Researchers have identified patients more likely to have treatable underlying lesions from brain-bleeds, allowing for faster treatment. The study found that patients over 85 were unlikely to have a treatable lesion, while those under 50 had a 37% chance of finding a structural lesion.
A new study suggests converting farmland to grasslands near existing natural areas for maximum environmental benefits. The conversion should consider balancing multiple goals, including improvement of nature and aquatic environments, biomass production, and land usage.
A new clinical trial shows that immunotherapy pembrolizumab is more effective than standard aggressive chemotherapy in treating people with recurrent head and neck cancer. The combination of pembrolizumab with platinum chemotherapy extended survival by 3.7 months, while the immunotherapy alone showed improved survival rates compared to...
The NCI-MATCH trial found a combination of dabrafenib and trametinib to be effective in treating patients with BRAF mutations across 17 distinct tumor types, including several rare cancer types. The treatment showed promising activity outside of currently approved FDA indications.
Dr. Wiebke Frey is using wind tunnel experiments and model simulations to investigate mixing processes at cloud edges, which affect cloud lifetime and climate sensitivity estimates. Her goal is to develop a reliable formulation for understanding entrainment, a key process in climate modeling.
A pre-specified secondary analysis of the TAILORx trial found that assessing a woman's recurrence risk based on classic clinical features adds prognostic information complementary to the 21-gene Recurrence Score test. This integration may help identify young women who can forego chemotherapy and those who may benefit from more effectiv...
Scientists have successfully derived Expanded Potential Stem Cells (EPSCs) from both pig and human cells, offering new opportunities to study human development and regenerative medicine. These EPSCs possess developmental potency, enabling researchers to investigate pregnancy complications and develop treatments for diseases.
Researchers at Oak Ridge National Laboratory developed MiniFuel to test nuclear fuels, detecting performance data faster than conventional methods. The lab also created an auto-surveillance tool to detect healthcare data errors in the Department of Veterans Affairs' system.
Research led by the University of Saskatchewan found a significant increase in extreme downpours globally over the past 50 years, coinciding with intensifying global warming. The study used thousands of rain records to analyze precipitation extremes, revealing a clear upward trend in torrential rain events across various regions.
Susan Band Horwitz, an NFCR fellow, has been named a Giant of Cancer Care for her pioneering work on Taxol and its role in stabilizing microtubules to prevent cancer cell growth. Her research enabled the development of life-saving medications for ovarian, breast, and lung cancers.
The University of Maryland will lead a five-year research effort with NOAA, focusing on satellite services, Earth system observations and services, and Earth system research. CISESS aims to improve weather and climate forecasts, build resilience to extreme events, and provide capabilities for data access and management.
Researchers used supercomputers to simulate complex earthquake ruptures, documenting interactions between faults and analyzing results with advanced visualization software. The model helps understand how faults interact during earthquake rupture, enabling scientists to study past earthquakes and possible future scenarios.
Researchers at Fred Hutchinson Cancer Center have successfully treated cancer patients with HIV using immunotherapy drug pembrolizumab. The study found that the drug was safe and effective in patients with well-controlled HIV, offering hope for inclusivity in future clinical trials.
The POLO trial shows that olaparib significantly reduces the risk of disease progression or death in metastatic pancreatic cancer patients with BRCA mutations. Progression-free survival was 7.4 months on the olaparib arm, compared to 3.8 months on the placebo arm.
A small randomized pilot study found that lower-amp ECT was as effective as standard amplitude ECT in treating suicidal thoughts, with faster relief and fewer cognitive side effects. Patients receiving low amp ECT also experienced higher degrees of relief from depressive symptoms.
A new study finds high levels of coal ash contaminants in sediments from Sutton Lake, suggesting multiple unmonitored spills have contaminated the eastern North Carolina lake and potentially other lakes near coal ash ponds. The research highlights the risk of large-scale unmonitored spills occurring at coal ash storage sites nationwide.
The ECOG-ACRIN Cancer Research Group's phase three trial, E2810, found that pazopanib treatment did not improve disease-free survival in Stage IV patients with no evidence of disease following a surgery to remove the metastases. Average survival for these patients is about two to three years and long-term survival is uncommon.
The research team conducted 'talking head' interviews with household objects, including a smart kettle, to understand our relationship with networked technologies. The experiment aims to uncover new ways of thinking and create practical tools for making sense of the IoT.
Researchers found a modest decrease in calls for younger children but an increase in calls for older children and adults following the adoption of a 2015 product safety standard. The study highlights the need for improved safety measures to protect vulnerable populations.
A study published by the American Psychological Association found that teenagers who didn't get enough sleep were nearly two times more likely to engage in unsafe sex than those who slept in extra hours on weekends. The researchers suggest finding a middle ground for teens and encouraging school districts to delay school start times.
A study by Virginia Tech researchers reveals that lithium-ion battery electrode failure is caused by the heterogeneity of individual particles, leading to inefficiencies in charging. The team used a synchrotron X-ray method to produce results and identified problems with batteries today, including uneven charging rates.
Research at Earlham Institute reveals that plant clocks oscillate faster as plants age, with wheat exhibiting more rapid oscillations under constant darkness. The study uses delayed fluorescence to measure daily patterns in crops, enabling breeders to select optimal clock rhythms for improved yields.
Researchers discovered two distinct subspecies of short-finned pilot whales in the Indian and Pacific Oceans, separated by the eastern Pacific Ocean. The study, published in Molecular Ecology, used genetic analysis to verify the findings, revealing that continents may not have been as significant a barrier to this species' evolution.
Muscle gradually increases Annexin A2 expression in the absence of dysferlin, driving fatty deposits and promoting adipocyte formation from fibro/adipogenic precursors. Shutting down Annexin A2 or blocking FAP differentiation arrests disease progression.
Researchers at Penn aim to better understand the connection between novel radiation therapies and immune systems to enhance cancer treatments. Five projects will investigate signaling pathways and genetics behind interferon and pattern recognition receptor signaling.
A mathematical model of fresh water lenses was developed to understand the interaction between physical factors and water storage, circulation, and resilience. The research has practical applications in managing water resources around the world, particularly in arid deserts.
Researchers used radiocarbon dating to identify a 1985 forgery, finding excess 14C in oil from seeds in the 1950s and 1960s. The technique could help detect modern forgeries by analyzing micropaint samples.
Bat species use self-generated Doppler shifts to detect prey motions and navigate, revealing new principles for sensory systems. The study found that pinna motion parallel to echo propagation maximizes Doppler shift, providing information on echo source direction.
Researchers found that nearly half of callers with Medicaid coverage were denied appointments due to lack of available clinicians. However, wait times were generally less than two weeks, indicating opportunities to improve access to buprenorphine treatment.
Recent advances in stem cell biology have enabled long-term culturing of organotypic intestinal or hepatic tissues derived from tissue-resident or pluripotent stem cells. Organoids can recapitulate the in vivo architecture, functionality, and genetic signature of the corresponding tissue.
Researchers have identified a potential therapy for limb girdle muscular dystrophy using lithium to improve muscle size and strength in mice. The findings suggest that inhibiting the protein GSK3beta with lithium chloride can lead to significant improvements in mouse strength and muscle mass.
A study predicts that operating costs for US state parks will surpass state budgets by the middle of the century due to increasing visitor numbers. Climate change may exacerbate this trend, with some scenarios suggesting a 756% increase in operating costs under one scenario.
David Schmale, a professor at Virginia Tech, has received a Fulbright US Scholar Program award to develop remote-sensing capabilities to detect and respond to harmful algal blooms in New Zealand. He will also create educational units for students to design and fabricate robots for environmental monitoring.
Researchers discovered a technologically distinct site with systematic flaked tool production, extending the history of such tools to around 2.61 million years ago. This finding suggests that stone tool production may have been reinvented multiple times in the past.
The Phase 1 clinical trial shows median survival of GBM patients was 3.5-fold the expected survival based on published modeling studies, with very few side effects among patients. The gene therapy uses O-benzylguanine and temozolomide with repair enzyme MGMT.
A study by Cornell University researchers suggests that climate change-induced heat stress will have a greater impact on crop yields than drought stress in the US. The analysis projects significant yield reductions of 8-48% for major crops like maize and spring wheat, with some crops more resilient to heat stress.
A study found that patients taking antihypertensive drugs had a decreased risk of developing dementia, with calcium channel blockers showing the most significant association. The study analyzed data from over 12,000 patients and suggested that these medications may help delay or reduce dementia onset.
Researchers from KAUST have exploited inkjet printing to generate high-efficiency solar cells, replacing inorganic semiconductors with lightweight and flexible organic materials. The technique allows for customized designs, rapid design changes, and low-cost manufacturing, making it suitable for a variety of applications.
A new study by Portland State University researchers found that Oregon's paid family leave policy is successful in supporting employees taking time off for family additions, but inequities exist in its implementation. The study highlights the need for explicit equity focus and supervisor training to ensure workplace fairness.
A nationwide survey of 487 women found that nearly two-thirds of breast cancer patients are unaware of surgical options that can minimize scarring. The study also revealed that many patients experience negative impacts from their scars, including feelings of self-consciousness and restricted clothing choices.
A new study by Cornell University provides insight into the mode of action of hyaluronic acid (HA) injections, finding a direct correlation between lubricating properties and pain relief in patients. The research suggests that HA products should be reclassified as drugs to better regulate their treatment options.
A new remote sensing technique can detect harmful algal blooms in the Red Sea with high accuracy, even accounting for frequent dust storms and aerosols. This approach has the potential to establish a real-time monitoring system to protect the region's vital economic and ecological resources.
An international team led by Laura Epp is analyzing ancient DNA from sediment cores, current ecological data, and anthropological studies to understand the interplay between climate change, grazing, and tundra vegetation. The project aims to generate scenarios for future ecosystem changes and develop solutions for local communities.
A new study found that LGBTQ adolescents who experienced weight-based victimization had increased odds of alcohol use, binge drinking, marijuana use, and cigarette use, as well as poorer self-rated health, higher depressive symptoms, and lower self-esteem.
Researchers discovered that a subset of natural killer cells with high Ly49H receptor levels expanded and remained detectable after the peak immune response, indicating a simple form of immunological memory. This finding could have significant implications for human NKs and their role in CMV infection.
Artificial floating islands harness solar energy to extract CO2 from seawater and produce hydrogen, which is then converted into methanol fuel. The study suggests a potential method for producing synthetic fuels with reduced greenhouse gas emissions.
A large-scale program delivering water filters and cookstoves to Rwandan homes reduced reported diarrhea and acute respiratory infection rates by 29% and 25%, respectively. Improved drinking water quality and immunological boosts may contribute to the observed health benefits.
Researchers develop method to mimic human decision-making, enabling computers to render multiple acceptable decisions. This allows for variability in computer systems, similar to human experts, and can lead to better performance.
Researchers have discovered a method to convert plastic waste into jet fuel using activated carbon as a catalyst. The process produces high-quality fuel with minimal environmental impact, offering a promising solution to the global plastic crisis.
Research reveals that urban pollution from Manaus significantly impacts cloud production and rainfall in the Amazon, with far-reaching consequences for regional and global climate patterns. The study found an average increase of 200% in secondary organic aerosols, leading to a 400% boost in aerosol formation.
Researchers discovered that prolonging phototropin photocycle enhances light sensitivity of chloroplast movement and leaf positioning in Arabidopsis thaliana, leading to increased biomass under low-light conditions. This finding suggests a strategy for improving photosynthetic efficiency and crop yields.
A study published in the Journal of Experimental Medicine found that phosphorylation of Regnase-1 allows IL-17 to trigger inflammation. Blocking this phosphorylation process could lead to therapeutic agents for treating autoimmune diseases related to IL-17, such as rheumatoid arthritis and multiple sclerosis.
A new classification system could better understand mineralogy as a process of universal and planetary evolution by accounting for minerals' distinct journeys. This system, proposed by Robert Hazen, groups minerals into natural kind clusters that reflect the inherent messiness of planetary evolution.
Shoukhrat Mitalipov, a germline gene therapy pioneer, argues that existing regulations can be strengthened to allow safe treatment. His 17-year-old son Paul also co-authored the editorial, highlighting the importance of understanding gene editing for non-scientists.
Scientists have found that sponges can collect and filter DNA from fish, seal, and penguin DNA in the water they filter, making them an ideal sampling unit for monitoring biodiversity. This method uses sponge tissue as a natural sampler, reducing processing time and risk of contamination.
A team of researchers developed a new technique using X-ray technology to map out damage in lithium-ion batteries. They created the most comprehensive view yet of battery electrodes, which are prone to degradation from repeated charging. The study could lead to more reliable and longer-lasting batteries for electric cars and smartphones.
A new study published in JAMA Pediatrics found that using limited formula in the first days of life does not negatively impact breastfeeding at 6 months. However, it may alter maternal attitudes towards breastfeeding and lead to shorter breastfeeding duration. The study tracked 164 babies born at UCSF Benioff Children's Hospitals and P...
A new study found that uncertainty in early-stage inventions can lead to lower budgetary support. Researchers investigated how university-based academic inventions are selected for support and discovered that background familiarity and scientific complexity improve support chances. The study aims to develop models and tools to access, ...
Researchers at University of Maryland Baltimore County develop new method to measure atmospheric hydroxyl radicals, a key molecule involved in methane breakdown. This improvement can enhance the accuracy of climate models and inform policy decisions on reducing methane emissions.
Research highlights increased risk of heart and blood vessel diseases among people with HIV due to interactions between traditional and HIV-specific risk factors. Additionally, stigma and barriers to healthcare can exacerbate these risks, emphasizing the need for better awareness and patient-focused care.