Research from Umeå University found that women have a statistically significant lower incidence of severe psoriasis compared to men. Women with psoriasis had significantly lower median PASI values, indicating less severe disease.
Researchers at UNC are developing an injectable drug delivery system that forms a long-lasting implant to steadily release anti-HIV medication. The goal is to provide durable, sustained protection from HIV transmission while improving adherence and allowing for easy removal.
The Hierarchical Taxonomy of Psychopathology (HiTOP) proposes viewing mental health as a spectrum, rather than categorizing it. This system simplifies diagnosis by recognizing that most patients have co-occurring disorders and classifying psychopathology at multiple levels of hierarchy.
Researchers at Washington University in St. Louis have discovered that astroglia, or astrocytes, help set the pace of the suprachiasmatic nuclei to schedule a mouse's day. Altering astrocyte clocks slowed mice's sense of time, highlighting their influence on daily behavior and physiological processes.
Researchers at Emory University are studying the 3q29 deletion syndrome, a genetic mutation associated with a 40-fold increased risk for schizophrenia. They will create a neuronal model of the syndrome using induced pluripotent stem cells and integrate their research with other targets identified in genetic studies.
A special issue of the Journal of General Internal Medicine reviews primary care innovation and suggests new models that prioritize population health and cost control. Experts highlight the importance of preserving trusting relationships between patients and primary care physicians to achieve better outcomes.
A new study published in Scientific Reports found that survivors of childhood brain tumors have more fat tissue overall, especially around the abdomen, compared to healthy children. This increased body fat may program their future risk of cardiovascular disease and Type 2 diabetes, impacting their outcomes.
Tropical cyclone Caleb formed on March 23 with heaviest precipitation near its western side, dropping rain at nearly 84 mm/h. The system will slow and weaken due to increasing wind shear and cooler sea surface temperatures over the next 3 days.
Researchers found that specific brain scan patterns can identify which treatment is most effective for individual patients with depression. Patients with positive connectivity in certain brain regions were more likely to achieve remission with cognitive behavioral therapy, while those with negative connectivity were more likely to resp...
A new study found that certain bacterial species and fungal families are present in both land-based sources and coral reefs, suggesting invasion. The researchers used high-throughput DNA sequencing to analyze water samples from coastal inlets, sewage treatment plants, and coral tissues.
New technologies enable basic scientists to build upon clinical genomicist work, promoting a virtuous cycle of bench-to-bedside collaboration. The researchers' recommendations prioritize data sharing, clinically relevant genes, and better data-management practices.
Researchers at Fraunhofer Institute develop a prototype lab-on-a-chip platform for automating molecular pathogen detection, enabling diagnostics in previously inaccessible situations. The platform integrates multiple processes without increasing complexity, promising to simplify pathogen analysis.
Capillaries in the brain's wire-like network can sense activity and generate signals to direct blood flow and deliver nutrients to neurons. This mechanism enables precise control over cerebrovascular blood flow to meet the brain's changing energy needs.
Chinese scientists have developed a fluorogenic probe, CVB-1, to detect the activity of multidrug-resistant carbapenemases in an assay system. This technique allows for rapid detection of antibiotic resistance activity by fluorescence, enabling specific treatment strategies and reducing the overuse of ineffective drugs.
A study published in ACS Chemical Neuroscience confirms that lorcaserin decreases the urge to use opiates like oxycodone, reducing use and craving. The researchers found that lorcaserin alters serotonin signaling to reduce cue reactivity associated with opiate use.
Declining plant diversity shifts flowering phenology at the same magnitude as global warming, according to a new study. This finding highlights the critical role of biotic interactions in understanding ecosystem changes and the impact on plant reproduction.
Researchers discovered that virus surface proteins can be used to improve vaccine purification by understanding their hydrophobic properties. By analyzing the protein structures and interactions with other surfaces, scientists hope to develop more efficient methods for detecting and concentrating viruses.
A team of chemists from Konstanz University has made a significant discovery about the effects of selective mutations on the alpha-synuclein protein. By applying magnetic probes to the protein, they found that these changes disturb the binding of alpha-synuclein to membranes.
Researchers at Karlsruhe Institute of Technology developed a method to predict protein structures using statistical analyses. This approach allows for the prediction of even complex protein structures without experimental determination, potentially leading to new treatments for diseases like Alzheimer's.
High-intensity physical activity for as little as 10 minutes a day may benefit young people with large waist measurements and elevated insulin levels. The study found that vigorous exercise was associated with reduced waist circumference and insulin levels, but had inconsistent effects on other biomarkers.
Robert J. Gatchel, a renowned University of Texas at Arlington psychologist, has been awarded the American Psychological Foundation's 2017 Gold Medal Award for Life Achievement in the Application of Psychology. He was recognized for his groundbreaking work on chronic pain behavior and its treatment.
A new supplement published in Neurosurgery highlights the need for neurosurgeons to evolve their practices to thrive in an evolving environment. Dr. Dong H. Kim's recommendations focus on improving patient satisfaction, reducing costs, and enhancing quality outcomes through quality improvement initiatives and innovative approaches.
Researchers from the University of Edinburgh found that disease spread varies depending on age at exposure and maternal age. Younger offspring were more susceptible to infection when mothers were younger, contradicting expectations that disease spreads in dense populations.
The common periwinkle has evolved a unique strategy for detoxifying heavy metals, featuring a three-domain metallothionein with increased binding capacity. This adaptation enables the snail to thrive in polluted environments.
A new EU report highlights knowledge gaps in reducing risks linked to space weather and recommends policy, industry, and science collaborations to close these gaps. The report also emphasizes the need for early warning systems and better communication between science and industry.
A new gene variant has been identified in the PTPRD gene that is associated with the accumulation of neurofibrillary tangles (NFTs) in the brain. The study found that this variant affects more than one mechanism of tangle accumulation and may be a key target for developing therapies targeting Tau pathology.
A low-pressure system is consolidating and strengthening in the Coral Sea, South Pacific Ocean, with sustained winds near its center. The Australian Bureau of Meteorology expects conditions to favor intensification as it approaches the north Queensland coast.
Scientists have identified a brown dwarf with a composition of over 99.99% hydrogen and helium, making it the most massive known to date. The discovery sheds light on the possibility of an undiscovered population of extremely pure brown dwarfs in our galaxy's ancient past.
Researchers at Brigham and Women's Hospital have discovered a new genetic variant linked to Tau pathology in Alzheimer's disease. The study, published in Molecular Psychiatry, highlights the potential for targeting the protein tyrosine phosphatase receptor-type delta (PTPRD) gene as a therapeutic strategy.
A new species of bird, Eoconfuciusornis, has been found with exceptionally preserved soft tissues, including feathers, skin, and collagen. The discovery provides valuable insights into the evolution of flight in birds, revealing unique features such as wing patagia and plumage patterns.
A systematic review found moderate evidence that duloxetine and venlaxine were effective in reducing neuropathy-related pain, while pregabalin and oxcarbazepine showed weak evidence. However, gabapentin was not more effective than placebo.
A University of Texas at Arlington biologist is conducting a novel study to quantify how susceptible coral species are to disease by examining their immunity. The research aims to determine the variability of coral immune traits and develop a predictive model to inform reef community structure.
Physicists use a new measurement technique to observe Alice winning and losing a quantum race simultaneously, verifying superposition. This breakthrough opens up new areas for study in quantum mechanics, including the role of causal relations.
Research highlights the importance of social context, including policies, peer groups, and family relationships, in developing ethnic/racial identity among youth. Studies show that strong familial and religious identities can lead to better well-being, while peer group support can enhance cultural identity.
A new approach using a combination of silver, titanium oxide and hydroxyapatite nanocoatings successfully inhibited bacterial growth on dental implants by 97.5%, reducing the risk of peri-implantitis. The findings have great potential for increased patient comfort and satisfaction, as well as reduced costs.
The OSIRIS-REx mission successfully tested its asteroid search instruments, detecting multiple Main Belt asteroids two magnitudes fainter than expected. The spacecraft's MapCam imager performed flawlessly, demonstrating improved imaging capabilities that will aid in avoiding natural satellites around target asteroid Bennu.
A University of Colorado Cancer Center study found that knocking down the Jumonji protein KDM3A inhibits Ewing's Sarcoma metastasis. The researchers also discovered another protein, Melanoma Cell Adhesion Molecule (MCAM), plays a crucial role in the cancer's spread.
Bismuth salts are used as efficient catalysts in organic and medicinal chemistry. Microwave irradiation enhances their catalytic power, allowing for rapid synthesis of medicinally active compounds such as hormones and anticancer drugs. The method is expedited and environmentally friendly.
Researchers analyzed genetic profiles of nearly 13,000 ALS/MND cases and over 30,000 schizophrenia cases, confirming that many associated genes are the same. The study reveals a 14% overlap in genetic susceptibility between the two conditions.
A new study found that stem cell therapy reduces lung inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The treatment also improves lung structure, suggesting it may repair damaged lungs.
A study published in Briefings in Functional Genomics investigates the role of epigenetics in cancer development, showing that disruptions can activate oncogenes or shut down tumor suppressors. The paper also highlights the link between epigenetic changes and metabolites, which can target and amplify gene expression.
Researchers found that over 60% of BRCA tests performed on unaffected women have increased since 2004, mainly driven by marketing efforts. However, study findings suggest that this trend may not lead to better diagnosis of those at risk, as many women without harmful mutations are still being tested.
Liquid crystals used for food coloring may have uses beyond food dyes, exhibiting unexpected characteristics that can be harnessed for sensors and other applications. The material responds dramatically to temperature, concentration, and pattern changes.