The new eMAGE method eliminates DNA breakage errors, enabling efficient genetic modifications with high accuracy. This technology has the potential to revolutionize disease treatment, antibiotic production, and industrial biotechnology applications.
Researchers have long used preprints to accelerate scientific discovery. A forgotten biology preprint experiment from the 1960s has been unearthed, revealing a long history of resistance to open knowledge sharing among publishers and learned societies.
A study published in the American Journal of Pathology found that higher levels of the protein CXCL5 are associated with clearer heart arteries and lower risk of coronary artery disease. Researchers believe that mimicking or increasing CXCL5 production could lead to new prevention and treatment strategies for CAD.
The University of Liverpool's Ultra-Sensitive Optical Coherence Tomography (Ultra-OCT) system is developing a state-of-the-art imaging technology to revolutionise the detection, diagnosis, and management of corneal eye conditions. The system boasts a resolution of 2 micrometres and can scan 1,000 times faster than existing OCT machines.
Researchers at Harvard T.H. Chan School of Public Health discovered Nrf1 protein's role in maintaining cholesterol balance within cells. The protein senses and responds to excess cholesterol, promoting protective countermeasures and potentially treating diseases where cholesterol metabolism is disrupted.
A major research project, HELIX, found that some climate impacts are unavoidable, while others can still be mitigated. Global warming of 1.5°C to 2°C could lead to sea level rise of 0.5m, affecting 2.5 million people in Bangladesh, and increased flood risk in parts of Asia, Europe, and America.
A new imaging machine developed at the University of Illinois estimates the number of kernels per ear and provides detailed information about each kernel's shape, size, and location. The technology has the potential to revolutionize plant breeding and genetic research by enabling high-throughput phenotyping.
Researchers have identified a peptide called θ-defensin 1 (RTD-1) found in Old World monkeys that has the potential to stop or reverse rheumatoid arthritis progression. RTD-1 treatment resulted in greater disease resolution and higher complete disease resolution rates compared to established treatments.
A new study published in Psychological Science found that spanking is associated with an increased risk of behavioral problems in children. Children who were spanked by their parents showed greater increases in behavior problems at ages 6 and 8 compared to those who were not spanked, according to the study.
A newly discovered fossil, Jablonskipora kidwellae, fills the missing evolutionary link in the history of bryozoans. The tiny marine creature lived 105 million years ago and evolved a unique structure to tap into flowing water, giving it a competitive advantage over other species.
The mouse immune system uses six different ways to identify invading bacteria, scanning the bacterial protein in detail. This effective immune response helps understand why certain bacteria can evade detection.
Optic nerve hypoplasia is a leading cause of childhood blindness in developed nations, and researchers have discovered the biological mechanism behind it. The condition affects brain growth during development, particularly with the CASK gene, which helps provide architectural support for neuronal communication.
New research challenges common perception that polar species are best at adapting to changing temperatures. Acclimation is most effective at temperate latitudes, with slow seasonal changes allowing for optimal adaptation. This could alter our understanding of which species are most vulnerable to climate change.
A new study using the High-Altitude Water Cherenkov (HAWC) observatory found that two rapidly spinning stars are unlikely to be the source of excess anti-matter particles near Earth. The observations rule out a simple explanation involving nearby collapsed stars, leaving dark matter as a possible culprit.
Researchers separate pain relief and breathing effects in opioids, revealing a 'biased signaling' mechanism with a 'therapeutic window' of safer alternatives. This finding could lead to new opioid medications without the risk of respiratory failure.
Researchers from the University of Seville have discovered that genes located near nuclear pores contribute to maintaining genome stability. The study found that anchoring DNA to the pore during transcription prevents DNA-RNA hybrids, a natural source of genome instability.
A new analysis of Pluto's hydrocarbon haze reveals a novel cooling mechanism controlling the dwarf planet's frigid atmosphere. The study proposes that haze particles absorb heat and emit infrared radiation, resulting in an atmospheric temperature of about 70 Kelvin.
A new study published in Pediatrics found that routine laboratory screenings for children entering foster care carry high costs and questionable medical benefits. Targeted screening may be a more cost-effective approach, particularly for conditions such as anemia, lead poisoning, chlamydia, and gonorrhea.
A new paper by physicist Stephen Jordan explores whether the universe holds solutions to difficult computational problems, such as number partitioning. The universe's background energy density is found to be close to zero, implying a stable material universe and potentially offering insights into these problems.
Researchers have identified specific chemical receptors in cells that could deceive bacteria and improve patient response to drugs. The study's findings suggest that targeting these receptors could help adapt antibiotics to better attack infections.
Researchers have demonstrated the full process of making kerosene, the jet fuel used by commercial airlines, using a high-temperature thermal solar reactor to create syngas. The feedstock is essentially unlimited, providing a potentially game-changing alternative to fossil fuels.
Cognitive psychologists found that people can accurately estimate both mean size and number of objects in separate tasks, suggesting two independent processes. This discovery can inform new approaches to statistical data visualization and education.
Anita Mattson's research focuses on naturally occurring molecules known as dimeric chromanones, which have high biological activity and may become powerful dual-action treatments for drug-resistant cancers. Her goal is to develop a new class of catalysts using silanediols to control the synthesis of these compounds.
Scientists have identified a common plasma wave as the cause of high-energy electron loss into Earth's atmosphere. Whistler mode chorus waves are created by fluctuating electric and magnetic fields, efficiently accelerating electrons. The findings provide an important piece of the puzzle to understand space weather predictions.
A new study of chimpanzee brain scans reveals a unique human brain structure, with the left hemisphere longer than the right. This asymmetry may hold the key to understanding how humans developed language ability.
The United Nations report emphasizes the need for mining companies to prioritize safety over economic considerations in managing mine waste. The report's recommendations include improving tailings dam government regulation and exploring alternative solutions to building massive dams that can cause devastating environmental damage.
A new Northwestern Medicine clinical trial found that stem cell therapy did not improve walking ability in people with peripheral artery disease, despite exercise showing significant improvements. The study led by Dr. Mary McDermott demonstrated that regular exercise can increase six-minute walking distance in patients with PAD.
African-American women with type 2 diabetes are disproportionately affected by ER-negative breast cancers. The study found a statistically significant association between type 2 diabetes and increased risk of ER-negative breast cancer in black women, particularly those with lower BMI.
A Phase I/II clinical trial found that cardiac progenitor cell infusions improved heart function and arm strength in patients with Duchenne muscular dystrophy. The study showed a 7% reduction in heart scar tissue and improved skeletal muscle function in the hands and forearms of patients who received the treatment.
Researchers are developing abuse-deterrent opioids with special coatings or infusions to make them harder to misuse, but at a higher cost. Novel painkillers and powerful opioid detectors are also being developed to help combat the crisis.
A randomized controlled trial found that text message reminders increased vaccine uptake among eligible patients, with the greatest effect seen in children under five years old. The study suggests cost-efficient strategies to improve vaccine uptake, particularly for vulnerable populations.
Researchers at LMU München precisely tune carbon dot's properties by introducing nitrogen atoms, enabling diverse applications. The study reveals that the physicochemical characteristics can be simply and precisely controlled, opening up new possibilities for energy conversion and bio-imaging.
A new data mining approach has identified the key publications that drove the development of five major anti-cancer drugs, revealing the importance of research collaboration, grants, and publications in breakthroughs. The study's findings have implications for research institutions planning collaborative efforts.
The UC Davis Department of Pediatrics has received a $2 million grant to fund a new telemedicine program for children in remote communities. The program will provide physiatry care for kids with cerebral palsy, spina bifida, and other disabilities, improving quality of life and preventing complications.
The Swedish government is investing SEK 1 billion in a research program to develop a superconducting quantum computer with greater computing power than current supercomputers. The goal is to create a functioning quantum computer with at least 100 qubits, enabling it to solve complex problems in fields like optimization, machine learnin...
Researchers found that FAIMS technology can effectively differentiate between pancreatic cancer patients and healthy individuals, with a sensitivity and specificity of 85% and 75%, respectively. The test is non-invasive, affordable, and can analyze up to 20 urine samples per hour.
A new study suggests that parents who smoke mistakenly rely on their own physical senses to gauge the presence of tobacco smoke in the air, leading to misconceptions about when and where children are exposed. This lack of awareness can result in inadequate measures being taken to protect children from secondhand smoke.
Research from MD Anderson Cancer Center finds improved adherence to surgical treatment guidelines, but chemotherapy guideline adherence remains largely unchanged. Informed patient-physician discussions are crucial for better survival outcomes and quality care.
A study published in the Journal of Wildlife Diseases found that minimizing rehabilitation time, treating diseases early, and controlling mosquitos can significantly improve African penguin survival rates. The researchers also identified body mass and hematologic parameters as important criteria for initial assessment and treatment.
A new study has identified six attributes associated with high-value primary care practices, including decision support for evidence-based medicine and careful selection of specialists. These attributes are linked to three themes: care traffic control, cognitive burden reduction, and value-based reimbursement.
A new approach, pharmacoscopy, has shown promising results in treating relapsed blood cancer. In the first clinical trial, 88.2% of patients achieved partial or complete remission with personalized therapies guided by pharmacoscopy.
Researchers at UC Davis have created a method to produce all 34 proteins required for mRNA translation in the correct proportions within a single mixed culture. This breakthrough enables rapid and high-purity reconstitution of cellular reactions, making it useful for various applications such as disease diagnosis and drug development.
Researchers at St. Michael's Hospital found that more than 80% of sudden cardiac arrests in competitive sports couldn't be predicted by screening programs. Only three out of 16 cases were caused by identifiable conditions, and these were not common enough to warrant widespread screening.
A new model proposes returning control over human life data to patients, accelerating biomedical research through a secure and transparent distributed personal data marketplace utilizing blockchain and deep learning technologies. This approach can resolve challenges faced by regulators and improve patient satisfaction.
Research at Weizmann Institute of Science uncovers mechanisms driving storms toward the poles. Mid-latitude storms steer further poleward in a warmer climate due to vertical structure and circulation near the tops of these weather systems.
A new alternative to sedation for children undergoing radiation therapy has been developed using behavior analysis training, allowing them to stay mostly motionless during treatment. The 'PROMISE' project is testing this method on healthy children under age 10 in a child-friendly laboratory.
A study by BMJ Group reveals nearly 120,000 excess deaths in England due to spending cuts on health and social care. The majority of these deaths occurred among the over-60s and care home residents.
Researchers at KIT have developed innovative fluorescent 3D structures to improve counterfeit protection in products like bank notes, pharmaceuticals, and car spare parts. These new security features can be easily integrated into various applications to prevent product piracy and counterfeiting.
A study found that a high-salt diet shrinks beneficial gut bacteria, leading to pro-inflammatory immune cells and high blood pressure. Probiotics can reverse these effects in mice and humans, suggesting potential therapeutic target for treating high blood pressure.
The 2017 AAAS Kavli Science Journalism Awards honored distinguished reporting on topics such as antibiotic-resistant infections, superbugs, and climate change. The winners included a Reuters team for their investigation into uncounted deaths from superbug infections.
A new transcatheter implant has been shown to be safe and effective in treating diastolic heart failure by reducing blood backup in the lungs. The device, a dime-size interatrial shunt, diverted blood flow from high-pressure chambers to low-pressure ones, improving pulmonary capillary wedge pressure readings.
A University of Stirling study found that single men are significantly less likely to take part in bowel screening tests compared to those living with a partner. The participation rate for men living alone was 57.6%, lower than the 77.8% of women living alone who took the test.
Researchers have developed an 'ionic analog to the electronic pn-junction solar cell' that harnesses light to generate ionic electricity, with potential applications in desalination and brain-machine interfaces. The technology shows promise for producing electricity to turn brackish water drinkable upon exposure to sunlight.
A team of researchers has created a process to transform residual toner powder from discarded printer cartridges into iron, offering an environmentally friendly way to reuse electronic waste. The method involves heating the toner powder to 1550 °C, resulting in a product with 98% pure iron.
The American Thoracic Society editorial emphasizes the need for effective tobacco control measures, citing the court-ordered publication of corrective statements by major US tobacco companies. The statements acknowledge the addictive nature of nicotine and the lethal effects of smoking on human health.
Research published in the Journal of Epidemiology & Community Health found that heavy drinking and smoking are associated with visible signs of physical ageing. Light to moderate drinking was not linked to biological ageing or slowing down the visible ageing process.
A new study from University College London suggests that machine learning can improve clinical trials by analyzing complex brain anatomy and detecting subtle changes in drug effects. The research used large-scale data from patients with stroke to test the concept of machine learning capable of modeling the human brain in its full compl...
Researchers found that porous types of wood can greatly increase the efficiency of water-to-steam conversion under sunlight. The findings could be used in a simple and inexpensive biodegradable device for water purification.
Researchers tracked North Atlantic right whales using passive acoustic monitoring, finding they use nearly the entire eastern seaboard during winter and move around more than thought. The study revealed changes in their time spent in some areas and confirmed their presence along the East Coast year-round.
A Polish Academy of Sciences team has developed a polymer 'love hormone' sensor that can detect micromolar concentrations of oxytocin, a biomarker associated with autism. The sensor's sensitivity is expected to increase to nanomolar levels, allowing for early diagnosis and potentially dramatic treatment efficacy improvements.