Long-term follow-up confirms that isoniazid prophylaxis reduces both severe morbidity and mortality among HIV-infected individuals. The study provides evidence for the WHO recommendation of isoniazid preventive therapy in HIV-positive patients, even with early antiretroviral treatment.
A study found that patients with recorded penicillin allergy were more likely to develop surgical site infections, but only if they received alternative antibiotics. The risk was 50% higher in these patients, highlighting the need for reevaluation of penicillin allergy testing guidelines.
Researchers found that atomic hydrogen makes up a majority of gas in younger galaxies, contradicting expectations. This discovery has significant implications for our understanding of the early Universe and the role of cold gas in star formation.
Researchers discovered that LSD1 removal in adult mice induces changes in gene activity similar to Alzheimer's disease. LSD1 protein is also perturbed in human brain samples with Alzheimer's and FTD, suggesting it as a central player in these neurodegenerative diseases.
Ancient South Americans discovered how to manipulate wild rice, leading to the growth of bigger rice crops with larger grains. The research, led by Professor Jose Iriarte, sheds light on the importance of wetlands and tropical forests in providing food for early human settlers.
Estimates of early industrial emissions of black carbon are inexact due to limited sampling before the mid-1950s. Researchers found regional black carbon concentrations peaked during the first decade of the 20th century and were linked to coal consumption, with concentrations becoming decoupled after 1960.
After having a baby, men tend to relax and women do household chores on their days off. In contrast, when both partners work, they split tasks more evenly. The study suggests that couples should discuss how to share household duties before the baby is born.
Physicists at JILA have confirmed the leading results on electron roundness using a unique spinning molecule technique, measuring its symmetry to provide new insights into fundamental physics and potential fossils of ancient asymmetry. The method offers future potential for more sensitive searches and tests of natural constants.
The University of Texas at Arlington has received a five-year, $1.3 million grant to renew its Veterans Upward Bound program, which improves college readiness and degree completion for veterans. The program has served over 580 veterans since its inception in 2012.
Researchers have discovered that patients with non-freezing cold injury, also known as 'trench foot,' have a significant reduction in nerve fibers within the skin. This damage causes chronic pain experienced by these patients. Understanding the root cause of the condition may lead to new treatments and improved prevention strategies.
The sale of unapproved antibiotics in India is increasing at the fastest rate, driven by fixed-dose formulations and contributing to rising antimicrobial resistance. Researchers urge the Indian government to take effective action to stop the sales and implement regulations.
Researchers at Goethe University Frankfurt have identified key molecules involved in regulating brain plasticity and memory. GRIP1, ephrinB2, and ApoER2 are found to interact and regulate AMPA receptor insertion at the synapse, influencing learning and memory.
Researchers use imaging technology to study a simplified human gut microbiome, finding a mixed community where each cell is next to cells of different species. The host appears to mix and prevent large clusters of single-bacteria species from forming.
Researchers debunk previous claims of preserved dinosaur blood, showing degraded organics in fossils rather than actual cells. Experimental treatments demonstrate keratin degradation into foul-smelling fluid under simulated burial conditions.
A new genetic sequencing approach enables precise identification of drug-resistant TB, a major public health threat worldwide. The TGen-UCSF team used Single Molecule-Overlapping Reads technology to detect variants of TB, even in cases where older technologies found no mutations.
A University of Texas at Arlington bioengineering professor and her team will integrate a portable brain imaging system with an advanced signal-processing technique for newborns. This project aims to provide real-time analysis needed to treat encephalopathy or brain swelling more quickly, saving the lives of sick babies.
A new study of children from Sweden and Finland found that the swine flu vaccine Pandemrix did not increase the risk of developing autoantibodies against insulin-producing beta cells or type 1 diabetes. In fact, vaccinated children in Finland showed a reduced risk of developing autoantibodies and type 1 diabetes.
Many opioid dosage combinations have no prescribing restrictions under Medicare formulary, suggesting an opportunity to limit opioid prescribing. Restricting coverage for prescription drugs is one strategy to decrease opioid prescribing.
A new computer program called SCENIC enables researchers to quickly and accurately identify different cell types in the human body. The method helps understand how cell fate is regulated and could lead to the discovery of master regulators and potential drug targets.
Bacteria self-organize to form a golden shell around their colony using gold nanoparticles, creating a functional pressure sensor. The researchers controlled the size and shape of the device by altering the growth environment, demonstrating a proof-of-principle for fabricating structured materials.
Researchers have developed a carbon monoxide-iron-based therapy that can inhibit the effects of rattlesnake and other venomous snakebites for up to an hour in animals. The therapy blocks hemotoxic venom enzymes, preventing destruction of blood's ability to clot and reducing the risk of internal bleeding and organ damage.
University of Wisconsin-Madison researchers have discovered an ancient loosening of a biochemical pathway that led to the evolution of characteristic red pigment in beets. The discovery sheds new light on how plants can produce various compounds and has implications for beet breeding programs.
A new study reveals that women with breast cancer who received more aggressive treatments were more likely to experience disruptions in employment. Women who underwent bilateral mastectomy with reconstruction had nearly eight times the risk of missing over a month of work compared to those who underwent lumpectomy.
A Swedish registry study found that dementia patients with stroke can receive thrombolysis treatment without increased risk of brain haemorrhage or death. However, those over 80 may experience worse functional outcomes and be more likely to be discharged to nursing homes.
A national study led by Michigan State University researcher Sacha Klein found that participating in Head Start may help prevent young children from being placed in foster care. Kids up to age 5 in the program were 93% less likely to end up in foster care than those without early care and education.
Pyroptosis, an explosive form of cell death, contributes to the high mortality rate of bloodstream infections by triggering excessive tissue injury. Caspase-11 is identified as a key enzyme in this process, making it a promising target for development of new treatments.
A new study found that the proportion of US hospital nurses with bachelor's degrees increased from 44% in 2004 to 57% in 2013. Despite this growth, the goal of 80% of nurses having a bachelor's degree by 2020 is unlikely to be met, projected to reach 64% by 2020 and 80% by 2029.
Research reveals that female brains activate more strongly in response to prosocial behavior compared to male brains, which prioritize reward from selfish actions. Cultural conditioning plays a significant role in shaping these differences, as women are often rewarded for prosocial behavior, leading to stronger neural responses.
Despite progress in HIV treatment and prevention, a durable end to the pandemic may require an effective HIV vaccine. Existing tools such as antiretroviral therapy and pre-exposure prophylaxis can effectively prevent HIV transmission and manage the disease.
A new study suggests that younger primary school children are more likely to be diagnosed with ADHD than their older peers in the same school year due to a relative age effect. This means that adults, such as parents and teachers, may misattribute signs of immaturity as symptoms of ADHD.
A new statistical model uses hospital patient data to predict platelet transfusion needs, enabling optimal inventory management and reducing waste. The approach could save healthcare systems up to $80 million annually if adopted nationwide.
An international team has produced a catalogue and atlas of the world's reptiles, linking it with existing maps for birds, mammals, and amphibians. The new data reveals urgent conservation concerns, including drylands and deserts, where conservation action is vital.
A study found that Delaware's expansion of comprehensive background check policies to include private-party sales resulted in a 25% increase in handgun background checks and a 34% increase for long guns. In contrast, Washington and Colorado experienced no overall change in background checks despite enacting similar policies.
Researchers tested participants' hearing and speech abilities before and after extreme noise exposure to determine if it caused permanent damage. The study found temporary changes in some functional tests but no evidence of hidden hearing loss.
Researchers have identified changes in molecular signaling related to neural plasticity, inflammation and neurodegeneration triggered by the psychedelic substance 5-MeO-DMT. This study suggests that classic psychedelics may induce neuroplasticity and exert antidepressant effects.
Climate model simulations suggest that a significant decrease in atmospheric CO2 concentrations could have led to global glaciation. The study indicates that Earth's coal deposits formed during this period may have been the trigger for such an event.
Four factors were identified as significant in helping women ex-convicts avoid recidivism: good nutritional health, good spiritual health, having a high school education, and having been convicted of drug offenses. These factors resulted in reduced likelihoods of recidivism ranging from 40% to 70%.
Hao Wu, a Penn Medicine genetics researcher, has received a 2017 NIH New Innovator award to pursue high-risk research on epigenome editing. The grant will fund his study of how the epigenome of heart muscle cells respond and adapt to changing environmental oxygen levels.
A new Yale study finds that Medicare plans place few restrictions on the coverage of prescription opioids, despite federal guidelines recommending such restrictions. The researchers highlighted an untapped opportunity for Medicare formularies to limit opioid prescribing, citing a modest increase in opiate coverage between 2006 and 2015.
M344 altered key gene expression in a cellular model of AD, preventing cognitive decline and improving memory. In mouse models, low-dose administration of M344 prevented cognitive decline and improved learning and memory.
A mouse study shows that cannabidiol treatment effectively reduces the severity and duration of seizures and their frequency. The study also found improvements in social interactions and reduced autism-like symptoms in mice with Dravet syndrome.
A new study by Ohio State University finds that moderately farsighted preschoolers have poorer scores on attention-related tests. The research suggests that uncorrected vision problems in young children can lead to deficits in learning and literacy.
Researchers have identified a gene that may provide potential therapy for cerebral cavernous malformations (CCMs), a condition characterized by enlarged and irregular blood vessels in the central nervous system. The study suggests using angiogenesis inhibitors, such as TSP1, to treat or prevent CCMs.
A new study will investigate the biological mechanisms triggered by exposure to air pollution during pregnancy, leading to lower birth weight in newborns. The research aims to understand how air pollution affects fetal growth and development.
Researchers from SingHealth, Duke-NUS Medical School, and NCCS have sequenced the complete genetic blueprint of durian, a tropical fruit known for its unique smell. The study reveals that durian has approximately 46,000 genes, nearly double those found in humans.
Compounded bioidentical hormone therapies are not FDA-approved, lack quality control, and have the same risks as FDA-approved hormone therapy products. Women often unknowingly choose these over FDA-approved options due to misconceptions about safety and efficacy.
Research at Universitat Autonoma de Barcelona suggests that green gentrification in cities may not equally benefit all residents, particularly socially disadvantaged neighbours. The process of recovering natural spaces tends to displace low-income populations, increasing chronic stress and negatively affecting their mental health.
Researchers have developed a new influenza vaccine that uses a nanoscale, controlled-release capsule to provide quick and long-lasting protection against pandemic A strains. The vaccine is based on the M2 protein, which remains constant across different flu viruses.
A Dartmouth-led study reveals Indigenous nations are adapting to invasive species through public programs, education, and collaborative efforts with non-Indigenous governments. These initiatives not only mitigate the impact of invasive species but also protect cultural identity and traditional economic knowledge.
The devices can be cut to the size needed for specific applications due to their symmetrical fractal wiring patterns. The modular generators could be inkjet printed on flexible substrates like fabric and manufactured using inexpensive roll-to-roll techniques.
NASA's Aqua and Suomi NPP satellites analyzed cloud top temperatures in Hurricane Nate, revealing the strongest storms were near the center of the tropical cyclone. Temperatures as cold as minus 80 degrees Fahrenheit indicate strong thunderstorms capable of heavy rain.
The NASA's Aqua satellite provided valuable temperature data to forecasters, showing the strongest storms were located in Hurricane Nate's eastern side. The storm's cloud top temperatures reached as low as minus 80 degrees Fahrenheit, indicating strong storms capable of heavy rain.
Researchers pack laser-written structures deep into silicon chips, enabling arbitrary 3D fabrication without layers above or below. The method also enables creating functional optical devices and 3D sculpturing of entire wafers.
A study by University of Utah Health found that 7% of US athletes and staff infected with mosquito-borne viruses during the 2016 Rio Olympics were positive for West Nile virus, Dengue fever, and Chikungunya. Most had mild symptoms or no symptoms at all, highlighting the importance of post-travel diagnostics.
Scientists have developed a new class of antifungal drugs called 'orotomides' to treat life-threatening invasive fungal infections. The novel mechanism of action offers hope for patients with leukemia and bone marrow transplantation, who are often affected by these infections.
Tropical Storm Nate is forecasted to produce life-threatening flash floods and mudslides across a wide area of Central America. The storm's center is expected to move across the northwestern Caribbean Sea, reaching the eastern coast of Mexico before moving into the southern Gulf of Mexico.
Scientists at NAIST have discovered a molecular pathway that explains how plant cells cease cell division upon DNA damage. The study found that the transcription factor family MYB3R prevents progression to the M phase of the cell cycle, allowing plants to maintain genome integrity.
The innovative method developed by JGU and Evonik Performance Materials GmbH allows for flexible reaction to available electricity supply, eliminating the need for customized electrolysis apparatuses. This breakthrough in electro-organic synthesis enables sustainable production of fine chemicals with minimal environmental impact.
Androgen receptor targeted imaging is emerging as a potential modality for early, rapid, and efficient diagnosis of prostate cancer. Current medical imaging reviews discuss traditional diagnostic approaches and summarize current imaging approaches using PSMA, BN, and AR targeted imaging.
A recent study found that polyvictimization - exposure to multiple forms of victimization - significantly erodes feelings of school safety, equity, and connection. The study highlights the need for schools to implement comprehensive policies addressing all forms of victimization to create a safe environment.