Researchers developed an algorithm to predict sex-specific adverse drug effects, identifying 20,817 adverse drug effects posing sex-specific risks. The algorithm addresses confounding biases and provides an opportunity to minimize adverse events by tailoring drug prescription and dosage to sex.
A patient with akinetic mutism, a rare condition causing temporary paralysis and speech absence, experiences a remarkable recovery after taking a sleeping pill. Brain scans reveal overactive brain regions that can be suppressed by the medication, allowing for temporary speech and movement.
Biomedical researchers at Georgia State University have identified a novel method for eradicating rotavirus and other viral infections using interleukin-18 and interleukin-22. The study shows that these cytokines can rapidly and completely eliminate viruses from intestinal epithelial cells, even in compromised immune systems.
Research reveals that a group of parasitic finch species in Africa have evolved to mimic their host's chicks with astonishing accuracy. The study found that nestlings of these 'brood-parasitic' finches mimic the appearance, sounds and movements of their grassfinch host's chicks.
The Chicago Center for HIV Elimination has been awarded $5 million to implement a COVID-19 testing project targeting low-income Latinx individuals and those with criminal justice backgrounds. The project will use an evidence-based Social Network Testing Strategy to increase testing rates among these populations.
Researchers developed a comprehensive tool to explore disease development patterns, identifying main highways of disease progression. The Danish Disease Trajectory Browser analyzes 25 years of public health data to discover frequent disease trajectories.
Physicists at the University of Arkansas have successfully developed a graphene-based circuit capable of capturing thermal motion and converting it into electrical current. The discovery proves a long-held theory that graphene can harness energy from its atomic motion.
A study by Uppsala University researchers suggests that nitric oxide may be an effective treatment for COVID-19, with antiviral properties that inhibit the replication of the SARS-CoV-2 virus. The compound is produced naturally in the body and has been shown to reduce inflammation and boost blood-oxygen saturation levels.
Researchers have identified a new target for creating flavivirus vaccines by targeting specific locations on the virus. This approach aims to remove memory B cells from the vaccination equation and avoid antibody-dependent enhancement of infection, which can result in more severe symptoms.
Controlling blood sugar levels boosts cognitive function, including thinking, learning, and remembering. However, more weight loss and exercise only improve executive function skills, while verbal learning and memory decline. Effective management of type 2 diabetes is crucial to offset its negative effects on brain health.
Scientists have discovered a new piece of DNA crucial for forming male sex organs in mice, revealing the Y-chromosome gene Sry has two distinct parts. The findings suggest this discovery could be used to manipulate sex ratios in agriculture and biological pest management, but not on human embryos.
Researchers at Northwestern University developed a quantitative model to understand how politicized environments affect US political opinion formation and evolution. The model incorporates three psychological effects: attraction/repulsion, tribalism, and perceptual filtering, to simulate how populations change their opinions.
Scientists have created a 3D tumour model for ovarian cancer, which can mimic the way tumour cells grow and respond to chemotherapy drugs. The new model has the potential to improve understanding and treatment of the disease.
A study by Indiana University researchers finds that 31 million people living on river deltas worldwide are at high risk of experiencing flooding and other climate-related impacts. River deltas contain 4.5% of the global population, but only 0.5% of the earth's land surface.
Researchers developed a new nanoscale metal-organic framework design to deliver targeted, personalized vaccines for cancer treatment. The approach leverages radiation treatment and the adaptive immune response to kill cancer cells directly and trigger an immune response against tumor cells.
Researchers at Gladstone Institutes are studying how cells regulate their energy levels and exploring ways to target energy regulation processes to treat diseases such as neurodegeneration and heart failure.
A German chemist is researching green hydrogen production using sunlight to meet the EU's climate targets. The goal is to replace fossil-based raw materials with sustainable green hydrogen for transportation, industry, and heating, aiming to become a global leader in this field by 2035.
A study by DESY's X-ray source PETRA III reveals that dry heating can form characteristic DNA base pairs without water or solvents. The team observed the formation of adenine-thymine and guanine-cytosine pairs at temperatures between 100-200 degrees Celsius, suggesting a possible alternative route to molecular recognition patterns in DNA.
A new study from University of East Anglia and University of Florence reveals that faecal transplants can alter gut microbiome, impacting spatial learning and memory in mice. The procedure may hold promise as a therapy to combat cognitive decline among the elderly.
Researchers found caesarean section and prolonged labour influence infant gut microbiome, linked to childhood obesity and allergic sensitization. The study identified specific bacteria and metabolic pathways involved in these health outcomes.
A pilot study comparing liquid biopsy with tissue-based test found that liquid biopsy results were approximately 10 days faster than tissue biopsy. Liquid biopsy identified actionable genes in 14 cases, while tissue biopsy only detected them in 11 cases.
The September nTIDE report reveals a decline in employment-to-population ratios and labor force participation rates for Americans with disabilities, due to the impact of the COVID-19 pandemic. This trend suggests that people with disabilities are leaving the labor market or no longer actively seeking work.
A new method developed by Drexel University researchers can rapidly reveal the genetic evolution and spread of COVID-19. By analyzing global genetic data, they identified at least 8 to 14 variants of the virus infecting Americans, some originating from Asia or Europe.
Researchers found that allowing farmers to harvest vegetation from riparian buffers minimally impacts water quality, with only slight annual average reductions in nutrient and sediment capture. The location of the buffer was most important, as buffers between fields and streams removed more pollutants than those near streams.
A new COVID test has been developed that omits scarce reagents needed for previous tests, providing accurate results with high accuracy (92%) and reliability. The two-step test is ideal for screening programs in both developing and developed countries, and could extend testing capacity to groups not currently being tested.
Research at the European Breast Cancer Conference highlights a significant difference in survival rates between breast cancers detected during screening and those detected in the interval between screenings. Screen-detected cancers have higher eight-year distant metastasis-free interval rates, even among high-risk tumours.
Researchers discovered that speech generates conical airflow that can travel up to 2 meters in 30 seconds, emphasizing the importance of time and distance in transmission. Saliva filaments form on the lips during consonant sounds, breaking into microscopic droplets that spread pathogens.
A study published in Nature Communications finds that a multiple sclerosis treatment inhibits coronavirus replication and reduces inflammation in human lung cells. Researchers are optimistic about the potential of dimethyl fumarate to combat COVID-19.
Researchers analyzed surgical outcomes in Swedish cataract surgeries from 2007-2016, finding that high-volume surgeons had a lower proportion of severe cases and complications. The study suggests that surgeons can improve patient safety by understanding the impact of case mix on outcomes.
Forsyth researchers discovered a way to reverse periodontal disease by stimulating stem cells with Maresin-1 and Resolvin-E1, two synthetic lipid mediators. This finding offers new therapeutic possibilities for treating systemic diseases associated with inflammation.
Researchers at Northwestern University have developed a new cell perturbation system that can deliver DNA, RNA, and proteins into cells with high efficiency and low toxicity. The Nanofountain Probe Electroporation system has the potential to revolutionize medical treatments by enabling quicker and more customized treatment plans.
The RESPOND project will create a diverse network of stakeholders to support critical 'super nodes' and accelerate product development. The grant builds on the success of the Massachusetts Manufacturing Emergency Response Team (MERT), which facilitated the production of over eleven million pieces of PPE during the COVID-19 pandemic.
Researchers analyzed woodpeckers' drumming signals to understand their function and diversification. Despite changes in structure, the amount of biological information about species identity remained consistent for 22 million years.
Researchers investigated whether avoiding cow's milk formula after birth affects young children's risk of developing asthma. The study found a significant decrease in recurrent wheeze among children who did not receive cow's milk formula.
Heavy rainfall was found to be occurring around the compact eye of Major Hurricane Marie, with NASA's Integrated Multi-satellitE Retrievals for GPM (IMERG) estimating rainfall rates ranging from 3-20mm/hour. The satellite data provides valuable insights into the storm's intensity and helps improve hurricane forecasting.
The Obesity Society has announced four honorees for its annual symposium, which will present the latest insights into preventing and treating obesity. The honorees represent a range of topics, including the effects of obesogenic medication on weight change outcomes.
A new study found that continuous positive airway pressure (CPAP) treatment can lower daytime resting heart rates in patients with prediabetes who have obstructive sleep apnea, reducing their risk of cardiovascular disease. Optimal CPAP treatment also lowers heart rates during the day, similar to regular exercise.
Research finds that oral cancer is promoted by periodontal pathogens and can be inhibited by a bacteriocin, a naturally occurring antimicrobial peptide. The study offers new insights into the development of oral cancer and suggests potential therapeutic applications for nisin, a commonly used food preservative.
Researchers analyzed data from over 3.6 million women to identify differences in hypertensive disorders of pregnancy among US states. The study found significant variations in prevalence rates, suggesting regional disparities in maternal health care.
Researchers used computer simulations to study the behavior of ancient ancestors, revealing their ability to adapt to different positions within the water. The findings suggest that these jawless vertebrates were not as limited as previously thought and had diverse lifestyles.
A researcher at the University of Oklahoma is conducting a study to investigate the role of menthol flavoring in smoking habits among young adults. The study aims to inform the FDA's decision on whether to ban menthol flavoring in cigarettes, which could reduce smoking rates among at-risk populations.
The GDPR's restrictive approach to international data transfers is hindering global biomedical research, including essential COVID-19 studies. The authors propose amendments to address this issue, ensuring the balance between individual privacy and societal benefits in research contexts.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
Researchers conducted transcranial magnetic stimulation (TMS) on themselves and a group of volunteers in zero gravity to assess its safety and efficacy. The study aimed to compare TMS results under Earth's gravity to those in zero gravity, with potential implications for long-term space missions.
Hurricane Marie is rapidly growing stronger and more powerful, with cloud top temperatures reaching as low as -80°F. The National Hurricane Center expects Marie to become a major hurricane late on Oct. 1, with rapid strengthening forecasted.
PATH will lead an international collaboration to optimize Cry5B protein as an inexpensive, broad-spectrum antiparasitic treatment suitable for adults, children, and pregnant women. The goal is to expand anthelmintic MDA campaigns and reduce the global burden of STH infections.
Researchers create detailed models of tip links, crucial components of the inner ear, to shed light on how hearing works. The study reveals key dynamics and interactions between proteins that form tip links, providing new insights into hearing loss and balance disorders.
A study found that 78% of people with sudden loss of smell had COVID-19 antibodies, highlighting the significance of this symptom. Loss of smell is a highly specific symptom of COVID-19 and should be urgently recognized globally.
A new sensor developed by Caltech researchers can rapidly detect COVID-19 infection in under 10 minutes, offering a potential solution for early diagnosis and monitoring. The sensor uses graphene and antibodies to detect specific proteins and chemical markers of inflammation, providing a full picture of the infection.
Researchers at Chalmers University of Technology have developed a novel concept for laser-based communications using an almost noiseless optical preamplifier in the receiver. This results in an unprecedented receiver sensitivity of one photon-per-information bit at a data rate of 10 gigabits per second.
Researchers at Ruhr-University Bochum discovered that certain drugs can activate glutamate receptors, rather than inhibiting them, due to their binding to specific receptor subtypes. This potentiation effect can lead to a stronger response and longer-lasting effects.
Patients value clear information about religious hospital policies and want early disclosure of potential restrictions. Women express frustration with lack of transparency, highlighting the need for more effort from healthcare institutions to inform patients.
Birds with larger eyes are better adapted to dark environments, while those in agricultural settings often have smaller eyes. The study found that eye size is linked to habitat and foraging technique, suggesting it could help inform research on birds' sensitivity to bright environments.
Researchers mapped genomic evolution of Vibrio cholerae bacteria in Argentina during the 1991-1998 cholera outbreak. The study distinguished between pandemic and non-pandemic lineages, influencing health policy and national alert surveillance system.
Researchers in China and Switzerland created biodegradable electronic blood vessels that can be actively tuned to address body changes after implantation. These flexible vessels mimic natural blood vessels and demonstrate promise as surrogate arteries in rabbits.
The PLOS journal has developed 10 guidelines to help lab leaders create anti-racist environments, promoting diversity and inclusion. The rules include organizing discussions about racism, amplifying BIPOC voices, and adopting dynamic research agendas.
Researchers at the Technion-Israel Institute of Technology have developed a floating laser resonator that breaks records in resonance enhancement. The device amplifies light power by an astonishing 10 million watts, equivalent to a large neighborhood's electricity consumption.
A comprehensive study of RGS proteins reveals how they modulate cell signaling and explains why people's responses to the same drugs can vary widely. The researchers created a roadmap for how GPCR signals are routed in cells, highlighting the potential for new treatment approaches for various conditions.
Rover Diagnostics' affordable and portable point-of-care test provides reverse transcription polymerase chain reaction (RT-PCR) results in eight minutes, faster than any other test of its kind. The platform is designed to be targeted at locations where rapid turnaround results are important.
Researchers at the University at Buffalo have received a grant to help pharmacies implement community health worker programs. These programs aim to improve patient access to critical services while lowering healthcare costs. By providing outreach, education, and support, community health workers can address complex patients with multip...