Biomedical engineers at Duke University have created artificial membrane-less organelles within human cells by controlling the phase separation of emerging class of proteins. This advance enables precise tuning of a single property to modulate existing cell functions or create new behaviors.
Researchers developed Ae DES to monitor and forecast environmental suitability for transmission of Zika, dengue fever, chikungunya and other diseases. The system combines multiple R0 models with climate information, generating probabilistic forecasts that are robust due to a large sample size.
Experiences of NY home health care workers caring for older adults and patients with chronic illnesses during the pandemic reveal high levels of stress and burnout. The analysis highlights the need for improved support systems to mitigate these effects.
Research suggests that people with low selenium levels are at risk of paracetamol overdose even when following dosage guidelines. A lack of selenium can slow down the body's ability to eliminate paracetamol, making it more toxic.
Researchers advocate photodynamic therapy as an additional treatment for COVID-19 patients to combat secondary infections. The technique uses light and a photosensitizing chemical substance to kill microorganisms in the respiratory tract, potentially improving prognosis and reducing transmission.
Researchers found that autistic individuals tend to be more direct and precise in their emails, while non-autistic people are more likely to include social niceties. This study highlights the importance of adapting our email styles to be more respectful of others' differences.
Tropical Storm Isaias is causing flooding in South and North Carolina due to heavy rain. The storm is expected to produce life-threatening flash flooding along the I-95 corridor and a risk of tornadoes from southeast Virginia to New Jersey.
Astronomers have discovered a Saturn-sized planet orbiting a small, cool star 35 light-years from Earth using the astrometric technique. The planet has a mass comparable to Saturn and orbits its star every 221 days. This discovery is significant as it reveals that smaller planets can exist around cooler stars.
Researchers at Tokyo University of Science used infrared laser irradiation to destroy amyloid fibrils, which are typical of neurodegenerative diseases like Alzheimer's. The study combines experimental and simulation results, showing that the process begins at the core of the fibril, where resonance breaks intermolecular hydrogen bonds.
Researchers developed a blood test that can identify babies at risk of serious neurodisabilities like cerebral palsy and epilepsy just hours after birth. The test looks for specific genes being switched on or off, which may provide new targets for treating brain damage before it becomes permanent.
Pediatric infectious disease experts provide recommendations on return to school for SOT children, considering factors like clinical risk, community transmission, and infection prevention measures. The majority of SOT recipients are expected to outweigh the risks and benefit from attending school.
Studies found cross-reactive T cell epitopes in unexposed individuals, suggesting a potential for pre-existing immunity. The discovery sheds light on the mechanisms behind natural immunity to SARS-CoV-2.
A new method, knowledge-primed neural networks (KPNNs), combines deep learning with biological interpretability to understand complex biological systems. KPNNs have been applied to large single-cell datasets, revealing unexpected diversity in cell-type-defining regulatory networks.
Researchers found that having two mutated copies of TP53 gene worsens the prognosis of myelodysplastic syndrome, a blood cancer. This study confirms that TP53 mutation status is the most important variable in predicting disease course.
Astronomers have discovered an exoplanet, K2-25b, that is surprisingly dense for its size and age, defying current planet formation theories. The exoplanet, orbiting a young star in the Hyades cluster, has a mass of 25 Earth-masses and a size slightly smaller than Neptune.
A new, efficient method to detect toxic heavy metals like arsenic, cadmium, and chromium in vegetables and drinking water has been developed by researchers at the University of Johannesburg. The technique combines established methods with automation and can test for multiple metals simultaneously.
Researchers from the Advanced Science Research Center at CUNY will explore new methods of chemical synthesis using mechanical force. The team aims to develop predictive rules that anticipate how reactive chemicals respond to mechanical stress, leading to more efficient and sustainable chemical syntheses.
A new laboratory will facilitate interdisciplinary collaboration in photon-based quantum applications, advancing secure communications, quantum computing, and fast information processing. The project aims to establish Paderborn University as a global leader in optoelectronics and photonics research.
Researchers from UCI School of Medicine evaluate anterograde and retrograde viral tracers for neural circuit analysis, providing guidance on experimental uses. The primer aims to advance the study of neural circuits using animal models to define mechanisms underlying neurodevelopmental and neuropsychiatric disorders.
Researchers studying cichlid fishes aim to understand genetic mechanisms controlling facial development, which may also apply to humans. The study's findings could help determine if certain medications prescribed for human diseases might cause facial malformations in unborn babies.
Researchers identified key drivers of secondary growth resumption in Northern Hemisphere conifers, including photoperiod and mean annual temperature. These factors interact with spring forcing and moisture availability to regulate wood formation.
Researchers developed a machine learning model to predict pandemic impact on fuel demand, analyzing mobility patterns and historical weekly motor travel trends. In another study, scientists found extraordinary fine-root growth with increasing temperatures in northern peatlands, indicating a previously hidden belowground mechanism that ...
A study on dairy cows' social grooming behavior found that cows form strong bonds through mutual cooperation and prefer individuals of similar age. Older cows groom more individuals, suggesting a 'peacemaker' role in the herd. These findings could inform innovative farm management strategies prioritizing cattle emotional and social needs.
A new study by the University of Exeter and others found that surface clean-up devices will not solve the ocean plastic problem, but could be more effective when used with river barriers. The research estimates that floating plastic will peak at over 860,000 metric tonnes by 2052.
A research team from CNIO and HKUST has discovered a specific genetic alteration in some glioma patients that evades the combined therapy, leading to resistance. The study provides clues on how to monitor therapy efficacy and may lead to changes in treatment methods.
Researchers at EPFL have developed a synthetic inhibitor of coagulation factor XII that efficiently blocks blood clotting without causing bleeding side-effects. The inhibitor has high potency and selectivity, but its short retention time requires constant infusion to achieve sustained thrompobrotection.
Researchers identified a promising soluble variant of the human receptor for SARS-CoV-2 that competes with monoclonal antibodies. The variant, dubbed sACE2.v2.4, neutralizes both SARS-CoV-2 and SARS-CoV-1 in cell-based assays.
Scientists discovered that identifying tumor-associated macrophage patterns in lung tumor tissue enables the prediction of disease progression. The study found that a higher number of tumor-promoting macrophages near the invasive margin is associated with lower patient survival rates.
Researchers at Max Planck Institute for Molecular Genetics discovered that epigenetic regulators control the development of different tissues and organs in early mouse embryos. By analyzing thousands of individual cells, they found that specific regulators have unique functions in every cell, making them difficult to study.
Scientists at the University of Queensland have improved the modeling of nuclear structure in francium atoms, allowing for more precise calculations of their magnetic moments. The new method enables uncertainties four times smaller than previous best values, which is crucial for testing fundamental physics theories.
Researchers are testing Functional Imagery Training (FIT) to help patients with alcohol-related liver disease stop drinking. FIT teaches people to create motivational imagery themselves, which can support long-term behavior change.
Research finds a speed-based scaling effect, where faster animation speeds lead to smaller perceived product sizes. Practitioners can leverage this effect by animating products like animals' movements for certain types of products.
Researchers confirmed a theory that networks of no more than 150 are optimal for internally sharing information, a concept proposed by British anthropologist Robin Dunbar in the 1990s. Understanding this 'Dunbar Number' is crucial for training teams and forming cohesive groups.
A new calibration-free version of a physical-based method can better detect long-term trends in continental-scale land evaporation rates than recent remote sensing-based approaches. This improvement is crucial for upgrading general circulation models' existing evaporation estimation algorithms to produce better climatic predictions.
Researchers develop mathematical model to understand droplet dispersion, finding no linear relation between droplet size and displacement. The study suggests creating an aerosol extractor device to trap small droplets, improving safety during medical procedures.
A survey by WMG, University of Warwick found that UK consumers are unconvinced about the privacy and security of smart home devices, with anxiety about potential breaches. The study suggests that businesses must address these concerns to increase consumer trust and adoption.
Researchers designed a silver plating to shield microwave waves and create uniform heating in liquids. This resolves the issue of water heated in a microwave not being the same as stovetop-heated liquid, promoting more consistent temperatures.
Researchers from Ruhr-University Bochum and Max Planck Institute discovered that the zinc component of the methanol catalyst is positively charged and has two copper-based active sites. This finding offers ideas for optimizing the catalyst in the future.
A new study found that flies from the Drosophila family have optimized their eye and nose sizes to adapt to different habitats, influencing behaviors such as courtship and habitat preferences.
The University of Minnesota has received $26 million to create an Engineering Research Center (ERC) focused on developing and deploying breakthrough bioengineering technology. The center, ATP-Bio, aims to preserve a wide range of biological systems, including cells, tissues, organs, and whole organisms.
A new study reveals that New England's trees are capturing more carbon from the atmosphere, driven by growing temperatures and increased precipitation. However, some forests are also becoming a source of CO2 due to invasive insects and climate-related stressors.
A study by University of East Anglia researchers found that banks with powerful CEOs and smaller boards are more susceptible to money laundering and take greater risks. The impact of money laundering is heightened by the presence of powerful CEOs, but large and independent executive boards can partially mitigate this effect.
The new clinical practice guideline published in CMAJ recommends a holistic approach to obesity management, focusing on root causes and patient-centered outcomes. The guideline targets primary health care professionals, policy-makers, and people living with obesity.
A new hybrid anode material, Ti2Nb10O29-x/HRGO, has been developed to improve the performance of lithium-ion batteries. The material exhibits excellent reversible capacity and cycling stability, making it a potential candidate for electric vehicles and mobile electronics.
The emergence of artemisinin-resistant malaria parasites in Rwanda marks a major concern for global health. Significant proportions of parasites carrying the R561H mutation have been detected, indicating that these resistant strains can spread between locations and acquire resistance to partner drugs.
NASA's Aqua satellite detected strong storms southeast of Typhoon Hagupit's center due to wind shear, with cloud top temperatures as cold as minus 63 degrees Fahrenheit. The storm made landfall in China's Zhejiang province with maximum sustained winds near 85 mph.
Treatment of unruptured intracranial aneurysms has become substantially safer over the past decade due to advancements in microsurgical techniques and endovascular technology. Endovascular embolization has shown a higher rate of favorable clinical outcomes compared to microsurgical clipping.
Research suggests autistic men have greater excitability in the medial prefrontal cortex, affecting social cognition and self-reflection. Women with autism exhibit a more intact response, associated with better camouflaging of social difficulties.
The COVID-19 pandemic has led to changes in the number of new cancer diagnoses in US patients. Researchers analyzed data from 2020 and found that there was a significant increase in new cases during the pandemic.
Researchers at Mount Sinai Hospital have discovered a novel genetic sequencing technology that identified the cause and treatment of a previously unknown severe auto-inflammatory syndrome. The technology, tailored to the patient's own genetic code, pinpointed an unknown mutation in the JAK1 gene causing permanent immune system activation.
The Apple Fire has grown to 26,850 acres with 15% containment, spreading into sparse wilderness areas due to low moisture content and high temperatures. NASA's Aqua satellite provided two images of the fire, including a true color image and one showing corrected reflectance bands for burn scar detection.
A new study validates the Rapid Arterial Occlusion Evaluation (RACE) scale for accurately identifying Large Vessel Occlusion (LVO) strokes in US-based EMS personnel. The RACE scale has been widely adopted in the US, but its validity was untested prior to this study.
Researchers at Ehime University have successfully synthesized a new type of polymer with a carboxy-functionalized dendron structure. The polymer demonstrates pH-responsive behavior due to the dense accumulation of side chains, paving the way for the development of new functional poly(substituted methylene)s.
Researchers create micropores in mouse skin, allowing drugs to diffuse through more easily, reducing pain from injections. The method has potential for transdermal delivery of insulin and other medications, alleviating daily injection needs.
Advanced computer simulation techniques have determined which low-and-middle income countries would benefit from using iron-containing micronutrient powders to tackle childhood anaemia, with 54 out of 78 countries showing a net benefit. Policymakers can use individual reports for each country to balance benefits and risks.
The ACTIV-3 clinical trial tests the safety and efficacy of a monoclonal antibody treatment in hospitalized COVID-19 patients. The trial aims to enroll approximately 300 volunteers with mild to moderate symptoms, who will receive either an intravenous infusion of LY-CoV555 or a saline placebo infusion.
A study by Radboud University Medical Center found that a single pill of dolutegravir per day is equally effective as a combination therapy in children, reducing dosage complexity and increasing treatment accessibility. This simplified dosing regimen has been integrated into World Health Organization guidelines and FDA approval.
A recent study by Boston University School of Public Health found that losing weight between young adulthood and midlife can lower the risk of developing arthritis. The researchers estimated that nearly a quarter of arthritis cases in the US are attributable to excess weight, corresponding to approximately 2.7 million people.
A machine learning algorithm using high-temporal-resolution growth curves distinguishes bacterial pathogen strains with 92-98% accuracy, predicting antibiotic resistance as well as genetic-based methods. The method has the potential to be faster, simpler, and less expensive than current techniques.
A new computational model called TransComp-R has been developed to improve the translation of drugs from animal studies to human clinical trials. The model identified an overlooked biological mechanism possibly responsible for a patient's resistance to infliximab, a drug for inflammatory bowel diseases.