A new article explores the role of inflammatory cytokines in creating T cell exhaustion in cancer, suggesting a direct pathway for therapeutic interventions. The study found that reprogramming exhausted T cells and anti-inflammation therapy may improve antitumor activity.
A new study from the University of Zurich reveals that people with high leadership abilities have a greater need for certainty when making decisions that affect others. This characteristic drives their willingness or unwillingness to take on responsibility, distinguishing leaders from followers.
Tropical Storm Shanshan has triggered warnings in the Marianas Islands due to powerful storms detected by NASA's Terra satellite. The storm is forecast to intensify and move towards Japan, with maximum sustained winds at 50 mph.
Researchers have identified a way to expand blood-forming adult stem cells from human umbilical cord blood, increasing their availability for transplant patients. This breakthrough could lead to more people being able to receive life-saving treatments without a suitable bone marrow match.
A young researcher at EPFL and SLF created a highly accurate digital simulation of an avalanche, offering insight into its complex mechanics. The simulation takes into account the snow's behavior as both a solid and fluid, allowing for more effective risk management in the mountains.
The Center for the Science of Synthesis Across Scales (CSSAS) brings together researchers to understand how molecular interactions control assembly and create new materials with revolutionary properties. The research focuses on protein-based building blocks, inorganic nanoparticles, and hierarchical synthesis.
Researchers analyzed ecological features and DNA sequencing data to reconstruct the tree of life of aquatic macroinvertebrates in Europe. They found that oldest lineages have higher functional diversity than younger ones, which is influenced by their ability to colonize new habitats.
A groundbreaking study by Oregon State University demonstrates the potential for genetically modified forest trees to prevent new seedlings from establishing. Researchers successfully engineered containment traits that limit the spread of genetically modified or exotic poplar trees, mitigating societal concerns over gene flow.
A Montana State University biochemist will study the role of microorganisms in breaking down and converting complex carbon compounds in the deep sea. The research aims to provide a benchmark for the field of deep-sea sediment microbiology and lay the foundation for future physiological studies.
Scientists from the Max Planck Institute for Chemical Physics of Solids discovered a magnetic Weyl semimetal in Co3Sn2S2, exhibiting a giant anomalous Hall effect. The material's unique properties make it an ideal candidate for realizing the quantum anomalous Hall effect at room temperature.
Research from Harvard T.H. Chan School of Public Health found pregnant women with low EPA+DHA serum levels had a significantly higher risk of early preterm birth compared to those with higher levels. The study suggests that adequate intake of long chain omega-3 fatty acids during pregnancy may help prevent preterm birth.
Researchers identify a new mechanism used by Henipaviruses to hijack the DNA-damage response machinery, allowing them to prosper in cells. This discovery may lead to the development of new anti-viral therapies.
A novel approach to creating super slippery industrial packaging aims to cut down on food waste by using naturally compatible vegetable oils. This method can be applied to inexpensive plastics like polyethylene and polypropylene, reducing waste and improving consumer safety.
The employment-to-population ratio for working-age people with disabilities decreased from 29.7% in July 2017 to 29.3% in July 2018. Despite the decline, experts believe that accommodations can play a crucial role in retaining employees with disabilities.
Research shows that cystic fibrosis affects the development of babies in the womb, leading to lower average birth weights. The study found that CF can impact birth weight even after accounting for premature birth, suggesting a potential link between CF and intrauterine growth.
Alessio Figalli, a CNRS researcher, has been awarded the 2018 Fields Medal for his groundbreaking contributions to calculus of variations, optimal control, and partial differential equations. His work focuses on optimal transport theory, which has far-reaching implications in fields such as economics, geometry, and probability.
Scientists at the University of Leicester have identified a protein that allows bacteria to detect amino acids in their surroundings, regulating their metabolism and sensing nutrient availability. This discovery could lead to new insights into how bacteria function and inform the development of drugs and antibiotics.
Scientists discovered a compact center surrounded by strong storms in Hurricane Hector using infrared satellite imagery. The coldest cloud tops circling the center were as cold as minus 70 degrees Fahrenheit.
Small-scale fisheries, such as soft-shell clams in Maine, are threatened by climate change, invasive species and unsustainable land use. Co-management approaches, based on shared responsibility, can build resilience by strengthening science-based decision making and promoting adaptive capacities like learning and leadership.
A new pilot clinical trial found that consuming crickets can help support the growth of beneficial gut bacteria and reduce inflammation in the body. The study showed an increase in beneficial gut bacteria like Bifidobacterium animalis and a decrease in inflammatory proteins.
Brazilian researchers have identified a key gene, ScGAI, that accelerates sugarcane growth by regulating developmental hormones such as ethylene and gibberellins. Silencing the gene in transgenic sugarcane lines resulted in increased culm volume and rapid internode elongation.
US and international physicists made substantial progress toward planning a system for mitigating disruptions on ITER, which can seriously damage the facility. Key methods outlined include shattered pellet injection to control disruptions, as well as simulation tools to predict plasma behavior and predict disruptions in time.
Researchers identify a shortlist of designable molecular knot types that can be easily self-assembled under physical and chemical conditions. The findings support the synthesis of novel topologies for potential applications in medicine, electronics, and nanocargo loading/unloading.
Researchers used a twin study to identify factors influencing chemical modifications to DNA across the genome, finding epigenetic marks are more similar between identical twins due to genetic variation. Environmental exposures like smoking and obesity also show partly genetic control.
Researchers have successfully imaged the surface structures of silver nanoparticles at atomic resolution using scanning tunnelling microscopy (STM). The technique allows for the identification of individual parts of molecules on the nanoparticle's surface, providing insights into their chemical properties and molecular interactions.
A new study by University of Iowa researchers reveals that older adults are less likely to recognize when they've made a mistake. Despite performing tasks similarly to younger adults, older participants acknowledged errors less often and were more adamant about not having made a mistake. This impaired ability has significant consequenc...
A European project aims to make pheromones an affordable alternative to conventional insecticides. Researchers are developing biotechnology-based pheromone production to reduce costs and environmental impact. The goal is to protect crops from pests like the fall armyworm, which poses a major threat to food security.
A new framework developed by Penn researchers measures and addresses the key factors contributing to inclusive learning and work environments in healthcare. The study identifies six factors: presence of discrimination, effective leadership and mentors, hierarchy, recognition, civility, and support for work-life balance.
The US is experiencing constraints on human capital in software and IT fields, driving multinational firms to establish R&D hubs abroad. This shift is expected to strengthen US-based firms through access to global talent.
Researchers found that even low levels of air pollution can cause significant changes in the structure of the heart, similar to those seen in early stages of heart failure. The study, which included over 4,000 participants, linked higher exposures to pollutants like PM2.5 and NO2 to larger ventricles and more pronounced remodelling.
African scientists developed diverse practices to combat tsetse flies, including late-season forest burning and innoculations, which were later adopted by Europeans as part of their 'science'. The book highlights the importance of understanding the connections between human and environmental mobilities in knowledge production.
Researchers developed a new technique to decode human motor intention from EEG using subliminal sensory stimulation. This method achieved nearly 90% single-trial decoding accuracy across tested subjects, within 96 ms of the stimulation, with zero user training and no additional cognitive load.
A study found that tropical tree species have distinct nutrient-capture strategies, with some producing more phosphatase in poor soils. The research highlights the importance of biodiversity for successful reforestation projects and suggests that applying basic biological processes can maximize carbon capture.
Research from Purdue University found that when two strains of a parasite infect a host, the combined virulence is often worse than with only one strain. This could be bad news for people affected by schistosomiasis, a disease prevalent in Africa, the Middle East, and the tropics.
A Dartmouth study found that Arctic mosquito populations depend on aquatic habitats and blood meal availability. The research indicates that female mosquitoes carrying eggs were most abundant near ponds in areas frequented by animals.
Nationwide Children's Hospital has launched an initiative to treat a neighborhood as a patient, targeting 'neighborhood effect syndrome' with housing development and community engagement. The Healthy Neighborhoods Healthy Families program has seen measurable improvements in housing stock, youth emotional health, academic performance, a...
A review published in Reviews in Endocrine and Metabolic Disorders suggests that transgender women on estrogen therapy are at increased risk for cardiovascular events. The data is unclear for transgender men, but the review highlights the need for further research on hormone therapy's effects in older populations.
A UC Riverside-led study found that adults' willingness to get HIV tested is influenced by factors such as stigma, education, provider recommendations, risk perceptions, and cost. The study also highlighted the need for targeted interventions to reach older adults and Hispanics, who are disproportionately affected by HIV in the US.
Researchers found that locusts use an OR-of-ANDs logical operation to compensate for variability in brain activity when recognizing smells. This allows the locusts to generalize and recognize the target odorant despite changes in context.
Researchers identified six factors associated with inclusion in healthcare organizations, highlighting the importance of creating a sense of belonging and recognition among employees. The study's findings have implications for reducing care disparities and improving cultural competencies.
A team of Boston College chemists has developed a technology to incorporate non-canonical amino acids into proteins made in eukaryotic cells, including humans. The novel strain of E. coli bacteria enables the facile engineering of the bacteria-derived genetic machinery, opening up new ways to probe and engineer protein function.
A study by UC Davis researchers found that low levels of cytomegalovirus (CMV) significantly impact microbe and immune cell populations, influencing the immune system's response to the influenza vaccine. CMV infection also alters gut microbiota, potentially diverting resources away from other threats.
A new study by San Francisco State University researchers found that students who sat up straight while taking math tests performed better than those who slumped over. Slumping was shown to be a defensive posture that can trigger negative memories, hindering clear thinking and performance.
Rice University researchers discovered that graphene reinforced with carbon nanotubes 'rebar' can withstand twice the stress of pristine graphene, making it more suitable for flexible electronics. The study demonstrated how rebar helps bridge cracks in graphene under strain.
Researchers at MUSC found that BDNF application to nucleus accumbens reduces cocaine-seeking behavior and reverses relapse. The study suggests BDNF has a fine-tuned effect on addiction, with timing-dependent impacts.
Research reveals that lipids in artificial cell membranes form clusters and domains due to interactions with hydrophilic polymer chains, similar to glycolipids in cell membranes. The study used fluorescence microscopy and AFM to examine the effects of PEG-modified lipids on domain formation.
Researchers created a scalable method to produce pure NCAs in less time and space, overcoming limitations of existing Fuchs-Farthing method. The new technique enables on-demand synthesis of NCAs for life-saving drugs and drug carriers.
The U.S. Department of Energy has awarded Argonne National Laboratory a $30 million grant to study ultrafast chemical processes on timescales of quadrillionths of a second. Researchers will use X-ray free-electron lasers to capture molecular movies, enhancing energy efficiency and applications in optoelectronics and solar energy.
Aryn Gittis' research establishes new therapeutic targets for Parkinson's therapies, using optogenetics to identify a subset of neurons in the globus pallidus that play a critical role in restoring movement. Her findings suggest targeting these cells could repair neural circuit dysfunction in diseases like Parkinson's.
Researchers suggest a system that charges drivers based on traffic volume, improving flow and reducing pollution. The proposed dynamic fee aims to make roads more efficient and equitable for all users.
A new study from Princeton University reveals that a large proportion of internet traffic passes through the US, despite efforts to reduce dependence. The Region-Aware Networking (RAN) tool allows users to reroute traffic, avoiding certain countries like Brazil, India, and Kenya.
A new study by Harvard Medical School researchers identifies three molecularly distinct subtypes of neurons responsible for transmitting information from the inner ear to the brain. These subtypes are selectively lost in aging mice and do not emerge properly in deaf-mouse models, suggesting a critical role in age-related hearing loss.
A study found that the end-Cretaceous mass extinction event led to the shift in dominance from lamniform to carcharhiniform sharks. Carcharhiniforms, including Tiger and Hammerhead sharks, proliferated in the post-extinction world.
Researchers investigate how a group of cells breaks off from a colony, leading to large-scale metastasis. Mechanical engineer Amit Pathak aims to understand the mechanisms behind disease pathways and fundamental cell behavior.
A new study reveals that the Terminal Classic Period drought led to significant reductions in rainfall and relative humidity in the Maya Lowlands. The research found annual rainfall decreased by nearly 50% on average, with up to 70% during peak drought conditions.
A University of Oxford study suggests that some people buried at Stonehenge had moved with and transported bluestones from the Preseli Mountains in west Wales. The research combined radiocarbon-dating with new developments in archaeological analysis to investigate the lives of those buried at the iconic monument.
A recent study found that nearly half of individuals with type 2 diabetes achieved remission after a weight-loss intervention. The research suggests that substantial weight loss at diagnosis can rescue beta cells and reverse the condition. However, only those who experienced early and sustained improvement in beta-cell function were ab...
Researchers from the Institute of Nuclear Physics found no anomalies in a rare decay of charmed baryons, potentially indicating 'new physics' is not present. They improved an upper limit on frequency by up to 100 times, but are still far from detecting any inconsistencies with predictions.
A long-term study confirms that cross-linked polyethylene hip implants significantly lower the rate of repeat surgery, with a cumulative revision rate of 11.7% compared to 6.2% for conventional polyethylene implants over 16 years. The use of XLPE implants also encourages total hip replacement in younger patients.
Nir Grossman's temporal interference (TI) approach stimulates deep brain regions without surgery, offering a new treatment option for brain disorders. TI uses multiple electric fields to target specific brain areas, improving spatial resolution and non-invasiveness.