Researchers at CU Anschutz Medical Campus found a correlation between hospital handoffs and increased mortality rates. The study analyzed data from 2008 to 2014 and found an absolute increase of 1.5-1.9% in hospital mortality rates among patients exposed to end-of-rotation transitions in care.
A new study by Johns Hopkins researchers reveals a strong link between angiotensin receptor autoantibodies and increased risk of frailty in older adults. The study suggests that common blood pressure drugs targeting the autoantibodies, called ARBs, may help protect against functional decline in some people.
A study published in JAMA found that end-of-rotation transitions in care were associated with increased mortality among hospitalized patients, particularly those with longer stays and complex conditions. The research included data from 10 university-affiliated US Veterans Health Administration hospitals.
The FDA's triclosan ban is a starting point for addressing antibiotic resistance and environmental concerns. Researchers emphasize the need for new chemicals that demonstrate both efficacy and safety in replacing banned substances.
Research found that 2.7% of US medical school students have disabilities, including ADHD, learning disabilities, and psychological disabilities, requiring accommodations.
Researchers at UC Berkeley discovered a bacterium, Vibrio fischeri, releases an enzyme that induces choanoflagellates into full mating frenzy. This finding suggests bacteria may influence animal mating.
A new study finds that work-life laws in Nevada's brothels benefit brothel and community interests, rather than protecting workers. The lockdown policy restricts prostitutes' movements, keeping them hidden from the public eye.
A new study found that optimizing hospital nutrition care can significantly reduce 30-day readmission rates and length of stay for malnourished patients. Implementing a validated nutrition screening tool and providing early treatment and education can lead to substantial improvements in patient outcomes.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers developed a microfluidic device that overcomes previous models of the blood-brain barrier, allowing for study of brain inflammation and its link to neurodegenerative conditions. The device was successfully tested with flying colors, paving the way for use in testing new drugs and compounds.
Researchers at Cornell University discovered a biological mechanism that converts nitrogen-based fertilizer into nitrous oxide, increasing atmospheric levels by 120%. The enzyme cytochrome P460 produced in ammonia-oxidizing bacteria leads to nitrous oxide production as a chemical coping strategy.
A study found that cannabis users in Australia recommended package warnings that focused on driving ability, mental health, and addiction risk, mirroring some expert warnings. However, users also suggested unconventional warnings not typically recommended by experts, highlighting the need for caution in packaging cannabis products.
Researchers at Emory Health Sciences have made a breakthrough in understanding how diabetes drugs interact with LRH-1, a protein that regulates metabolism of fat and sugar. The study found that small changes to compounds can significantly impact their binding pocket interaction.
The study found no difference in progression-free survival among patients receiving standard care, additional chemotherapy, or a second round of autoHCT. Researchers suggest that adding new therapies to the standard treatment may not provide significant benefits for patients with multiple myeloma.
The Consortium for Medical Education in the Delta (C-MED) will provide clinical education for third- and fourth-year medical students from NYITCOM at A-State. The program aims to address the shortage of primary care physicians in rural communities, with plans to train at least 30 residents annually.
Researchers from Lomonosov Moscow State University have isolated a unique strain of lactic acid bacteria, Lactococcus lactis subsp. lactis 194, from Buryat milk that possesses a wide range of antimicrobial action against Gram-positive and Gram-negative bacteria. The strain also shows antifungal properties, making it a promising candida...
Researchers found that specific cells in the medial septum fire at higher rates when a mouse moves faster, influencing activity in the brain's navigation center. This 'speedometer cell' data bus relays speed information to the entorhinal cortex, essential for spatial orientation.
Researchers at the Institute for Basic Science discovered that amino acid L-methionine activates calcium channels in plant guard cells, regulating stomatal opening and closing. This process is crucial for maintaining adequate intracellular calcium levels in plants, essential for growth and breathing.
The GeroScope algorithm identified 10 substances with potential geroprotector properties, including PD-98059 and NAC. The study suggests that computer modeling can significantly reduce the time and cost of developing new drugs.
A new material developed by Yuebing Zheng could lead to the creation of erasable and rewriteable optical chips. The material, which combines light-sensitive molecules with a plasmonic surface, allows for wireless erasure and rewriting of optical components.
Long-term datasets show mosquito populations increased ten-fold in NY, NJ, and California over the past five decades. Urbanization and residual DDT concentrations drove these changes, contrary to initial expectations linked to climate change.
A systematic review and meta-analysis found that nearly 27% of medical students experience depression or depressive symptoms, with only 16% seeking treatment. The study suggests stress and anxiety from medical school may contribute to these mental health issues.
Researchers discovered a subset of lung tumors sensitive to MEK inhibitors, offering new hope for up to 10% of lung cancer patients with ATM mutant gene. The study's findings could pave the way for precision medicine and targeted treatment strategies.
Researchers have developed a new method to interpret the West Antarctic Ice Sheet Divide core, extracting data on sea surface temperatures and tracking climate change. The technique reveals signs of an entropy increase around 10,000 years ago, suggesting human impacts on climate began before the Industrial Revolution.
Research found that US school shootings were lower in states with mandatory background checks on gun purchases and higher spending on mental health services and public education. The study analyzed media coverage of school shootings between 2013-2015, finding a link between state-level factors and the frequency of these incidents.
A small molecule could provide a new therapeutic approach to fighting excessive weight gain in cases where diets or exercise have no effect. The research team found that blocking a specific protein promotes gene expression of the protein that burns calories and prevents fat gain.
NASA analyzed Hawaii's heavy snowfall using GPM satellite data, finding precipitation rates exceeding 9.3 inches per hour in intense storms. The average freezing level was determined to be around 14,127 feet, with slopes reaching as low as 12,795 feet.
A MU study found that Hispanic adults with diabetes experienced significant improvements in blood sugar levels through peer support interventions. The meta-analysis of 17 randomized control trials suggests that these interventions can be an effective way to improve glycemic control and health education for minority patients.
Researchers at the University of Illinois have discovered hot atomic hydrogen atoms in the thermosphere, a layer of the atmosphere above 250 kilometers. This finding contradicts previous assumptions and has significant implications for understanding atmospheric escape and the behavior of satellites in low Earth orbit.
A recent study identifies inherited genetic mutations in the IKZF1 gene as a major risk factor for pediatric ALL. The variants affect protein Ikaros, crucial for white blood cell development, and reduce cancer cells' sensitivity to chemotherapy drug dasatinib.
A Stanford patient has become the first infant to receive an experimental drug that shows significant improvement in motor milestones and function. The drug, nusinersen, is being rapidly progressed through regulatory approval, with FDA approval expected within two months.
Research shows that ibrutinib can benefit patients with GVHD who don't respond to corticosteroid treatment, with 71% experiencing sustained improvements. Ibrutinib targets specific immune cells involved in GVHD, offering a new therapeutic option for those with limited treatment options.
Researchers at Technical University of Munich are collecting infrastructure data via an open source platform using crowdsourcing. The OpenGridMap app allows volunteers to map wind turbines, solar power plants, transformer sub-stations and power lines, generating a denser network of verified grids.
Dr. Martin M. Katz has been recognized with the ACNP Paul Hoch Distinguished Service Award for his over 50 years of dedication to the organization and its mission. He made significant contributions to the theoretical understanding of antidepressant mechanisms, serving on key committees and editing notable publications.
A combination of brentuximab vedotin and nivolumab has been found to be safe and effective in treating recurrent Hodgkin lymphoma, with 64% of patients experiencing significant tumor reduction. The therapy has manageable side effects and shows promise as an alternative curative regimen for relapsed disease.
A Phase IB/II study found that combining nivolumab with azacitidine improved response rates (34%) and overall survival (9.3 months) in patients with acute myeloid leukemia, compared to a historic response rate of 12-15% with azacitidine alone.
Research highlights how humans impact the evolution of other species, leading to rapid changes in a few years to decades. Examples include commercial fishing, invasive species, and urbanization, which drive evolutionary adaptations.
Researchers uncover regional diversity in plant species exploited during Pre-Pottery Neolithic A, challenging previous assumptions about the importance of cereals. The study suggests that legumes played a crucial role in eastern Fertile Crescent regions and contributed to chronological dissimilarities in cereal domestication.
David H. Yang, an MIT undergraduate, has been awarded the 2017 AMS-MAA-SIAM Morgan Prize for his exceptional research in algebraic geometry and geometric representation theory. Yang's work has been recognized for its excellence, with three papers published or in preparation in prominent mathematical journals.
A new optical chip enables astronomers to capture clear images of exoplanets near their host sun, overcoming the challenge of intense solar brightness. This breakthrough technology uses an interferometer to cancel out sunlight and detect fainter planet light, paving the way for discovering planets with conditions suitable for life.
A study from Dana-Farber Cancer Institute found that 30% of lymphoma patients with autologous transplants carry genetic mutations increasing their risk of developing second blood cancers and dying from other causes. The most commonly mutated gene was PPM1D, associated with an abnormal condition called CHIP.
Researchers found that users who customize their online news portal based on personal interests are less systematic in processing information. They also discovered that this 'self-as-source' perception can make users more willing to accept persuasive messages and advertisements.
Researchers discovered a possible explanation for the occurrence of large-scale DNA expansions that cause over a dozen neuromuscular and neurodegenerative disorders. These expansions are controlled by genes involved in repairing DNA breaks, leading to the formation of extra repeats.
Researchers at the University of Wisconsin-Madison have developed a novel approach to reprogram cells from one type to another using artificial transcription factors. This method enables efficient and unbiased conversion of cells, paving the way for faster research and potential therapeutic applications.
Researchers at the Weizmann Institute of Science have identified a promising new combination therapy for triple negative breast cancer, which inhibits tumor growth and survival while preventing drug resistance. The therapy targets EGFR and PYK2 molecules, leading to a more potent therapeutic effect than inhibiting either molecule alone.
A new study finds that recalling past misdeeds during conflicts can be detrimental to relationships, even if no one mentions them. Those with high attachment anxiety are especially prone to thinking about past transgressions in the present, leading to more destructive reactions and poor relationship outcomes.
Public health advocates from around the world are using various tactics to reduce tobacco company influence, including pension fund reform and smoke-free legislation. Efforts have shown positive impacts on public health, such as a 13% decrease in all-cause mortality in Ireland.
The KAT tool analyzes K-mer datasets to identify error levels, biases, and contamination in sequencing data. It also checks genome assemblies for completeness and accuracy without external reference data.
Using a one-minute shared decision-making aid can reduce unnecessary hospitalization and advanced cardiac testing for patients with low-risk chest pain. The study found that the aid resulted in greater patient knowledge, increased patient involvement in decision-making, and reduced admissions for observation.
Researchers used CRISPR gene editing to tweak genes in popular tomato varieties, allowing them to flower and produce ripe fruit weeks earlier. This rapid method enables more plantings per growing season and adapts crops to cooler climates.
Researchers discovered evidence of cereal domestication at Tell Qarassa North archaeological site, revealing advanced farming communities and varying domestication rates across regions. The study provides crucial insights into the origins of agriculture and its impact on human societies.
The W7-X stellarator in Germany has produced high-quality magnetic fields consistent with its complex design, achieving an error rate of less than one part in 100,000. This finding could be a key step toward verifying the feasibility of stellarators as models for future fusion reactors.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
A Stanford study found that the Syrian civil war caused a significant decrease in agricultural irrigation and reservoir storage in Syria, with irrigation land decreasing by 47% and reservoir storage dropping by 49%. This reduction has led to increased flow in neighboring countries like Jordan, exacerbating water scarcity issues.
A recent study by Queen's University researcher Dr. Robert Campbell found that young ophthalmologists are struggling to secure practice opportunities after total provincial surgical rates plateaued in Ontario. The study suggests a pressing need for effective career counselling and policy changes to address the issue.
Researchers have developed a catalyst that flexibly molds reaction product handedness, ensuring correct enantiomeric form. The system's self-amplifying action enhances stereoselectivity with each cycle, holding promise for biologically active compounds and new insights into biological systems.
Researchers at Tokyo Institute of Technology have developed a new method to scale down the size of silicon insulated gate bipolar transistors (IGBTs), achieving significant energy savings through reduced ON resistance. By reducing mesa width, gate length, and oxide thickness, they increased the injection enhancement effect and decrease...
A team of researchers has identified the genetic mechanisms driving the metamorphosis that transforms flounders from symmetrical larvae to asymmetrical adults. The discovery sheds new light on an evolutionary puzzle, but also has practical implications for the fishing industry, which faces significant losses in flounder aquaculture.
A Northwestern University study found that applying petroleum jelly to high-risk newborns can prevent eczema, a costly skin disorder. The cost benefit of prophylactic moisturization was $353 per quality-adjusted life year, making it an affordable option.
Researchers at the Salk Institute identified a microprotein involved in clearing out genetic material that's no longer needed, shedding light on gene regulation and mRNA recycling. The discovery highlights the importance of overlooked microproteins and their potential role in disease.