Researchers found that high levels of both amyloid and tau proteins impair memory functions, but only when amyloid burden is also high. The study suggests that anti-amyloid therapies may be beneficial in reducing memory impairment in the early stages of Alzheimer's disease.
The Johns Hopkins-developed sensor combines accuracy levels approaching PCR testing with the speed of rapid antigen tests, offering a strong advantage over existing methods. It can be used for mass testing in disposable chip formats or on rigid or flexible surfaces.
A recent study published in Translational Psychiatry found that pharmacogenetic testing significantly improved symptoms in patients with treatment-resistant depression. The study involved 276 patients and showed a nearly two-fold increase in remission rates compared to treatment as usual.
Researchers used machine learning to predict the most important factors underlying heavy metal pollution remediation in biochar-treated soils. Biochar nitrogen content and application rate were found to be the most crucial features in determining HM immobilization, with soil properties also playing a significant role.
Researchers at TUM have developed a new process for producing ethanol from waste wood and hydrogen, resulting in a lower cost compared to traditional methods. The process has the potential to reduce greenhouse gas emissions by 75% and can be used as a low-carbon fuel alternative.
Researchers have created a biobank of breast cancer organoids from 87 patient tumor samples, including nearly half that are 'triple negative', an aggressive form of the disease. The biobank allows scientists to test specific drugs on those cancers in a dish, potentially leading to better treatment options.
Colorado State University researchers have developed a system that creates renewable energy while diverting waste from landfills, producing valuable products like sustainable aviation fuel and cleaning solvents. The ReSOURCE system can offset the carbon dioxide equivalent of 6.2 million cars a year.
A recent study found that formerly incarcerated men face a dilemma when deciding whether to use their prison credentials, which can signal redeemable qualities but also perpetuate negative stereotypes. Changing credential names or having them issued by external organizations may provide short-term solutions to overcome these issues.
Dr. Elaine S. Jaffe is being recognized for her pioneering work in hematopathology, including the discovery of novel pathological entities and her development of standardized diagnostic criteria for lymphoma and leukemia. She has also made significant contributions to advancing cancer research, diagnosis, treatment, and prevention.
A study found that Listeria monocytogenes survives better at lower storage temperatures in both cured and soft cheeses. The bacteria can thrive in these conditions, posing a risk to public health despite refrigeration.
A large population-based study found chronic low back pain (CLBP) associated with reduced brain volume in pain-processing areas, including the ventrolateral prefrontal cortex and amygdala. This association remained significant after adjusting for sociodemographic, health, and lifestyle factors.
Researchers are combining optogenetics and fMRI to study the links between brain activity and behavior. This hybrid approach allows for targeted manipulation and monitoring of brain function in awake and behaving rodents, providing valuable insights into neural mechanisms.
A new study discovered a previously unknown mechanism in roundworms that protects their egg cells from division errors, which could lead to new strategies for combatting infertility in humans. The study found that removing certain proteins allowed another motor protein to kick in as a backup, restoring the spindle structure and allowin...
A recent study found that child abuse investigations by Child Protective Services (CPS) do not necessarily prevent poor sexual health outcomes in adolescent girls. In fact, the researchers discovered that girls who underwent investigation were more likely to experience adverse sexual health outcomes, including STIs and pregnancy, befor...
A study identifies new biomarkers that predict the presence of subclinical atherosclerosis, providing a non-invasive way to detect cardiovascular disease. The research team analyzed blood plasma samples and validated three proteins as biomarkers, improving the prediction of cardiovascular risk.
Researchers developed a foldable sensor sheet using kirigami principles, enabling wearable devices to conform to the human body and detect electrocardiographic signals. The sensor measures 200 square millimeters and can accurately relay heart data across multiple people, making it suitable for early diagnosis of disease.
Researchers found that an appreciation of the US dollar leads to higher stock returns, while a decline in local currency stock returns accompanies a weaker dollar. Emerging market economy stocks with high dollar beta tend to have higher average returns.
Daily physical activity has been associated with a lower risk of disabling dementia among Japanese adults. Researchers found that moderate-to-vigorous physical activity was inversely related to the risk of developing severe cognitive decline.
A new study by a University of Georgia researcher finds that plastic bag bans or fees can lead to an increase in the sale of smaller trash bags, potentially offsetting any reduction in plastic waste. Sales of larger trash bags remain relatively unchanged.
A study led by Max Planck researchers found that parrots with large relative brain sizes have longer lifespans, averaging up to 30 years. This suggests that increased cognitive ability may help parrots navigate threats and enjoy longer lives.
A new study found that women's health research is disproportionately focused on reproductive years, particularly pregnancy, leaving few articles on major causes of illness and death. Non-communicable diseases, such as cancer and cardiovascular disease, are poorly covered in women's health publications.
The study demonstrates the potential of using 'translating' nanoparticles to facilitate communication between bacteria and yeast, enabling applications in medicine, agriculture, and synthetic biology. The team's findings pave the way for regulating interactions between bacteria and human cells.
A study published in European Heart Journal found that serum sodium levels can help identify adults with a greater chance of experiencing heart disease. The research suggests that staying well-hydrated and consuming sufficient amounts of fluids throughout life may also reduce the risk of severe heart problems in the future.
Researchers at Lund University have found a link between microRNA levels and insulin secretion in type 2 diabetes. By reducing the levels of miR-200c, they were able to increase insulin secretion in human cells.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
Researchers observed rapid electron precipitation from low-Earth orbit using the ELFIN mission, which was caused by whistler waves affecting electrons in the Earth's magnetosphere. The findings demonstrate that whistler waves are responsible for far more electron rain than current theories and space weather models predict.
A team of researchers has developed a MEMS scanning lidar that can detect objects reliably even in shaky environments. The long-range MEMS lidar prototype uses a digital controller to suppress errors caused by vibrations, allowing for stable 3D imaging and object detection.
A new literature review of 90 research papers found that changes in income have a major impact on child abuse and neglect rates. Improvements in income reduce the numbers being harmed, while reductions increase them.
Researchers at Martin Luther University Halle-Wittenberg create a new shape-stabilized phase change material that can absorb significantly more heat and is made of harmless substances. The material, which can be used as large panels integrated into walls, can store up to 24 times more heat than conventional concrete or wallboard.
Researchers have designed a manganese dioxide/carbon nanosheet composite material to address electrode morphology and size distribution issues. The composite exhibits superior electrochemical properties, including higher specific capacitance, better multiplicative performance, and lower internal resistance.
A recent study examined changes in suicide rates in Japan from 2009 to 2021, including during the COVID-19 pandemic. The findings indicate a significant increase in suicides during this period, particularly among young people and those with mental health conditions.
Chronic skin wounds and biofilm infections pose significant challenges in healthcare. A new NIH-funded project aims to develop a novel class of molecules targeting bacterial iron homeostasis to combat these infections. The researchers have identified proof-of-concept small molecules that can inhibit the BfrB-Bfd protein-protein interac...
Developers are integrating optical coherence tomography (OCT) machines into sensor packages to create fast and accurate LiDAR systems. These advancements enable robots and cars to see the world in a more natural and safe manner, improving interaction with humans.
A new study by researchers from the Annenberg Public Policy Center finds that exposure to alternative health media can affect beliefs about consequential health-care issues like vaccination. After Dr. Mehmet Oz endorsed the MMR (measles-mumps-rubella) vaccine on a March 2019 episode of “The Dr. Oz Show,” significantly more people in hi...
Researchers at Insilico Medicine have used AI to identify potential targets that are implicated in multiple age-related diseases and also play a role in the basic biology of aging. The study resulted in the identification of 69 high-confidence targets with potential high druggability.
A new study suggests that people with type 1 diabetes who have high levels of psychological resilience are more likely to manage their condition successfully. The research found that those with low resilience also had poorer blood sugar control after two years.
Researchers have discovered two distinct classes of cancer-associated fibroblasts that accumulate in the pancreatic tumor microenvironment and play opposing roles. The study suggests that targeting these unique cell populations may improve treatment outcomes for pancreatic cancer patients.
Financial markets are highly efficient, making it challenging for investors to predict performance and achieve lasting profits. Research reveals that pockets of predictability are interspersed with periods of little to no evident predictability, self-extinguishing due to competitors emulating edges.
A new app called Metaboseek has been developed to streamline the analysis of comparative metabolomics data, helping researchers identify valuable compounds. The app was created by a postdoctoral research associate and is now essential to his lab's work.
A new study reveals AI's potential in reducing workload for radiologists and improving breast cancer detection rates, with favorable histopathologic characteristics associated with better prognosis. The technology has shown encouraging results for cancer detection, but evidence related to its use in real screening settings is limited.
A study by Ohio State University researcher Yasuyuki Motoyama found that small, high-growth firms in Columbus moved either downtown or to the suburbs, often near their original location. The study suggests that these businesses can drive local economic growth and contribute to regional development.
Researchers used AI to detect dialects in zebra finch songs, showing they play a key role in mate choice. Females prefer males who sing the same dialect as their parents, indicating cultural trait importance over physical appearance.
Seismologists have developed methods to take wave signals from seismometers and reverse engineer features of the medium they pass through, known as seismic tomography. A new full-waveform inversion model uses 3D wave simulations and data sensitivities at the global scale to improve the resolution of current seismic models.
Researchers advocate for a paradigm shift in forecasting corrosion damage within reinforced concrete structures, citing the flaws of using a single theoretical concept. A multiscale, multidisciplinary approach is needed to quantify corrosion rates and develop reliable forecast models.
The project aims to replace fossil materials with innovative bio-based materials from agricultural tree crops. Poplars are grown on poorly nutrient-supplied soils and used to develop sustainable products, including furniture and household items.
A rehabilitation psychologist's role is to guide patients through the process of rehab and recovery, addressing cognitive, behavioral, and emotional barriers that hinder progress. These experts can help individuals adjust to a new diagnosis, stay motivated during recovery, and deal with the emotional aftermath of hospitalization.
Researchers at Penn Medicine have developed a new approach to alter immune cells for CAR T cell therapy in just 24 hours, cutting manufacturing time from nine to 14 days. This could make the therapy more cost-effective and accessible to more patients.
Research found that invasive earthworms significantly reduce the number of insects, biomass, and species richness above ground in Canadian forests. The study suggests that changes in soil conditions caused by earthworms may also affect vegetation, but no significant alteration was detected.
Researchers at University of Gothenburg found that process water from the food industry can be used as fertilizer in land-based seaweed cultivation, increasing growth rates by over 60% and protein content quadrupled. This sustainable approach could provide an alternative source of protein in future foods.
Researchers at Temple University found that individuals with prior COVID-19 infection experienced rapid antibody production after the first vaccine dose, but showed little increase after the second dose. This contrasts with those without a history of infection, who exhibited massive responses after the second dose.
Researchers developed an estimation strategy to maximize accuracy while minimizing cost of soil carbon sampling, leveraging publicly available data. The new approach reduces the number of samples needed by up to 28% compared to random selection.
Researchers have discovered that UV-LED lights can inactivate coronaviruses and HIV within seconds, making them a promising tool for disinfecting public spaces. The study found that repeated exposure to UV light is key to catching virus particles, and the lights are easy to retrofit into existing fixtures.
Katalin Karikó, a Hungarian-born biochemist, received the 2022 Vilcek Prize for Excellence in Biotechnology for her decades-long research leading to the development of safe and effective mRNA vaccines. Her work has had a profound impact on culture and society, particularly in the fight against COVID-19.
A new study on Mars' ice deposits provides insight into the planet's past climate, matching layers to Martian orbital dynamics with unprecedented resolution. The findings help scientists understand Mars' climate history and identify potential periods of habitability.
Researchers from around the world have developed new breeding tools to help potato breeders adapt their crops to a changing climate. The collaboration identified useful traits, such as local adaptability and climate flexibility, in wild varieties of potatoes, which can be used to cut down on the time and cost of developing new cultivars.
A new study shows that a potential treatment for Alzheimer's disease, sargramostim, improves cognitive function in people with Down syndrome and normal aging mice. The drug reverses learning and memory deficits, nerve cell loss, and brain abnormalities in mouse models of Down syndrome and aging.
A large NIH-funded study found significant disparities in acute asthma care utilization among Black, Latino, and white children. Black children accessed community health centers less frequently than white children, while Latino children were more likely to visit CHCs for comprehensive care.
Scientists have developed a new approach to expand the target range of CRISPR/Cas systems, allowing for slight variations in target DNA while maintaining local specificity. This technology could help realize the potential of CRISPR/Cas-based gene therapy and pathogen diagnosis, particularly for diagnostics.
Researchers found that one viral protein suppresses infection with hepatitis E. However, experimental studies in mice revealed a different pattern, suggesting the two viruses affect each other in complex ways. Further analysis of liver cells is needed to shed light on the underlying causes of co-infection.
A University of Illinois study found that neighborhoods with fewer trees have higher medical costs and poorer health outcomes. Residents in areas with more tree cover incur $374 less in medical costs per year, a difference that translates to approximately $194 million annually.