A study published in Cancer Medicine suggests that exosomes produced by adipose-derived mesenchymal stem cells can effectively deliver RNA-based anti-cancer treatments to bladder cancer tumors. This novel approach shows promise as a potential therapeutic agent for bladder cancer treatment, offering new hope for patients.
Research in Nature reveals the intrinsic activation mechanism of orphan GPCRs, a family offering new opportunities for cancer drug development. The study uncovers key molecular factors governing receptor activation and function modulation.
Scientists at KAUST have studied charge carrier behavior in perovskite thin films using laser pulses and terahertz radiation. They found that increased density of charge carriers narrows the energy gap for electrons to be excited by light, and charge carriers become more localized at higher densities.
Researchers at Georgia Institute of Technology have developed micro-rocker bots that can move precisely on a solid surface using a single electromagnetic coil. The robots, about the size of a particle of dust, are controlled by a magnetic field generated by the coil and can perform well-controlled movement with selectable direction.
Researchers at Memorial Sloan Kettering Cancer Center have obtained exquisite views of the androgen receptor using cryo-electron microscopy. The study reveals unique features of the receptor that enable it to turn on a wide range of genes, distinct from other hormone receptors. This newfound understanding provides clues to how androgen...
A mutated gene in more than 20% of breast cancer recurrences promotes metastasis and resistance to hormone therapy. Researchers identify potential vulnerabilities, leading to the development of personalized treatment approaches.
The study found an increase in mass shootings and proportion of women and children shot, highlighting worsening structural inequalities. The researchers emphasize the need for investment in public education, employment, and social services to address gun violence.
Researchers developed a model to identify vulnerable geographic areas for Wolbachia-carrying mosquito release, maximizing protection against dengue. The approach prioritizes areas with the greatest vulnerability, allowing targeted interventions.
Researchers subject Oreos to various tests, finding that the cream almost always separates onto one wafer, regardless of flavor or amount of filling. The team's study provides insights into the properties of yield stress fluids and offers a new approach to understanding non-Newtonian materials.
A new online program has been shown to improve health-related quality of life among adult stroke survivors. The study found that participants who received access to the program had higher scores on health-related quality of life and reported fewer problems with personal care and daily activities.
A study demonstrated that red blood cell vesicles can effectively carry immunotherapeutic RNA molecules to target breast cancer cells. This technology shows promise for delivering therapeutic RNA molecules to disease sites without degradation.
A cross-racial study of 1.87 million US veterans found significant differences in dementia incidence across five racial groups, with Hispanic and Black veterans at highest risk. Rates were significantly higher for Hispanics (99%) and Blacks (55%), while Asian veterans showed a 24% increase compared to whites.
A University of Helsinki research team used holographic duality to model early universe phase transitions and their potential impact on gravitational wave signals. The study, published in Physical Review Letters, suggests that such collisions could create powerful ripples in spacetime detectable by satellite missions like LISA.
Researchers discovered that checkpoint inhibitors can activate regulatory T cells, which can counteract the immune response. Blocking PD-L1 enhanced effector Treg activity, reducing ability to control parasite infections. This finding highlights complexity of immune system's balance between controlling pathogens and protecting healthy ...
Researchers from MIT found that Oreo creme tends to stick consistently to one side of the cookie, regardless of twisting speed or milk exposure. The study used a custom-made 'Oreometer' instrument to investigate cookie mechanics and encourage further research on rheology.
A randomized controlled trial found that an online program improved health-related quality of life among adult stroke survivors by promoting healthy lifestyle behaviors and reducing disability. The study showed significant benefits in personal care and daily activities for those who received access to the online program.
A new study finds that public praise energizes essential workers, while those who don't receive it experience negative emotions and poor coping mechanisms. Essential workers in less visible fields like corrections officers face significant challenges due to lack of appreciation.
A new study led by NYU researchers found that cannabis edibles mimicking popular snack foods have high THC content and may be easily confused for them, increasing the risk of accidental ingestion by children. The products often exceeded maximum limits set by state regulations, raising concerns about public health.
Wildfires in the Pacific Northwest are altering seasonal air pollution patterns and causing a spike in unhealthy pollutants in August. The research found that carbon monoxide levels have increased sharply, indicating the extent of smoke's impacts on clean air gains.
A new study by Yale University researchers found that medication treatment services are often not located in the most vulnerable communities, leaving them at risk of disrupted access to treatment during disasters. The study suggests that preparedness for natural disasters should prioritize those placed at highest risk.
A new study from the University of Georgia found that only about one-third of infants enrolled in WIC meet the daily recommendation for vitamin D by 13 months. Experts recommend increased education and supplementation to address this issue, which can lead to diseases like rickets and Type 1 diabetes.
Researchers find evidence of water pockets beneath the icy surface of Europa, which could facilitate exchange between the subsurface ocean and nutrients from neighboring celestial bodies. The discovery suggests a dynamic ice shell that supports habitability on the Jupiter moon.
Rutgers scientists found that inhaled nanoparticles can migrate from the lungs to the placenta and possibly fetal tissues after maternal exposure throughout pregnancy. This discovery raises concerns about the potential health effects of nanoparticle exposure on human fetuses.
Researchers propose that well-designed computerized clinical decision support can facilitate team approaches to healthcare, enhancing communication and coordinating group effort. The tool provides evidence-based information and guidance, enabling primary care physicians to oversee a diverse healthcare team more efficiently.
A study has identified a new protein, Creb-binding protein (CBP), as a prognostic marker for above-average patient survival in HPV-positive head and neck carcinoma. CBP inhibitors are being developed as targeted therapies that can improve quality of life by reducing side effects associated with conventional chemotherapy or radiotherapy.
A study published in Nature Communications found that BMP9 treatment restored capillary density and improved alveolarization in mice with ACDMPV. The treatment showed promise for improving care for BPD and CDH, two conditions that also affect lung development.
A genome-wide screening using CRISPR-Cas9 identified KEAP1 and Nrf2 as key molecules in sorafenib resistance. The study found that ML385 can enhance the killing effect of sorafenib, while FGF21 positively regulates Nrf2 expression.
Researchers found plasma neurofilament light levels were elevated in all types of frontotemporal dementia, and in people who had mutations but hadn't shown symptoms yet. Higher levels of the protein were associated with greater disease severity and increased just before symptom onset.
A novel mesh plug treatment, Woven EndoBridge (WEB), has been shown to be equally effective in treating sidewall brain aneurysms compared to bifurcation aneurysms. The study found a complication rate similar between the two approaches and demonstrated the safety and efficacy of WEB for sidewall aneurysms.
A study examined the frequency of FDA's extrapolation of pivotal trial data to approved indications, finding it occurred in 45% of cases. This practice may lead to different clinical results in real-world use compared to trials.
Dr. Lauren Southerland will receive the award for her pioneering multidisciplinary geriatric models of care for older adults with emergency healthcare needs. Her research focuses on quality improvement, implementation science, and incorporating geriatric care into ED care.
A new portable COVID-19 test can detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples. The test uses a genetic phenomenon called S-gene target failure to identify the alpha variant, and can be used at home or other settings.
A recent study led by the University of Bonn found no evidence of iron fertilization stimulating algae growth and sequestering CO2 in the Antarctic Ocean during ice ages. Instead, other processes such as sea ice cover and ocean stratification prevented CO2 from escaping into the atmosphere.
A new study by CUNY SPH researchers found that nearly 40% of NYC parents are hesitant to vaccinate their young children against COVID-19, with many citing safety concerns. The study suggests that mandates may be key in increasing vaccine coverage among children.
The SLAS Technology April issue delves into the potential of single-cell transcriptomics for producing transcriptomes from heterogeneous samples. Kind et al. present a new process that reduces sequencing library preparation time by over 75% using the 10X Genomics Single Cell 3' kit.
New PSU research predicts the disappearance of Olympic Peninsula glaciers by 2070, with some remaining as tiny shells. The study highlights the impact of global warming on glacier mass and ecology in the region.
A new study from the University of Kansas found that effective change agents and realistic timelines are crucial for successful change implementation. The study identified six key organizational change management practices to achieve high adoption of change initiatives in the AEC industry.
Patients hospitalized with COVID-19 pneumonia are at a higher risk of developing new-onset dementia compared to those with other types of pneumonia, according to a recent study. The median time interval between infection and dementia diagnosis was 182 days for COVID-19 patients.
A national study found that differential response programs, which provide voluntary services to families at risk of child maltreatment, were associated with a 19% reduction in substantiated reports of child maltreatment and a 25% decrease in neglect reports. These programs also led to a 17% reduction in foster care placements.
Researchers at HKU have identified a new protein, SBK1, that regulates lipid metabolism in the liver and alleviates health problems caused by fatty liver disease. The study found that SBK1 activity reduces lipid accumulation, inflammation, hyperlipidemia, and hyperglycemia in mice with fructose-induced fatty liver disease.
Researchers found a clear link between elevated amyloid beta levels and the development of anxiety and apathy in Alzheimer's patients. These symptoms occur mainly due to underlying brain changes, not psychological reactions. The study suggests that psychiatric symptoms could be used as alternative outcome measures in treatment trials.
A study on the Three Gorges Dam reveals that it has caused significant reductions in annual average CO2, CH4, and N2O emissions in the Yangtze River. The dam's impact extends thousands of kilometers downstream, challenging previous assumptions about large dams' effects on greenhouse gas emissions.
The study analyzed drug-drug interactions associated with adverse clinical outcomes and/or adverse drug reactions in patients with COVID-19. Drug interaction checkers were found to be helpful in identifying such events, suggesting their potential utility in real-world settings.
A systematic review and meta-analysis of 108 studies found that people with severe mental illness, including schizophrenia, have twice the cardiovascular-related mortality rate as the general population. The association has grown stronger over recent decades, with a possible link to changes in antipsychotic use and smoking prevalence.
A Canadian study of over 12,000 hospital admissions found that updated product label changes did not reduce rates of accidental acetaminophen overdose. The study suggests additional measures are needed to prevent these episodes beyond just labeling changes.
A new study found that microglia regulate neuronal subtypes differently in response to bacteria, affecting intrinsic excitability. Pyramidal cells exhibited lower excitability, while Purkinje cells showed higher excitability when modulated by microglia.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
Researchers from HKUST have identified secondary RNA elements that control DICER's cleavage activity, improving miRNA expression and shRNA design for effective gene silencing. The study provides a foundation for designing accurate and efficient short-hairpin RNAs.
Scientists tracked Cryptosporidium in real-time, revealing a simplified lifecycle that completes in three days with only three stages: asexual cells, male cells, and female cells. This understanding paves the way for potential vaccines or therapies to combat the disease.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A recent commentary in the Journal of the National Cancer Institute highlights the disproportionate cancer burden facing Asian Americans, largely attributed to historical prejudices and language barriers. The authors emphasize the need for increased funding and representation in clinical trials to address these disparities.
Scientists have found a new way dunes can form on Io's surface, which is icy and roiling. The researchers used mathematical equations to simulate the forces on a single grain of basalt or frost and calculate its path.
A study by Osaka University researchers reveals patients waited years for diagnosis of rare diseases like hereditary angioedema. Long diagnostic delays can be fatal, and raising awareness is key to improving treatment.
The 29th annual CNS meeting will feature scientific talks, posters, and receptions, with a focus on the latest advances in cognitive neuroscience. Registered press members will have access to these sessions, as well as a quiet Press Room, while COVID safety protocols are in place.
Researchers at Dartmouth have built the world's first superfluid circuit using pairs of ultracold electron-like atoms, allowing for controlled exploration of exotic materials like superconductors. The circuit enables analysis of electron movement in highly controllable settings.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
A Baylor College of Medicine study finds that type I interferon is a major driver of memory and cognitive loss in a mouse model of Alzheimer's disease. Blocking IFN reversed these memory and cognitive deficits in the animal model, suggesting that inflammation plays a key role in AD progression.
Researchers compared mechanical aeration and biofiltration systems to minimize odorous compounds in sewage treatment plants. Biofilters with pruning waste and sludge compost showed efficacy, but lasting effects were variable depending on compound type.
A new evidence-based matching program aims to improve treatment outcomes by pairing patients with therapists based on their previously established effectiveness strengths. The program, funded by PCORI, has shown promising results in reducing symptoms and improving patient care.
Researchers detected aphantasia through pupillary response to imagining dark and light objects. Participants without aphantasia showed a larger pupillary response when asked to imagine vividly, indicating the absence of visual imagery in those with aphantasia.