Researchers are developing a nonopioid drug, ML351, to treat certain types of chronic pain. The drug targets a novel signaling pathway responsible for chronic pain development and has shown promise in preclinical studies.
A new study from Stanford University suggests that the deep ocean's stable temperatures enabled the emergence of complex life forms during the Ediacaran period. The research proposes that animals needed a haven from temperature fluctuations, which were less severe in the deep ocean, allowing them to thrive with limited oxygen supplies.
A study published in Molecular Psychiatry found that chronic peer victimization during adolescence can lead to structural changes in the brain, including decreased volume in areas related to anxiety and depression. The research suggests that early intervention may help mitigate these effects.
A University of Liverpool study found that popular restaurant chain meals in the UK and internationally have excessive calorie content, with only a small minority meeting public health recommendations. The researchers call for the food industry to reduce calories in their products and mandatory labelling of all restaurant food.
A new study led by UCalgary researcher finds that early caffeine treatment has no long-term negative effects on neurodevelopment, but is associated with better cognitive scores. The therapy also reduces the risk of cerebral palsy and hearing impairment in premature babies.
Researchers developed a method to obtain polyester from plant oil by functionalizing polymerization, preventing loss of Undecenol and disrupting molecular chain-building process. The concept has potential transfer applications for other renewable resources.
Researchers found that greater cognitive activity throughout life delays the appearance of symptoms and reduces grey matter loss in the brain. Participants with higher educational levels, language proficiency, and cognitive stimulation showed better neuropsychological test scores and slower disease progression.
Scientists at the University of Texas Health Science Center have engineered a novel human stem cell line for skeletal muscle, enabling faster and more efficient generation of muscle stem cells. The breakthrough could lead to disease modeling, gene correction, and potential cell therapy for patients with muscle disorders.
MeCP2 duplication syndrome, a rare genetic disorder affecting mainly boys, may benefit from new treatments by blocking key protein interactions. Researchers at the University of Edinburgh identified a crucial part of the protein binding to NCoR as responsible for disease symptoms, paving the way for therapies that target this interaction.
Researchers at IIT found that single plant leaves can generate more than 150 volts of electricity, enough to power 100 LED light bulbs. An 'hybrid tree' made of natural and artificial leaves can convert wind into electricity, providing a new sustainable energy source.
Researchers at University of Notre Dame have developed a new mathematical approach to solve NP-hard problems using analog computing. The 'solver' has the potential to find better and possibly faster solutions than digital computers for complex optimization problems.
A new study published in the journal Heart found that Latinos exposed to pesticides at work are twice as likely to have cardiovascular disease. The study, based on survey responses from 7,404 employed Latinos, also found increased risk of atrial fibrillation among those with occupational exposure to metals or pesticides.
Researchers at ETH Zurich have developed porous lightweight materials that approach theoretical maximum stiffness, outperforming traditional truss-based structures. These novel plate-lattice materials are stiffer, stronger, and more efficient than their counterparts, opening up new possibilities for various applications.
NASA's GPM mission provided detailed data on rainfall rates within Tropical Cyclone Owen's remnants as they approached the Queensland coast. The satellite's instruments revealed intense rainfall rates of over 32.4 mm/h and 52 mm/h in feeder bands, indicating a potentially intensified cyclone.
A large clinical study in Australia and New Zealand aims to better understand sepsis treatment practices and evaluate the effectiveness of a reduced fluid approach. The study, funded by the Emergency Medicine Foundation, will investigate how intravenous fluids are used to treat sepsis patients.
Researchers have synthesized and described metastable phases of high-pressure silica, coesite-IV and coesite-V, with crystal structures drastically different from earlier models. These new materials exist at extreme pressures and challenge Pauling's rules on bonding in inorganic materials.
Yale researchers used Google's algorithm to understand how information is transferred between enzyme sites, identifying crucial amino acids. This breakthrough could lead to new antibiotics, pesticides, and herbicides, combining data science with molecular dynamics simulations and NMR spectroscopy.
A new care model at Nemours Children's Hospital reduces the use of medication for children with autism spectrum disorders in emergency visits. The REACH Program uses distraction objects and rewards to manage anxiety and agitation, leading to improved patient experiences.
Researchers found that sharing a meal with a counterpart improves negotiation outcomes, leading to faster deal-making and lower losses. The study revealed that coordination during meal consumption was key to collaboration during negotiations.
A study by researchers at University of Granada found that attention training improves intelligence scores and brain function in pre-school age children. The benefits are greater when an educator implements a coaching strategy to help the child understand their training process.
The US military seeks to protect its troops against chemical attacks with a new color-changing fabric developed by University of Cincinnati Professor Anastasios Angelopoulos. The fabric, made from the polymer Nafion, detects chemical agents in the air while preventing them from interacting with the skin.
A £36k lifetime cap on care costs could cost £3.6 billion by 2035, while ensuring a minimum level of social care for all older people with high needs would also cost around £3.6 billion. The proposed reforms investigated include previous plans and suggestions for caps on care costs, free personal care, and easing the means test.
A new study by the University of Konstanz and the University of Sussex found that animals can detect complex odor mixtures more quickly and reliably than individual pure compounds. This suggests that our olfactory systems may be better suited to handle mixed smells, which are a common aspect of our environment.
The Society for Healthcare Epidemiology of America has issued a new expert guidance on how hospitals can reduce infections associated with anesthesiology procedures and equipment. The guidance recommends steps to improve infection prevention through increased hand hygiene, environmental disinfection, and continuous improvement plans.
A new review of 28 scientific studies substantiates that changes in diet, prescription medications, and physical activity reduce food cravings. Losing weight and avoiding frequent eating of certain foods are proven strategies to manage cravings.
New work from the Carnegie Supernova Project provides precise calibrations for using type Ia supernovae to measure cosmic distances. This improvement helps astronomers better understand how fast the universe is expanding and the potential impact of dark energy on this process.
Researchers from NUST MISIS developed a new hybrid catalyst for carbon monoxide oxidation using hexagonal boron nitride and silver nanoparticles, achieving full conversion at 194 degrees Celsius. Increasing silver concentration may reduce the temperature further.
A recent study published in the journal Radiology found that digital mammography significantly increased breast cancer detection by 14 percent compared to screen film mammography. The technology improved detection of early-stage cancers, including ductal carcinoma in situ, without increasing recall rates.
PSMA-targeted PET/MRI performs equally well as clinical nomograms to determine risk for advanced disease in high-risk prostate cancer patients, providing valuable information for treatment planning. The study results show whole-body imaging with 68Ga-PSMA-11 PET/MRI offers a one-stop shop for staging and guiding treatment options.
A study published in Nature Communications has uncovered additional mechanisms of insecticide resistance in mosquitoes, which had not been previously recognized. The research used a bioinformatics approach to integrate data from multiple studies and identified new gene families and pathways involved in resistance.
The five-year study will investigate the use of electroconvulsive therapy (ECT) to treat severe agitation and aggression in people with Alzheimer's disease. Researchers will compare ECT treatment plus standard therapies to standard therapies alone for individuals with moderate-to-severe Alzheimer's dementia.
Research on brain activity shows that sensory responses to visual patterns change between childhood and adulthood in people with autism, mirroring a genetic change associated with autism in fruit flies. The study provides insight into the mechanisms underlying sensory issues in autism, potentially leading to new treatments.
Research reveals a strong association between workplace exposure to metals and pesticides and an increased risk of coronary heart disease and atrial fibrillation. The study suggests that cumulative exposure may be more harmful, particularly for Hispanic/Latino workers who may face language barriers and limited resources.
Researchers discovered that a drug initially developed for Alzheimer's disease has antibacterial properties, potentially breaking antibiotic resistance in bacteria. The findings suggest the drug could be repurposed to treat infectious diseases.
Scientists from the Salk Institute discovered a new protein complex that keeps embryonic stem cells at their fullest potential, allowing them to maintain their indefinite potential. This discovery could provide a future target for regenerative therapies.
Researchers have developed a new theory to better predict the behavior of nanoclusters when a metal is introduced, reducing experimental time and costs. The theory enables the precise control of nanocluster size, shape, and composition, opening doors for tailored properties in nanotechnology.
A recent study found that treatment with active vitamin D did not decrease cardiovascular events in patients undergoing hemodialysis. Researchers tested oral alfacalcidol, an active form of vitamin D, to see if it improved clinical outcomes. The results showed no significant benefit for patients without secondary hyperparathyroidism.
A survey of psychiatrists found that a substantial proportion believe their electronic prescribing systems provide incorrect warnings, potentially leading to inadequate treatment. The study highlights the need for more research on the accuracy and usefulness of automated alerts.
The Harrington Discovery Institute has awarded over $700,000 to 10 US scientists for their innovative medical research. These scholars will support the commercialization of their work and have access to expertise and oversight in all aspects of drug development.
Researchers found that females have a higher risk of salt-sensitive hypertension due to impaired blood vessel relaxation. A low-salt diet and drug treatment restored healthier blood pressure and endothelial function in female mice.
Researchers found that relationship impairment interferes with treatment seeking among post-9/11 military veterans, particularly men, while facilitating treatment seeking among women. The study suggests a sex difference in the role of relationships on treatment use.
Researchers have developed a microfabrication method to create flexible light guides just over one micron wide in clear silicone, enabling smaller and more complex light-based devices. The tiny waveguides can be used for biomedical sensors, endoscopes, and wearable devices, with low light loss and high biocompatibility.
Researchers have developed a new technique using antibodies cloned from patients who recovered from Candida infections, showing potential in treating and diagnosing these life-threatening fungal infections. The discovery could lead to the development of novel antifungal drugs through mycoBiologics, a spinout company.
Scientists at FEFU create non-destructive method to visualize and quantify defects in transparent materials like single crystals, glasses, and ceramics. The method uses confocal laser scanning microscopy (CLS) to retrieve characteristics of high-density objects with enhanced precision.
Scientists identified that loss of two genes drives serrated colorectal cancer and found a combination treatment that has treated the cancer in mice. This discovery holds implications for patient care and may provide insights into the link between inflammatory bowel disease and colorectal cancer.
Researchers at the University of Iowa used a multidisciplinary approach to identify 90 FDA-approved drugs that may have potential as anti-seizure treatments. Gene expression profiling and bioinformatics revealed that these drugs significantly reduced seizures in zebrafish models.
Researchers discovered hypoxic dead zones in urban streams, caused by erosion and nutrient runoff. The study highlights the vulnerability of freshwater ecosystems to pollution and climate change.
Cell biologists at University of Münster create mini-measuring device to analyze molecular forces in desmosomes. They find that desmosomes only experience stress when cells are pulled, and the degree of stress depends on force magnitude and orientation.
A recent study reveals a significant increase in worldwide dementia cases over the past 26 years, with the number of people suffering from Alzheimer's disease and other dementias rising to 43.8 million in 2016. This represents a 117% growth, attributed to both aging and global population growth.
A new analysis by University of Maryland professor Ben Shneiderman reveals that research papers with multiple coauthors receive significantly more citations. The study found that university-corporate collaborations produce breakthrough research with substantial impact. Researchers and universities recognize the power and benefits of pa...
Researchers found a novel time-keeping mechanism within liver cells that contributes to disease development when its natural rhythm is disrupted. The study suggests that the circadian clock modulates HNF4A's classical functions, providing a potential explanation for diseases such as diabetes and cancers.
Iron plays a significant role in ferroptosis, a type of programmed cell death, by inducing lipid oxidation and ROS formation. A recent review by MSMU scientists reveals that glutathione peroxidase 4 reduction is the primary mechanism driving this process.
A new study by Johns Hopkins Medicine reveals that humans are hardwired to maximize rewards, leading to faster movement towards desirable outcomes. The research found that richer rewards result in quicker eye movements and decision-making, with implications for understanding human behavior and economic theory.
Researchers studying fetal exposure to inflammation aim to understand its impact on infant immune responses and potential prevention methods. High levels of Th17 cells in pregnancy-inflammation mothers and preterm babies have been linked to tissue damage, but their role in infection protection is unclear.
The NIH will fund HIV care and prevention research in counties with high rates of new HIV cases nationwide. The new initiative leverages partnerships with local health authorities and community-based groups to test sustainable interventions.
A new study from the University of Bath and UK universities reveals that international academics in the UK contribute significantly to public engagement, policy, industry, and non-governmental organisations. Foreign-born academics record 40% more international engagement activities than native-born colleagues.
A new study finds striking inconsistency in parental leave policies at top residency programs, highlighting the need for balance between medical training and personal/family needs. The average maternity leave was 6.6 weeks, with paid leave policies averaging only 3.9 weeks for same-sex couples or adoptive parents.
Lancaster University's Movement For Movement initiative embeds physical activity into medical students' training, recognized as a UK best practice exemplar by the WHO. The resources empower future doctors to positively impact individual and population health.
New studies suggest that current pesticide regulations fail to account for potential health threats to non-honeybee bee species, which are equally important pollinators. Researchers are calling for more diverse models, such as solitary bees and bumblebees, to be included in risk assessments.
A recent study published in eLife found a strong relationship between copy number changes in genes and cancer patient outcomes. The researchers identified specific biomarkers that can determine a patient's prognosis, providing new hope for personalized cancer treatment.