that dark matter is less dense and more evenly spread throughout space.
A new study detected traces of THC, a primary psychoactive chemical in marijuana, in the urine of children exposed to secondary marijuana smoke. Higher concentrations were found in non-white children compared to white children. Researchers call for further investigation into secondhand marijuana smoke exposure as a potential health risk.
Researchers at Penn State are using a computer program to analyze water quality data from Pennsylvania's streams, rivers, and private wells to detect potential environmental impacts of Marcellus Shale gas drilling. The study found that methane concentrations tend to be higher around fault lines.