Researchers have found that blocking DHPS, an enzyme necessary for activating elF5A, can reduce inflammation and improve glucose control in mice. The study suggests macrophages play a key role in inflammation in obesity, and targeting this pathway may be a promising approach to treating the condition.
A new study using Neanderthal fragments suggests that generation intervals have fluctuated over the past 40,000 years, with human life history changing in response to environmental and cultural factors. The research found that Eurasian populations reproduced at a younger age than those in Europe, indicating a difference of 3-5 years in...
Researchers are studying how climate change is forcing animals to evolve and adapt, with changes in beak and ear sizes reported in birds and tail length increases in mice, experts warn that these changes may have unintended ecological consequences
Scientists from HKUST and PolyU develop an in-vitro vesicle formation assay to study cargo clients and factors that mediate vesicular trafficking. The study reveals cytosolic proteins associated with vesicle membranes, including FAM84B and PRRC1, and uncovers novel cargo proteins dependent on GTP hydrolysis.
Research finds that patients undergoing planned surgery in independent sector hospitals have shorter hospital stays and lower readmission rates than those treated in NHS hospitals. The study analyzed data from over 3.5 million patients and found significant differences in length of stay, emergency transfers, and readmissions.
Researchers at Duke University have developed an open-source software platform called ASCENT that allows non-experts to create patient-specific, 3D models of nerves being electrically stimulated. This enables more accurate predictions and potentially new therapies for diseases such as diabetes and cardiovascular disease.
A new study reveals that climate change will affect Antarctic seals, such as crabeater and Weddell seals, in distinct ways. Crabeater seals are more vulnerable due to their specialized diet and breeding on unstable pack-ice, while Weddell seals are less affected.
A recent study published in Genome Biology found direct evidence that CTCF governs chromatin accessibility, a critical process for gene expression. By using cutting-edge technologies and a multidisciplinary approach, researchers discovered CTCF's role in rewiring genome-wide chromatin assembly.
Researchers at RMIT University developed highly versatile, cost-effective 3D printed catalysts that could tackle the challenge of overheating in hypersonic aircraft. The new catalysts show promise for fuelling the future of hypersonic flight by simultaneously cooling the system.
Researchers at Georgia Institute of Technology developed improved carbon membranes that can efficiently separate para-xylene from its siblings, reducing energy consumption by up to three times. The breakthrough could lower energy costs in producing commodity chemicals and fuels.
Researchers found that temperature during insect development impacts the protective effect of Wolbachia against viruses. Lower temperatures reduce protection, while higher temperatures enhance it. This discovery has significant implications for initiatives like the World Mosquito Program and understanding Wolbachia biology.
A study from Michigan Medicine found that people with type 2 diabetes are more likely to develop a cytokine storm during coronavirus infection due to the enzyme SETDB2. Administering interferon beta increased SETDB2 and decreased inflammatory cytokines in diabetic mice, offering potential therapy for severe COVID-19.
Research suggests that overweight and obese asthmatic children are less likely to respond to inhaled steroid medication, leading to more frequent asthma attacks. The study used genetic variants linked to BMI to investigate this link, finding a correlation between higher BMI z-scores and poor ICS response.
A study by Binghamton University found that companies that express remorse in the wake of a product failure are more likely to encourage customers to repurchase from them. The researchers also discovered that remorseful statements can help stave off retaliatory actions such as lawsuits by framing messages that match consumers' natural ...
Researchers developed lab-on-a-chip optical biosensors for real-time COVID-19 detection, overcoming low viral load challenges. These sensors utilize light beam interactions to detect viruses, enabling faster diagnosis and controlling outbreaks.
A study using machine-learning models trained on over 1 million companies reveals that AI can accurately predict the success of startups. The tool, developed by researchers, has the potential to help investors make informed decisions and avoid significant losses.
A Tohoku University research group discovered that Peyer's patches and specific bacteria facilitate the transfer of maternal IgA to breastmilk, boosting newborn immunity. This finding has significant implications for developing probiotics to improve breastfeeding quality.
Researchers found educational workshops improved women's household decision-making and financial literacy in Nigeria. The programs were most effective in areas where women were less active, but showed inconsistent results in other domains.
A new tool has been developed to identify genetic influences behind sex-biased diseases, such as lupus, which affect females more frequently. The tool analyzes genes that escape X chromosome inactivation, a process that ensures females do not overexpress genes on their X-chromosomes.
Researchers are using tree rings and sediments to reconstruct Atlantic hurricane history over millennia. By combining these natural archives with global climate model simulations, they aim to refine the record of history's hurricanes.
A randomized clinical trial shows that a community-based weight management program delivered at health centers improved BMI in Hispanic children aged six to 12. The program, which included text messaging and connections to community resources, also reduced sugary beverage consumption, increased physical activity, and led to healthier l...
A new study found that young children with cancer are at a higher risk of permanent hearing loss due to the chemotherapy drug cisplatin. The study, published in the journal CANCER, reveals that up to 75% of children under 5 years old experienced hearing loss after treatment.
A Massachusetts General Hospital physician suggests that emoji could facilitate communication between patients and doctors, particularly in emergency medical settings. The use of emoji has the potential to improve patient-doctor communication, especially for those with disabilities or language barriers.
Physicist Eve Armstrong aims to understand the origins of elements heavier than iron using weather prediction technique data assimilation. With a two-year NSF EAGER grant, she and her team will predict whether supernova stardust gave rise to these heavy elements.
Scientists are still unraveling how pathogens adapt to changing conditions, including climate change and global trade. Genome sequencing and big data technologies have revealed that dramatic events like hybridization between pathogen species can lead to rapid evolution of virulence on new host plants.
The Agrobiodiversity Index reveals that globally, biodiversity and agrobiodiversity are in decline, with only a fraction of species contributing to crop production. Maintaining diversity is vital for achieving sustainable food systems.
Researchers at the University of California - San Diego have developed COVID-19 vaccine candidates made from plant viruses and bacteriophages, which can be stored and shipped without refrigeration. These vaccines trigger high production of neutralizing antibodies in mice, offering a potential solution for global distribution efforts.
A new method improves forecasting of toxic algae blooms by analyzing chemical markers from zooplankton in mussels, allowing for earlier warnings and more accurate predictions.
Researchers developed a lightweight and flexible passive air-breathing PEMFC with simplified components. The new design allows for easy assembly and folding, reducing the number of parts and increasing power output when connected in series.
A new study published in Nature Communications reveals that low-risk and high-risk neuroblastoma have distinct cell identities, which can affect survival rates. The researchers identified a progenitor cell type found in fetal adrenal tissue, which may contribute to the development of aggressive neuroblastoma in older children.
A new study suggests that emergency management officials often lack the numeracy skills needed to make best evacuation decisions based on data. The most numerate officials provided additional evacuation times to their coastal communities, while less numerate ones gave less advance warning and over-evacuated tens of thousands more people.
Researchers have created a new technology to enhance therapeutic antibodies' ability to attack blood cancer cells by leveraging the human immune system. This approach combines IgM and IgG antibodies, resulting in a single molecule with increased complement activation.
Patients with nontuberculous mycobacterial disease are hospitalized sooner and more often than their age- and sex-matched counterparts, according to a study published in CHEST. The risk is higher for people with compromised immune systems or damaged airways.
Researchers successfully simulated the capsid disassembly step of hepatitis B viral infection at an unprecedented atomic level, identifying specific regions of the capsid protein that contribute to breakage. This high-accuracy simulation can help design drugs to interrupt these processes and prevent chronic infection.
A new computer model developed by Columbia University researchers accurately predicts the likelihood of individuals being colonized with MRSA in hospital settings. The model identifies asymptomatic carriers, who are responsible for most of the spread, and suggests targeted interventions to control infections.
A team of researchers characterized different bacterial populations isolated from the International Space Station's potable water system, exploring their functional properties and long-term interactions. The study aimed to improve microbial risk assessments for human-built environments in space and on Earth.
Researchers developed a nanoporous super multi-element catalyst containing 14 elements through de-alloying. This alloy exhibits excellent water electrolysis properties due to the multi-element superposition effect. The breakthrough creation has potential for future development into an omnipotent and versatile catalyst.
Researchers have identified global hotspots where bird malaria is spreading rapidly, with significant impacts on bird populations. The study found that climate and forest conditions play a crucial role in predicting infection risks, highlighting the need for conservation efforts to protect bird species from this deadly disease.
Researchers found that patients taking omega-3 supplements showed stable memory function compared to those in the control group. However, no significant differences were observed in biomarkers in spinal fluid samples. The study provides valuable insights into the potential effects of omega-3 on Alzheimer's disease.
Researchers have developed an AI program that can spot signs of lung cancer up to a year before diagnosis using CT scans. The program was trained on 888 patients and tested on a separate set of 1179 patients, achieving a 97% accuracy rate in detecting malignant tumours.
Researchers at Arizona State University studied the physics behind humans balancing coffee while walking, revealing a natural mode of flexibility that mimics human motion. The findings can be used to design smart robots to adaptively handle complex objects in changing environments.
A new study from Lund University reveals that psychiatric and cognitive symptoms emerge at an early stage in Huntington's disease, highlighting the importance of targeting the emotional brain. Researchers identify changes in oligodendrocytes and white matter in the limbic system, suggesting a need for new treatment approaches.
A study found that boosting a cellular response to misfolded proteins actually shortens lifespan, contradicting previous research. The discovery highlights the complexity of aging and suggests new targets for disease prevention.
A new study by the University of York and Natural England finds that only 9% of Britain's land area has legal status for biodiversity protection. The researchers suggest prioritizing areas with high landscape value, but argues this approach is inefficient and may not deliver intended goals.
A new study found that non-Hispanic Black and Mexican American adults are diagnosed with type 2 diabetes at an average age of 46-47 years old, four to seven years earlier than non-Hispanic white adults. Preventive measures such as nutrition counseling and physical-activity programs can prevent or delay the onset of diabetes.
Researchers analyzed large datasets to find biomarkers that could help select immunotherapy treatment for older patients. The analysis suggests that factors such as mutational burden and immune checkpoint protein expression are associated with increased response to immunotherapies in older patients, despite lower general immunity.
A study published in Nature's Communications Biology reveals how geckos steer in mid-air and stabilise landings using their heads and tails. Researchers found that a shorter tail length results in increased adhesive foot force, crucial for successful vertical landing.
Researchers are developing a vaccine to prevent oxycodone use disorder, which affects half of those treated with existing medications. The experimental vaccine has shown promise in preclinical studies and is now being tested in a phase 1a/1b clinical trial at Columbia University.
Researchers at Kyoto University have made a groundbreaking discovery by creating functional sperm cells from mouse pluripotent stem cells. The breakthrough has significant implications for male fertility and reproduction, providing a new model for generating male germ cells in a test tube.
Researchers tracked five species of large land birds flying nonstop over the open ocean, exploiting wind and uplift conditions to save energy. The study reveals that many land birds rely on atmospheric support to complete their migrations, making them vulnerable to climate change.
The new QIBA profile provides a framework for evaluating the reliability of cartilage compositional imaging measurements, including T1rho and T2 mapping. It establishes minimum detectable changes in these values, enabling early detection of cartilage abnormalities and potentially preventing osteoarthritis.
Researchers at University of Toronto found that the brain's prefrontal cortex generalizes perceptual experiences from different senses, producing sensations even without direct experience. The study used functional magnetic resonance imaging and massage stones to capture neural activity patterns in the brain.
Researchers found that coral communities in the Phoenix Islands Protected Area (PIPA) are recovering from past heatwaves, with heat-tolerant offspring repopulating the reefs. This study provides a source of hope for coral reef conservation and restoration, highlighting the potential for some reefs to keep pace with ocean warming.
Scientists at Kobe University have created plants that can identify polychlorinated biphenyls and endocrine-disrupting chemicals, which contaminate soil and water. The plant-based method offers a convenient and inexpensive way to monitor toxicity levels.
Researchers identified three types of impasses: wanted, forced, and unwanted, each requiring specific solutions. Wanted impasses can be resolved by negotiating on interest levels, accelerating processes, and offering symbolic concessions.
A $992,000 VA Merit Review grant will fund research on non-neuronal activity after binge drinking to understand its impact on synaptic dysfunction and alcohol use disorder. The study aims to identify novel mechanisms, specifically astrocytes, involved in the dysregulation of neuronal activity.
Researchers have developed an AI-powered tool, Roofpedia, to track sustainable roof adoption worldwide. The tool uses satellite images to gauge cities' green and solar roof penetration, with Singapore ranked third in solar roof coverage.
A new study by University of Bristol researchers found that people's comfort in their surroundings affects their walking patterns, with those feeling relaxed having regular stepping patterns regardless of environment. The study suggests well-designed urban environments can benefit wellbeing, concentration, and attention similar to natu...
Researchers from Nagoya Institute of Technology synthesized elastic polymer films with versatile elongation and fracture properties using photo-modulus patterning. The films' Young's modulus can be controlled by post-preparation photo reaction, making them suitable for diverse applications.
Researchers sequenced the genomes of an ancient date palm leaf and found evidence of hybridization with wild relatives. The study sheds light on the evolution of date palms in North Africa, showing that genetic material from another species was present 2,200 years ago.