Researchers have found that chromatin remodeling proteins, essential for DNA replication and gene expression, are frequently mutated in human cancers. These mutations indicate tumor suppressive functions, making chromatin remodelers promising new targets for targeted cancer therapy.
Researchers followed 1,455 women for 15 years, finding four distinct trajectories for hot flashes and night sweats. Characteristics such as education level, alcohol consumption, and depression/anxiety levels were associated with different symptom patterns.
A follow-up study of two US Army veterans with traumatic brain injuries (TBI) finds that while progress is slow, close personal relationships and medical care can sustain them over time. The researchers attribute the men's resilience to the importance of these factors in their recovery.
The IBS team successfully detected hot electrons in a liquid interface, expanding the possibilities for catalytic reactions. This breakthrough may lead to highly efficient devices for applications such as fuel cells and artificial photosynthesis.
Researchers discovered a previously unknown interaction between metabolic pathways in two tissues, triggering a key step in maturation and regulating the transport of lipids from storage to reproductive cells. This intertissue dialogue is a remarkable strategy to precisely choreograph the transition to adulthood.
A new study found that daughters and sons of mothers who married young are more likely to want to marry in their late teens or early 20s, while those whose moms divorced tend to delay marriage. This suggests that children's marital expectations may be influenced by their parents' choices.
A Dana-Farber Cancer Institute study found that repeated doses of an immunotherapy drug, ipilimumab, restored complete remission in some patients with relapsed blood cancers after a stem-cell transplant. The treatment reduced cancer in 59% of the patients.
Researchers at the University of Oxford have made breakthrough in treating HIV by targeting its dormant cells. A novel protein called ImmTAV has been shown to effectively kill latently infected cells in laboratory conditions.
Mobile health technology has the potential to improve healthcare quality and expand access to services, but researchers warn that current measures may not be enough to safeguard patient data. The authors propose several research challenges to address issues like data sharing, authentication, and anonymity.
A Swedish study found that trigger events like exposure to violence were linked to increased risk of violent crime among patients with schizophrenia and bipolar disorder. The study also revealed a higher risk for individuals without psychiatric diagnoses who experienced similar triggers.
Researchers from George Washington University have received a $28 million grant to develop an innovative cell therapy approach to eliminate HIV reservoirs. The project, named 'BELIEVE,' aims to enhance the immune system's ability to kill HIV-infected cells.
Tropical Storm Darby strengthened rapidly, with maximum sustained winds reaching 70 mph and gusts exceeding 110 kph. NASA used satellite imagery to estimate the storm's minimum central pressure at 998 millibars.
A new UBC study found that telling stories depicting black individuals positively can reduce implicit racial bias in children aged 9-12. This intervention was more effective than previous research, which showed biased attitudes from as young as five.
A team of researchers has identified an enzyme called Aurora kinase that plays a key role in the regeneration process of single-celled organisms like Stentor. By inhibiting this enzyme, they were able to speed up the healing process without any negative side effects.
Researchers at Moffitt Cancer Center will investigate prostate cancer metastasis using a multi-disciplinary approach that integrates molecular, cellular and clinical information into mathematical models. The goal is to better understand the key factors driving disease progression and identify new therapeutic targets for prevention.
The US Army's MHRP is part of a collaborative research team awarded $4.6M per year to develop an integrated approach to finding an HIV cure. Researchers will study immune responses generated by therapeutic vaccines and broadly neutralizing antibodies.
A CCNY-led study reveals differing treatment options for women smokers, finding varenicline significantly improves quit rates compared to nicotine patch and bupropion. The research highlights the importance of considering sex differences in smoking cessation pharmacotherapy.
The University of Texas at El Paso received $1.9 million from the NSF to address PCAST report findings on uninspiring introductory courses and faculty unwelcoming atmosphere, aiming to foster positive student identities in computer science.
Researchers suggest Rembrandt used lenses and projections to achieve realistic self-portraits, citing Chiaroscuro effects and unusual head proportions. The study's findings support the idea that Old Masters utilized optical technology.
Research suggests that prolonged drug use can damage the brains of cocaine and methamphetamine users, leading to difficulty with moral decision making. The study found abnormal neural activity in the frontal lobes and limbic regions of their brains during moral processing.
Researchers reviewed polypharmacological drugs for their role in treating epilepsy, highlighting their potential as broad-spectrum anticonvulsants. These medications have been shown to reduce seizure episodes and improve quality of life by targeting multiple pathways involved in the disorder.
Researchers explore cyclic opioid peptides with constrained topographical structure, offering improved affinities and selectivities at target receptors. The benefits of cyclization have been enhanced through the generation of polycyclic peptides, promoting increased stability and therapeutic potential for novel therapeutics.
A new study by Colorado State University researchers suggests that women's decision to leave a STEM path after Calculus I is largely driven by confidence in their math abilities, rather than ability itself. If the same percentage of women as men stuck with STEM after Calc I, the percentage of women entering the STEM workforce could be ...
A large international study found that being overweight or obese significantly increases the risk of dying prematurely, with a BMI of 40.0-<60.0 kg/m2 associated with nearly three-fold risk.
A review article argues that telehealth will transform healthcare delivery, providing access to care at a lower cost. The authors identify three trends reshaping telehealth: making care more accessible, expanding its application beyond acute conditions, and migrating from hospitals to home and mobile devices.
When bacteria are confined to millimeter-sized, fluid-filled oval tracks, they quickly organize into a collective motion, with individuals moving in opposite directions. The research, published in the New Journal of Physics, shows that mechanical interactions between bacteria and their surroundings drive this complex behavior.
Researchers found cavefish have high body fat levels and insulin resistance but remain healthy. They may hold the key to understanding human diseases like non-alcoholic fatty liver disease and type 2 diabetes.
Researchers are using multidisciplinary approaches to genetically improve disease resistance, flooding tolerance, and cell wall composition in sorghum. This work aims to maximize the usefulness of sorghum as a bioenergy crop while minimizing input requirements.
A University of Utah study found that traditional lawn watering recommendations are often inaccurate for urban conditions in Los Angeles. By measuring evapotranspiration in shaded areas, researchers developed a new approach to adjust watering rates and achieved higher accuracy than existing models.
Researchers at EPFL have developed an osmotic power generation system that delivers unparalleled efficiency, using a new type of membrane just 3 atoms thick. The system harnesses the movement of salt ions between fresh water and seawater to generate electricity.
Researchers are using bioreactors to intercept nitrogen-rich drainage water from tile-drained fields, neutralizing the nutrient that causes problems for aquatic ecosystems. The trenches enhance a natural process, converting nitrogen into benign gas, and have shown promise in improving water quality.
Microalgae have tremendous potential in industrial biotechnology due to their applications in food, medications, and environmental biotechnology. The University of Cologne's new method using Porous Substrate Bioreactors (PSBR) reduces liquid consumption by up to 100 times, making it more cost-efficient and energy-saving.
A new study using Bayesian inference models shows that humans anticipate future events based on past experiences, but the accuracy of their responses differs from reality when stimuli are accelerated or delayed. This suggests that our brain continuously updates probability of encountering future stimuli.
Recent studies support the use of spinal cord stimulation (SCS) as a safe and effective treatment for chronic back and limb pain. SCS uses low-voltage electrical stimulation to block pain signals via a small device implanted in the body.
Research reveals specific gut microbiota imbalances contribute to insulin resistance, a precursor to type 2 diabetes. The study identified two bacteria, Prevotella copri and Bacteroides vulgatus, as key drivers of BCAA production, leading to insulin resistance in mice.
Researchers have identified 10 genetic mutations that can confer resistance to methotrexate, a chemotherapy agent, using a new 'back-to-the-future' approach combining traditional and deep sequencing techniques. This breakthrough offers potential leads for making the drug more reliable.
A study reveals that viruses have driven protein adaptation in humans and other mammals, with 30% of all protein adaptations since humans' divergence from chimpanzees being influenced by viruses. This discovery sheds light on the impact of viruses on cellular machinery and could lead to new therapeutic leads against viral threats.
A University of Washington professor argues that closing parts of the ocean to fishing is not enough to protect marine biodiversity and ecosystems. He suggests regulating fisheries over the entire economic zone as a more effective approach to conservation.
A national initiative prioritized research on venous thrombosis (VTE) in cancer patients, citing a 20% prevalence rate and increased risk with chemotherapy. The study identified key areas for future research, including platelet contributions to VTE and the impact of cancer therapies on blood cells.
Researchers aim to create more small, energy-burning fat cells that enable the body to use fat as fuel rather than store it as unhealthy padding. By studying the protein HDAC9, they hope to develop new treatments for obesity-related diseases like diabetes and cardiovascular disease.
Researchers at Texas A&M University have developed nanosystems that can cross the gastrointestinal tract and blood-brain barriers, enabling oral delivery of difficult-to-administer drugs. This approach uses non-competitive active transport to bind to cells, allowing the drug to be absorbed by the body.
Research highlights the intertwined pathways regulating apoptosis and cellular senescence in cancer and aging. The review suggests that harnessing benefits of both processes could lead to new combination therapies, while limiting drawbacks.
A new, minimally invasive procedure called Descemet stripping has shown promise in treating Fuchs endothelial dystrophy (FED), a common eye disease. The procedure restored clear vision to three out of four patients without the need for corneal transplants.
A recent study by Binghamton University found significant ethnic differences in circadian blood pressure variation among African American, Hispanic American, Asian American, and European American women. The research suggests that genetic and cultural factors contribute to these variations, which can inform personalized treatment approa...
A new study from TSRI researchers reveals the role of a gene called Mkx in maintaining and strengthening tendons in animal models. The findings may bring doctors closer to using gene therapies to grow and repair tendons.
A team of scientists has discovered that the intestinal nervous system protects the bowel's lining against inflammation and microbial aggressions. The researchers found that this mechanism is under control of the Ret protein, which regulates the production of interleukin-22, a molecule important for gut repair.
A study published in PLOS ONE suggests climate shifts influenced human subsistence strategies but not the driving factor behind cultural and technological innovations during Middle Stone Age. Researchers found that environmental variation did not coincide with these innovations, implying other factors drove human innovation.
A new study found that children born to unmarried mothers with no father listed on their birth certificate are more likely to experience weight-related issues. The research suggests that paternal involvement may play a crucial role in influencing childhood obesity outcomes, particularly in terms of feeding practices and prenatal care.
Researchers used high-intensity focused ultrasound to ablate placental blood vessels in sheep, successfully occluding vessels with minimal complications. The technique shows promise for treating twin-twin transfusion syndrome and related pregnancy disorders.
A new $13 million study will revisit patients first screened between the 1960s and 1980s to evaluate how early life risk factors affected brain health and dementia risk. Researchers aim to explore racial and ethnic differences in dementia rates and risk factors.
Colorado State University researcher Jesse Wilson is developing a new microscope that can distinguish between benign and malignant pigmented skin lesions without a biopsy. The pump-probe technology uses a simpler laser source that's already widely used in telecommunications applications, making it more realistic for melanoma applications.
Researchers created a mini-brain model to study idiopathic autism, revealing early neuronal overgrowth and dysfunctional cortical networks. The model shows a defective Wnt pathway and misregulated neurotransmitters, leading to reduced excitatory synapses and functional defects.
Researchers investigated the impact of vitamin D on vascular access outcomes in patients with chronic kidney disease, revealing potential benefits for reducing RAAS activity. Vitamin D deficiency has been linked to cardiovascular diseases, including CKD and ESRD-related complications.
A study by the University of East Anglia found that tropical hardwoods do not grow back to commercial levels after selective logging, posing a risk to their survival. The research highlights the need for sustainable forestry practices to manage yields and maintain forest biodiversity.
Researchers created a high-resolution atlas of rhesus monkey brain development, revealing how gene expression changes across time. The study highlights the importance of understanding primate brain development to identify neurodevelopmental processes involved in disorders like autism and schizophrenia.
A $450,000 grant will fund a collaboration between Indiana University and the US Navy to develop new methods for inspecting microelectronic components used in critical military systems. Computer vision technology will be applied to improve the integrity of electronic circuitry, reducing defects and ensuring equipment reliability.
Researchers discovered that a signaling molecule called TGF-beta inhibits genes important for glucose and fat burning, reducing insulin sensitivity. The study suggests that a tailored training program could help prevent type 2 diabetes by overcoming this molecular response.
Researchers at UCLA found opposite responses in the right front of the insular cortex between men and women, a critical area for emotions and blood pressure control. The study suggests differences in brain structure and function might contribute to varying clinical symptoms in medical disorders.
Researchers at CWRU discovered how bacterial resistance enzymes spread and avoid destruction by anchoring themselves in cell membranes. This mechanism allows bacteria like NDM-1 to resist destruction triggered by low zinc levels, enabling their widespread dissemination and antibiotic resistance.
Researchers developed a cloud-based system using big data analytics and topic modeling to analyze startup companies' business descriptions. The approach identifies potential matches based on business proximity, geographic location, social links, and common investor ownership.