Researchers at Boston University are developing a novel approach to deliver anti-retrovirals directly to lymphatic tissues to combat HIV replication. This targeted approach aims to improve drug penetration and eradicate virus reservoirs.
The QXDx BCR-ABL %IS Kit uses Droplet Digital PCR technology to detect deep molecular response values with high reproducibility and precision. This allows for more confident disease management decisions in patients with chronic myeloid leukemia.
Hybrid experimental platforms combine microscopes and software to interface living cells with control algorithms in real-time. Researchers can create new and easily reconfigurable cellular behaviors using external control of living tissue.
The Ontario Institute for Cancer Research has launched the Cancer Therapeutics Innovation Pipeline to translate new discoveries into cancer therapies. The pipeline selected 10 projects for funding and will provide guidance from industry and academia experts.
Researchers have identified 6,000 families of genes exclusive to mammals, which play a crucial role in defining their unique characteristics. These genes are involved in the structure of skin, mammary glands, and defense against pathogens.
Researchers develop targeted delivery vehicles for multiple sclerosis drugs using extracellular vesicles, offering a potential treatment breakthrough. The new method uses naturally occurring vesicles to deliver small molecules of RNA that boost myelin production in oligodendrocytes.
Recent observations of four colliding galaxies in the Abell 3827 cluster suggest that SIMPs, strongly interacting massive particles, may be a new candidate for the universe's elusive dark matter. SIMPs would interact strongly with themselves via gravity but weakly with normal matter, overcoming a major failing of WIMP theory.
Tropical Depression Dahlia's center was found to be devoid of rainfall by NASA's Global Precipitation Measurement mission. The storm was weakening and moving south at 10 knots, with cooler sea surface temperatures and wind shear expected to lead to its dissipation.
Researchers found that captive gorillas can learn to clean food without witnessing others do it first. In 75% of trials, gorillas demonstrated food cleaning techniques when given dirty apples coated with sand.
A recent study found that California's urban forest canopy cover per capita is the lowest in the US, despite providing significant ecosystem services valued at $8.3 billion annually. The state's arid climate and high population density may contribute to this result.
A national survey of physicians found that those with a social network member with poor breast cancer prognosis are more likely to recommend routine mammograms for younger and older patients. This suggests the need for better understanding the personal experiences that shape clinicians' practices.
A research group at the University of Tokyo has quantified the impacts of three electron-scattering mechanisms on silicon carbide (SiC) power semiconductor devices. The team discovered that suppressing electron scattering can reduce resistance under the SiC interface by two-thirds, which is expected to lower energy consumption in elect...
A research team has quantified blind spots in protein function, revealing that 30% of proteins with unknown functions are enzymes. This discovery has significant implications for understanding rare genetic diseases and could lead to a better insight into the onset and triggers of inherited metabolic diseases.
Researchers at Kanazawa University developed a novel carboxylate-type liquid zwitterion that can dissolve biomass cellulose with low toxicity to microorganisms. This innovation enables efficient ethanol production without washing or separation processes, reducing energy input and increasing energy efficiency.
A new study identifies a handful of regional allergen molecules that predict the onset and persistence of respiratory allergic diseases. The findings suggest a potential for developing individualized risk prediction charts and could accelerate preventive strategies and novel treatments.
A research group at Osaka University has identified key molecules involved in severe malaria. The study found that RIFIN proteins expressed on infected erythrocytes suppress the host immune response by binding to an inhibitory receptor, contributing to the pathogenesis of severe malaria.
A recent study by the University of Kent has identified Myosin VI as a key protein involved in the production of specific genes linked to breast cancer cell growth. This discovery may lead to new diagnostic clues and therapeutic targets for patients with oestrogen-sensitive breast cancer.
Research by University of California, Riverside expert Kate Sweeny finds that mindfulness meditation can help individuals cope with waiting for potentially bad news. The study, published in Personality and Social Psychology Bulletin, found that mindfulness reduced the stress associated with waiting, particularly when compared to other ...
Researchers decode interactions between materials and structures in nature-inspired composites like nacre and tooth enamel. The model reveals key factors influencing composite properties and provides insights into designing lightweight, multifunctional structural composites.
Researchers found that new immigrants initially provide little information to help the group but become fully integrated and valued members within five months. They suggest that an integration period is necessary before the benefits of an increased group size can be realized.
Researchers have identified two key locations to protect sea turtles: the waters off eastern Central Florida and the Great Bahama Bank. The study found that females who eat in southern areas tend to have more offspring, highlighting the importance of understanding where they forage.
Researchers found blood pressure declines were steepest in patients with dementia and heart failure, but also occurred without diagnoses. The study highlights the importance of reevaluating treatment for hypertension in older patients.
Researchers developed a point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings. The device, using disposable lateral flow cards, measures total serum bilirubin levels with high accuracy, suggesting a potential solution for resource-limited settings.
The SEA-PHAGES program has been shown to significantly impact students' attitudes towards science, leading to increased persistence and confidence among underrepresented groups. By providing authentic research experiences, the program has been found to be more effective in developing key traits that influence students' intent to persis...
A study of nearly 62,000 hospitalizations found that 17.6% of PAD patients were readmitted within 30 days after revascularization procedures, with complications being the primary cause of readmission for 30% of cases. Strategies to prevent readmissions focus on high-risk patients with PAD and improving post-procedure care.
Researchers found that ERK activity propagates as a wave, guiding cells to migrate in the opposite direction. This mechanism may be used to suppress cancer cell infiltration.
A Yale-led study shows that thyroid hormone therapy significantly resolves fibrosis in the lungs of mice, leading to increased survival. The researchers found that normalizing mitochondria function in epithelial cells protects them from damage and allows resolution of fibrosis.
A new study from Washington State University found that frequent marijuana use can strengthen the relationship between pain and depression and anxiety in patients with opioid addiction. This suggests that marijuana may not be an effective treatment for managing these symptoms.
A new study found that even large physician practices struggle with the new payment system, and those that don't report data face significant financial penalties. The researchers suggest improving infrastructure to support smaller practices and reducing the burden on reporting performance data.
Carnegie Mellon University engineers have developed a high-density EEG system that captures neural activity at a higher spatial resolution than ever before. The new technology has the potential to improve source detection in epilepsy and enhance our understanding of brain function.
Researchers simulated massive collisions after the Moon's formation, finding that moon-sized objects delivered significantly more mass to the young planet. This late accretion period lasted for hundreds of millions of years and had important consequences for the earliest evolution of Earth.
A new study from Columbia University Medical Center suggests that DNA sequencing may offer real clinical value in diagnosing and managing patients with chronic kidney disease. The researchers analyzed 92 adults with kidney disease, yielding a diagnosis in 22 participants, including 13 individuals whose cause of kidney failure was unknown.
A recent study published in Nature Geoscience suggests that natural atmospheric particles can cool the planet and offset some of the temperature rise due to climate change. The research highlights the need for complex interactions to be well-represented in climate models.
Researchers found that patients with heart cell damage (PMI) had six times more likely to die within 30 days compared to those without PMI. The high death rate persisted up to one year after surgery.
A new study finds that while the US consistently provides more funding for development assistance for health than any other country, some high-income European nations have surpassed the US's assistance in per capita and expenditure measurements. The US ranking fifth at $714 contributed to DAH for every $1 million in national income.
A survey of over 6,000 Brazilian teenagers found that parental attention and responsiveness can significantly reduce the risk of drug abuse in adolescence. The study also revealed that well-off students are more likely to engage in binge drinking and polydrug use.
A new treatment aims to direct an immune response against a misshapen protein found exclusively on cancer cells, offering hope for children with deadly diffuse intrinsic pontine glioma. The protein target is a neoantigen that can be used to develop more selective and potent immunotherapies.
A Michigan State University researcher has received three grants totaling $2.7 million to study how reforms to institutional policies, practices, and teaching can be leveraged to help undergraduates succeed in science, technology, engineering, and mathematics. The project aims to explore how universities improve STEM education when the...
Researchers at the University of Pennsylvania have developed a new dental material that can kill bacteria and resist biofilm growth without harming surrounding tissue. The material is effective with minimal toxicity and can withstand severe mechanical stress.
Researchers at UC Berkeley have developed a robotic learning technology called visual foresight, enabling robots to predict and manipulate objects they've never seen before. This breakthrough allows for autonomous learning of complex skills without human supervision or prior knowledge.
Melt drainage through percolation continues even with low melt fractions, suggesting all but 1-2% of melt can be drained. This process enables planetesimal core formation.
A new study found that under 5% of those referred for opioid treatment from the criminal justice system were directed to medication-assisted programs, while 40% of clients referred by other sources attended these programs. This referral gap highlights a missed opportunity for effective treatment among at-risk groups.
A team of scientists used computer simulations based on recent observations to determine the radius of neutron stars. The calculations suggest a minimum radius of 10.7 km for these dense objects.
Researchers at Rice University have refined a method to train robots to collaborate with humans through gentle physical feedback. The approach allows robots to adjust their trajectory in real-time and learn from human interaction, enabling more efficient and effective collaboration.
A new tool, QuoCo, tracks cognitive performance in adults, allowing physicians to identify potential Alzheimer's patients. The tool uses age, education, and Mini-Mental State Examination scores to plot cognitive performance over time.
Scientists have discovered a mass emergence of rare mantis-flies in an Australian macadamia orchard, capturing the first-ever images and videos of their larval stage. The larvae feed on unknown prey, prompting further research to uncover their diet.
The study found that the number of women using modern methods increased by 28.8 million between 2012 and 2017, but progress varies widely across countries. Countries like Kenya, Mozambique, and Malawi made rapid strides in increasing modern contraceptive use, exceeding pre-FP2020 expectations.
Chinese physicists manipulate heat transfer to reduce waste and create invisible thermal cloaks. Their experimental results confirm equations predicting thermal conductivity of periodic materials.
Peregrine falcons use proportional navigation guidance similar to guided missiles, which could be applied to small drones. This method relies on line-of-sight information and doesn't require target speed or distance data. The research may also provide insights into pursuit behaviors of other predatory species.
Researchers found that leftover cancer cell debris can stimulate tumor growth, but resolvins can block this response. The study suggests a new approach to enhance cancer therapy and prevent recurrence.
A study by UMMS researchers has identified a protein called GDF6 as a primary role in metastatic melanoma, found to be expressed in 80% of human melanomas and correlated with increased melanoma growth and spread. The findings offer new therapeutic potential for treatment-resistant skin cancer.
Researchers have developed an inactivated Zika purified virus (ZPIV) vaccine that induced an immune response in participants and was well-tolerated, according to Phase 1 clinical trial results.
Cedars-Sinai finds that pharmacy staff taking medication histories reduces errors in both patient records and medication orders by over 80%. Pharmacy staff are now assigned to take medication histories for high-risk patients admitted through the Emergency Department.
New research from the University of Bristol demonstrates that cells use F-actin to reshape their nucleus and reorganise their genome after cell division. This process is essential for life, but was poorly understood until now.
A clinical study validated the effectiveness of NEST360°'s low-cost jaundice detector, BiliSpec, which accurately diagnoses bilirubin levels with comparable accuracy to expensive laboratory tests. The device's affordability could bring testing for jaundice within reach for cash-strapped hospitals in sub-Saharan Africa.
Over 5,000 heart transplants annually worldwide, with significant improvements in immunosuppression and donor sourcing. The 50th anniversary celebrates pioneers like Christiaan Barnard and Norman Shumway.
Researchers created an animal model that closely replicates the human form of Alzheimer's disease, including pathological tau protein and amyloid plaques. This breakthrough allows for testing of new therapies targeting both pathologies.
A rapid diagnostic test has been developed to detect iron and vitamin A micronutrient deficiencies, providing results in under 15 minutes. The test achieved high sensitivity and specificity for both conditions, making it a valuable tool for healthcare professionals.
Researchers found that adults who experienced high stress in childhood have difficulty attending to cues that indicate a potential loss or punishment, leading to poor decision-making. This biological response may be linked to an underactive brain region responsible for processing risk and reward.
Researchers found that pigeons process space and time in ways similar to humans and other primates, using a common neural coding mechanism. This suggests that abstract concepts are not processed separately and that lower-order animal species can exhibit high-level decision-making abilities.