The US National Institutes of Health (NIH) has awarded a grant to Sydney-based company Kinoxis Therapeutics to develop a potential treatment for opioid withdrawal. KNX100, a small molecule therapeutic drug candidate, is being developed to treat opioid-use disorder and other substance use disorders.
A two-year study in Sydney's urban coastal environments reveals that some beaches have elevated levels of antibiotic-resistant bacteria following rainfall. The research highlights the exchange between human wastewater streams and natural ecosystems, posing a risk to human exposure to antibiotic-resistance bacteria.
Researchers discovered that supernatural beings are attractive due to mind-based abilities, ambiguity, and the potential for eliciting both love and fear. This finding has implications for understanding the psychology of belief and devotion in religious contexts.
A study by UCLA researchers found that adding ribociclib to standard hormone therapy significantly improves overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer. The combination treatment demonstrated a 28% reduction in risk of death and improved progression-free survival.
Researchers at Intermountain Medical Center found that wrist-worn step trackers can estimate exercise capacity and determine health status of patients with pulmonary disease. This technology allows for more frequent monitoring of patient progress and disease management, enabling early interventions to improve outcomes.
New research from the University of Oxford suggests that poorly reported placebos can influence treatment outcomes, leading to incorrect inferences about a new treatment's effects or harms. The study highlights the need for more transparent reporting of placebo components in clinical trials.
An international study used human retinal cells to demonstrate how the Toxoplasma parasite creates a distinctive eye lesion. Researchers identified proteins produced from infected cells that push neighboring uninfected cells to overgrow and create a characteristic lesion.
The Antarctic ozone hole's decline has indirectly helped increase sea ice due to altered atmospheric and oceanic circulations. Ozone-induced changes impact sea surface temperatures and dynamics of sea ice.
A recent study published in the New England Journal of Medicine found that nintedanib slows the progression of a broad range of scarring lung diseases. The medication was shown to be effective in patients with progressive fibrosing interstitial lung disease, regardless of the underlying cause or pattern of lung fibrosis.
Two studies show that CDK4/6 inhibitors plus fulvestrant significantly improve overall survival in hormone receptor-positive advanced breast cancer. The combination is recommended as a standard of care for patients with metastatic disease.
A new phase III trial found that immune therapy added to chemotherapy improved pathological complete response in patients with early triple negative breast cancer, leading to a clinically meaningful benefit and potential cure for more patients. The study also indicated an improvement in event-free survival.
A smart shirt has proven to be accurate in measuring breathing, with results similar to traditional equipment, according to European Respiratory Society research. The Hexoskin senses chest movements and records air volume, heart rate, and movement, making it a practical alternative for monitoring lung function.
A survey of 905 Italian truck drivers found that nearly half suffer from at least one sleep-related breathing problem, with a significant risk of OSA due to lifestyle factors such as poor diet and physical inactivity. The study highlights the importance of compulsory testing for sleep-related breathing problems among haulage companies.
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
A Rutgers study reveals that new risk factors have emerged for heart valve infections, which can be deadly and affect patients with heart disease or artificial valves. The study found a significant increase in hospital-acquired cases, attributed to staphylococcus bacteria, highlighting the need for tailored prevention strategies.
Researchers developed a more efficient statistical model to analyze extreme weather events globally, identifying regions with high precipitation levels and predicting their frequency. The model can handle vast amounts of data from multiple locations, providing valuable insights for disaster planning.
Researchers discovered mechanically delivered projectile weapons in Europe dating back 45,000-40,000 years, indicating modern humans had a hunting advantage over Neanderthals. The spearthrower and bow-and-arrow technologies allowed for higher impact energy hunting strategies, leading to the replacement of Neanderthals.
Scientists at the University of Hong Kong and Hunan Normal University have realized a giant magnetic field through moiré pattern engineering. The magnetic flux per supercell is quantized, and the field magnitude scales inversely with the square of the moiré period.