Researchers identified ezetimibe and evolocumab as effective alternatives for patients with muscle-related statin intolerance, demonstrating significant reductions in LDL-C levels. The study suggests that both drugs can be administered successfully in such patients, although with varying efficacy.
Researchers found that SSRI antidepressants cause decreased bone density in mothers during lactation, leading to higher risks of fractures. Folic acid supplementation may mitigate this effect, suggesting women may need more folic acid while breast-feeding.
A safe, minimally invasive treatment called bariatric arterial embolization (BAE) has been shown to lead to sustained weight loss in severely obese people. BAE targets the stomach's hunger hormone production, reducing appetite and resulting in significant weight loss.
Intermediate-risk patients who received TAVR with SAPIEN 3 had improved outcomes compared to surgical aortic valve replacement after one year. The trial showed reduced rates of death, stroke, and moderate or severe aortic insufficiency in TAVR patients.
The DANAMI-3-DEFER trial found that delayed stent implantation in STEMI patients did not reduce death from any cause, hospitalization for heart failure, or subsequent heart attacks. The study's findings contradict previous promising preliminary studies and may be due to the trial's limited sample size and patient selection.
A new study found that abaloparatide-SC increased bone mineral density in the spine and hip, reducing the risk of vertebral and nonvertebral fractures. The treatment also showed promise in a broad range of postmenopausal women with osteoporosis, regardless of baseline patient characteristics.
Researchers found that intravenous beta blockers before angioplasty in STEMI patients did not reduce heart attack severity or improve blood flow, according to the EARLY-BAMI trial. The study showed a slight decrease in ventricular arrhythmias but no significant differences in other endpoints.
A new study suggests that taking antibiotics in early childhood may disrupt the gut's microbial ecosystem and increase the risk of developing prediabetes in adolescence. The researchers found that a depletion of beneficial bacteria, such as Ruminococcus species, was associated with higher rates of antibiotic use.
A study found that familial hypercholesterolemia mutations account for less than 2% of cases with severely elevated LDL levels, but significantly increase the risk of coronary artery disease. Gene sequencing identified individuals at high risk who may benefit from additional preventive therapies.
Renan Uflacker received the Society of Interventional Radiology Foundation's Leaders in Innovation Award for his pioneering work in interventional radiology. The award recognized his contributions to transforming the field through innovative treatments for liver disease, peripheral vascular disease and aneurysms.
A new study by the Cleveland Clinic has identified statin intolerance objectively, showing that evolocumab is a more effective option for lowering cholesterol in patients who are intolerant to multiple statins. The PCSK9 inhibitor reduced cholesterol levels by 52.8%, while ezetimibe had a smaller reduction of 16.7%.
In a clinical trial of 100 obese men, researchers found that adding testosterone treatment to calorie restriction resulted in increased fat loss and preserved muscle mass. The study suggests that testosterone treatment may be a useful adjunct to weight loss in obese men with low testosterone levels.
A phase 3 clinical trial showed evacetrapib reduced LDL cholesterol by 37% and HDL cholesterol by 130%, but failed to lower rates of major cardiovascular events. Researchers attribute the lack of benefits to the drug's inability to translate improved cholesterol levels into clinical outcomes.
Researchers from the University of Pennsylvania found that heart transplants can be performed in adult patients with prior corrective surgery for congenital heart disease with excellent outcomes. The study, which included 17 consecutive patients, showed a 100% survival rate at both 30 days and one year.
Women who underwent uterine fibroid embolization reported improved sexual function, including pain, desire, arousal, and satisfaction. About nine in 10 women also experienced a better overall quality of life, with average scores increasing from 45 to 71 one year after treatment.
Patients who received a physician discussion using Chest Pain Choice increased their knowledge about their risk and options, answering 53% of questions correctly. The study also found that patients who used the tool were more likely to recommend discussing their care with their physicians, 68.9% compared to 61.2%.
A higher volume of TAVR procedures is associated with improved patient outcomes, including lower death rates and vascular complications. The study, which analyzed data from nearly 50,000 patients, found that even hospitals performing fewer than 100 cases showed significant improvements in patient outcomes with higher procedure volumes.
A new study found that AMH levels are related to high testosterone secretion and abdominal adiposity, making it a possible surrogate for ovarian antral follicle number. Additionally, AMH levels were correlated with age and body mass index, indicating its potential as a biomarker for PCOS diagnosis in obese adolescent girls.
New research from South Korea suggests that higher dietary calcium intake may lower the risk of cardiovascular disease in older people, but not stroke and fracture risk. In a population with low calcium intake, higher dietary calcium was significantly associated with decreased risk of CVD.
Researchers have discovered a new potential therapy that can protect transplanted human pancreatic islets from dying. The study suggests that pretreating cells with a peptide hormone called cholecystokinin (CCK) may enhance the curative potential of islet transplant for Type 1 diabetes.
A new study found that combining a temporary intestinal bypass device with the drug liraglutide improves diabetes control and weight loss in patients. The combination treatment resulted in significant weight loss (12.8 kg) and improved glycated hemoglobin levels compared to other treatments.
Researchers at Northwestern University developed an ovary bioprosthesis implant using a 3D printer, allowing mice to bear live young after ovary removal. The technology aims to restore fertility and hormone function in women affected by cancer treatments or born with reduced ovarian function.
Researchers investigate how changes in light exposure may contribute to breast cancer development. Extended periods of nighttime illumination disrupted normal cellular behaviors and gene expression, particularly in hormone-dependent tissues like the breast.
A study of nearly 4,000 children found that infants with high BMI as young as 4-6 months are at risk of early-childhood obesity. Infants with BMI above the 85th percentile by 6, 12, or 18 months are strong predictors of severe obesity by age 6.
A study from Intermountain Medical Center Heart Institute found that low levels of both total vitamin D and bioavailable vitamin D are associated with poor cardiovascular outcomes, including heart attacks. The research evaluated 4,200 participants and discovered that measuring these two components is crucial in predicting major adverse...
Whey protein diet participants lost the most weight and experienced reduced hunger and glucose spikes compared to other diets. The study found that a high-protein breakfast containing whey protein induced greater satiety and reduction of glucose spikes after meals.
Researchers found that brominated fire retardants stimulate an adrenal gland hormone, leading to potential development of cardiovascular disease. The study's results suggest a link between these chemicals and high blood pressure, cardiac hypertrophy, and congestive heart failure.
A new study suggests that liraglutide, a diabetes drug, reduces the brain's reward response to high-fat foods, making them less desirable. This effect may be beneficial for individuals with Type 2 diabetes who tend to overindulge in fatty foods as a coping mechanism.
A study published in the Endocrine Society reveals that anabolic steroid abuse is associated with severe blood pressure increase and hypertension. The research found that daytime and nighttime blood pressures were higher among ongoing AAS abusers compared to former abusers and non-users.
A study of 41 male veterans found that blast concussions frequently result in hormone changes, causing problems like fatigue, depression, and poor quality of life. Researchers detected hypopituitarism in 44% of affected veterans, with those experiencing hormonal abnormalities showing poorer sleep quality and increased depressive symptoms.
A new study found that estrogen replacement therapy improves verbal memory and cognitive flexibility in young female athletes with amenorrhea. The study showed significant improvements in both immediate recall of words and ability to switch between tasks, even when controlling for age and pre-treatment test scores.
A new study from Brazil found that skin tanning protects against harmful UV irradiation but limits the skin's ability to produce vitamin D. The study, which evaluated 986 participants, showed that 72% had vitamin D deficiency and most people exposed to high levels of sunlight were deficient.
A global trial showed statins alone reduced adverse cardiovascular events in people with average cholesterol and blood pressure, while blood pressure-lowering medications were only beneficial in those with hypertension. The study suggests statins can be used more widely to prevent heart disease.
Research from Australia suggests that women with PCOS report a higher prevalence of asthma, which is also linked to excess weight. The study found that PCOS status and body mass index were independently associated with asthma.
A new study found that those who lose more weight are most likely to keep it off, but also experience weight cycling. Patients who lost high percentages of their initial body mass index (BMI) were more likely to maintain their weight loss over time.
Researchers from San Diego State University have developed a portable balance board called BTrackS that provides fast, objective feedback on an athlete's balance disruption following a suspected concussion. The technology has been found to be about twice as effective as the most widely used balance test for concussion nationwide.
Steroid medications like prednisolone suppress brown fat's activity, leading to weight gain and obesity. Researchers found that steroid use increases energy storage from food instead of burning it through brown fat.
A study found that oxytocin nasal spray decreases impulsive behavior in overweight men, allowing for better self-control and reduced food intake. The treatment showed promising results with minimal side effects, suggesting a potential new approach to treating obesity.
A recent study published by The Endocrine Society found that radioactive iodine treatment can impair a woman's remaining egg supply, known as ovarian reserve. Women who received high doses of radiation had significantly lower levels of anti-Müllerian hormone (AMH) after treatment.
The American Society for Biochemistry and Molecular Biology honored prominent researchers with various awards, including the Herbert Tabor Research Award, FASEB Excellence in Science Award, and ASBMB Plenary Lectures. These recognition include notable scientists such as Robert G. Roeder, Bonnie L. Bassler, Peter Walter, Charles Brenner...
A Paleolithic-type diet improved insulin sensitivity, reduced abdominal adiposity and body weight in obese postmenopausal women. The diet high in polyunsaturated fatty acids may have long-term beneficial effects on obesity-related disorders.
A recent study published in the New England Journal of Medicine found that taking statins and antihypertensives can reduce cardiovascular disease events by 25-30% in patients at intermediate risk. The research also suggests that combining these medications can be an effective way to prevent heart attacks and strokes globally.
A non-inferiority trial found TAVR to be at least as safe and effective as surgery in intermediate-risk patients with severe aortic stenosis. The study showed similar rates of death and disabling strokes after two years, but TAVR patients had shorter hospital stays and lower major complications.
The study found that women have a significantly higher prevalence of peripheral artery disease, while men have a higher prevalence of carotid artery stenosis and abdominal aortic aneurysms. Diabetes is also identified as a major risk factor for developing PVD, even in patients without heart disease.
A recent study found that patients with severe, symptomatic aortic stenosis who underwent transcatheter aortic valve replacement (TAVR) with the SAPIEN XT device had similar two-year clinical outcomes to those who underwent surgical aortic valve replacement. Additionally, TAVR was associated with reduced severe bleeding, length of stay...
A new study found that effectively treating depression can reduce a patient's chance of having a stroke, heart failure, a heart attack, or death. Effective treatment for depression reduces a patient's heart risks to the same level as those who never had short-term depression.
Researchers found that a new low-dose vaginal estrogen capsule significantly improved symptoms of menopausal vulvar and vaginal atrophy in postmenopausal women. The treatment, TX-004HR, showed improvement in vaginal cell regeneration, pH levels, and painful sexual activity.
A recent study of nearly 3,000 patients found that elevated levels of glycoprotein acetylation (GlycA) offset the benefits of high-density lipoprotein (HDL) cholesterol in preventing heart disease. Inflammation of artery walls is a contributing factor to heart attacks and strokes.
A new study from Intermountain Medical Center and Johns Hopkins Hospital found that abdominal obesity, or having an apple-shaped body, is a strong predictor of serious heart disease in diabetic patients. Waist circumference was also shown to be a stronger predictor of left ventricular dysfunction than total body weight or BMI.
A study of nearly 8,500 people found that low thyroid function increases the risk of developing Type 2 diabetes by 13%, with a higher risk for those already with prediabetes. Screening for thyroid function may be beneficial in individuals at risk of developing diabetes.
Researchers have demonstrated the creation of a chemically active 3D-printed structure that can mitigate pollution. By adding nanoparticles to a polymer, they created a matrix that breaks down organic pollutants when exposed to natural light.
A new study found that BPA directly affects the mammary gland of mouse embryos, potentially raising breast cancer risk. The research, presented at the Endocrine Society's annual meeting, suggests that exposure to endocrine disruptors like BPA in utero may be a key factor in increased breast cancer incidence.
Elderly adults who live in homes with cooler temperatures during the winter season tend to have smaller waistlines compared to those living in warmer environments. Researchers found that safe cold exposure can be an effective preventive measure against obesity.
A new hybrid molecule has been developed by NYU Tandon researchers that can carry and deliver anti-cancer drugs to malignant cells. The protein-gold nanoparticle composite enhances small-molecule loading, sustained release, and increased uptake in breast cancer cells.
A study from the University at Buffalo found that women who prefer more intelligent partners tend to distance themselves from STEM fields, performing poorly on math tests and showing lower identification with math. This effect is specific to perceived masculine fields of math and science.
Research suggests that haemodynamic forces play a critical role in shaping endothelial cells during angiogenesis, leading to the expansion and maintenance of vascular lumens. The study's findings challenge previous ideas about blood flow's impact on vascular development.
A Kyoto University research team found that males can 'cost' less when there are more females, increasing the competitiveness of sexual reproduction. This discovery may have implications for studies on the evolution and sustainability of sex in nature.
Researchers at MIPT and Prokhorov General Physics Institute divide magnetic vortices into two types, one with isotropic resistance and another with anisotropic behavior. This discovery could lead to the development of faster and more compact processors and non-volatile memory.
A study found that people living in activity-friendly neighborhoods take up to 90 minutes more exercise per week. The research team mapped neighborhood features and physical activity was measured using accelerometers.
Researchers at the University of Pennsylvania have discovered that the occipital place area (OPA) plays a key role in perceiving boundaries during navigation. By using transcranial magnetic stimulation to disrupt normal processing, the team found that participants made more errors navigating around boundaries but not landmarks.