A new study published in Gastrointestinal Endoscopy found that capsule endoscopy can effectively rule out active upper GI bleeding or high-risk lesions in patients presenting with symptoms of possible UGIB. This reduces unnecessary hospital admissions and improves patient outcomes.
The RAPID institute aims to improve efficiency and productivity in industries like oil and gas, pulp and paper, and chemicals. Researchers from PNNL and OSU will develop breakthrough technologies to save over $9 billion annually.
Researchers at UCR developed therapeutic monoclonal antibodies that selectively block the action of faulty matrix metalloproteinases (MMPs), targeting cancer cell spread. Inspired by camelid antibodies, these human antibodies have convex binding sites ideal for interactions with concave MMP sites.
Researchers at Kyushu University have developed a new simulation method to predict the behavior of oil, carbon dioxide, and water in underground reservoirs. The approach can help identify optimal sites for carbon sequestration, which could significantly increase energy supply and combat climate change.
The USDA is providing up to $5 million in funding for research on cyber-physical systems to improve efficiency and sustainability in the agricultural industry. This initiative aims to develop data-driven analytical tools throughout the food supply chain to promote smarter decision-making and reduce waste and increase safety.
Researchers have created a tiny radio receiver using atomic-scale defects in pink diamonds, enabling it to operate in harsh environments and human bodies. The device uses nitrogen-vacancy centers, which can emit single photons or detect weak magnetic fields.
DBA's molecular mechanisms involve ribosomal protein deficiency, leading to p53 pathway activation and microRNA34A-mediated decreased red blood cell formation. Exogenous nucleosides may alleviate symptoms by reducing DNA damage response and increasing energy metabolism.
Researchers at Johns Hopkins University have developed a new bioinformatics tool to evaluate the accuracy of current methods for identifying cancer-promoting mutations. The study found that existing methods need improvement and shared their methodology publicly to aid others in developing more precise ways to target tumor growth.
A new 'deep rendering mixture model' enables computers to learn about the visual world largely on their own, using a semisupervised learning method. The algorithm achieved higher accuracy than previous methods in distinguishing handwritten digits, even with limited training examples.
Researchers have identified a new way of blocking cancer cell invasion using calcium channel blockers, which can stop breast and pancreatic cancer from spreading. The team discovered that these drugs target the sticky finger-like structures on cancer cells, rendering them inactive.
A recent study published in Psychotherapy and Psychosomatics shows that cognitive therapy on its own has a much better effect over the long term than just drugs or a combination of the two. Nearly 85% of patients improved or became healthy using only cognitive therapy.
Researchers at Rice University have discovered a simple way to recycle waste carbon dioxide into valuable fuel using nitrogen-doped graphene quantum dots. The dots proved nearly as efficient as copper in converting CO2 into small batches of ethylene and ethanol, with the ability to keep their catalytic activity for a long time.
Researchers characterized dendritic cells across different human organs, revealing constant surface profiles and tissue-specific signals. The study sheds light on the development of new immune therapies and cancer treatments.
Bacteria play a crucial role in determining the health of birds at the top of the food web. Seabirds feeding in areas rich in sulfate-reducing bacteria have high levels of mercury. This study suggests that bacteria provide a buffer to variation in mercury within the environment.
Researchers from GFZ GeoForschungsZentrum Potsdam developed a new method called 'erosion painting' to visualize erosion rates. By applying paint patterns on rock surfaces and monitoring their removal over time, scientists can analyze the spatial distribution and intensity of erosive processes.
Researchers found that nerve growth factor and tuft cells stimulate gastric tumor growth through aberrant cholinergic signaling, providing a potential therapeutic target for stomach cancer. Blocking nerve growth factor receptor inhibited stomach cancer growth in mice.
For the first time, a biodegradable polymer coating has been synthesized using chemical vapor deposition, addressing a long-standing gap in degradable implant coatings. The coating's degradation rate can be controlled by adjusting the ratio of monomer types and side groups.
A study of 450 patients found 72 with 75 unique gene mutations, affecting 16 percent of younger-onset CRC cases, suggesting genetic counseling and multigene panel testing for early-onset patients
Researchers found that KRAS mutant cancer cells form more stress granules in response to chemotherapy, making them harder to kill. A new compound target, 15-d-PGJ2, may help improve treatment outcomes by blocking this coping mechanism.
Researchers used partial cellular reprogramming to reduce signs of aging and extend lifespan in mice with premature aging mutations. The approach altered epigenetic changes, suggesting that aging is a plastic process.
The USDA has awarded $3.4 million to seven research projects aimed at developing new wheat varieties with improved yield and adaptability to different regions. These grants will support international collaboration on wheat research and help meet growing demand for wheat worldwide.
Researchers at Saint Louis University found that silencing a protein in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in animal models. This breakthrough could lead to new treatments for insulin-resistant obese or overweight patients.
A new method has been developed to identify suitable protein structures directly from patients' tumor cells using mass spectrometry. This approach allows for the identification of mutated peptides presented on the surface of cancer cells with high accuracy and speed.
Researchers have identified nearly two-dozen solid electrolytes that could replace volatile liquids in smartphones and laptops. The AI-powered approach allows for rapid screening of materials, identifying the most promising candidates for further study.
A University of Alberta study found that proton pump inhibitors (PPIs) decrease capecitabine's effectiveness in gastric cancer treatment, reducing progression-free survival by over a month and overall survival by two months. PPIs can also affect colorectal cancer treatment efficacy.
Researchers have combined CRISPR gene editing with single-cell genomic profiling to understand nuanced cellular processes. The new technology enables precise manipulation of genes in individual cells, revealing previously unknown functions and advancing the field of genetic engineering.
A new study from Lund University found that women with a high expression of the ER-beta estrogen receptor in their tumours had better outcomes after undergoing chemotherapy. The research could lead to more frequent check-ups and additional treatment for high-risk patients.
A new study published in Diabetes Care shows that IUDs and subdermal implants are the safest hormonal contraceptives for women with diabetes, with low rates of thromboembolic events. The findings expand pregnancy planning options for this population, encouraging physicians to offer these effective and safe birth control methods.
The EurekAlert! Fellowships support early-career science reporters from emerging economies to attend the AAAS Annual Meeting and network with peers. The 2017 fellows demonstrated outstanding performance in science news reporting, showcasing their solid grasp of timely issues and everyday relevance.
A study by researchers found that people in low relationship power situations vent their frustrations through buying opposite-brand products, such as switching from Diet Coke to Pepsi. This behavior is more effective than doing nothing or expressing frustration openly.
The University of Nevada, Reno's Global Water Center is launching a new 5-year initiative to preserve the Mekong River's biodiversity and ecosystem. The project aims to study the river's climate, hydrology, and biodiversity, build partnerships for sustainable development, and educate communities about the importance of a healthy Mekong.
Researchers at Nagoya University have synthesized stable antiaromatic nickel norcorroles and investigated their interactions, revealing face-to-face interactions that form a triple-decker structure with aromatic characteristics. The resulting materials exhibit nonlinear optical properties and potential applications in optoelectronics.
A new biochemical study from Johns Hopkins researchers found that a common genetic variant associated with type 2 diabetes risk makes a protein that is more efficient than its less risky counterpart. The 'hyperactive' zinc transporter protein may be slowed down to lower diabetes risk, according to the findings.
A new biomarker enzyme ALDH1A3 has been identified in mesenchymal glioma stem-like cells, which are responsible for the tumorigenicity of glioblastoma multiforme tumors. The researchers have developed a small molecule inhibitor GA11 that targets this enzyme and has shown potent efficacy in preclinical testing.
Researchers at Beth Israel Deaconess Medical Center discovered that a subset of neurons anticipates the effects of drinking by preparing the body for an influx of water seconds before consumption. This 'top-down' control helps regulate intake and prevent negative consequences.
Researchers have created a new seafloor map that provides detailed information about the 2015 eruption at Axial Seamount. The map reveals 14 separate lava flows containing nearly 156 million cubic meters of lava, as well as precise locations of eruptive fissures.
Research by Dr Pallavi Amitava Banerjee found that STEM enrichment schemes had no direct impact on math GCSE results. Despite this, the activities aimed to improve student understanding of science and maths, as well as break stereotypes about STEM subjects being only for 'the brainy'.
Researchers have discovered a star that ingested some of its planets, revealing a violent history for the planetary system. The star's composition suggests it devoured four planets, preserving lithium and other elements in its atmosphere.
Researchers used supercomputer simulations to confirm the link between human-induced climate change and deadly heat waves in India and Pakistan. The study found a substantial increase in the likelihood of such heat waves, with chances expected to rise as global warming continues.
Researchers developed a new framework for faster control of a quantum bit, accelerating switching with unprecedented speed. The technique enables less prone to errors in high-speed operation, paving the way for quantum applications like secure communications and simulation of complex systems.
A special issue of Cancer Epidemiology highlights the importance of cancer registration in resource-constrained settings, demonstrating cost savings through economies of scale. The study reviews cancer registries in Kenya, Uganda, Colombia, India, and Barbados, offering lessons for other countries with similar constraints.
Researchers urge environmental movement to proactively seize opportunities under a Trump presidency, citing China and other countries' plans to implement the Paris climate treaty regardless of US involvement. The next four years will be challenging, but proactive action can strengthen the movement beyond the Trump presidency.
Researchers propose a new type of traveling wave pattern that can adapt to varying system sizes, shedding light on bacterial cell division processes. The 'stretchable map' theory offers insights into protein self-organization and surface mapping on growing cells.
WPI researchers develop a liquid biopsy chip that can trap and identify metastatic cancer cells in small amounts of blood. The device uses antibodies attached to carbon nanotubes, which create an electrical signature that can be detected to identify captured cells.
Researchers found that Neptune-mass worlds are likely the most common type of planet to form in icy outer realms. The study provides insight into the types of planets waiting to be found far from a host star, where scientists suspect planets form most efficiently.
Researchers at Stanford University School of Medicine used optogenetics to show that inducing synchronized activity in a specific nerve tract within the thalamus is sufficient to cause seizures, while disrupting it can terminate them. This finding may lead to improved ways of reducing or preventing absence seizures in susceptible child...
A recent study published in the New England Journal of Medicine found that Zika-linked abnormalities in human fetuses are more common and severe than initially thought. Out of 125 pregnancies among Zika-infected women, 46% resulted in birth defects or fetal death, with microcephaly being only one of several complications.
E-cigarette vapour exposure has been shown to be genotoxic and cytotoxic in human lung cells at high doses. In contrast, Vype e-cigarette vapour produced no DNA damage even at 28 times the equivalent smoke dose. The findings suggest that e-cigarettes are safer than smoking cigarettes.
Researchers at the University of Rochester Medical Center have identified a potential new treatment approach for lysosomal storage disorders, which cause disruptions in cellular functioning. The study found that repurposed drugs can overcome toxic build-up in affected cells, improving survival rates and quality of life.
A UK soft drinks industry levy is estimated to have significant health benefits, especially among children. The study finds that reducing sugar content and increasing prices of high-sugar drinks will have the greatest impact on health.
A Massachusetts General Hospital team has identified a key genetic pathway underlying metformin's ability to prevent and suppress cancer growth. By targeting the nuclear pore complex and enzyme ACAD10, metformin slows cell growth and extends lifespan in both human cells and the C.elegans roundworm.
Researchers at the University of Helsinki have successfully corrected Parkinson's disease motor symptoms in mice using a PREP blocker treatment. The treatment, which blocks the formation of alpha-synuclein aggregates, restored motor skills and cleared brain accumulations within two weeks.
Scientists analyzed hundreds of viral genome sequences to identify evolutionary patterns in rabies viruses that jump between host species. The study found unique trends in bat-related and dog-related rabies strains, suggesting different evolution rates and host jumping mechanisms.
Research by Dr. Josef Penninger found that RANKL inhibition can delay and prevent breast cancer development in mice with mutated BRCA1. The loss of RANK also impaired tumor progression, raising the possibility of a novel targeted approach for breast cancer prevention.
The new database provides a comprehensive overview of the world's lakes, with estimates of over 180,000 cubic kilometres of water stored in more than 1.4 million lakes. The study also reveals that lakes in hilly or mountainous regions tend to be deeper than those in flat landscapes.
Researchers used microseeding technique to overcome hemihedral twinning in protein crystals. The method successfully produced untwinned crystals of LigM, leading to improved crystal structure determination.
Researchers have discovered a potential new approach to combat malaria by disrupting mosquito hormone signaling, reducing transmission and lifespan, and blocking parasite development. The findings suggest that applying DBH to bed nets or spraying it indoors could be an effective alternative to insecticides.
Researchers at FAU are developing a new hybrid device to combine magnetic resonance imaging and angiography for faster stroke diagnosis and treatment. This innovative approach aims to reduce the time needed for patient transfers and save valuable time when treating stroke patients.
Research at Kobe University found that horses send signals to humans both visually and physically when faced with unsolvable problems, adapting their behavior based on humans' knowledge. This high social cognitive ability may have been acquired during domestication, enabling horses to form close bonds with humans.
This review article discusses the neural control mechanisms behind fly larval locomotion, a complex motor behavior shared by both vertebrate and invertebrate species. Key findings from Drosophila models reveal the crucial role of genes in regulating locomotor rhythm and pattern generation.