A study published in Cell Reports reveals that human acute myeloid leukemia (AML) stem cells are dependent on the transcription factor RUNX1, which could lead to lasting remissions or even cures. The researchers used induced pluripotent stem cells from a patient with AML to recreate leukemia stem cell biology in the lab.
Experts from Regenstrief Institute, Mayo Clinic and The Pew Charitable Trusts call for urgent action to address patient matching rates, which vary widely. The correct sharing of electronic health data among healthcare providers is crucial for identifying COVID-19 infected individuals and supporting future vaccination efforts.
A research team from Singapore University of Technology and Design has discovered a new strategy to resolve contact resistance in 2D semiconductor devices. They found that an ultrathin film of Na3Bi can be used as a metal contact with low contact resistance, retaining the intrinsic electronic properties of 2D semiconductors.
Researchers from the University of Helsinki have found strong evidence for the presence of exotic quark matter inside the cores of the largest neutron stars in existence. The new results were published in Nature Physics and combined recent findings from theoretical particle and nuclear physics with astrophysical measurements.
Scientists have created a sodium-ion battery that can deliver high energy capacity and recharge successfully, keeping over 80% of its charge after 1,000 cycles. This breakthrough has the potential to replace rare and expensive lithium-ion batteries with more abundant and affordable materials.
A special issue of Frontiers in Ecology and the Environment synthesizes climate-change refugia science developments, highlighting conservation successes and future directions. The article highlights the importance of 'slow lanes' to protect native species and ecosystems from climate change impacts.
A new study found that the diets of reef fish dictate how fast different species evolve, with big vegetarian fish driving biodiversity. The study's authors built an evolutionary tree of life for nearly all fishes associated with reefs, examining variation in rates of species formation and asking what drives it.
A UConn study found that most Americans are experiencing stress related to COVID-19, but also adhering to social distancing guidelines. The survey showed high stress exposure and vulnerable demographic groups, with younger adults and men showing potentially worrisome lack of adherence to CDC guidelines.
Researchers used silicone dog tags as passive environmental samplers to collect data on everyday chemical exposures in dogs and their owners. They found significant correlations between exposure levels for owners and pets, as well as similarities in urinary biomarkers.
Researchers have identified similarities and differences in ocean acidification on both coasts of North America, with the east coast experiencing a near-equilibrium pattern and the west coast showing enhanced acidification due to upwelling. The study highlights vulnerable hot spots, particularly in northern waters where rising carbon d...
A new clinical trial has validated a remote genetic counseling approach, enabling women to assess their cancer risk from the comfort of their own homes. The study showed that skipping personalized counseling did not increase patients' distress and may lead to increased access for genetic testing.
Captisol, developed at KU in 1990, enhances solubility and chemical stability of remdesivir. It was invented by Valentino Stella and Roger Rajewski to address insoluble drugs' limitations.
Researchers have discovered that current CO2 levels surpass a 23-million-year-old record, suggesting unique greenhouse disruption. The findings imply that ecosystems and temperature might be more sensitive to smaller changes in CO2 than previously thought.
A new learning analytics system uses Natural Language Processing (NLP) to extract insights from open-ended student feedback, providing faculty with detailed information on their teaching practices and curriculum development. The system aims to help instructors refine their teaching methods and improve overall student learning outcomes.
Research reveals that cancer clusters exhibit higher metastatic potential than single cells due to increased resistance to natural killer cell-mediated destruction. The study suggests enhancing the ability of activated NK cells to eliminate cluster metastasis could provide a complementary cancer therapy approach.
Researchers found that when hippocampal neurons are already firing at high rates before seeing a word, participants are more successful in encoding and remembering the word later. This suggests that the hippocampus may have a specific mode for facilitating memory formation.
Researchers analyzed over 200,000 spiral galaxies, finding a pattern of asymmetry in their spin directions that suggests the early universe may have been spinning. The study also reveals complex cosmological multipoles, which indicate a non-symmetric structure to the universe.
Researchers at MIT demonstrate the mass production of carbon nanotube field-effect transistors (CNFETs) using a commercial manufacturing facility. This breakthrough enables the creation of 3D microprocessors with unprecedented energy efficiency and performance, potentially surpassing silicon-based technology.
The interface of genomic information with the electronic health record emphasizes the importance of patient autonomy, access, and privacy in integrating genomic data into EHRs. The document provides guidelines on data storage, access, and usage, aiming to optimize benefits while minimizing harm, and recommends standards for interoperab...
A study found an association between lower humidity and increased COVID-19 cases in Sydney. Lower humidity makes airborne viruses more transmissible due to smaller aerosol size, increasing exposure for others. Further research is needed to determine this relationship's extent and impact on case notification rates.
Scientists have developed a new approach to chromatin immunoprecipitation (ChIP) called FloChIP, which uses microfluidics to automate and lower the cost and complexity of the technique. This method can perform multiple ChIP-seq assays simultaneously and reproducibly in an automated way.
Researchers found that dry air drives changes in how plants drink and breathe, with global warming predicted to shift this process more than previously thought. Plants will use less water than expected during hot droughts, but plant growth and carbon uptake may suffer.
Researchers at Ben-Gurion University have successfully controlled the microbiome of cattle, inhibiting their methane production and reducing greenhouse gases. The findings, published in Nature Communications, provide a new approach to mitigating climate change by targeting the animal microbiome.
Quasiperiodic structures exhibit unique beauty and intriguing physics, but a lack of overarching framework hindered understanding. Researchers establish versatile tools for exploring quantum behavior in diverse quasiperiodic settings, demonstrating the strength of their approach to uncover new physical mechanisms.
Scientists have discovered that a mutant protein associated with familial ALS disrupts neurotransmission at the squid giant synapse. Intermittent high-frequency stimulation restores synaptic function, suggesting a new approach to therapeutic intervention for ALS. This study provides insights into fundamental synaptic physiology and off...
A new study aims to develop an evidence-based intervention program to prevent suicide among LGBTQ youth and young adults. The SDSU research team will work with social workers to provide coping strategies, support groups, and mental health resources to individuals who have attempted suicide.
Researchers at Peter the Great St.Petersburg Polytechnic University created a solid-state thin-film battery with high specific energy density, suitable for miniature devices like biosensors and smartwatches. The new technology uses Atomic Layer Deposition to produce lithium nickelate cathodes, improving performance and efficiency.
Hurricane flooding can lead to widespread water pollution, affecting human health and ecosystems. Researchers have developed an algorithm to identify flooded areas beyond state-mapped hazard zones, with a focus on vulnerable communities and potential sources of pollution.
Researchers at UC San Diego developed a new nanosensor, SNACS, to monitor SnRK2 protein kinase activity in live plant cells. This allows for the study of drought tolerance mechanisms in unprecedented detail, providing insights into how plants respond to environmental stress.
The ES Matrix approach has been applied to assess ecosystem services in various studies, allowing for a higher number of ES assessment than other methods. However, the approach often lacks transparency and variability analyses, recommending improved applications and method elucidation.
Researchers have successfully recreated the process of creating matter from light using high-power lasers. The new method produces electron-positron pairs, mimicking conditions during the first minutes of the universe and providing an improved model for studying antimatter.
Researchers found that p53 plays a crucial role in regulating cell division and apoptosis only during pluripotent stem cell differentiation, resolving years of conflicting results. The study used various chemotherapy drugs to induce apoptosis in ESCs and showed that p53 is not essential for cell cycle arrest or apoptosis prior to diffe...
Researchers found that cancer cells activate an inflammatory response when in contact with fibroblasts, making it harder for viruses to infect them. By blocking this signaling pathway, oncolytic viruses can more effectively target cancer cells, offering a potential treatment option.
A machine learning-based analysis of San Francisco Police Department DNA samples found that selective sampling increases DNA match yields by 45.4% while minimizing costs. Processing all samples in a kit doubles positive matches but is only slightly less efficient.
A new study led by Ohio State University researchers has identified a protein within immune cells called PCBP1 that helps shape optimal immune responses to cancer. Higher PCBP1 activity promotes cytotoxic T-cell functions, while lower levels trigger the expression of factors that suppress cancer immune responses.
Researchers discovered that the Mediator complex selectively safeguards a small set of cell-type-specific genes, which form densely connected regulatory circuits. This finding suggests that Mediator is not generally required for all gene transcription and instead plays a crucial role in directing cell-type-specific functions.
Researchers at Uppsala University developed a new test method to measure hydroxychloroquine levels in patients with systemic lupus erythematosus (SLE). The analysis method, based on high-resolution mass spectrometry, reveals significant individual variations in medication metabolism.
A comprehensive review of 172 studies found that physical distancing of at least 1 meter reduces COVID-19 transmission risk, while face coverings and eye protection may provide additional benefits. However, no intervention offers complete protection, emphasizing the need for combined measures.
SYNB1891, an engineered E. coli Nissle strain producing cyclic di-AMP, demonstrates anti-tumor activity and generates immunological memory in preclinical models of cancer. The therapy is being evaluated in a Phase 1 clinical trial for patients with advanced solid tumors or lymphoma.
The report found many coral reefs to be in surprisingly good health, with abundant and diverse coral and fish communities. Reefs far from shore or protected in Marine Protected Areas were in particularly good condition, but nearshore reefs showed signs of fishing pressure.
Cold tolerance is more variable than heat tolerance across plant species and regions, reflecting evolutionary and geographical histories. Temperate plants are particularly vulnerable to climate change.
More than 500 terrestrial vertebrate species are on the brink of extinction, with fewer than 1,000 individuals remaining. Human activities in tropical and subtropical regions have driven the collapse of regional biodiversity, threatening numerous species.
Tropical Storm Amanda formed on May 31 over the eastern Pacific Ocean, near Guatemala's coast. The storm quickly moved inland and weakened due to mountainous terrain, dissipating by May 31. Its remnants are expected to generate heavy rainfall over Central America and southern Mexico.
Researchers created a multimodal digital holographic microscope that can produce 3D fluorescence and phase images of living cells without scanning. This technology has the potential to increase our understanding of stem cell processes in plants and revolutionize biology.
Transnational judicial training offers a win-win for judges and courts in Asia. By sharing best practices and strategies, countries can enhance their judicial systems and strengthen regional integration.
The mesopelagic zone, or Twilight Zone, holds the largest and least exploited fish reserves in the oceans, crucial for global carbon cycle and sustainability. Climate change and growing population demand threaten this ecosystem.
Research suggests fluctuating estrogen levels make alcohol more rewarding to female mice, potentially increasing susceptibility to alcohol use disorders. Activating estrogen receptors increases dopamine release and binge drinking behavior in female mice.
Researchers examine the effect of anti-fake news regulations on capital markets, citing anecdotal evidence of negative impacts. The study aims to fill an existing academic gap and provide insights for regulators and big corporations.
A new analysis approach helps identify when and where to conduct food safety inspections, reducing waste and lost sales. The researchers found that food recalls are delayed by 1-2 months, peaking from mid-August through mid-September.
A new study has identified the top sources of empty calories in children and teens, with soft drinks, cookies, and pizza emerging as major contributors. The research suggests that more than 25% of the calories consumed by children and adolescents come from added sugars and solid fats.
Researchers found that loggerhead sea turtles harbor thousands of microscopic organisms, including nematodes, on their shells. The study adds at least 111 new species to the list, revealing a complex relationship between turtle migration patterns and microbial communities.
The study found that SARS-CoV-2 infects nasal-lining cells more efficiently than lower-airway cells, suggesting the importance of wearing masks to limit transmission. The researchers also discovered a new reverse genetic platform for SARS-CoV-2, which will support national vaccine efforts.
Piya Ghose, an assistant professor of biology at UTA, has established a new lab with $2 million in CPRIT funding. Her research focuses on programmed cell death, which can lead to cancer through tumor creation. Ghose's work aims to understand how tumors behave throughout the body and could lead to breakthroughs in cancer treatment.
Research shows a significant increase in annual maximum one-day precipitation in North America, with anthropogenic forcing detected across the continent and smaller regions. The study suggests that human-induced warming has contributed to intensifying extreme precipitation events.
Researchers discovered new variants of feldspar stable under extreme pressure conditions, potentially altering seismologic signatures and plate dynamics. The high-pressure polymorphs were formed through severe geometrical distortions in the tetrahedral framework.
Researchers created a mini-insulin molecule that combines human insulin's potency with the fast-acting potential of cone snail venom, potentially improving blood sugar control. The hybrid insulin has the same potency as human insulin but acts faster, making it a prime candidate for new diabetes treatments.
Extreme horizontal branch stars, with four to five times hotter than the Sun, show giant magnetic spots that cause regular brightness variations. These spots are also linked to superflare events, explosions of energy several million times more energetic than similar eruptions on the Sun.
Researchers developed flexible sensor technology to detect fabric deformation, opening doors for smart textiles in clothing, hospital beds and robots. The technology measures time between sent and received signals to determine deformation location, type and intensity.
Researchers at KAIST developed a universal virus detection platform using reactive polymer-grafted double-stranded RNAs, which can detect viruses without prior knowledge of their genomic sequences. This platform provides enhanced sensitivity and can be used to quickly differentiate infected populations from non-infected ones.
Researchers found APRIL protein essential for plasmacyte development and immunoglobulin production in humans. A deficiency in APRIL leads to reduced plasmacyte numbers and increased susceptibility to infections.