A Tufts University-led team discovered that embryonic brain signals direct the migration of immune cells to infection sites, significantly improving embryo survival rates. Without a brain, embryos are more susceptible to bacterial infections and succumb quickly.
Researchers at Rice University have created a grooved method to seed 3D-printed scaffolds with living cells, enabling the growth of different tissue types in a single platform. This innovative approach protects cells from heat and shear stresses, allowing for the creation of hard implants that can heal bone, cartilage, or muscle.
Researchers at Texas Tech University Health Sciences Center have identified the specific region of serotonin type 3A receptor that interacts with the RIC-3 chaperone protein. This discovery could lead to more effective treatments for diseases such as Alzheimer's, Parkinson's, and schizophrenia.
Researchers found that linker histone H1 undergoes liquid-liquid phase separation in the nucleus, forming droplets with densely packed DNA and enriching with protein HP1α. This process segregates heterochromatin from euchromatin, revealing a new function of histones in gene regulation.
Researchers created a neural network that autonomously finds solutions well-adapted to quantum advantage demonstrations, aiding in developing new efficient quantum computers. This breakthrough enables the prediction of quantum advantages in complex networks, which is crucial for creating cost-effective and reliable quantum devices.
A DNA study of over 10,000 people has identified naturally occurring gene variants that reduce the risk of Alzheimer's disease by impairing tyrosine phosphatase activity and cell survival. The findings suggest PI3K/Akt/GSK-3β signalling pathway as a key target for therapeutic drugs.
Researchers have discovered a new mechanism by which cells respond to environmental stresses, including high temperature, dryness and high salination. The study found that a cytoplasmic sensor enhances MAP kinase phosphorylation, leading to a more accurate and robust response than previously thought possible.
A study published in BMJ Evidence-Based Medicine found that people with conflicts of interest were more likely to provide positive testaments about psychiatric drug treatments. The authors recommend stricter management or prohibition of COIs to promote transparency and validity in the approval process.
Scientists have made an important discovery that could lead to more effective treatments for people living with multiple sclerosis (MS). The study found that drugs targeting the IL-17 molecule may not need to get across the blood-brain-barrier to be effective in treating MS.
A new study predicts the Len Small levee will continue to fail even if repaired due to erosion and increased precipitation. The levee's failure has caused severe damage to homes and businesses, and agricultural land degradation.
US sales of toddler milks more than doubled from 2006 to 2015, driven by increased TV advertising spending and lower prices. This surge in sales occurred despite health experts' recommendations that parents not serve toddler milks, citing added sugars and lack of nutritional benefits.
Rice University engineers developed a deep learning system that uses capsule neural networks to predict extreme weather events, such as heat waves and winter storms, with high accuracy. The system achieves 85% accuracy in five-day forecasts by identifying patterns in pressure systems and regional areas.
Scientists at the University of Freiburg created nanoparticles with polysaccharides, which allow them to pass through the kidneys and be excreted in urine. This breakthrough enables the combination of tumor accumulation and kidney clearance in a single nanoparticle, paving the way for safer nanomedicine administration.
A new study found that caregivers' self-care strategies are crucial in managing stress and improving family needs for children with Fetal Alcohol Spectrum Disorders (FASD). Caregivers who report greater confidence in their ability to use self-care also experience reduced parental distress and higher parenting satisfaction.
A new technique uses seismic waves from distant earthquakes to image the subterranean structure of Cleveland volcano. The study, published in Scientific Reports, resolved the architecture of the lower and middle crust for the first time, providing crucial information for emergency planning and saving human lives.
In Mediterranean Protected Areas, red coral colonies (Corallium rubrum) have recovered partially, with health levels comparable to those of the 1980s. The study highlights the effectiveness of marine protections and underscores the need for urgent protection measures in Mediterranean biodiversity hotspots.
Researchers at University of Cambridge discovered that sand dunes interact with and repel each other as they move, with turbulent swirls controlling the distance between them. The study used a unique experimental facility to observe long-term behavior, challenging existing theories on dune interaction.
Researchers find wooden pallets have a slightly lower carbon footprint than plastic pallets on both one-trip and 100,000-trip basis. Heat-treated wooden pallets incur a 20-30% lower carbon footprint than methyl bromide-fumigated ones.
Researchers at Johns Hopkins Medicine have proposed five quality measures for medical billing, including itemized bills, price transparency, and service quality. The measures aim to reduce financial toxicity and promote transparency, enabling patients to make informed decisions about their healthcare costs.
The EU-funded IN-FET project develops novel nanodevices to treat neurological diseases like epilepsy and Parkinson's by modulating nerve cell activity. The project uses ion-based technology to correct hyper-excitability in brain cells, offering a natural approach to treating these conditions.
Researchers at the Technical University of Berlin introduce a new method to synthesize α-amanitin, a highly selective inhibitor of RNA polymerase II. This synthetic route allows for large-scale production and could lead to cancer treatment advancements.
Researchers at Princeton University have found a link between microbes and cancer in threatened Santa Catalina foxes, with ear mites and Staphylococcus pseudintermedius playing a key role. The study shows that a shift in the microbiome allows antibiotic-resistant infection to take hold, leading to chronic inflammation and tumor growth.
Researchers at Texas A&M University have developed biodegradable hydrogels that create a fertile environment for bone stem cells to grow and proliferate. The study found that the space created by degrading hydrogels enables stem cells to thrive, remodel their local environment, and form intricate cellular networks.
Researchers have successfully isolated kidney stem cells from urine, expressing markers similar to bone marrow-derived mesenchymal stem cells and renal stem cell markers. The isolated cells can differentiate into various kidney cell types, including proximal- and distal-tubules and podocytes.
The University of Massachusetts Amherst will conduct a 12-year study on the socioeconomic impacts of casino gambling in Massachusetts, with a focus on employment and public health effects. The study aims to identify populations at higher risk of problem gambling and inform prevention and treatment programs.
A Danish registry study found a significant association between neurological disorders, including dementia and Parkinson's disease, and increased risk of suicide. The study analyzed nearly 40 years of data for 7.3 million people, revealing that those with neurological conditions were more likely to die by suicide.
A new study suggests that human cooperativity is an outcome of competition between cultural groups. Researchers found that culturally different groups compete, leading to the spread of traits that give groups a competitive edge, including cooperation.
A recent study analyzed the antimicrobial resistance genes in the mouth and gut microbiome, finding distinct resistome profiles with varying levels of diversity. The researchers' findings suggest that expanding human resistome studies to other body areas is crucial for understanding the spread of antibiotic resistance.
Researchers found an 85% greater snow depth in burned areas compared to non-burned areas. Severe wildfires can lead to increased flood potential, loss of nutrients, and erosion for downstream communities.
Researchers used travel data to estimate that the virus was introduced to at least 128 cities in China before the Wuhan quarantine began. The study suggests that early travel during the Spring Festival season seeded cases far beyond the Wuhan region.
A new study found that over half of US opioid prescriptions for dental procedures exceeded the recommended 3-day supply, with nearly 1/3 of patients receiving more powerful opioids than needed. The study suggests that improving guidelines and education for dentists can help reduce overprescription.
Researchers found a new long non-coding RNA, PRECSIT, that regulates the growth and invasion of squamous cell carcinoma in skin. PRECSIT's expression is linked to the tumor suppressor gene p53, promoting cancer progression via STAT3 signaling.
A team of Yale researchers has discovered a way to reverse type-2 diabetes and liver fibrosis in mice, highlighting the potential for targeting TET3 protein. The studies, published in Cell Reports and Nature Communications, also suggest that TET3 plays a role in fibrosis development and may be a key target for treatment.
A new study found that Medicaid expansion significantly reduced uninsured rates among low-income residents in the Diabetes Belt. The increase in insurance coverage helped address access to care issues, leading to improved health outcomes and quality of life for those affected by diabetes.
Researchers at Oxford University Press USA have identified new ways to prevent skin scarring after injuries. The study suggests that pressure therapy, silicone treatment, and early laser intervention can reduce scar formation and improve therapeutic response. These findings offer promising hope for patients with hypertrophic scars.
A team of chemical engineers has developed a new way to produce medicines and chemicals on demand using portable biofactories embedded in water-based gels. The approach could help people in remote villages or on military missions access critical medicines and daily use chemicals.
Scientists at the University of Bonn have developed a new method to study the structure of long ribonucleic acids, which are crucial for cellular regulation. The technique involves marking specific locations on the RNA with artificial flags and measuring their distances using a molecular ruler.
A new imaging system, Flyception2, has recorded ultra-precise brain activities in flies during various stages of mating, including courtship. The study reveals surprising findings about brain nerve cells' activity patterns, with P1 neurons inactive during copulation and mAL neurons switched on.
Research from Binghamton University found that publicly sharing goals only affects those who care about public perception. Immediate feedback and high incentives are crucial for goal persistence after a failure. People who don't value public reputation aren't affected by the public or private nature of a goal.
Research from the University of Warwick found that shorter sleep duration is associated with increased depression and anxiety in children. The study examined brain structure and cognitive performance in 11,000 children aged 9-11, revealing lower brain volume in areas involved in emotional regulation.
Researchers at Michigan State University developed a new method to detect protein density in blood plasma using magnetic levitation. This technique could lead to improved disease diagnosis and treatment by identifying distinct patterns of proteins associated with various health conditions, such as opioid abuse and multiple sclerosis.
Researchers aim to create a less expensive and efficient natural gas storage system using super-absorbent materials, enabling smaller tanks for vehicles.
A new species of thalattosaur, Gunakadeit joseeae, has been discovered in Southeast Alaska, providing insights into the marine reptile's family tree. The fossil, which is the most complete thalattosaur ever found in North America, dates back over 200 million years.
ITMO University researchers have developed a DNA-based nanorobot that can detect and destroy pathogenic RNA strands in cancer cells. The nanorobot, which costs $20 to produce, uses deoxyribozymes to cleave bonds in an RNA strand, effectively blocking the production of harmful proteins and killing cancer cells.
A new study found that peace of mind plays a significant role in parents' attitude towards vaccines, with reassurance from knowledge of benefits and healthcare providers influencing decisions. The research suggests that decision makers should consider these benefits when making funding decisions.
Researchers at the University of Toronto have found a complex system of filaments and liquid droplet dynamics that enables the repair of damaged DNA in cell nuclei. This discovery challenges previous assumptions about DNA damage and highlights the value of cross-disciplinary research.
A new study found that general anesthesia in cesarean delivery is associated with a 54% increase in the odds of severe postpartum depression requiring hospitalization. Women who received regional anesthesia had a lower risk of developing suicidal thoughts or self-inflicted injury.
Researchers found niche mutations to have higher mortality than EGFR, but similar mortality to KRAS mutations. Next-generation sequencing helps identify a large panel of mutations for precise treatment selection.
A survey of 1,923 NC State students found that nearly 10% experienced homelessness and over 14% struggled with food insecurity in the previous 30 days. The study highlights the need for institutions to address these challenges and provide support services for students facing housing and food insecurity.
A study on co-creation in research reveals the benefits of collaborative models, including improved communication dynamics and decision-making techniques. Practical tools for managing cross-disciplinary research projects have been developed to address the challenges of complexity and diversity.
A study by University of Arizona researcher Terrence Hill found that gun ownership is not associated with improved happiness or better sleep. Gun owners were more likely to be married, which was driving their reported happiness. However, a separate study on sleep disturbance showed no difference between gun owners and non-gun owners.
A new handheld 3D skin printer has been developed to accelerate wound healing of large, severe burns. The device deposits sheets of skin using 'bio ink' made from mesenchymal stem cells, which promotes skin regeneration and reduces scarring.
Researchers describe key chest CT imaging findings in Wuhan coronavirus patients, highlighting bilateral ground-glass and consolidative pulmonary opacities. The study's findings suggest that lung cavitation, discrete nodules, and lymphadenopathy are characteristically absent in cases of 2019-nCoV.
A new study suggests that roughly half of opioid prescriptions written by dentists in the US exceed federal guidelines for pain management. Dental procedures like extractions can lead to significant pain, and researchers found that some dentists are overprescribing opioids as a result.
Researchers found that Clostridium perfringens enterotoxin induces CLDN4 nuclear translocation, enhancing epithelial-mesenchymal transition, stemness, and invasive ability in oral squamous cell carcinoma cells. The complex of YAP1, CLDN4, and zona occludens-2 was formed by CPE treatment, suppressing YAP1 phosphorylation and activating it.
Researchers from Kazan Federal University have developed a new reagent to combat hydrate formation in Arctic oil production, reducing environmental harm. The chitosan-graft-Polyacrylamide reagent slows down hydrate formation and ensures safe transportation of products in optimal temperature ranges.
Researchers discovered that zebrafish heart muscle cells switch from fatty acids to sugars for energy, enabling regeneration. This metabolic shift is crucial for heart regeneration and may hold potential for human heart regeneration after a heart attack.
Researchers have identified a new treatment target for preventing acute kidney injury, which affects up to 10% of hospitalized patients. High levels of soluble urokinase plasminogen activator receptor (suPAR) are linked to the risk of acute kidney injury, and reducing suPAR levels may help prevent damage to healthy kidneys.
A new study finds that zoos with large, iconic animals like rhinos and tigers tend to have higher attendance and contribute more to conservation funding. However, the research also suggests that zoos can increase conservation impact by diversifying their species collections.
New research shows that feeding bluebirds can significantly impact parasitic nest flies and improve nestling survival. The study found that supplementing birds with food reduces the parasite load and improves antibody levels, which help kill the parasites. The timing of feeding is also crucial, with early feeding benefiting young birds...