A yearlong program for adolescent refugee girls in Sub-Saharan Africa successfully promoted healthy transitions to adulthood, reducing reports of sexual and physical violence. The COMPASS program taught life skills geared to build girls' knowledge of violence risk factors and empower them to advocate for their rights and physical safety.
Researchers developed an AI Clinician system that predicts and recommends optimal treatment strategies for patients with sepsis, showing a higher chance of survival compared to human doctors. The system analyzed 100,000 hospital records and made more reliable treatment decisions than humans.
Researchers from the University of Queensland recreated 450-million-year-old enzymes to accelerate chemical reactions, offering a cheaper alternative to current processes. The ancient enzymes showed improved performance at high temperatures, lasting about 100 times longer than natural enzymes.
A deep neural network trained on annotated radiographs from senior orthopedic surgeons helps reduce misinterpretation of fractures in emergency department clinicians. The system demonstrated the transfer of expertise from specialists to generalist clinicians, leading to improved accuracy.
A team of CU researchers has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. The study found that patients with RA are at risk of developing progressive pulmonary fibrosis, enabling potential interventions to prevent this condition.
A QUT research study reveals that female journalists report more emotional investment and management strategies compared to their male counterparts. Visual journalists often suppress or enhance their emotional displays while dealing with editorial decisions, and only a few participants have access to formal support.
The DOE has funded Argonne's high-efficiency latent heat thermal energy storage system (TESS) for use in building applications and process/manufacturing industries. TESS can store waste heat, reducing costs and increasing energy efficiency, especially during periods of high electricity pricing.
A recent study found that plants with strong defense capabilities against insects exhibit slower growth rates and compromised reproductive success. The research suggests a trade-off between defense and growth in plant biology, where investing more energy in defense reduces resources available for growth and reproduction.
The long-term effects of smoked cannabis on lung health are unclear due to conflicting research findings. The authors emphasize the need for well-designed studies to address pressing gaps in knowledge and resolve lingering myths.
A new protein sequencing method has been developed, enabling the identification of individual protein molecules with high sensitivity and throughput. This advance has the potential to reveal new biomarkers for cancer diagnosis and enhance understanding of healthy cell function.
A randomized controlled trial found that Transcendental Meditation significantly improved emotional intelligence and reduced perceived stress among school district staff. The study's findings have implications for organizations seeking to improve employee well-being and performance.
A systematic review and meta-analysis of non-digital board games found promising results in improving health-related knowledge and behaviors. The study evaluated 21 studies and revealed that board games can be a widely disseminable method for delivering the benefits of games for health.
A new study reveals children as young as 7 experience negative impacts of discrimination, with a strong sense of ethnic-racial identity acting as a protective factor. The research suggests that promoting understanding and belonging to one's ethnic group in early development can help mitigate these effects.
Researchers build a genetic profile for section Nigri of Aspergillus fungi, allowing for comparisons within and across the subgroup. The study reveals thousands of new genes, species-specific gene clusters, and insights into species diversification and evolution.
Researchers found that coral bleaching causes a decrease in aggressive behavior among butterflyfish, suggesting a link between bleaching and population declines. The study suggests that fish adjust their behavior in response to environmental stressors, but these changes may not be sustainable in the long term.
A new immunotherapy combination shows durable clinical benefits in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer, with 60% objective response rate and 84% of patients experiencing tumour shrinkage. The treatment is also well-tolerated, with manageable side effects.
Researchers at Osaka University have discovered a huge novel transport channel and its associated protein transport motor that is essential for chloroplast formation. The motor complex functions as an import motor in a close association with the transport channel, utilizing an ancient enzyme to extract proteins from the membrane.
A phase III study found that immunotherapy with pembrolizumab improves overall survival in patients with recurrent or metastatic head and neck cancer, particularly those expressing PD-L1. The treatment also showed longer response duration and median response duration compared to standard chemotherapy.
A new paper proposes a broadly applicable formal definition of semantic information, which emphasizes how information contributes to a system's ability to perpetuate itself. Semantic info is causal necessary for a system to maintain its existence over time.
The Bureau of Reclamation has allocated $3.9 million for research projects to address water management needs in the western United States. These projects will provide innovative solutions to support water and power facility managers, customers, and stakeholders.
A new study shows that stereotactic ablative radiotherapy (SABR) is as safe and effective for patients with one kidney as it is for those with two. The treatment provided high local control and cancer-specific survival rates, with minimal impact on renal function.
Researchers find increased TC activity at northern sites after 1920, posing a threat to regions currently outside the impact zone. Younger trees are more likely to experience disturbance at high latitudes, supporting a poleward shift in tropical cyclone hazards.
A global study found microplastics in every single stool sample from eight countries, with up to nine different types identified. The presence of microplastics may affect human health through bioaccumulation and transmission of toxic chemicals.
Tropical Storm Yutu rapidly intensified from a tropical depression, becoming a storm with strong thunderstorms and winds of up to 50 mph. The storm is expected to pass just north of Saipan late Wednesday night or Thursday morning, posing a threat to Guam.
Researchers are using real-time learning to create a unified theory on how to optimize microgrid capacity through DC distribution. The team aims to create optimal power profiles for power electronic converters in DC distribution networks.
A new study shows that targeting the specific genomic mutation PIK3CA in hormone receptor-positive HER2-negative advanced breast cancer patients significantly improves progression-free survival. The study found that nearly twice as long PFS was observed in patients with PIK3CA mutations treated with alpelisib compared to the placebo gr...
Low-income obese patients lost a clinically meaningful amount of weight using a free phone app and coaching calls in a primary care clinic. The study found that 43% of participants lost more than 5% of their body weight, while 56% reached a healthy weight loss threshold.
A phase III trial demonstrated that chidamide, an HDAC inhibitor, improves progression-free survival compared to placebo plus exemestane in patients with hormone receptor-positive advanced breast cancer. Serious adverse events were reported, but the treatment regimen was generally well-tolerated.
Researchers at the University of Warwick have discovered a novel acid antibiotic, Scleric Acid, by engineering DNA from soil bacteria. The compound shows moderate antibacterial activity against Mycobacterium tuberculosis and has potential applications as a biocatalyst for manufacturing high-value chemicals.
A study by San Francisco State University found that 25% of young adults experienced clinically significant stress after the 2016 US election, comparable to witnesses of a mass shooting. The study also highlighted strong impacts on racial and ethnic groups, as well as gender, political affiliation, and religion.
A special journal issue explores the relationship between rising oxygen levels and the emergence of complex life, suggesting that increased oxygen may have driven innovation in animal body plans. However, debate remains among scientists regarding the cause-and-effect relationship between oxygenation and the evolution of complex life.
Researchers found that Asian elephants possess numerical skills comparable to those in humans, unaffected by distance, magnitude, or ratios. The study used a touch-panel task to train an Asian elephant named Authai to judge relative quantities, with a success rate of 66.8%.
New study using cryo-EM reveals structural asymmetry in spherical viruses like dengue and Zika, challenging long-held assumptions about icosahedral symmetry. The research found that many viruses have nearly icosahedral structures, with unique features like 'belly buttons' on their outer layer.
Researchers developed a machine learning algorithm to predict properties of compounds for efficient phosphors in LEDs. The algorithm reduced the search time from weeks to just 30 seconds, identifying sodium-barium-borate as a promising material with 95% efficiency and outstanding thermal stability.
Critically ill patients are not benefiting from antipsychotic medications in treating delirium in ICUs, with no significant difference in duration or outcomes compared to placebo. The MIND USA study screened nearly 21,000 patients and found that these drugs bring risk without benefit.
Researchers at the University of Groningen have successfully created nanosized ferroelectric materials using hafnium oxide, which can store information like magnetic bits. The discovery could lead to more efficient and compact computer memory by leveraging the unique properties of these materials.
Researchers at UNIGE discovered that α and δ cells can take over insulin production when β cells are damaged, leading to a phenomenon of cell plasticity. This finding opens the door to new treatments by harnessing the body's regenerative capacities.
A new protocol developed by Cleveland Clinic Akron General Hospital reduces opioid use after colorectal surgery, resulting in shorter hospital stays. The Enhanced Recovery After Surgery (ERAS) protocol includes pre-emptive pain management, non-opioid general anesthesia, and postoperative programmed non-narcotic analgesics.
A new type of protein complex has been discovered in human cells, which attaches to its surroundings and plays a key role in cell division. This discovery challenges current knowledge of cell division and may provide answers to an unanswered question about how cells remain attached to the matrix during division.
A new study found that gaps between screen time and outdoor time are most pronounced for girls, African American students, and eighth graders. Connection to nature plays a positive role in young people's physical health and psychological development, but contemporary children are spending less time outdoors than their predecessors.
Undernutrition delays puberty onset by enhancing AMPK levels in the hypothalamus of female rodents. Overexpressing active AMPK also delays puberty, implying its role in regulating female puberty via kisspeptin signaling.
A recent study published in JNeurosci found that nose breathing enhances memory consolidation. Researchers compared the effects of nose and mouth breathing during a one-hour consolidation period after participants were exposed to various odors. Nose breathers showed increased odor recognition, suggesting that nose breathing may facilit...
A study published in Nature Genetics found that long non-coding RNA MALAT1 suppresses breast cancer metastasis, contradicting its previously described role as a metastasis promoter. The researchers used mouse models to show that MALAT1 binds and inactivates TEAD, a transcription factor involved in promoting metastasis.
A study on Carolina chickadees in Washington, D.C. reveals that non-native plant biomass can reduce arthropod populations, forcing birds to switch diets or reproduce less. The findings suggest a link between non-native plants and the decline of insectivorous bird populations.
Researchers report a 100% major pathological response rate in early-stage colon cancers with mismatch repair deficiencies treated with nivolumab and ipilimumab. The regimen was well-tolerated, and patients underwent radical resection without delays.
A recent study published in JAMA Surgery found that patients taking aspirin alone had similar protection against blood clots as those on anticoagulant treatments. Aspirin use has become increasingly popular among Michigan surgeons, with 70% of surgeons prescribing it to patients after knee replacement surgery.
Engineers at the University of Colorado Boulder have developed a 3D printing method that allows for fine-grain control over rigidity, enabling the creation of complex geometries similar to those found in blood vessels. This technology could lead to personalized treatments for hypertension and vascular diseases.
Research from Michigan State University found that proactive help can lead to less gratitude for the helper and lower esteem for the person receiving help. Experts advise waiting to be asked for help instead of going out looking for problems to solve.
A study on Darwin's finches reveals two pathways of species generation and diversification driven by selective mating based on body and beak size. The authors note that hybridization between similar lineages can drive speciation, highlighting the importance of conservation of diverse environmental conditions.
A UC Davis study found that negative chat has a much longer tail and stronger snowball effect than positive chat, affecting the original speaker for up to eight minutes. Positive messages also have a ripple effect, but it's shorter-lived, lasting only two seconds.
Yale-NUS researchers have discovered a combination of pharmaceutical drugs that extend healthy lifespan and delay ageing in microscopic worms. The study, published in Developmental Cell, lays crucial groundwork for further research into designing drug combinations that produce the same effect in mammals.
Research reveals a 6% annual increase in European colorectal cancer incidence rates among adults aged 20-39 years between 2008 and 2016. This trend is driven by increased risk factors such as sedentary lifestyles, obesity, and poor diets.
Researchers found a global decline in nitrogen availability due to climate change, which can impact forest carbon sequestration and ecosystem health. The study suggests that even with reduced carbon emissions, many ecosystems will face nitrogen limitations, highlighting the need for sustainable land management practices.
Cristiano Fanelli uses artificial intelligence to optimize particle detectors and study exotic hybrid mesons. He aims to apply deep learning techniques for accurate particle identification, revolutionizing nuclear physics research.
Researchers have created a new class of electronic materials that combine protein nanowires with polymers, offering improved biocompatibility, stability, and sensing capabilities. The material can be easily processed into wearable devices and is made from sustainable, renewable resources.
A new agent has been developed to combat anthrax by reprogramming the human immune system's siderocalin protein to neutralize a special iron complexing agent produced by the bacterium. This approach is expected to provide an effective treatment against the life-threatening infection.
Researchers at Karolinska Institutet discovered high levels of antiphospholipid antibodies in patients who suffered a heart attack without any autoimmune conditions. The study involved 800 patients and found that 11% had elevated IgG antibody levels, which is associated with blood clots.
Advanced liver disease patients who accept liver transplants from older donors (over 70 years old) have a reduced risk of death, regardless of their Model for End-stage Liver Disease score. The study found nearly a twofold decrease in mortality beyond 90 days with acceptance of an older donor.
A team of researchers at inStem has developed a nucleophilic polymer-based topical gel that can deactivates pesticides on the skin through nucleophilic-mediated hydrolysis, preventing pesticide-induced toxicity and lethality. The gel shows broad-spectrum activity against commonly used pesticides in India.
Scientists developed a new method to record limb control neural circuits in fruit flies using two-photon microscopy. The study found different patterns of activity across neurons during movement and behavior, including walking and grooming.