Researchers at Case Western Reserve University have developed a technique to produce long chain molecules with trefoil-like shapes, which could lead to more stable protein structures and high-value polymers. The National Science Foundation has awarded a three-year grant to scale up the production of knotted polymers.
New research reveals that singlet oxygen plays a crucial role in triggering coral bleaching by expelling algae from coral tissue. The findings may help protect reefs and support marine species dependent on them.
A study published in JAMA Cardiology found that blacks with atrial fibrillation have nearly double the risk of adverse outcomes compared to whites. The study analyzed data from the Atherosclerosis Risk in Communities (ARIC) Study and found significant racial differences in outcomes related to AFib.
Researchers found that non-profit CEOs with higher 'warmth' scores tended to have lower total revenue and funding from private sources. In contrast, for-profit CEOs who appear more powerful are often associated with greater success in the corporate world.
A study found that most older adults (72%) are up-to-date with screening, but timely follow-up rates vary by age and comorbidity. The research emphasizes the need for personalized risk assessment tools to improve screening completion and follow-up among this vulnerable population.
Researchers observed wild boars and warthogs aligning themselves along the magnetic north-south axis, with a slight preference for east. The animals' internal compass helps them navigate while foraging for food and inhabiting new areas.
Children with epilepsy experience significant long-term socioeconomic consequences, including higher healthcare costs. The study found that people with epilepsy are unable to catch up with their peers in overall health, education, and social status.
The Dark Bordered Beauty moth is facing a severe decline due to habitat loss caused by the removal of Creeping Willow plants, which are essential for its caterpillars. Conservation efforts aim to boost Creeping Willow populations and modify grazing regimes to secure the moth's long-term future in England.
A novel combination of sorafenib and pemetrexed showed promise in a phase 1 clinical trial, with 61% of patients experiencing tumor growth delay. The therapy was particularly active in breast cancer patients, with one complete response and multiple partial responses.
Scientists discover that daily doses of pre-harvest UV-C light increase stilbenoid production in grapes, offering a natural method to prevent pathogens and reduce synthetic pesticide use. This approach shows a significant 86-fold increase in stilbenoid concentrations, resulting in higher disease resistance.
Researchers at University of Innsbruck successfully simulated lattice gauge theories and particle-antiparticle pairs using a quantum computer. This breakthrough paves the way for studying complex aspects of the Standard Model, complementing high-energy physics experiments.
Astronomers have used X-ray reverberation mapping to map the flow of gas near a newly awakened black hole for the first time. The study provides insights into the 'killer' black hole's hidden structures, revealing high-energy X-rays originate from a compact region near the black hole.
A new study suggests that consuming walnuts and other whole foods as part of a healthy diet may help maintain independence in aging women. Higher intake of fruits, vegetables, and omega-3 fatty acids from walnuts was associated with reduced rates of physical impairment.
A recent meta-analysis in Scientific Reports supports the link between omega-3s and reduced mortality. The analysis showed a 9% reduced risk of all-cause death associated with high versus low omega-3 intake.
Despite familiarity with writing standards, teachers report shortcomings and lack of training in implementing them, as well as concerns over state writing tests. The study highlights the need for educators and policymakers to prioritize attention to writing practices.
Researchers analyzed nearly three decades of air samples from Alaska's North Slope and found little change in long-term methane emissions. The findings suggest that processes regulating methane emissions need more study, as the Arctic warms faster than other regions.
Researchers developed mini-gut organoids from cystic fibrosis patient cells to screen drugs and personalize treatment. The mini-guts responded to CFTR-targeting therapies in vitro, correlating with clinical trial data and paving the way for tailored treatments.
Researchers found that negative feedback loops act as a shock absorber to buffer damage from mutations, allowing genes to mutate without compromising function. This mechanism may foster long-term adaptation while reducing immediate fitness risk, with implications for evolution and cancer treatment.
Researchers found that mass treatment of humans and pigs with chemotherapy and vaccination can interrupt the transmission of Taenia solium infection. The study was conducted in Peru's Tumbes Province, where the disease is highly endemic.
Researchers developed a way to predict glass compositions and their properties, enabling faster development of new products such as lighter windows for more fuel-efficient cars. The 'glass genome' model uses computer simulations to explore possible combinations of materials, optimizing them for industrial production.
States with robust prescription drug monitoring programs saw a significant reduction in opioid-related overdose deaths, with an average of 1.55 fewer deaths per 100,000 population compared to states without such programs. Implementing these programs could prevent over 600 additional overdose deaths nationwide.
A study at IRB Barcelona discovered that Mitofusin 2 is required to preserve healthy muscles in mice, with its loss associated with muscle wastage and sarcopenia. The protein could serve as a therapeutic target to ameliorate sarcopenia in the elderly.
Researchers found that impulsive children raised in non-coercive environments tend to drink less alcohol than their peers, as they thrive under proper care and attention. High impulsivity at age 6 was associated with lower alcohol use at age 15 when maternal coercive practices were infrequent.
Researchers found that glucosamine plays a critical role in early embryonic development, helping embryos proliferate normally. This could aid in avoiding birth defects in diabetic pregnancies and improving future stem-cell treatments. Glucosamine is also essential for embryonic cells to grow and develop.
Researchers discovered that methylation of RNA can strengthen memory formation by reducing the brain's ability to remove methyl groups. This process may have significant implications for treating memory-related disorders such as post-traumatic stress disorder or phobia.
A recent study published in BJU International found that smoking can cause DNA damage in sperm, leading to decreased fertility. The research included 20 non-smokers and 20 smokers and analyzed protein alterations in their sperm. Sperm with altered DNA may lead to health problems in offspring.
Researchers aim to identify genetic risk and prevention factors for Alzheimer's disease by analyzing genomic sequence data from thousands of individuals. The new center will provide a common database for critical information sharing and interpretation, enabling progress against the insidious disease.
A recent study reveals that red pigmented snow algae blooms in the Arctic significantly reduce albedo, leading to a runaway effect of accelerated melting. The findings suggest a universal model for algal-albedo interaction and quantify additional melting caused by algal blooms, shedding new light on climate change impacts.
A new study published in Science Translational Medicine found that the experimental drug CX546 counters the negative effects of general anesthesia on nerve signaling and learning ability in young mice. This research holds promise for preventing long-term neurocognitive deficits in children who undergo multiple surgeries requiring anest...
Researchers found that blocking acetylcholine in genetically modified mice caused Alzheimer's-like pathology, highlighting the importance of this neurotransmitter for brain health. The study suggests that targeting one of the affected messenger RNA pathways may lead to a reversal of dementia progression.
A UCLA-led study estimates that nearly 28,500 deaths in the US could be prevented annually through use of a new FDA-approved class of cardiovascular medication. The therapy helps reduce mortality in patients diagnosed with heart failure and reduced ejection fraction by enhancing protective hormonal systems.
Researchers found that lizard tails evolved differently based on the type of predator, with blue and UV light reflectance varying in communities with weasel or snake predators. A cryptic brown tail also emerged in island populations where birds are the primary predators.
Older adults who engage in more than 20 leisure activities per week are less likely to experience post-operative delirium. Research suggests that reading, emailing, and playing computer games can reduce the risk of delirium following surgery.
The structure-mapping engine (SME) enables computers to reason more like humans and make moral decisions by leveraging cognitive science theories. SME can handle the size and complexity of relational representations needed for visual reasoning, cracking textbook problems, and solving moral dilemmas.
A study found that surgeons who admit to bias towards their specialty increase patient trust and lead to more surgical treatments. Patients who hear this admission are nearly three times more likely to choose surgery, indicating a significant influence on patient decision-making.
The project, funded by the EPSRC, seeks to create tiny plasma bubbles for medical imaging and industrial processes. Researchers aim to improve cancer treatment and quality of life with enhanced diagnosis and treatment options.
NIST's N4 watt balance conducts its first measurement of Planck's constant, achieving accuracy of 34 parts per billion. This result is consistent with other countries' measurements and sets the stage for a new kilogram definition by 2018.
Research shows that 5-year-old children outperform younger counterparts in taking turns, a fundamental social behavior. Chimpanzees also demonstrate cooperation but fail to adopt consistent turn-taking strategies.
Researchers found that seven of ten populations selected high-quality forage in early stages of growth, while others favored leading or trailing edges. This study provides insights into how animals track plant growth and will aid in understanding impacts of climate change on big game habitats.
Eating irregularly is linked to a higher risk of metabolic syndrome and obesity. The authors argue that considering the timing of meals alongside dietary choices could lead to better public health outcomes. Research highlights the importance of studying chrono-nutrition and its impact on our internal body clocks.
Researchers develop CAR T cell therapy targeting a specific glycopeptide found on cancer cells but not normal cells, showing promise in treating leukemia and pancreatic cancer in mice. The therapy demonstrates improved survival rates and potential for broad applicability to various cancers.
Researchers at Johns Hopkins Medicine successfully diagnosed or ruled out suspected brain infections using next-generation genetic sequencing. The technique has the potential to bring diagnosis rates for inflammatory brain disorders and infections closer to 100 percent, enabling more effective treatment.
A new study from the University of Liverpool found that taking notes during trials enhances jurors' memory of trial evidence. Jurors who were allowed to review their notes had superior memory recall compared to those who didn't.
A study found that genetically raised CRP levels are linked to a reduced risk of schizophrenia. The researchers also discovered associations between elevated CRP and increased risks for arthritis, bipolar disorder, and high blood pressure.
Researchers at Mayo Clinic are exploring the potential of genetic testing and electronic health records to tailor antidepressant treatment. The study finds that genetic variation can affect patient reactions to drugs, offering a unique opportunity to develop pharmacogenetic guidelines.
A review of 60 studies found that plant-based therapies like phytoestrogens and herbal remedies may improve menopausal symptoms, such as hot flashes and vaginal dryness. However, the evidence is limited by quality and more rigorous studies are needed to confirm these findings.
Researchers have devised a method to recycle millions of tons of plastic garbage into liquid fuel by breaking down polyethylene with alkanes. The process is more efficient and milder than current methods, using readily available substances from oil refining.
Researchers found that mosquito bites enhance the replication of viral infections like Zika and dengue by triggering an inflammatory response in the body. Anti-inflammatory medications may be effective in stopping this process and preventing severe illness.
A UW-led team is developing an implantable wireless device that can assess, stimulate and block the activity of nerves controlling organs. The device could help restore bladder function in people with spinal cord injuries or those suffering from incontinence.
Researchers found charge density waves extending deeply into superconducting regions, allowing for new ways to manipulate superconductivity. The discovery paves the way to controlling the superconducting state itself.
The National Institutes of Health has launched a multi-country study to investigate the health risks associated with Zika virus infection during pregnancy. The study aims to enroll up to 10,000 pregnant women across several locations affected by Zika outbreaks, followed throughout their pregnancies and into early childhood.
A new model developed by researchers at Shanghai Jiao Tong University provides a fuller understanding of supercooled large droplet icing mechanisms. The model identifies a different icing mechanism than previously identified and incorporates heat generated from impact thermodynamics.
A study published in JAMA found that US diets improved between 1999 and 2012, with increased whole grain consumption and reduced sugar-sweetened beverages. However, disparities in diet quality persisted by race/ethnicity and income level.
A commentary in CMAJ warns that offering medical assistance in dying to people with psychiatric illnesses could lead to premature deaths and stigmatization of vulnerable groups. The authors highlight the need for a clear policy framework to address these challenges.
New studies find exclusive breastfeeding for six months reduces conduct disorders in children, while enriched play/stimulation by age two boosts cognitive development. Additionally, 'responsive stimulation' improves emotional-behavioral problems in impoverished rural children.
Research reveals three common burrow features: a horizontal platform for monitoring and warming up, spiral bends to deter predators, and an enlarged terminal chamber for refuge and feeding. Burrow architecture may change in response to soil composition, hardness, and moisture.
Researchers found that players with high-value hands glance right, while those with low-value hands glance left. This suggests that gaze patterns can be used to infer hand value, potentially helping blackjack players make better decisions.
A new study published in CardioRenal Medicine suggests that patients with more inflammation prior to kidney transplantation are at higher risk of developing diabetes after surgery. The researchers also found that a patient's fat stores play a role in this process, and that reducing inflammation before transplant may help prevent diabetes.
The Boreal felt lichen, a critically endangered species, is expected to decline by 49% within 25 years if conservation efforts are not increased. Human impacts such as air pollution and habitat destruction are major contributors to the decline.
A study published in Epigenetics & Chromatin identified a critical role for methyl-CpG-binding protein 2 (MeCP2) in regulating gene expression involved in pain perception. MeCP2 was found to be increased after nerve injury, leading to changes in downstream genes that can cause pain.