Researchers developed a computer machine-learning model that accurately predicts which AML patients will go into remission following treatment. The model was trained using bone marrow data and medical histories of AML patients, achieving 100% accurate predictions for remission and 90% accurate predictions for relapse.
A UCLA-led team of scientists has discovered a white dwarf star with an atmosphere rich in carbon, nitrogen, oxygen, and hydrogen, the components of water. The study suggests that the planetary system associated with the white dwarf contains materials necessary for life.
Researchers from the University of Maryland have developed a blood test that can help doctors diagnose schizophrenia more quickly. The test measures oxidative stress in blood samples, which may be linked to the disorder and its treatment response.
A new supplemental issue of The Gerontologist presents the findings of the largest national survey on LGBT older adults' health and well-being. Findings show that LGBT older adults face higher rates of disability, cardiovascular disease, depression, and social isolation.
A new research framework developed by the University of Queensland aims to identify and track ecosystem services at risk due to growing human demand. The framework allows for analysis of supply and demand, natural system condition, and future demand changes, providing a basis for global assessments.
Researchers conclude that warming climate causes gas hydrate breakdown, but emissions are small and mostly remain in undersea sediments. The study challenges the popular perception of catastrophic methane releases from hydrates.
African penguins are getting stuck in the wrong part of the sea due to fishing and climate change, leading to reduced food supply and higher mortality rates. Researchers suggest that translocating chicks to safe areas or implementing spatial fishing closures could help protect the endangered species.
Researchers found that bacteria can quickly adapt to antibiotic treatments by evolving dormancy mechanisms. Once tolerant, they rapidly acquire resistance mutations, making it difficult for antibiotics to kill them. This discovery has important implications for the development of new antibiotics.
A decline in automobile travel from 2003-2014 showed a significant reduction in car crash deaths, particularly among young men. Physical activity levels remained unchanged during this period.
A new study reveals gills originated earlier than thought, suggesting a link between active lifestyle and evolutionary history. Gills develop from the same embryonic tissue in jawed and jawless vertebrates, supporting a single origin of these respiratory organs.
Researchers have developed a new method of genetic engineering that creates artificial restriction enzymes with enhanced sequence specificity and defined sticky ends. This technology has the potential to revolutionize genomic research and gene editing by improving precision and reducing obstacles posed by existing restriction enzymes.
A computational model of emphysema has been developed to compare novel and traditional treatments, showing that mechanical forces play a critical role in disease progression. The study suggests that newer lung volume reduction techniques can achieve comparable outcomes as current surgical approaches.
Scientists developed a generative neural network to create new pharmaceutical medicines with specific properties. The network, trained on millions of molecular structures, identified 69 potential anticancer compounds and hundreds more using a powerful extension of the method.
A new ultra-low dose four-in-one pill has shown remarkable results in treating high blood pressure, with all patients experiencing significant drops in blood levels within 4 weeks. Researchers also found no side effects associated with the treatment, which could be a game-changer for patients worldwide.
Researchers identify factors determining when containment or aggressive treatment is best, providing new guidance for physicians and patients. Containment strategies can prolong treatment life and improve outcomes in certain situations.
The new method can pinpoint kidney damage in under three-quarters of an hour, using blood/urine with the help of fumarase. Researchers expect the method to be transferable to patients soon, and are currently testing it on patient blood samples.
A new study from Tufts University reveals that honey bees fine-tune their nutrient-seeking behavior based on the seasonality of their floral diet. Bees forage for minerals like calcium, magnesium, and potassium in water sources that reflect what's lacking in their pollen-based diet.
Researchers develop new method to analyze shale samples using NMR and molecular dynamics simulations, helping determine hydrocarbon presence and extraction difficulty. The approach improves identification of gas, oil, and water in organic shales.
A new MBL study has shed light on the origin of vertebrate gills, indicating they evolved around 600 million years ago. The research corrects a long-held misunderstanding that gills developed separately and independently in two vertebrate lineages.
Researchers at Lund University discovered that malaria mosquitos are sensitive to horseradish, similar to the effects of heat on vertebrates. This finding suggests a shared molecular mechanism underlying temperature sensing in insects and animals.
Two research papers use OMG observations to document how meltwater and ocean currents interact along Greenland's west coast, improving seafloor maps used to predict future melting and sea level rise. The study also reveals the role of meltwater in cooling warmer subsurface water and tracking its impact on glacier melt rates.
A team of researchers at Johns Hopkins Medicine has identified a crucial enzyme, RAG-2, that enables precise DNA rearrangement during white blood cell development. This process is essential for producing novel antibodies that recognize and combat viruses and bacteria.
Researchers discovered that an algorithm called additive increase, multiplicative decrease (AIMD) is used both in engineered systems like the Internet and biological networks like the human brain. This finding sheds light on how the brain manages information and potentially helps understand learning disabilities.
A recent study published in Immunity reveals how killer cells coordinate with dendritic cells to create an army of immune cells. The research, conducted by the University of Bonn, found that killer cells form a team and trigger chemical signals to recruit other cell types, leading to a coordinated and strong immune response.
A novel microfluidic device models human kidney function, exhibiting more natural cell behaviors than traditional culturing methods. The device's glomerular filtration system is crucial for healthy cell function and accurately predicting renal drug toxicity in humans.
Researchers found that combining a kinase inhibitor and an oncolytic herpes virus results in significantly increased antitumor efficacy against MPNST and neuroblastoma. The study suggests that this combination could lead to improved treatment options for patients with these rare cancers.
Researchers at UCSB discovered a way to confer electricity-generating ability on non-electrogenic bacteria by feeding them synthetic iron-containing molecules. This technique has potential applications for sustainable electricity generation and wastewater treatment.
Researchers at Princeton University have developed a new terahertz chip technology that can generate and capture intricate details of terahertz waves. The system uses tiny devices inside the microchip to read patterns created by the waves, enabling potential applications in medical imaging, communications, and drug development.
A researcher argues that permitting some individuals to continue self-injuring in mental health units can be a more respectful and less harmful approach than traditional methods. This harm reduction strategy aims to reduce the risk of serious injury while acknowledging the individual's autonomy.
New research uncovers a connection between Crohn's disease and spondyloarthritis, finding that IgA-coated E. coli bacteria trigger inflammation in Th17 cells. This discovery may lead to the development of diagnostic tools and therapies targeting both conditions.
Researchers at Tokyo Institute of Technology create porous protein crystals with increased porosity, allowing for the accumulation and storage of exogenous molecules in living cells. The engineered crystals showed high stability and ability to retain fluorescent dyes in live cells.
Researchers found that high cortisol levels in hair samples tracked closely with standard diagnostic techniques for Cushing Syndrome. The study's findings suggest that hair analysis may prove useful as a less-invasive screening test or confirmatory tool for the condition.
Researchers at Boston Children's Hospital have identified a new cause of brain defects in tuberous sclerosis complex (TSC) patients. The study reveals that a protein called connective tissue growth factor (CTGF) impedes oligodendrocyte development and myelination in the brains of TSC patients.
Chemists have developed a new technique called redox activated chemical tagging (ReACT) that selectively links chemicals to proteins. This method could transform the way drugs are developed, proteins are probed, and molecules are tracked and imaged.
Physicists at University of Bonn create method to quickly and precisely sort large numbers of atoms, pushing development of future quantum computers forward. The technique allows atoms to interact with each other in targeted manner to exploit quantum-mechanical effects for calculations.
Patients with primary non-English language fluency face disparities in completing kidney transplant evaluations, ultimately affecting their access to a transplant. Researchers found that linguistically isolated households were linked to lower likelihoods of transitioning to active waitlist status and incomplete evaluations.
A study by University of California San Francisco researchers found that installing a bedside interpreter-phone system improved understanding of healthcare procedures among patients with limited English. The system reduced errors and disparities in care, especially for Chinese- and Spanish-speaking patients.
The Reference Catalog of Galaxy SEDs (RCSED) contains value-added information about 800,000 galaxies, derived from the elaborated data analysis. The catalog presents properties such as stellar composition, brightness at various wavelengths, and galaxy spectra obtained by the Sloan Digital Sky Survey.
A large-scale study detected high levels of antibiotic resistance genes in estuaries along China's coastline, with some samples containing up to 100 million genes per gram of sediment. The study suggests that human activity, particularly inadequate wastewater treatment, is the primary cause of this environmental pollution.
Researchers have developed a direct radiolabeling method for nanomaterials using nanographene, eliminating the need for chelators. This approach significantly improves bioimaging accuracy and reduces biases. The method was tested in mice models and showed promising results.
A recent study found that antibiotic use among travelers increases the risk of contracting antibiotic-resistant ESBL intestinal bacteria. In fact, up to 80% of those taking antibiotics brought the most resistant strains back home with them. The use of antibiotics while traveling selects for the broadest spectrum of resistance.
A new study analyzing ancient horse fossils reveals that patterns of migration and environmental changes are key drivers of evolutionary development. Contrary to the rapid phenotypic evolution theory, researchers found no significant difference in body size evolution between lineages with high and low speciation rates, suggesting that ...
Researchers used time-reversed convection modeling to reconstruct ancient mantle structure, finding a second upwelling contributing to the Deccan Traps eruption. A currently active hotspot, Réunion, was also active 65 million years ago.
Scientists are investigating how increased cell death from high blood pressure leads to inflammation and further increases blood pressure. They aim to identify targets that could block unintended results without suppressing the natural immune response.
Researchers at Harvard have developed a new flow battery that stores energy in organic molecules dissolved in neutral pH water. The battery loses only one percent of its capacity per 1000 cycles, making it long-lasting and cost-effective.
Tropical Cyclone Carlos was detected by NASA's Terra satellite as it moved south of La Reunion Island. The storm showed a tight circle of thunderstorms around its center and maximum sustained winds of 63.2 mph (102 kph). Further intensification is expected over the next 24 hours before weakening due to vertical wind shear
The team estimated the solar nebula's lifetime using ancient meteorites that formed 4.653 billion years ago, suggesting it disappeared within the first 4 million years of the solar system's formation. The findings indicate that gas giants Jupiter and Saturn must have formed early in the solar system's history.
Researchers developed hand-held spectrometers using meta-lenses, enabling real-time monitoring of pollutants and toxic chemicals. The devices can be customized and mass-produced, offering significant potential for applications in healthcare diagnostics and environmental monitoring.
Scientists have developed a new system to aid identification of potential drug targets and treatments for human papillomavirus (HPV) infection. The system uses genetic engineering techniques to quickly test the effects of chemicals on viral growth, identifying compounds that can block HPV replication.
A 24-patient outbreak was halted after identifying docusate as the underlying source of the bacteria, leading to a national recall. The investigation improved infection prevention practices for patients.
A team of biomedical scientists has identified a molecule that targets the EphA4 receptor, a gene associated with rapid ALS progression. The research aims to delay motor neuron death and explore potential applications in spinal cord injury, Alzheimer's disease, and some cancers.
Researchers at Mount Sinai Health System have developed an algorithm that predicts bone marrow transplant patients' risk of developing graft-versus-host disease. The 'MAGIC algorithm' uses two proteins in blood samples to determine a patient's risk, allowing for early intervention and potentially saving lives.
A newly discovered beetle species, Nymphister kronaueri, has been found to hitch a ride on the back of army ants as a means of transportation. The beetle uses its strong mandibles to anchor itself tightly to the ant's body, mimicking the shape and appearance of the ant's abdomen.
Researchers at Uppsala and Umeå University found that the molecular composition of sediment organic matter controls methylmercury formation. Organic compounds from phytoplankton are linked to high mercury methylation rates, while carbon compounds from the watershed do not have this effect.
A new mobile Critical Care Recovery Program aims to bring post-ICU care to patients in their homes, improving brain health and reducing rehospitalization rates. The 12-month program will be followed by a multi-disciplinary team to develop personalized recovery plans.
A $2 million Gates Foundation grant will support the development of novel test protocols to accelerate the creation and deployment of next-generation vector control products. The project aims to improve the understanding of vector control approaches and produce better-informed products to combat malaria in Africa.
A new mathematical analysis provides guidance for treating infections and tumors with drug resistance, suggesting that containment may extend effective life and improve patient outcomes in some cases. The study identifies two main factors influencing the choice between containment and aggressive treatment.
Researchers developed a scalable metamaterial film that efficiently reflects solar energy while allowing objects to shed heat through infrared thermal radiation. The material has been successfully tested in field trials, demonstrating significant radiative cooling powers even under direct sunlight with zero energy consumption.
Scientists have confirmed novel theoretical work on Mott insulators, revealing a unique form of magnetism that arises when these materials are cooled below a critical temperature. This discovery helps to shed light on the complex interactions between electrons in these materials, which are crucial for developing new electronic devices.
A study by academics at the University of East Anglia suggests that insights from behavioral science can help design road signs to encourage drivers to switch off their engines while waiting at railway crossings. Researchers found that simple visual and written cues doubled the rate of people turning off their engines, with a more effe...