A study found eight classes of health conditions common among pediatric obese patients, including respiratory and sleep disorders. The researchers used a pattern mining algorithm on electronic health records of 49,694 patients to identify clinically similar subtypes.
Researchers developed a new method to synthesize polyimidazolium organic cages that can encapsulate metal nanoparticles, leading to improved catalytic performance. The new catalysts show superior activity in various reactions, with tunable NHC sites enhancing interactions between the shell and the metal nanoparticles.
Researchers tracing nitrogen pollution affecting the Mesoamerican Reef Region reveal that agricultural operations are responsible for the vast majority of nitrogen pollution. The study highlights the need for tailored management strategies to mitigate nutrient input and protect coral reef and seagrass health.
Researchers at Queen's University Belfast have secured a £228,900 grant to develop an mRNA vaccine targeting protein p53 in triple negative breast cancer. The project aims to improve treatment options for patients with this aggressive form of the disease.
A new scientific statement from the American Heart Association finds that social isolation and loneliness are associated with a 30% increased risk of heart attack or stroke. Younger adults, including Gen Z, experience increased social isolation and loneliness due to higher social media use and less in-person engagement.
A new study published in Cochrane Reviews found that tocolytics, or preterm delay treatments, are beneficial for women worldwide. The researchers reviewed 122 clinical trials and concluded that the benefits of these drugs outweigh any risks associated with side effects.
Researchers, led by TUM's Senthold Asseng, are exploring ways to close the genetic yield gap of 51% in wheat to meet increasing global demand. Utilizing advanced breeding techniques and interdisciplinary approaches combining genetics, soil, and climate science can lead to richer harvests.
TCT 2022 will feature late-breaking clinical science presenting the safety and effectiveness of minimally invasive techniques, pharmaceuticals, technologies, and devices for treating or preventing cardiovascular disease. The event takes place September 16-19 in Boston at the Boston Convention and Exhibition Center.
Research finds that grassland biodiversity and resilience are the result of a slow process over hundreds of years, not rapid recovery. Ancient grasslands have unique characteristics that develop over time and can be conserved to maintain ecosystem functions.
The NIH has launched an experimental science rigor initiative to improve the quality of research funded by the National Institutes of Health. The initiative provides a comprehensive, modular, and adaptable platform to host educational content on rigorous research, supporting the development of courses in experimental rigor.
The NCI-backed Molecular Targets Platform streamlines and catalyzes drug development by integrating pediatric cancer targets and pathways. This platform empowers researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.
A study by UT Southwestern researchers found an 'infodemic' of misinformation and disinformation on Twitter using #scamdemic and #plandemic hashtags, with 80% of users left to post false information. The work aims to combat echo chambers and promote accurate health messaging on social media.
Microglia that express the APOE4 gene cannot metabolize lipids normally, leading to a buildup of excess lipids that interferes with nearby neurons' ability to communicate. Restoring normal lipid metabolism in microglia may help treat some symptoms of Alzheimer's disease.
A new Oregon State University study found significant differences in hop aroma profiles between Oregon and Washington-grown hops, affecting beer flavor. The research suggests that regional identity, similar to terroir in wine, can be attributed to specific growing environments.
Researchers examine voting decisions when favored candidates commit moral transgressions, identifying key factors affecting support. Strong ideological identity and severity of transgression influence voter loyalty, with significant differences between conservatives and liberals.
Researchers at Dartmouth Cancer Center developed a new approach for detecting and quantifying tumor heterogeneity in breast cancer. High levels of heterogeneity are linked to poor patient outcomes, while specific proteins regulate its extent. The study aims to utilize this approach in therapeutic decision-making.
Researchers have developed a novel dual-atom catalyst design that can reduce the environmental impact of ammonia production. The new design uses a hybrid of iron and molybdenum to activate dinitrogen, resulting in a more efficient and eco-friendly method for ammonia synthesis.
Researchers developed a monoclonal antibody that binds E-cadherin, strengthening cell adhesion and preventing cancer metastasis. The antibody, 19A11, has two binding modes that increase adhesive strength through salt bridge formation.
Researchers developed a method to produce generic CAR T cells from induced pluripotent stem cells (iPS cells), which could be produced at scale for multiple patients. The new cells showed enhanced anti-tumor activity and comparable efficacy to current clinical-grade cells.
Researchers successfully engineered E. coli collected from human and mice gut microbiomes, showing potential to treat diseases such as diabetes. The engineered bacteria retain their activity for the entire lifetime of the host and positively influence diabetes progression in mice.
New research suggests that plant-based beef alternatives could reduce US carbon footprint by 2.5-13.5%, mostly by decreasing cow numbers. However, this shift could disrupt the agricultural workforce, threatening up to 1.5 million industry jobs and exacerbating issues like fair wages and health equity.
Researchers have developed a new chip-based beam steering device that eliminates aliasing errors, enabling high-quality beam steering over large fields of view. The device, published in Optica, has the potential to revolutionize lidar applications in autonomous driving, virtual reality, and biomedical sensing.
A recent study from the University of Geneva suggests that ketamine's therapeutic use may be safe due to its limited impact on dopamine levels and neuronal communication. The research found that ketamine triggers a short increase in dopamine, but also inhibits a specific receptor that prevents addiction progression.
New research reveals that only 1 in 5 Syrian children living in refugee camps exhibit resilience to mental health problems. The study found that factors such as the child's environment, caregiver interactions, and access to resources significantly impact their ability to recover from war trauma.
A recent study published by the German Cancer Research Center found that inflammation in early life leads to a permanent decline in functional blood stem cells, suppressing their ability to regenerate. Mice exposed to inflammatory challenges developed clinically relevant features of aging, including anemia and decreased number of cells...
A new study reveals that droughts in the Amazon rainforest can lead to a ripple effect, causing widespread damage and biodiversity loss. The research team used network analysis to understand the complex workings of the forest's moisture recycling system.
The study investigated the effects of combined endocrine-disrupting chemicals (EDCs) on liver function and metabolic homeostasis in mice models. Significant changes were observed at high EDC exposure levels, including liver weight increase, lipid buildup, and elevated blood glucose levels.
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
A computational modeling study explores the relationship between desire for more and happiness, finding a potential bias in our pursuit of pleasure. The research suggests that this bias can lead to unhappiness, highlighting the importance of balance and moderation.
Scientists at KAUST have successfully created a semiconductor material with multiple exciton generation, resulting in a photocurrent quantum efficiency of over 100%. This breakthrough could lead to improved solar cells and light-harvesting applications.
Researchers have mapped RNA diversity in human tissues at unprecedented depth, discovering tens of thousands of novel transcripts. The study used long read sequencing to catalog the genetic code's transcripts, shedding light on how genetic and environmental differences affect gene regulation.
The Gerlich Group at IMBA found that histone acetylation establishes a sharp surface boundary on chromosomes, resisting microtubule perforation. Chromatin phase separation and DNA looping by condensin cooperates to build mitotic chromosomes with unique physical properties.
Researchers found higher levels of brain cell damage and inflammation markers in women with severe preeclampsia compared to those with uncomplicated pregnancies. The study used health record data from the Rochester Epidemiology Project and explored extracellular vesicles as potential early risk indicators.
The Nature's Notebook platform has collected over 30 million phenological records, enabling data-driven natural resource management. The platform is well-suited for answering well-defined questions but faces limitations in addressing unplanned queries due to spatial and temporal unevenness and species biases.
Scientists have identified possible 'thermal refugia' where coral reefs are more likely to survive warming oceans. An interactive global atlas has been created with locations of these areas, providing a starting point for conservation efforts.
A new study of over 8 million pregnancies found that pregnant women with inflammatory bowel disease (IBD) are at a higher risk of gestational diabetes, postpartum hemorrhage, and other complications. IBD can also lead to longer hospital stays and increased medical costs.
PubCaseFinder, a clinical decision support system, has been updated to provide more precise phenotyping and automated differential diagnosis. The new version enables users to filter ranked lists using causative genes, modes of inheritance, and disease names, making it easier for medical professionals to diagnose rare and genetic diseases.
Researchers discovered that giant viruses, known as bacteriophages, construct a shielded compartment that acts like a nucleus in human cells, protecting their genetic material. The nuclear-like structure allows certain components inside while serving as a defense mechanism against bacterial threats.
The researchers developed a versatile model that takes into account factors such as infection rates, mortality, and recovery. They found that limiting contacts through quarantine is effective in reducing disease incidence and suppressing the virus.
A team of researchers from Boston University and EcoHealth Alliance will develop models to predict disease emergence and spread. They aim to identify location hotspots for pathogen emergence and determine the most effective pandemic mitigation strategies using data from COVID-19, H1N1 flu, and Ebola Virus Disease.
A study published in Neurology found that factors such as educational attainment, occupation, and social activities can create a 'cognitive reserve' that protects against Alzheimer's disease. Participants with higher childhood cognitive skills, education, and social engagement showed less cognitive decline over time.
Using a new technology dubbed OrganEx, Yale researchers restored blood circulation and cellular functions in pigs up to an hour after death. The findings may help extend the health of human organs during surgery and expand the availability of donor organs.
Researchers have centralized over 300 key figures in the Human Impacts Database, providing information on global plastic production, standing livestock population, and sea level rise. The database aims to promote collective quantitative literacy of the Anthropocene.
Researchers used a spin-based amplifier to constrain hypothetical axions, providing a way to explore promising parameter space. They showed that long-lived nuclear spins can enhance exotic signals by a factor of over 40.
A team led by Northwestern University captured millimeter-wavelength light from a neutron star merger for the first time, revealing one of the most energetic short-duration gamma-ray bursts. The discovery opens up new study areas, as scientists can now observe more of these events with ALMA and other telescope arrays.
Researchers uncovered the sophisticated mechanism of bacterial Tc toxin's action by utilizing cryo-EM and protein NMR 3D snapshots. The subunits assemble like a syringe, triggering the release of toxic enzymes that disturb cytoskeleton regulation, leading to paralysis.
A team of researchers found that two SARS-CoV-2 proteins, NSP6 and ORF7a, are essential for activating the NF-κB pathway, leading to elevated cytokine levels. The study suggests that targeting this pathway may offer a strategy to stop the virus.
A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity. The new method, developed by Xiaoping Bao, mass-produces CAR-neutrophils from human pluripotent stem cells with superior and specific antitumor activities against glioblastoma.
Ben-Gurion University researchers Dr. Moti Salti and Dr. Dafna Bergerbest propose a framework to objectively compare subjective experiences and reveal their neuronal basis. They focus on numerosity as a field where objective criteria can be established, aiming to map individual transfer-functions at both behavioral and neuronal levels.
A new Curtin-led study found that young girls are just as likely to experience language difficulties despite more boys being referred for support services. The study, published in the Journal of Paediatrics and Child Health, identified smoking during pregnancy as a significant predictor of DLD.
A team of UNLV physicists has replicated room-temperature superconductivity at the lowest pressure ever recorded, building on their 2020 landmark discovery. By tuning the composition of carbon, sulfur, and hydrogen, scientists have produced a material that retains its state of superconductivity at lower pressures.
A study of 2,031 U.S. adults found that half intended to get their child vaccinated, but only one-fifth planned to do so within three months. The findings highlight the need for increased efforts to boost parental confidence in COVID-19 vaccines for children under four years old.
A new study reveals that many perimenopausal women are using medical cannabis as an adjunct treatment for menopause-related symptoms, with the most common indications being sleep disturbances and mood/anxiety.
Researchers at Helmholtz Munich discover vitamin K's ability to inhibit ferroptotic cell death and identify the warfarin-insensitive enzyme FSP1. This finding may lead to novel therapeutic strategies for diseases associated with ferroptosis.
Researchers at the University of Cambridge have developed a smart lighting system based on quantum dots, which can dynamically reproduce daylight conditions in a single light. The system achieves excellent color rendering, a wider operating range than current technology, and a wide spectrum of white light customization.
Researchers recorded millimeter-wavelength light from a fiery explosion caused by the merger of a neutron star with another star, confirming it as one of the most energetic short-duration gamma-ray bursts ever observed. The results reveal that the explosion left behind one of the most luminous afterglows on record.
Researchers found that adjusting sowing dates for wheat in eastern India can increase production by 69% while maintaining rice productivity. The study provides new recommendations for rice sowing dates and cultivar types to accommodate earlier wheat planting.
A recent study published in PLOS Global Public Health found a correlation between perceived stress and hair cortisol concentration in Mexican and Icelandic women. The research suggests that cortisol levels, often associated with stress, can be detected in an individual's hair.
A USTC research team has elucidated the high-resolution structures of the PIN1 protein and its interaction with auxin and inhibitor NPA, shedding light on the mechanism of auxin transport. The study provides a new method for studying auxin transport using mammalian HEK293F cells.