Dana-Farber researchers will present findings related to stem cell transplant, lymphoma, leukemia, and multiple myeloma treatment, including a study on the benefit of hematopoietic cell transplantation in older patients with high-risk myelodysplastic syndrome. Another study explores the impact of clonal hematopoiesis in donors on recip...
Researchers developed virus-like probes that can validate rapid COVID-19 tests across the globe. These stable probes are made from viral particles and have improved accuracy, stability, and cost-effectiveness compared to existing positive controls.
Researchers at Brigham and Women's Hospital developed a small-molecule inhibitor targeting SerpinB9 protein in cancer cells, weakening its defense mechanisms and triggering cell death. The approach shows promise for treating 'cold tumors' that evade immunotherapies.
Marcy Stutzman, a Jefferson Lab staff scientist, has been named a Fellow of the American Vacuum Society for her work on producing ultra-high vacuum environments. She contributes to the smooth operation of the lab's primary particle accelerator by ensuring high-quality equipment and maintaining a contamination-free environment.
Researchers found that flies in apple orchards can acquire fire blight bacteria from sugary droplets on diseased trees and transmit it to uninfected shoots. This discovery provides new insights into the disease cycle and highlights the importance of integrating historical literature into modern research.
Researchers discovered vitamin D regulates calcium in the distal intestine, a previously unknown role. This finding has implications for treating bowel disease and calcification disorders.
Dr. Olga Boukrina receives a $10,000 grant to study reading deficits in stroke survivors and develop personalized treatment for aphasia. Her ongoing research aims to identify markers that can help clinicians detect reading problems early in rehabilitative care.
New research reveals that European colonization significantly increased rates of soil erosion and alluvium accumulation in North America, with impacts felt for centuries.
New research suggests that dolutegravir, a widely used 'wonder drug' for HIV treatment, may not be as effective in patients with resistant strains of the virus. The study found that individuals with efavirenz-resistant mutations were less likely to achieve viral suppression when treated with dolutegravir.
A study by Penn State researchers found that cultural factors significantly impact gesture choices, with some gestures differing between American and Chinese participants. The team identified common ground among cultures for similar purposes and actions.
Researchers at Memorial Sloan Kettering Cancer Center found that tumors with high mutation burden, particularly those with BRCA2 mutations, respond better to immunotherapy. This discovery may lead to more precise treatments for patients with BRCA2 mutations.
A large Swedish registry study found that DOAC use did not reduce the rate of hospitalisation, intensive care or fatality due to COVID-19. The study included over 100,000 patients with atrial fibrillation and over 350,000 individuals with cardiovascular disease.
Researchers at the University of Illinois developed a method to create 3D images of fiber orientation in composite materials, enabling accurate predictions of thermal conductivity. This innovation has far-reaching implications for designing high-performance materials and heat shields.
The Alzheimer's Association, Global Brain Health Institute, and Alzheimer's Society have partnered to fund 23 small-scale pilot projects addressing global challenges in dementia. These projects focus on innovative approaches to awareness, diagnosis, treatment, and care for individuals with Alzheimer's disease and other dementias.
A new study from Brigham Young University finds that alcohol-free hand sanitizer is just as effective at disinfecting surfaces from the COVID-19 virus as alcohol-based products. The study uses benzalkonium chloride and other quaternary ammonium compounds, achieving a 99.9% kill rate within 15 seconds.
A recent study published in Nicotine & Tobacco Research reveals significant racial and ethnic disparities in the effectiveness of anti-smoking measures. Non-Hispanic white smokers have seen a higher reduction in cigarette use, highlighting the need for targeted public health efforts to address disparities.
Chronic graft-versus-host disease (cGVHD) causes skin thickening due to the production of TGFβ1 by apoptotic keratinocytes stimulated by interferon-γ, according to researchers at the University of Tsukuba.
Researchers discovered a critical subunit, CatSper1, in winning sperm's racing stripes that helps control mobility and navigation. Sperm with intact channels advance further in the reproductive tract, while those without are eliminated.
A repurposed mouse model has been shown to develop symptoms of severe COVID-19 and milder disease, including loss of the sense of smell. The study found that convalescent plasma protected the mice against lethal disease, suggesting a promising tool for understanding COVID-19 and developing new treatments.
Researchers at Johns Hopkins Medicine investigate using UVC light to disinfect CT scanning machines, which can eliminate SARS-CoV-2 virus particles in minutes. They also explore the relationship between low Ct values in diagnostic tests and infectiousness.
Researchers found that counties with above median income show significant compliance increase after receiving stimulus funds, while economically disadvantaged communities remain non-compliant. The study suggests targeted economic relief may limit COVID-19 spread among vulnerable populations.
A new study found that public health services are failing to meet targets to reduce avoidable sight loss, with a significant increase in cases despite a decrease in prevalence. Cataract is the leading cause of blindness, accounting for 15 million people, and treatable by surgery.
Researchers used statistical analysis of zircon ages to determine continental formation timelines. The study suggests that modern-scale watersheds formed as early as 2.7 billion years ago.
Researchers have discovered an experimental drug called ISRIB that can reverse age-related declines in memory and mental flexibility in mice. The study suggests that a
Researchers report factors preventing effective launch of oncology biosimilars, including market share struggles and patent litigation lawsuits. The 'Pay-for-Delay' strategy by AMGEN and Genentech/Roche holds the market hostage.
Researchers identify succinate as a key molecule released by muscle cells during exercise, triggering tissue remodeling and increased strength. The study found that succinate levels rise in muscle fibers and interstitial spaces after exercise, leading to improved metabolic efficiency and enhanced athletic performance.
Researchers investigated acoustic properties of eVTOL aircraft and found that smaller rotors generate more broadband noise. Co-axial co-rotating rotors may offer better performance and lower noise than conventional rotors, with stacked rotor configurations potentially producing the lowest noise levels.
A team of scientists from Nanyang Technological University, Singapore discovered that the protein NLRP1 detects the human rhinovirus (HRV) and triggers an immune response leading to inflammation in the lungs.
A new study found that popular kids' TV shows and films depict up to 8.66 painful incidents per hour, often focusing on extreme violence, and fail to show empathy towards characters in pain, with boys more likely to experience severe pain than girls.
A recent study by University of Missouri researcher Jo-Ana Chase found that family caregivers often struggle with medical and nursing tasks after a hospital-to-home transition. Resources like home health care nurses or aides can serve as a central point-of-contact to improve coordinated care.
A University of Toronto study found that drivers can become over-reliant on automated vehicle displays, leading to decreased monitoring of the road. In contrast, an in-vehicle display system providing information on surrounding traffic showed promise in ensuring driving safety by keeping drivers engaged and attentive.
A POSTECH research team identified the mechanism behind neurological diseases such as dementia, autism, and schizophrenia. They found that BDNF regulates AMPA receptors, which are crucial for synaptic function in nerve cells. The study provides clues to treating development or degenerative brain diseases like autism and dementia.
Researchers found that inflammasomes, a type of immune cell complex, are activated in response to SARS-CoV-2 infection, leading to excessive inflammation and potentially life-threatening complications. The study provides new insights into the disease's progression and suggests potential therapeutic targets.
Researchers analyzed nearly 80,000 manuscript submissions to ASM journals and found women are underrepresented in publications. Manuscripts with female authors were rejected at a higher rate than those with male authors.
A team of researchers discovered ancient human landscape modifications in Amazonia, revealing a 2,000-year-old civilization that used fire to clear patches and alter the forest composition. The findings contradict previous theories on extensive savannah formations during the current Holocene period.
Research aims to examine impact of organisational cultural tightness on employee creativity and firm innovation in Asia. Tight cultures may hinder certain aspects but potentially foster other creative aspects.
A new study published in Scientific Reports confirms that common house spiders carry harmful bacteria and can transmit them through their fangs when biting. The study found that some of these bacteria are multi-drug resistant, making infections difficult to treat with regular medicine.
Researchers at Penn State and the University of Michigan have developed an inexpensive therapy to prevent antibiotic resistance. The 'anti-antibiotic', cholestyramine, reduces fecal shedding of daptomycin-resistant bacteria by up to 80-fold, providing a potential solution to the growing problem of antimicrobial resistance.
A recent study published in PLOS ONE found that three percent of primary school-aged children have self-harmed by age 11-12. Factors associated with self-harm include persistent symptoms of depression or anxiety, bullying, and poor emotional control. Early intervention strategies are necessary to address these issues.
A study published in Annals of Internal Medicine found that nearly 40% of US adults with overweight and 10% with obesity do not consider themselves overweight. This lack of self-awareness is linked to lower attempts to lose weight and contributes to rising obesity rates.
A new study models the climate on a future supercontinent, predicting significant changes in temperature and habitability. The Amasia scenario, with continents converging around the poles, would lead to colder temperatures and more snowfall, while the Aurica scenario, closer to the equator, would result in warmer temperatures.
A recent analysis reveals that older adults are more resilient to the pandemic's mental health effects than expected. Key factors include internal resources like stress response, cognitive capacity, and personality traits, as well as external resources like social connections and financial stability.
A machine learning model developed in Finland can identify best cancer drug combinations to selectively kill specific cancer cells with unique genetic or functional profiles. The AI model accurately predicts how different drug combinations inhibit particular cancer cells, paving the way for more effective cancer treatments.
A team from Marine Biological Laboratory has confirmed that insect wings evolved from leg lobes on an ancestral crustacean. The study used genomic approaches and long-ago scientific papers to settle the controversy, revealing a 300-million-year-old transition to land-dwelling.
A transition to hydrogen-powered mobility in Germany's heavy duty vehicle segment could achieve a deep reduction in emissions, with potential of -57 MtCO2eq annually. Green hydrogen offers competitive advantages over battery electric vehicles, particularly for heavy loads and longer driving ranges.
Researchers found that shorter delays in neurofeedback training significantly increase efficacy, enabling sustainable changes. This breakthrough opens new potential for NFB therapy in anxiety, depression, epilepsy, and other conditions.
A KU Leuven vaccine candidate, RegaVax, has shown promise in protecting against Covid-19 and yellow fever in hamsters and monkeys. The vaccine works after a single dose and offers long-lasting immunity to Covid-19.
The new PSMA PET imaging technique has been shown to detect significantly more prostate lesions than current standard-of-care techniques. This breakthrough could lead to better treatment outcomes and more precise care for men with prostate cancer.
Researchers found nine genes in mako sharks that relate to tumor suppression and wound healing, surprising given the low incidence of cancer in these animals. The study also suggests that mako sharks may have monochrome vision, a common trait among all shark species.
A landmark study led by the University of Sydney found that cannabidiol (CBD) in cannabis does not affect driving ability. In contrast, moderate amounts of tetrahydrocannabinol (THC) produce mild impairment lasting up to four hours.
A new transistor detects glyphosate in drinking water at 0.26 parts per million, outperforming conventional sensors with a detection limit of 0.95 ppm. The device works by adding copper ions that bind to the herbicide molecules, causing a detectable reduction in electric current.
Researchers identify 'digital thought clones' that collect personal data in real-time and predict user decisions. Experts advocate for a human-centered framework to protect data ownership and control, citing EU regulations as a foundation for legislation.
Scientists from the University of Groningen developed a machine learning-based algorithm, PySurf, which reduces electronic structure calculations significantly. The software requires several orders of magnitude less computational time than existing direct dynamics software and is available as an open-source free download.
Scientists discovered SLC25A51 as a key regulator of NAD transport into the mitochondria, a process linked to various physiological and pathological processes. The study opens possibilities for new metabolic therapies against ageing and cancer.
Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
Researchers at the University of Tsukuba used gene editing to introduce diversity into tomatoes, improving their nutrition and environmental sustainability. The study found that 10 out of 12 resulting tomato lines contained high levels of carotenoids, a precursor to vitamin A with antioxidant properties.