Researchers identified microRNA-146a in osteoclast-derived extracellular vesicles, which regulate bone cell function. The study suggests that miR-146a-rich EVs may act as a potential biomarker for osteoclast presence and regulate target cells.
Researchers explore small molecule replacement therapy to rescue craniofacial defects by manipulating Wnt and Eda/Edar signaling pathways. The study provides novel candidates for therapeutic treatment of patients with craniofacial defects.
A study presented at the American Association for Dental Research Annual Meeting found that saliva liquid biopsy accurately detected EGFR mutations in lung cancer patients, with high accuracy rates. The test showed promise as a non-invasive diagnostic tool for detecting actionable EGFR mutations.
Researchers developed a caries risk tool to identify toddlers at risk of developing caries by age four through medical settings. Minority, Medicaid, and rural children had higher caries rates at 30 months-of-age, with several questionnaire items associated with cavitated caries.
A study found that adjunctive use of minocycline microspheres significantly reduced levels of subgingival bacterial species and improved clinical outcomes for patients with peri-implantitis. This resulted in a greater reduction in pocket depth compared to mechanical debridement alone.
The National Dental Practice-Based Network (PBRN) has been established as a learning health system, leveraging data infrastructure to advance scientific knowledge and improve patient care. The network's collaborative processes have enabled over 25 studies, 100 peer-reviewed papers, and demonstrated practice change since its inception.
Researchers conducted focus groups with children (8-12 years) and adolescents (13-17 years) to elicit perceptions of oral health. Three themes emerged: maintaining good oral health for longevity, positive associations between oral health and relationships, and benefits of orthodontic treatment. These findings inform the development of ...