A phase 2 double-blind study found that brexanolone reduced HAM-D scores by 21 points in women with severe PPD, compared to an 8.8-point reduction in the placebo group. The medication was generally well-tolerated and showed sustained effects beyond a 30-day follow-up period.
A recent study published in CANCER found that Asian women are less likely to receive timely follow-up tests after an abnormal mammogram compared to non-Hispanic White women. The study highlights disparities in breast cancer screening and outcomes among Asian ethnic groups, with Vietnamese and Filipino women facing the longest delays.
Pomper is recognized for his work on developing new imaging agents targeting cancer and central nervous system processes. He oversees several federally funded programs at Johns Hopkins, advancing the field of molecular imaging.
Researchers demonstrated the efficacy of targeted photodynamic therapy (tPDT) to treat prostate cancer before and during surgery, using a PSMA-targeting agent coupled with photosensitizers. The technique optimizes prostate cancer care by allowing visualization of tumors prior to surgery and providing real-time guidance to surgeons.
Fowler has made significant contributions to brain research, developing the radiotracer F-18-FDG to measure brain glucose metabolism non-invasively in humans. Her work has facilitated advances in the study of the human brain and malignant tumor detection.
A KAUST-led team reveals a short regulatory gene that adapts to dynamic environments by tagging genes for repression. This discovery offers a new paradigm for gene regulation, linking the genome with the environment and providing insights into cellular plasticity.
A new study reveals that lianas prevent canopy trees from producing fruit, reducing the availability of a critical food resource for tropical animals. The effects of removing lianas are dramatic, with a 173% increase in canopy tree production five years after removal.
Researchers developed a scanner that unites optical, radioluminescence, and photoacoustic imaging to evaluate thin-cap fibro atheroma (TCFA) in the earliest stages. This could lead to a paradigm shift in coronary artery disease diagnosis and assessment.
Researchers found that participants with higher fasting plasma glucose levels lost more weight on a high-fiber, low-glycemic diet compared to those with lower blood sugar levels. Participants with high fasting blood glucose had lost an average of 9.4% body weight, while those with low fasting blood glucose had lost 4.1%.
Researchers from KAUST have developed a model predicting how climate change impacts plankton populations. Temperature, nutrient availability, and mortality rates influence the numbers of heterotrophic planktonic prokaryotes.
This study evaluated the effects of fluoride bleaching agents on human enamel. It found that fluorine bleaching agents increased the concentration of fluorine, calcium, and phosphorus ions in the enamel without altering its microhardness.
A study found that brain receptors involved in addiction adapt to chronic drinking by reducing their bioavailability, but return to normal after detoxification. This can serve as a predictor of long-term sobriety success.
The grants will support pre-clinical and clinical diagnostic and therapeutic research, including the development of new imaging agents and clinical trials on therapy safety and efficacy. The Brain SAFTIE initiative aims to identify gaps in existing knowledge and facilitate collaboration among experts.
Researchers found that blood sugar and fasting insulin biomarkers predict weight loss success. For people with prediabetes, a fiber-rich diet without calorie restriction is effective, while those with type 2 diabetes benefit from a diet rich in healthy fats.
A new review investigates the relationship between pain and opioid misuse, revealing that pain can drastically change the brain's natural opioid system. The study aims to understand how pain affects addiction treatment, with the ultimate goal of developing more effective treatments for chronic pain.
A novel study found that short duration of breastfeeding and maternal obesity are associated with an increased risk of nonalcoholic fatty liver disease (NAFLD) in adolescents. Breastfed infants who were fed infant formula milk before six months had a 40% increased likelihood of NAFLD.
Scientists worldwide agree on a dictionary of terms to study sedentary behavior, an emerging global public health priority. The consensus definitions aim to facilitate research interpretation and comparison, helping to reduce confusion and advance the field of sedentary behavior research.
A large pragmatic trial found that checking finger-stick blood sugars did not offer significant advantages in blood sugar control or quality of life for non-insulin treated type 2 diabetes patients. The study suggests that the costs of home blood glucose monitoring may outweigh its benefits for this population.
The journal published two ultraviolet radiation datasets covering China, providing long-term measurements from 1961 to 2014. This move aims to promote translational applications for the general public by making atmospheric and physical oceanographic data traceable and citable.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have developed a new type of carbon nanomaterial that can change shapes and colors depending on the solvent used. The material exhibits tunable emission spanning a wide range of colors in various solvents.
A randomized trial found that self-monitoring of blood glucose levels in patients with non-insulin-treated type 2 diabetes did not improve glycemic control or health-related quality of life after one year. The study suggested that SMBG should not be routine for most patients, contradicting existing practice.
A new study presents data from an FDA-approved clinical trial testing the generic vaccine BCG to reverse advanced type 1 diabetes. The findings suggest that BCG may induce a permanent increase in expression of genes that restore beneficial regulatory T cells (Tregs) preventing autoimmune attacks on the body's own tissue.
A pioneering contact lens therapy has shown considerable potential to impact the rising prevalence of myopia in children, slowing its progression by 59%. The dual-focus contact lens was effective in reducing the rate of juvenile-onset myopia, with no side effects common to alternative pharmacological therapies.
The UNIST design team has developed Quietto, an interactive desk clock that uses a concrete and milled wood interface to show upcoming daily schedules. The award recognizes the unique approach to designing a tangible interface using concrete and introducing a new way of understanding time and schedule.
Researchers at OIST used one-atom-thin graphene film to drastically enhance the quality of electron microscopy images of biological specimens. The low-energy electrons interact strongly with the virus sample but not with the background graphene layer, providing high contrast and resolving tiny details.
The EV-FPS test correctly identifies men with aggressive prostate cancer 40% more accurately than current PSA tests. It has the potential to eliminate up to 600-thousand unnecessary biopsies and reduce hospitalizations annually in North America.
Researchers created a numerical 'tweezers' tool to study nucleus interactions, finding that local forces play a crucial role in determining attraction or repulsion. The study sheds light on the parameters controlling these nuclear forces, which inform nuclear structure.
Researchers confirm Nipponosaurus is a valid taxon and a juvenile dinosaur that has not reached sexual maturity. It was discovered to have unique characteristics, including a wide shelf-like structure on the lower jaw and extremely short front legs.
The NIH-funded Einstein-Rockefeller-CUNY Center for AIDS Research aims to prevent HIV transmission and develop a cure. The center will focus on behavioral science, clinical translation, biomarker discovery, and HIV vaccine development to improve population health outcomes.
Research finds that soft shelled turtles in China are spreading cholera due to the presence of Vibrio cholerae pathogens. The study used bioluminescent proteins to observe the bacteria's colonization on the turtles' surfaces and intestines.
A study by UNIST has introduced a method for remote detection of hazardous radioactive substances, increasing sensitivity 4,800 times over conventional methods. The new device can detect radioactivity at distances of tens to 100 km, enabling early warning systems and improved safety measures.
Balinese rice farmers' planting patterns create fractal designs that yield optimal harvests without global planning. The pattern's emergence is driven by water availability and pest damage, making the system more resilient. Farmers adapt locally, taking individual decisions that optimize their own harvests, resulting in a stable system.
In a clinical trial of 86 patients with colorectal and other cancers, scientists found that half respond to pembrolizumab due to mutations in their tumors. This could lead to a new standard-of-care including mismatch repair deficiency testing to identify patients who may benefit from immunotherapy.
A phase 3 trial found that a lumacaftor and ivacaftor combination improves lung function in children with cystic fibrosis, reducing air clearance time by 15 days. The treatment also slows chloride levels in sweat, suggesting it corrects gene mutations.
Researchers at Huntsman Cancer Institute discovered a new science that could provide better therapeutic options for Philadelphia chromosome-positive ALL patients. The new drug inhibits DNA repair proteins, reducing leukemia load by 50-70% in mouse models.
A recent study explores the species-area relationship and volume-species relation, finding that higher canopies are associated with more plant species due to increased biospace. This correlation is observed across different climate zones, suggesting a fundamental role in ecology.
A recent study suggests that targeted removal of senescent cells can delay the onset of age-related pathologies, such as osteoarthritis. The research team found that selectively destroying these old cells can reduce pain, promote new cartilage growth, and create a pro-regenerative environment.
Researchers found that radiation therapy can alter neural networks and lead to cognitive decline in patients with brain tumors. The study suggests that the treatment may cause broader adverse effects, including thinning of the brain cortex and increased segregation between brain regions.
A Vanderbilt University Medical Center study found that most women who undergo a cesarean childbirth are prescribed more opioid pain medications than needed when released from the hospital. Most patients use opioids for an average of eight days after discharge, with many storing unused tablets in unlocked locations.
Researchers will develop coral disease forecasting models for Hawai'i, U.S.-affiliated Pacific Islands, and the Great Barrier Reef using field work, experimental data, and satellite information. The project aims to identify local environmental stressors increasing disease susceptibility and prioritize management practices.
Researchers have created a new alloy that exhibits superelastic behavior at the nanoscale, requiring much higher stress to deform than larger materials. This discovery opens up new channels for developing flexible microsystems and electromechanical nanosystems, including implantable devices with potential applications in smart healthcare.
A group of scientists found that parasitic nematode species can thrive without sex by using large, duplicated genomes. These genomes provide a reservoir for adaptation to different environments and plant hosts, giving the nematodes an evolutionary advantage over their sexual relatives.
A new IUPUI study found that African-Americans in lower-income brackets have a lower risk of binge drinking during adolescence, but a higher risk at older ages. Higher incomes show comparable risks across racial groups.
Researchers from ITMO University and Hebrew University have developed a method to recover protein structure after chemical denaturation, working for both specific molecules and multiprotein systems. The technology simplifies and cheapens the production of drug proteins for Alzheimer's and Parkinson's treatment.
Researchers at Rice University have created hydrogel strings using a compound found in mussels, allowing for controlled growth of cells on surfaces. The aligned fibers promote ordered cell growth, making it possible to direct cell growth from one location to another.
A new research design from Perelman School of Medicine scientists provides a more effective way to assess the safety of newly approved drugs and those with rapidly increasing or declining use. This trend-in-trend method can identify rare side effects and provide accurate results, even in the absence of comparable control groups.
Researchers have developed a novel method to create stable and low-cost electrodes from discarded stainless steel mesh, ideal for potassium-ion batteries. The new electrode design uses a waste material to store potassium ions, overcoming the limitations of sodium ion batteries.
Low-income patients in non-expanded states are more likely to travel out of state for abortion care, pushing procedures into the second trimester. This highlights the growing inaccessibility of abortion services and the need for compassionate public health policies.
A new study found that a molecular compound called CLR01 improves balance and coordination in mice with early-stage Parkinson's disease. CLR01 reduces the amount of toxic alpha-synuclein protein in the brain, which is thought to contribute to the development of the disorder.
A new study found that oral prednisone reduced immune responses to AAV-based gene delivery, resulting in a 60% decrease in cytotoxic T cell infiltrates. The treatment also increased PD-L2 levels, which induce programmed T-cell death, suggesting a potential therapeutic benefit for gene therapy.
A new study published in Social Science and Medicine found that a rewards programme increased weight loss magnitude and duration by more than twice as much as a control group. The programme, which offered cash or lottery tickets for meeting monthly weight loss goals, also led to higher rates of sustained weight loss.
Among older patients with diabetes, being overweight reduces the risk of early death by 18% compared to normal weight counterparts. However, this survival benefit is only observed in older patients and diminishes over time.
A Clemson University graduate discovered that certain toxicants can disrupt the maturation of Daphnia magna by altering lipid levels, affecting development and reproductive rates. The study found that triclosan and atrazine can lead to stunted growth and altered lipid allocation in newborns.
A phase III clinical trial showed that combining lesinurad with febuxostat was more effective at lowering blood urate levels than febuxostat alone. The combination group achieved target urate levels in significantly more patients over 12 months.
Experts agree on routine screening, medication-assisted treatment, and addressing pain management for women with opioid use disorder. Research is needed to improve outcomes for affected women, newborns, and families.
A team of researchers at RWTH Aachen University used the Cray XC40 Hazel Hen supercomputer to simulate turbulent multiphase flows, paving the way for more accurate modeling and design of cleaner coal plants. The study's findings support the team's goal of improving CO2 emissions from coal power plants.
Using the Hubble Space Telescope, astronomers measured the deflection of light rays as they passed near a white dwarf star, providing a solid estimate of its mass. The result confirms theoretical predictions and offers insights into the star's structure and composition.
Researchers studying space-traveling flatworms found that microgravity affects their regeneration, behavior and microbiome. The worms' bodies underwent permanent changes after exposure to space, including spontaneous fission and altered biological states.
Researchers created a new form of ultrastrong, lightweight carbon by pressurizing and heating glassy carbon to extreme temperatures. This material has unique properties that make it suitable for various applications, including aerospace engineering and military armor.
A six-month text messaging program improved blood sugar levels in low-income Hispanics with Type 2 diabetes, rivaling some glucose-lowering medications. The study found that participants who engaged more with the messages had better A1C measures.